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31. 发明授权

US5808166A Method for producing 3,4-dihydroxy-3-cyclobutene-1,2-dione 失效
标题翻译： 3,4-二羟基-3-环丁烯-1,2-二酮的制备方法
公开(公告)号：US5808166A
公开(公告)日：1998-09-15
申请号：US973157
申请日：1997-12-03
申请人： Ikuo Shimizu , Takeshi Usami , Hiroshi Toyoda , Asako Okajima , Shoshiro Matsushita
发明人： Ikuo Shimizu , Takeshi Usami , Hiroshi Toyoda , Asako Okajima , Shoshiro Matsushita
IPC分类号： C07C45/43 , C07C45/63 , C07C49/517 , C07C49/707
CPC分类号： C07C49/707 , C07C45/43 , C07C45/63 , C07C49/517
摘要： In the formulae, R.sup.1 represents alkyl; and R.sup.2, R.sup.3 and X independently represent halogen. The present invention relates to a method for producing 3,4-dihydroxy-3-cyclobutene-1, 2-dione of general formula (II) by hydrolyzing 3-alkoxy-2, 2, 4, 4-tetrahalogenocyclobutanone derivative of general formula (I).
摘要翻译： PCT No.PCT / JP97 / 01133 Sec。 371日期1997年12月3日第 102（e）日期1997年12月3日PCT 1997年4月2日PCT公布。第WO97 / 37961号公报日期1997年10月16日<式>式中，R 1表示烷基; R2，R3和X独立地表示卤素。本发明涉及一种通式（Ⅱ）的3,4-二羟基-3-环丁烯-1,2-二酮的制备方法，该方法通过水解通式（III）的3-烷氧基-2,4,4,4-四卤代环丁酮衍生物一世）。

32. 发明授权

US5585368A 20-position modified pharmaceutically active vitamin D series compounds 失效
标题翻译： 20位修饰的药物活性维生素D系列化合物
公开(公告)号：US5585368A
公开(公告)日：1996-12-17
申请号：US80841
申请日：1993-06-24
申请人： Andreas Steinmeyer , Gunter Neef , Gerald Kirsch , Katica Schwarz , Ruth Thieroff-Ekerdt , Herbert Wiesinger , Martin Haberey
发明人： Andreas Steinmeyer , Gunter Neef , Gerald Kirsch , Katica Schwarz , Ruth Thieroff-Ekerdt , Herbert Wiesinger , Martin Haberey
IPC分类号： A61K31/59 , A61P3/08 , A61P17/00 , A61P35/00 , A61P35/02 , A61P37/00 , C07C35/32 , C07C45/30 , C07C49/172 , C07C49/517 , C07C49/753 , C07C69/013 , C07C69/12 , C07C401/00 , C07F7/18
CPC分类号： C07F7/1856 , C07C401/00 , C07C45/30 , C07C45/305 , C07C49/517 , C07C49/753 , C07C69/013
摘要： The invention relates to vitamin D derivatives, modified in 20-position, of general formula I ##STR1## in which X, Y, Z, R.sub.1, R.sub.2 as well as R.sub.3 have the meaning indicated in the description, process for their production and their use as agents for treatment of hyperproliferative diseases of the skin.
摘要翻译：本发明涉及通式I的维生素D衍生物，其中X，Y，Z，R 1，R 2以及R 3具有说明书中指出的含义，其制备方法和它们用作治疗皮肤过度增生性疾病的药剂。

33. 发明授权

US5225608A Sandalwood odorants 失效
标题翻译：檀香气味
公开(公告)号：US5225608A
公开(公告)日：1993-07-06
申请号：US741852
申请日：1991-08-06
申请人： Robert Eilerman , Philip Christenson , John Yurecko, Jr. , Thomas Zebovitz
发明人： Robert Eilerman , Philip Christenson , John Yurecko, Jr. , Thomas Zebovitz
IPC分类号： C07C43/13 , C07C43/15 , C07C43/178 , C07C43/315 , C07C45/40 , C07C45/49 , C07C45/51 , C07C45/62 , C07C45/67 , C07C45/72 , C07C47/198 , C07C47/21 , C07C49/517 , C07C49/753 , C11B9/00
CPC分类号： C11B9/0034 , C07C43/13 , C07C43/15 , C07C43/1781 , C07C43/315 , C07C45/40 , C07C45/49 , C07C45/513 , C07C45/515 , C07C45/62 , C07C45/673 , C07C45/72 , C07C47/198 , C07C47/21 , C07C49/517 , C07C49/753 , C07C2101/14 , C07C2101/16
摘要： The present invention relates to novel substituted cyclohexanol compounds possessing a sandalwood aroma which are useful as fragrance materials. The invention also provides methods for synthesis thereof through a novel aldehyde intermediate. The compounds of the invention have the formula: ##STR1## wherein A is ##STR2## and wherein R.sub.1 is methyl or ethyl, R.sub.2 -R.sub.7 are independently hydrogen or methyl with the proviso that a maximum of two of the substituents R.sub.2 -R.sub.7 are methyl, and R.sub.8 is hydrogen, lower alkyl (C.sub.1 to C.sub.5) or acyl. The invention also provides fragrance compositions which utilize the compounds of the invention to impart a sandalwood aroma to perfume compositions, colognes and perfumed articles.
摘要翻译：本发明涉及具有檀香香味的新型取代的环己醇化合物，其可用作香料。本发明还提供了通过新的醛中间体合成它们的方法。本发明的化合物具有下式：其中A为，其中R1为甲基或乙基，R2-R7独立地为氢或甲基，条件是最多两个取代基R2-R7为甲基，R8为氢，低级烷基（C1〜C5）或酰基。本发明还提供了使用本发明化合物赋予香薰组合物，古龙水和香料制品的檀香香气的香料组合物。

34. 发明授权

US4994619A Substituted cyclic ketones, substituted cyclic enones, and process for producing the same 失效
标题翻译：取代的环酮，取代的环状烯酮及其制备方法
公开(公告)号：US4994619A
公开(公告)日：1991-02-19
申请号：US207549
申请日：1988-06-16
申请人： Fumie Sato , Kazutaka Arai , Katsuaki Miyaji
发明人： Fumie Sato , Kazutaka Arai , Katsuaki Miyaji
IPC分类号： B01J23/40 , B01J25/00 , C07B61/00 , C07C45/00 , C07C45/56 , C07C45/59 , C07C45/67 , C07C49/395 , C07C49/403 , C07C49/487 , C07C49/493 , C07C49/497 , C07C49/517 , C07C49/703 , C07C49/707 , C07C49/753 , C07C67/00 , C07C69/66 , C07C221/00 , C07C225/14 , C07C253/10 , C07C255/31 , C07C323/52 , C07D261/20 , C07F7/18
CPC分类号： C07C49/493 , C07C45/56 , C07C45/673 , C07C49/497 , C07C49/707 , C07D261/20 , C07F7/1856 , Y02P20/55
摘要： The present invention relates to substituted cyclopentanone and cyclohexanone derivatives and substituted cyclopentenone and cyclohexenone derivatives, which are useful as intermediates for pharmaceutical products and agricultural chemicals and especially useful for the synthesis of prostaglandins, and also to a process for producing the same.

35. 发明授权

US4927975A Process for preparing certain decahydro-7H-3-ol-7-ones 失效
标题翻译：制备某些十氢-7H-3-醇-7-酮的方法
公开(公告)号：US4927975A
公开(公告)日：1990-05-22
申请号：US223636
申请日：1988-07-25
申请人： Marie-Madeleine Bouton , Jean Jacques , Andre Pierdet
发明人： Marie-Madeleine Bouton , Jean Jacques , Andre Pierdet
IPC分类号： C07C69/013 , A61K8/00 , A61K8/11 , A61K8/35 , A61K8/37 , A61K8/49 , A61K31/045 , A61K31/12 , A61K31/215 , A61K31/22 , A61K31/44 , A61K31/4406 , A61K31/455 , A61P17/00 , A61P43/00 , A61Q5/00 , C07C45/00 , C07C45/61 , C07C45/67 , C07C49/513 , C07C49/517 , C07C49/737 , C07C49/753 , C07C67/00 , C07C69/03 , C07C69/08 , C07C313/00 , C07C323/13 , C07D213/79 , C07D213/80 , C07D317/70 , C07D317/72 , C07C49/403 , C07C49/497 , C07C49/603
CPC分类号： C07D213/80 , C07C49/513 , C07D317/70 , C07D317/72 , C07C2103/16
摘要： Novel antiandrogenic compositions comprising an antiandrogenically effective amount of at least one compound of the formula ##STR1## wherein R is alkyl of 1 to 4 carbon atoms, R.sub.1 is alkyl of 1 to 2 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms optionally interrupted with a heteroatom, alkenyl and alkynyl of 2 to 8 carbon atoms optionally interrupted with a heteroatom, formyl and acyl of an organic carboxylic acid of 2 to 18 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.4 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, the dotted lines indicate optional presence of a double bond between the 4(5) and 5a(6) carbons and the wavy line indicates that R.sub.4 may be in the .alpha.- or .beta.-position and a non-toxic, pharmaceutical carrier or excipient and a method of treating hyperandrogenic conditions in warm-blooded animals.

36. 发明授权

US4855322A Oxygenated alkyl substituted bicyclo alkanes 失效
标题翻译：氧化烷基取代的双环烷烃
公开(公告)号：US4855322A
公开(公告)日：1989-08-08
申请号：US56467
申请日：1987-06-01
申请人： Walter J. Kasha , Chantal S. Burnison
发明人： Walter J. Kasha , Chantal S. Burnison
IPC分类号： C07C43/18 , A61K20060101 , A61K8/00 , A61K8/04 , A61K8/34 , A61K8/35 , A61K8/36 , A61K8/368 , A61K8/37 , A61K31/12 , A61K31/19 , A61K31/21 , A61P17/00 , A61Q5/02 , C07C20060101 , C07C35/02 , C07C35/23 , C07C43/12 , C07C43/13 , C07C43/162 , C07C43/178 , C07C45/29 , C07C45/30 , C07C45/45 , C07C45/63 , C07C45/65 , C07C45/67 , C07C45/68 , C07C47/28 , C07C47/38 , C07C49/385 , C07C49/443 , C07C49/477 , C07C49/493 , C07C49/497 , C07C49/503 , C07C49/513 , C07C49/517 , C07C49/523 , C07C49/587 , C07C49/743 , C07C59/00 , C07C59/205 , C07C59/76 , C07C59/82 , C07C59/88 , C07C59/90 , C07C59/92 , C07C61/00 , C07C62/00 , C07C69/14 , C07C69/24 , C07C69/716 , C07C69/74 , C07D317/72 , C07F1/02 , C11D3/48
CPC分类号： C07C43/13 , C07C43/12 , C07C43/162 , C07C43/1781 , C07C45/292 , C07C45/305 , C07C45/45 , C07C45/63 , C07C45/65 , C07C45/67 , C07C45/673 , C07C45/68 , C07C49/443 , C07C49/493 , C07C49/497 , C07C49/503 , C07C49/513 , C07C49/523 , C07C49/743 , C07C59/82 , C07C59/88 , C07C59/90 , C07C59/92 , C07D317/72 , C07F1/02 , C07C2102/44
摘要： A compound of the formula ##STR1## wherein Q is CO, CH(OR), CR(OH), or CR (OC)-lower alkyl); R is H, or C.sup.1-2 -alkyl;X is hydroxyalkyl,methoxy-C.sup.2-11 -alkyl, ethoxy-C.sup.2-11 -alkyl or oxo-C.sup.2-11 -alkyl, formyl-C.sup.2-11 -alkyl,carboxy-C.sup.2-11 -alkyl or (C.sub.1-2 -alkyl) oxycarbonyl-C.sup.2-11 -alkyl;c is 1 or 2;p or w are 0, 1 or 2 and the sum of p and w is 1 to 4;and a pharmaceutically acceptable salt thereof.
摘要翻译：其中Q是CO，CH（OR），CR（OH）或CR（OC） - 低级烷基）的式（I）化合物; R为H或C 1-2 - 烷基; X是羟基烷基，甲氧基-C2-11 - 烷基，乙氧基-C2-11 - 烷基或氧代-C2-11-烷基，甲酰基-C2-11 - 烷基，羧基-C2-11 - 烷基或（C1-2 - 烷基）氧羰基-C2-11烷基; c为1或2; p或w为0,1或2，p和w的和为1〜4; 及其药学上可接受的盐。

37. 发明授权

US4744820A Cyclohexenone derivatives, their manufacture, and their use as agents for regulating plant growth 失效
标题翻译：环己烯酮衍生物，其制备及其作为调节植物生长的试剂的用途
公开(公告)号：US4744820A
公开(公告)日：1988-05-17
申请号：US14542
申请日：1987-02-13
申请人： Michael Keil , Ulrich Schirmer , Dieter Kolassa , Wilhelm Rademacher , Johann Jung
发明人： Michael Keil , Ulrich Schirmer , Dieter Kolassa , Wilhelm Rademacher , Johann Jung
IPC分类号： A01N35/06 , B01J31/00 , C07C45/00 , C07C45/45 , C07C45/51 , C07C45/54 , C07C45/71 , C07C49/517 , C07C49/523 , C07C49/577 , C07C49/583 , C07C49/753 , C07C49/757 , C07C67/00 , A01N31/06
CPC分类号： C07C49/757 , A01N35/06 , C07C45/518 , C07C45/64 , C07C49/753 , C07C2101/02 , C07C2101/16
摘要： Cyclohexenone derivatives of the formula ##STR1## where R.sup.1 is --CHO or --CH(OR.sup.3).sub.2, R.sup.2 is alkyl or alkoxyalkyl, each of 1 to 4 carbon atoms, or cyclopropyl, and R.sup.3 is alkyl of 1 to 8 carbon atoms, and salts thereof, processes for their manufacture, and their use as agents for regulating plant growth.
摘要翻译：其中R 1为-CHO或-CH（OR 3）2，R 2为1至4个碳原子的烷基或烷氧基烷基或环丙基，R 3为1至8个碳原子的烷基，及其盐，其制备方法，及其作为调节植物生长的试剂的用途。

38. 发明授权

US4482727A Certain 1,3-cyclohexanedione adducts of substituted phenoxyphenoxypropionic acids and their use as an herbicide 失效
标题翻译：取代苯氧基苯氧基丙酸的某些1,3-环己二酮加合物及其作为除草剂的用途
公开(公告)号：US4482727A
公开(公告)日：1984-11-13
申请号：US510141
申请日：1983-07-01
申请人： David L. Lee
发明人： David L. Lee
IPC分类号： A01N39/00 , A01N43/16 , C07C59/68 , C07D309/32 , C07C49/517
CPC分类号： C07D309/32 , A01N39/00 , A01N43/16 , C07C59/68
摘要： Compounds having the structural formula ##STR1## wherein R is hydrogen or halogen, R.sup.1 is halogen, R.sup.2 is hydrogen or C.sub.1 -C.sub.4 alkyl, R.sup.3 is hydrogen or C.sub.1 -C.sub.4 alkyl, and X is oxygen or methylene useful as post-emergent herbicides against annual and perennial grasses.
摘要翻译：具有结构式的化合物，其中R是氢或卤素，R 1是卤素，R 2是氢或C 1 -C 4烷基，R 3是氢或C 1 -C 4烷基，X是氧或亚甲基，其用作后芽除草剂，一年生和多年生草。

39. 发明授权

US4479966A 6,9-Methano-PGI2 analogues 失效
公开(公告)号：US4479966A
公开(公告)日：1984-10-30
申请号：US113502
申请日：1980-01-21
申请人： Masaki Hayashi , Yoshitaka Konishi , Yoshinobu Arai
发明人： Masaki Hayashi , Yoshitaka Konishi , Yoshinobu Arai
IPC分类号： A61K47/48 , C07C45/64 , C07C45/65 , C07C45/67 , C07C49/517 , C07C405/00 , C07D309/12 , C07C177/00 , C07C59/46
CPC分类号： B82Y5/00 , A61K47/48969 , C07C405/0083 , C07C45/64 , C07C45/65 , C07C45/673 , C07C49/517 , C07D309/12 , Y02P20/55
摘要： Prostaglandin I.sub.2 analogues of the formula: ##STR1## [wherein the symbol between the carbon atoms in positions 5 and 6 represents a single or double bond, Y represents ethylene or trans-vinylene, R.sup.1 represents hydrogen, alkyl of 1 to 12 carbon atoms, aralkyl of 7 to 12 carbon atoms, cycloalkyl of 4 to 7 carbon atoms optionally substituted by alkyl of 1 to 4 carbon atoms, phenyl optionally substituted by chlorine, trifluoromethyl, alkyl of 1 to 4 carbon atoms or phenyl, a --C.sub.m H.sub.2m COOR.sup.7 group (wherein m represents an integer of from 1 to 12 and R.sup.7 represents alkyl of 1 to 4 carbon atoms), a --C.sub.n H.sub.2n OR.sup.8 group (wherein n represents an integer of from 2 to 12 and R.sup.8 represents hydrogen or alkyl of 1 to 4 carbon atoms) or a ##STR2## group (wherein R.sup.9 and R.sup.10 each represent alkyl of 1 to 4 carbon atoms and n is as hereinbefore defined), R.sup.2 represents hydrogen or a hydroxy-protecting group, R.sup.3 represents hydrogen or a hydroxy-protecting group which is eliminated under acidic conditions, R.sup.4 represents hydrogen, methyl or ethyl, R.sup.5 represents a single bond or alkylene of 1 to 4 carbon atoms optionally substituted by a chlorine atom (provided that, when R.sup.5 is alkylene substituted by chlorine, R.sup.6 represents hydrogen or alkyl) R.sup.6 represents hydrogen, alkyl or 1 to 8 carbon atoms, cycloalkyl of 4 to 7 carbon atoms optionally substituted by alkyl of 1 to 8 carbon atoms, or phenyl or phenoxy optionally substituted by cholrine, trifluoromethyl or alkyl of 1 to 4 carbon atoms, and when represents a double bond that bond is E, Z or a mixture thereof and when, represents a single bond, the absolute configuration of C.sub.6 is R, S or a mixture thereof] and, when R.sup.2 and R.sup.3 represent hydrogen, cyclodextrin clathrates of such acids and esters and, when R.sup.1, R.sup.2 and R.sup.3 represent hydrogen, non-toxic salts thereof and, when R.sup.1 represents ##STR3## in which n, R.sup.9 and R.sup.10 are as hereinbefore defined, non-toxic acid addition salts thereof, are new compounds, possessing prostaglandin-like activity.

40. 发明授权

US4387250A Phosphonium salts, process for their preparation and use of same as starting materials for preparing unsaturated bicyclic compounds 失效
标题翻译：鏻盐，其制备方法和用于制备不饱和双环化合物的起始原料
公开(公告)号：US4387250A
公开(公告)日：1983-06-07
申请号：US219814
申请日：1980-12-22
申请人： Arnoldus Uijttewaal , Roger Snowden
发明人： Arnoldus Uijttewaal , Roger Snowden
IPC分类号： C07C5/00 , C07C1/00 , C07C1/32 , C07C5/25 , C07C13/32 , C07C45/67 , C07C45/69 , C07C49/457 , C07C49/517 , C07C67/00 , C07F9/54
CPC分类号： C07F9/5435 , C07C1/324 , C07C13/32 , C07C45/673 , C07C45/69 , C07C49/457 , C07C49/517 , C07C5/2562 , C07C2102/32
摘要： New phosphonium salts useful as starting materials for preparing unsaturated bicyclic compounds. Process for their preparation.
摘要翻译：新的鏻盐可用作制备不饱和双环化合物的起始原料。其准备过程

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