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1. 发明授权

US10374162B2 Fullerene derivatives 有权
公开(公告)号：US10374162B2
公开(公告)日：2019-08-06
申请号：US15312448
申请日：2015-05-26
申请人： Merck Patent GmbH , Nano-C, Inc.
发明人： Nicolas Blouin , Stephane Berny , Edward A. Jackson , Henning Richter
IPC分类号： H01L51/00 , C07C35/44 , C07C69/157 , C07C69/16 , H01L35/24 , C07C69/12 , H01L51/42
摘要： The invention relates to fullerene derivatives of formula I, to mixtures and formulations containing them, to the use of the fullerene derivatives, mixtures and formulations as organic semiconductors in, or for the preparation of electronic devices, especially organic photovoltaic (OPV) devices and organic photodetectors (OPD), and to electronic devices comprising, or being prepared from, these fullerene derivatives, mixtures or formulations.

2. 发明授权

US09573879B2 Monoesters, inner complex salts or monoester salts of hexahydro-beta-acid and application thereof as animal feed additives 有权
标题翻译：单酯，六氢-β-酸的内复合盐或单酯盐，作为动物饲料添加剂的应用
公开(公告)号：US09573879B2
公开(公告)日：2017-02-21
申请号：US15119288
申请日：2014-03-19
申请人： GUANGZHOU INSIGHTER BIOTECHNOLOGY CO., LTD.
发明人： Xianfeng Peng , Zonghua Qin , Jijun Huang
IPC分类号： C07C69/12 , C07F1/08 , C07F3/02 , C07F3/00 , C07F3/06 , C07F13/00 , C07F15/06 , C07F15/02 , C07C49/713
CPC分类号： C07C69/12 , A23K20/10 , A23K20/121 , C07C49/713 , C07C69/16 , C07C69/28 , C07C2601/16 , C07F1/08 , C07F3/003 , C07F3/02 , C07F3/06 , C07F13/005 , C07F15/025 , C07F15/065
摘要： Disclosed are monoesters, inner complex salts or monoester salts of hexahydro-β-acid, and application thereof as animal feed additives. The compounds as shown in formula (I), (II) and (III) show low toxicity or non-toxicity to animals, and have higher stability and better growth promotion effects than those disclosed in other patents, which make them more suitable to be applied as growth promoters used in feed and have a very good application prospect in cultivation industry.
摘要翻译：公开了六氢-β-酸的单酯，内复合盐或单酯盐，以及作为动物饲料添加剂的应用。式（I），（II）和（III）所示的化合物对动物的毒性或毒性低，具有比其他专利中公开的更高的稳定性和更好的生长促进效果，这使得它们更适合于用作饲料中生长促进剂，在栽培行业具有很好的应用前景。

3. 发明授权

US09440899B2 Purification method 有权
标题翻译：净化方法
公开(公告)号：US09440899B2
公开(公告)日：2016-09-13
申请号：US14569813
申请日：2014-12-15
申请人： Rohm and Haas Electronic Materials LLC
发明人： Christopher D. Gilmore , Chi-Wan Lee , Peter Trefonas, III , William Williams, III , Qiuzhe Xie
IPC分类号： C07C69/28 , C07C69/12 , C07C69/92 , C07C41/42 , B01D3/00 , C07C67/40 , C07C43/13 , C07C41/44
CPC分类号： C07C41/42 , B01D3/009 , C07C41/44 , C07C43/13 , C07C67/08 , C07C67/40 , C07C69/12 , C07C2603/50 , C07C69/24 , C07C69/78 , C07C69/76
摘要： A method of separating a secondary alcohol compound from a primary alcohol compound using selective acylation is provided.
摘要翻译：提供了使用选择性酰化从伯醇化合物中分离仲醇化合物的方法。

4. 发明授权

US09238604B2 Process and intermediates for preparing macrolactams 有权
标题翻译：制备马来酰胺的方法和中间体
公开(公告)号：US09238604B2
公开(公告)日：2016-01-19
申请号：US14239393
申请日：2012-08-16
申请人： Feng Xu , Guy Humphrey , Tao Pei , Zhiguo Jake Song , Tao Wang , Laura Artino
发明人： Feng Xu , Guy Humphrey , Tao Pei , Zhiguo Jake Song , Tao Wang , Laura Artino
IPC分类号： C07K5/08 , C07K5/10 , C07K5/12 , C07D401/12 , C07C35/04 , C07K5/083 , C07D403/12 , C07D498/16 , C07C67/14 , C07C69/013 , C07C69/12 , C07C269/04 , C07C271/34 , A61K38/00
CPC分类号： C07C35/04 , A61K38/00 , C07C67/14 , C07C69/013 , C07C69/12 , C07C269/04 , C07C271/34 , C07D403/12 , C07D498/16 , C07K5/0808 , C07K5/126
摘要： The present invention includes compounds useful as intermediates in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing macrolactams from the intermediates. One use of the methods and intermediates described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. HCV NS3 inhibitory compounds have therapeutic and research applications.
摘要翻译：本发明包括可用作制备中性物质的中间体的化合物，制备中间体的方法，以及从中间体制备大环内酯的方法。本文描述的方法和中间体的一个用途是制备能够抑制HCV NS3蛋白酶活性的大环内酰胺化合物。 HCV NS3抑制化合物具有治疗和研究应用。

5. 发明授权

US09073825B2 Methods and intermediates for preparing macrolactams 有权
标题翻译：制备大环内酯的方法和中间体
公开(公告)号：US09073825B2
公开(公告)日：2015-07-07
申请号：US14239391
申请日：2012-08-16
申请人： Nobuyoshi Yasuda , Jeffrey T. Kuethe , Guy Humphrey , Gregory L. Beutner , Yong-Li Zhong , Edward Cleator , Carl Baxter
发明人： Nobuyoshi Yasuda , Jeffrey T. Kuethe , Guy Humphrey , Gregory L. Beutner , Yong-Li Zhong , Edward Cleator , Carl Baxter
IPC分类号： A01N43/04 , A01N43/42 , C07C35/04 , C07K5/083 , C07D403/12 , C07D498/16 , C07K5/12 , C07C67/14 , C07C69/013 , C07C69/12 , C07C269/04 , C07C271/34 , A61K38/00
CPC分类号： C07C35/04 , A61K38/00 , C07C67/14 , C07C69/013 , C07C69/12 , C07C269/04 , C07C271/34 , C07D403/12 , C07D498/16 , C07K5/0808 , C07K5/126
摘要： A first aspect of the present invention describes a compound selected from group consisting of: wherein R is either H, C(O)RA, or C(O)NHCH(X)COOH; provided that X is a C2-C6 alkyl, or a C3-C8 cycloalkyl and RA is a C1-6 alkyl or aryl; These compounds are used to make Compound A
摘要翻译：本发明的第一方面描述了选自下组的化合物：其中R是H，C（O）RA或C（O）NHCH（X）COOH; 条件是X是C 2 -C 6烷基或C 3 -C 8环烷基，RA是C 1-6烷基或芳基; 这些化合物用于制备化合物A.

6. 发明申请

US20130005767A1 THERAPEUTIC COMPOUNDS 审中-公开
标题翻译：治疗化合物
公开(公告)号：US20130005767A1
公开(公告)日：2013-01-03
申请号：US13616017
申请日：2012-09-14
申请人： David W. Old , Vinh X. Ngo
发明人： David W. Old , Vinh X. Ngo
IPC分类号： A61K31/192 , A61K31/381 , C07C59/90 , C07C321/00 , C07D277/56 , A61K31/426 , C07D307/68 , A61K31/341 , C07C69/92 , A61K31/235 , C07D257/04 , A61K31/41 , C07F9/38 , C07C69/12 , A61K31/222 , C07D333/62 , C07D213/68 , A61K31/44 , C07D307/79 , A61K31/343 , C07D405/12 , A61K31/4709 , C07D215/20 , A61K31/47 , C07D409/12 , A61P27/02 , C07D333/40
CPC分类号： C07D409/12 , C07C51/47 , C07C59/72 , C07D213/61 , C07D213/64 , C07D215/26 , C07D217/24 , C07D257/04 , C07D277/56 , C07D307/68 , C07D307/79 , C07D333/40 , C07D333/62 , C07D405/12 , C07D417/12 , C07F9/3834 , C07F9/58
摘要： Disclosed herein are compounds of the formula or salts or bioisosteres thereof. Therapeutic methods, medicaments, and compositions related thereto are also disclosed.
摘要翻译：本文公开的是式的化合物或其盐或生物电子等排体。还公开了与其相关的治疗方法，药物和组合物。

7. 发明申请

US20050209101A1 Process and apparatus for fluid bed reactions 审中-公开
标题翻译：流化床反应的方法和装置
公开(公告)号：US20050209101A1
公开(公告)日：2005-09-22
申请号：US11124141
申请日：2005-05-09
申请人： Stanley Becker , Timothy Bristow , Robert Clarke , Michele Fiorentino , David Newton , Ian Reid , Bruce Williams
发明人： Stanley Becker , Timothy Bristow , Robert Clarke , Michele Fiorentino , David Newton , Ian Reid , Bruce Williams
IPC分类号： B01J8/24 , B01J8/18 , B01J8/22 , C07B61/00 , C07C51/215 , C07C51/25 , C07C53/08 , C07C67/05 , C07C67/055 , C07C69/12 , C07C69/15 , C07C253/24 , C07C253/26 , C07C255/08 , C08G85/00
CPC分类号： C07C253/26 , B01J8/1818 , B01J8/22 , B01J2208/00115 , B01J2208/00884 , B01J2219/00263 , C07C51/215 , C07C51/252 , C07C253/24 , Y02P20/582 , C07C57/145 , C07C53/08 , C07C255/08
摘要： A process and apparatus for contacting (a) at least one gaseous reactant and (b) at least one liquid selected from the group consisting of reactants, coolants and mixtures thereof in the presence of a fluidised bed of catalyst, in which the liquid is introduced into the reactor through at least one inlet located within the fluidisation zone and the gaseous reactant is introduced into the reactor through at least one inlet located within the fluidisation zone adjacent the support means.
摘要翻译：一种用于在（a）至少一种气体反应物和（b）在其中引入液体的催化剂流化床的存在下将选自反应物，冷却剂及其混合物的至少一种液体接触的方法和装置通过位于流化区内的至少一个入口进入反应器，并且通过位于邻近支撑装置的流化区内的至少一个入口将气态反应物引入反应器。

8. 发明授权

US5958376A Iodinated X-ray contrast media 失效
标题翻译：碘化X射线造影剂
公开(公告)号：US5958376A
公开(公告)日：1999-09-28
申请号：US793927
申请日：1997-06-27
申请人： Anna Rydbeck , Torsten Almen , Mikkel Thaning , Sven Goran Andersson , Lars-Goran Wistrand , Klaes Golman
发明人： Anna Rydbeck , Torsten Almen , Mikkel Thaning , Sven Goran Andersson , Lars-Goran Wistrand , Klaes Golman
IPC分类号： A61K49/04 , C07C33/46 , C07C43/295 , C07C49/255 , C07C49/83 , C07C69/02 , C07C69/12 , C07C233/25 , C07C235/16 , C07C237/46 , C07C275/28 , C07C275/40 , C07C275/42 , C07C307/10 , C07C311/29 , C07C317/22 , C07C233/00 , C07C273/00
CPC分类号： C07C237/46 , A61K49/0433 , C07C233/25 , C07C235/16 , C07C275/42
摘要： The invention provides iodinated bis phenyl compounds, useful as X-ray contrast agents, of formula (I) (wherein each C.sub.6 R.sub.5 moiety may be the same or different; each denotes a hydrogen or iodine atom or a group M, two or three non-adjacent R groups on each C.sub.6 R.sub.5 moiety denoting iodine atoms and one, two or three R groups on each C.sub.6 R.sub.5 moiety denoting M groups; X denotes a group providing a 1, 2 or 3 atom chain linking the two C.sub.6 R.sub.5 groups, preferably where X is or contains in the bridging chain a carbonyloxy group each C.sub.6 R.sub.5 group being a triodophenyl group or a group in which each R is other than hydrogen; and each M is independently a non-ionic hydrophilic moiety, M preferably being a non-ionic hydrophilic moiety comprising a monohydroxy- or polyhydroxy-alkyl group) and isomers, especially stereoisomers and rotamers, thereof. ##STR1##
摘要翻译： PCT No.PCT / GB95 / 02264 Sec。 371日期：1997年6月27日 102（e）日期1997年6月27日PCT提交1995年9月22日PCT公布。公开号WO96 / 09285 日期：1996年3月28日本发明提供了可用作式（I）的X射线造影剂的碘化双苯基化合物（其中每个C 6 R 5部分可以相同或不同;各自表示氢或碘原子或基团M，每个C6R5部分上两个或三个不相邻的R基团，表示碘原子，每个C6R5部分上含有一个，两个或三个R基团，表示M基团; X表示提供连接两个C 6 R 5基团的1,2或3个原子链的基团，优选其中X是桥连环中或在桥连环中含有碳氧基，每个C 6 R 5基团是三苯基或每个R不是氢的基团;每个M独立地是非离子亲水部分，M优选是非离子亲水部分，包含单羟基或多羟基 - 烷基的离子亲水部分）和异构体，特别是立体异构体和旋转异构体。

9. 发明授权

US5324863A Process for the production of di-trimethylolpropane 失效
标题翻译：二羟甲基丙烷生产工艺
公开(公告)号：US5324863A
公开(公告)日：1994-06-28
申请号：US30020
申请日：1993-03-24
申请人： Carl-Axel Sjogreen , Goran Axelsson
发明人： Carl-Axel Sjogreen , Goran Axelsson
IPC分类号： C07B61/00 , C07C41/09 , C07C41/14 , C07C41/42 , C07C43/10 , C07C43/13 , C07C67/29 , C07C67/54 , C07C69/12 , C07C69/21
CPC分类号： C07C41/09 , C07C67/08 , C07C67/28
摘要： Process for the production of di-trimethylolpropane (di-TMP), which comprises subjecting a solution containing less than 3 per cent by weight, preferably less than 1 per cent by weight of water, free trimethylolpropane (TMP) and/or partial ester between TMP and a monocarboxylic acid or its anhydride having 1-4 carbon atoms in the chain, which partial ester on average contains 1.0-2.5, preferably 1.0-2.0 ester groups per molecule to an etherification reaction by heating to 50.degree.-200.degree. C., preferably 70.degree.-190.degree. C. in the presence of an acid catalyst in solid state or in dissolved state until at most 30%, preferably at most 15% of the total content of free TMP and partial ester of TMP in the solution has been etherified to free di-TMP and partial ester of di-TMP respectively, at the same time continuously removing etherification water formed at the etherification reaction under vacuum at a pressure of 0.1-200 mm Hg, preferably 0.1-50 mm Hg or by an azeotropic distillation by means of a compound such as hexane, toluene, xylene or the like forming an azeotropic mixture, and recovering free di-TMP and di-TMP bonded as a partial ester respectively from the reaction mixture in a suitable way.
摘要翻译： PCT No.PCT / SE91 / 00589。 371日期1993年3月24日 102（e）1993年3月24日PCT 1991年9月9日PCT公布。公开号WO91 / 10633 日期：1991年7月25日。用于生产二 - 三羟甲基丙烷（二-TMP）的方法，其包括使含有少于3重量％，优选小于1重量％水的溶液，游离的三羟甲基丙烷（TMP ）和/或TMP与单羧酸或其酸酐在链中具有1-4个碳原子的部分酯，该偏酯平均每分子含有1.0-2.5，优选1.0-2.0个酯基，通过加热至 50℃-200℃，优选70℃-190℃，在酸性催化剂存在下，以固态或溶解状态，直至游离TMP和部分的总含量的至多30％，优选至多15％已经将溶液中的TMP酯醚化以分别释放di-TMP和di-TMP的部分酯，同时在0.1-200mm Hg，优选0.1的压力下，在真空下连续除去醚化反应生成的醚化水 -50 mm Hg或共沸d 通过形成共沸混合物的己烷，甲苯，二甲苯等化合物进行蒸馏，分别以合适的方式从反应混合物中回收作为偏酯结合的游离二-TMP和二-TMP。

10. 发明授权

US5296630A Process for continuously producing an anhydrous methyl acetate/methanol mixture 失效
标题翻译：连续生产无水乙酸甲酯/甲醇混合物的方法
公开(公告)号：US5296630A
公开(公告)日：1994-03-22
申请号：US488276
申请日：1990-03-02
申请人： Heinz Erpenbach , Klaus Gunther , Gerog Kohl
发明人： Heinz Erpenbach , Klaus Gunther , Gerog Kohl
IPC分类号： B01J27/02 , B01D3/14 , B01J27/16 , C07B61/00 , C07C20060101 , C07C27/00 , C07C67/03 , C07C67/08 , C07C67/54 , C07C69/12 , C07C69/14
CPC分类号： C07C67/08 , C07C67/54 , Y02P20/582
摘要： A process for continuously producing an anhydrous methyl acetate/methanol mixture by esterifying acetic acid and methanol in the presence of an acidic esterification catalyst is indicated, which comprises carrying out the esterification in a distillation column having n=20 to 50 distillation trays,a) the acetic acid being fed together with the catalyst to a distillation tray which is at a distance of 0.5 n to 0.8 n from the still bottom,b) feeding 50 to 80% by weight of the total methanol to the still bottom and the remaining methanol to a distillation tray which is 2 to 10 trays above the acetic acid feed tray,c) feeding methanol and acetic acid into the distillation column at a molar ratio of (1.5 to 3):1,d) setting a reflux ratio of (0.75 to 1.5):1,e) taking off the anhydrous methyl acetate/methanol mixture at the top of the column andf) a water/methanol/acetic acid bottom product with the catalyst from the still bottom.
摘要翻译：指出了在酸性酯化催化剂存在下通过酯化乙酸和甲醇连续生产无水乙酸甲酯/甲醇混合物的方法，其包括在具有n = 20至50个蒸馏塔的蒸馏塔中进行酯化，a）将乙酸与催化剂一起加入蒸馏塔中，蒸馏塔与静止底部的距离为0.5〜0.8n，b）将50〜80重量％的总甲醇加入到剩余的底部，剩下的甲醇到乙酸进料塔上方为2至10个塔盘的蒸馏托盘，c）以（1.5-3）摩尔比将甲醇和乙酸进料到蒸馏塔中：d）设定回流比为（0.75 至1.5）：1）e）在柱顶部除去无水乙酸甲酯/甲醇混合物，f）与底部催化剂的水/甲醇/乙酸底物产物。

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