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1. 发明授权

US5228898A Substituted bicycloheptandione derivatives 失效
标题翻译：取代的双环蛋白衍生物
公开(公告)号：US5228898A
公开(公告)日：1993-07-20
申请号：US651266
申请日：1992-02-03
申请人： Akiyoshi Ueda , Shigemi Suga , Hiroyuki Adachi , Toshio Aihara , Kazuyuki Tomida , Hideki Yamagishi , Hideo Hosaka
发明人： Akiyoshi Ueda , Shigemi Suga , Hiroyuki Adachi , Toshio Aihara , Kazuyuki Tomida , Hideki Yamagishi , Hideo Hosaka
IPC分类号： C07D239/26 , A01N31/06 , A01N35/06 , A01N37/18 , A01N37/34 , A01N37/42 , A01N41/06 , A01N41/08 , A01N41/10 , A01N43/40 , A01N43/54 , A01N43/56 , A01N43/76 , A01N43/78 , C07C20060101 , C07C45/67 , C07C49/323 , C07C49/433 , C07C49/477 , C07C49/517 , C07C49/733 , C07C49/747 , C07C49/792 , C07C49/813 , C07C49/83 , C07C49/84 , C07C65/36 , C07C67/30 , C07C69/76 , C07C201/12 , C07C205/45 , C07C205/46 , C07C253/30 , C07C255/56 , C07C309/86 , C07C317/24 , C07C317/44 , C07C323/22 , C07C323/52 , C07D213/50 , C07D213/61 , C07D213/70 , C07D231/16 , C07D239/34 , C07D239/38 , C07D239/52 , C07D239/56 , C07D239/58 , C07D277/24 , C07D277/34 , C07D521/00
CPC分类号： C07D213/70 , A01N35/06 , A01N37/18 , A01N37/42 , A01N41/06 , A01N41/10 , A01N43/40 , A01N43/56 , A01N43/78 , C07C205/45 , C07C255/56 , C07C317/24 , C07C45/673 , C07C45/676 , C07C49/433 , C07C49/477 , C07C49/517 , C07C49/733 , C07C49/747 , C07C49/792 , C07C49/813 , C07C49/84 , C07C65/36 , C07C69/76 , C07D213/50 , C07D213/61 , C07D231/16 , C07D277/34 , C07C2102/20
摘要： This invention relates to substituted bicycloheptadione derivatives with high herbicidal activity which are represented by general formula (I) ##STR1## (where R.sup.1 is a lower alkyl group, a phenyl group which may be substituted, an aralkyl group which may be substituted, or a heterocyclic group which may be substituted;R.sup.2 is, same or different, a halogen, an alkoxy group, an alkylthio group, an alkylsulfonyl group, an alkyl group, an alkoxyalkyl group, or an alkoxylcarbonyl group, and n is 0 to 4;R.sup.3 and R.sup.4 are, same or different, hydrogen or a lower alkyl group).
摘要翻译： PCT No.PCT / JP90 / 00850 Sec。一九九二年二月三日 102（e）日期1993年2月3日PCT Filed 1990年6月29日PCT公布。公开号WO91 / 00260 PCT 1991年1月10日。本发明涉及通式（I）表示的具有高除草活性的取代二环庚二酮衍生物（Ⅰ）（其中R1是低级烷基，可被取代的苯基，可被取代的芳烷基或可被取代的杂环基; R 2相同或不同，为卤素，烷氧基，烷硫基，烷基磺酰基，烷基，烷氧基烷基或烷氧基羰基基团，n为0至4; R 3和R 4相同或不同，为氢或低级烷基）。

2. 发明授权

US3579588A 6,6,7,7-tetrachlorobicyclo(3.2.0) heptan-2-one 失效
标题翻译： 6,6,7,7-TETRACHLOROBICYCLO（3.2.0）HEPTAN-2-ONE
公开(公告)号：US3579588A
公开(公告)日：1971-05-18
申请号：US3579588D
申请日：1968-07-24
申请人： DOW CHEMICAL CO
发明人： DILLING WENDELL L
IPC分类号： C07C45/69 , C07C49/477 , C07C49/00 , B01J1/10
CPC分类号： C07C49/477 , C07C45/69
摘要： THE PRESENT DISCLOSURE IS DIRECTED TO THE COMPOUND 6,6,7,7-TETRACHLOROBICYCLO(3.2.3)HEPTAN-2-ONE, ITS METHOD OF PREPARATION AS WELL AS ITS USE AS A BACTERICIDE AND FUNGICIDE.

3. 发明授权

US6075015A Vitamin D compounds and method of preparing these compounds 失效
标题翻译：维生素D化合物及其制备方法
公开(公告)号：US6075015A
公开(公告)日：2000-06-13
申请号：US863947
申请日：1997-05-27
申请人： Jose P. Sestelo , Antonio Mourino , Jose L. Mascarenas , Sebastianus J. Halkes , Jan Zorgdrager , Gerhardus D. H. Dijkstra , Jan-Paul van de Velde
发明人： Jose P. Sestelo , Antonio Mourino , Jose L. Mascarenas , Sebastianus J. Halkes , Jan Zorgdrager , Gerhardus D. H. Dijkstra , Jan-Paul van de Velde
IPC分类号： C07C35/32 , C07C45/29 , C07C49/477 , C07C49/513 , C07C401/00 , A61K31/59
CPC分类号： C07C401/00 , C07C35/32 , C07C45/292 , C07C49/477 , C07C49/513 , Y10S514/861 , Y10S514/863
摘要： Vitamin D.sub.3 analogues of the formula (I): ##STR1## wherein R.sub.1 is hydrogen or hydroxy, R.sub.2 is (C.sub.1 -C.sub.3)alkyl, hydroxy(C.sub.1 -C.sub.3)alkyl, (C.sub.1 -C.sub.2)alkoxymethyl, (C.sub.2 -C.sub.3)alkenyl, or (C.sub.2 -C.sub.3)alkynyl, R.sub.3 is a branched or unbranched, saturated or unsaturated aliphatic 3- to 5- membered hydrocarbon or oxahydrocarbon biradical, having at least 3 atoms in the main chain and being optionally substituted with one or more substituents selected from epoxy, fluoro and hydroxy, R.sub.4 is sec. or tert. (C.sub.3 -C.sub.6)alkyl or (C.sub.3 -C.sub.6)cycloalkyl, A and B are each individually hydrogen or methyl, or A and B together from methylene. The compounds of the present invention exhibit pharmacotherapeutic activities, including in particular, the treatment of osteoporosis, renal osteodystrophy, osteomalacia, skin disorders such as psoriasis and other hyperproliferative skin diseases, eczema and dermatitis, nmyopathy, leukemia, breast and colon cancer, osteosarcomas, squamous cell carcinomas, melanoma, certain immunological disorders, and transplant rejections. Several methods of synthesis, including reaction of an ester compound of general formula (IX) with an inorganometallic compound of formula (III) followed by deprotection or, alternatively, first finalization of the C.sub.17 -side chain are also disclosed.
摘要翻译：式（I）的维生素D3类似物：其中R1是氢或羟基，R2是（C1-C3）烷基，羟基（C1-C3）烷基，（C1-C2）烷氧基甲基，（C2-C3）烯基或（ C 2 -C 3）炔基，R 3是支链或非支链的饱和或不饱和的脂族3-至5-元烃基或氧杂烃双基，在主链中具有至少3个原子，并且任选地被一个或多个选自环氧基，氟和羟基，R4是秒。或叔。（C 3 -C 6）烷基或（C 3 -C 6）环烷基，A和B各自独立地为氢或甲基，或A和B一起为亚甲基。本发明的化合物具有药物治疗活性，特别包括治疗骨质疏松症，肾性骨营养不良，骨软化症，皮肤疾病如牛皮癣和其它过度增生性皮肤病，湿疹和皮炎，纳米病，白血病，乳腺和结肠癌，骨肉瘤，鳞状细胞癌，黑素瘤，某些免疫性疾病和移植排斥。还公开了几种合成方法，包括通式（IX）的酯化合物与式（III）的无机金属化合物反应，然后进行脱保护，或者也可以首先终止C17-侧链。

4. 发明授权

US5449668A Vitamin D compounds and method of preparing these compounds 失效
标题翻译：维生素D化合物及其制备方法
公开(公告)号：US5449668A
公开(公告)日：1995-09-12
申请号：US70998
申请日：1993-06-04
申请人： Jose P. Sestelo , Antonio Mourino , Jose L. Mascarenas , Sebastianus J. Halkes , Jan Zorgdrager , Gerhardus D. H. Dijkstra , Jan-Paul van de Velde
发明人： Jose P. Sestelo , Antonio Mourino , Jose L. Mascarenas , Sebastianus J. Halkes , Jan Zorgdrager , Gerhardus D. H. Dijkstra , Jan-Paul van de Velde
IPC分类号： C07C35/32 , C07C45/29 , C07C49/477 , C07C49/513 , C07C401/00 , A61K31/24 , A61K31/205
CPC分类号： C07C401/00 , C07C35/32 , C07C45/292 , C07C49/477 , C07C49/513 , Y10S514/861 , Y10S514/863
摘要： The invention relates to a new vitamin D compound of the general formula ##STR1## wherein: R.sub.1 is a hydrogen atom or a hydroxy group;R.sub.2 is a (C.sub.1 -C.sub.3)alkyl group, a hydroxy(C.sub.1 -C.sub.3)alkyl group, a (C.sub.1 -C.sub.2)alkoxymethyl group or a (C.sub.2 -C.sub.3)alkenyl or alkynyl group;R.sub.3 is a branched or non-branched, saturated or unsaturated aliphatic 3- to 5 -membered hydrocarbon or oxahydrocarbon biradical, having at least 3 atoms in the main chain and being optionally substituted with one or more substituents selected from epoxy, fluoro and hydroxy;R.sub.4 is a sec. or tert. (C.sub.3 -C.sub.6)alkyl group or a (C.sub.3 -C.sub.6)cycloalkyl group; andA and B are each individually hydrogen atoms or methyl groups, orA and B form together a methylene group.The invention further relates to a method of preparing these compounds and to their use in pharmacotherapy and cosmetics.
摘要翻译：本发明涉及通式（I）的新的维生素D化合物，其中：R1是氢原子或羟基; R2是（C1-C3）烷基，羟基（C1-C3）烷基，（C1-C2）烷氧基甲基或（C2-C3）烯基或炔基; R3是在主链中具有至少3个原子且任选地被一个或多个选自环氧基，氟和羟基的取代基取代的支化或非支化的饱和或不饱和脂族3-至5-元烃或二烃基双基。 R4是秒或叔。（C 3 -C 6）烷基或（C 3 -C 6）环烷基; A和B各自为氢原子或甲基，或A和B一起形成亚甲基。本发明还涉及这些化合物的制备方法及其在药物治疗和化妆品中的应用。

5. 发明授权

US2658079A Process of halogenating the pi-position of camphor and its alpha-haloderivatives 失效
标题翻译：卤化樟脑及其α-卤素衍生物的脯氨酸的方法
公开(公告)号：US2658079A
公开(公告)日：1953-11-03
申请号：US22900351
申请日：1951-05-29
申请人： TAKEDA CHEMICAL INDUSTRIES LTD
发明人： HIROSHI NISHIMITSU , MASAMOTO NISHIKAWA , HIKOICHI HAGIHARA
IPC分类号： C07C45/63 , C07C49/477
CPC分类号： C07C49/477 , C07C45/63

6. 发明授权

US5077274A Bicyclo[10.2.0]tetradecan-13-one, fragrance use thereof, process for preparing same and dichlorinated intermediate used in said process 失效
标题翻译：双环[10.2.0]十四烷-13-酮，其香料用途，其制备方法和用于所述方法的二氯化中间体
公开(公告)号：US5077274A
公开(公告)日：1991-12-31
申请号：US596506
申请日：1990-10-12
申请人： William J. Evers , Howard H. Heinsohn, Jr.
发明人： William J. Evers , Howard H. Heinsohn, Jr.
IPC分类号： C07C45/45 , C07C45/65 , C07C49/385 , C07C49/477 , C11B9/00
CPC分类号： C11B9/0049 , C07C45/455 , C07C45/65 , C07C49/385 , C07C49/477
摘要： Described is the novel compound, bicyclo[10.2.0]tetradecan-13-one having the structure: ##STR1## as well as the use thereof in augmenting or enhancing the aroma of consumable materials including perfume compositions, colognes and perfumed articles (including solid or liquid anionic, cationic, nonionic or zwitterionic detergents, fabric softeners, cosmetic powders and hair preparations). Also described is a process for preparing said bicyclo[10.2.0]tetradecan-13-one using as a reaction intermediate the compound having the structure: ##STR2##
摘要翻译：描述了具有以下结构的新型化合物双环[10.2.0]十四烷-13-酮，以及其在增加或增强消耗材料的香气中的用途，包括香料组合物，古龙水和香料制品（包括固体或液体阴离子，阳离子，非离子或两性离子洗涤剂，织物柔软剂，化妆粉和头发制剂）。还描述了制备所述双环[10.2.0]十四烷-13-酮的方法，该方法使用具有以下结构的化合物进行反应：

7. 发明授权

US4304944A Bicyclic ketones 失效
标题翻译：双环酮
公开(公告)号：US4304944A
公开(公告)日：1981-12-08
申请号：US124526
申请日：1980-02-25
申请人： Brian J. Willis , Robert G. Eilerman
发明人： Brian J. Willis , Robert G. Eilerman
IPC分类号： C07C45/62 , C07C45/67 , C07C49/443 , C07C49/633 , C11B9/00 , C07C49/477 , C07C49/623
CPC分类号： C11B9/0049 , C07C45/62 , C07C45/67 , C07C49/443 , C07C49/633
摘要： Novel bicyclic ketones having the structure: ##STR1## wherein R is a C.sub.1 -C.sub.5 alkyl group, either straight-chain or branched, and saturated analogs have been prepared. These compounds exhibit floral and woody odors and/or desirable flavor properties, and are useful as fragrance and/or flavor materials. The compounds are conveniently prepared from alkylidene cyclopentanones by Michael addition with alkyl metalloacetoacetates and subsequent decarboxylative cyclization of the adducts. The saturated analogs may then be prepared by hydrogenation.
摘要翻译：具有以下结构的新型双环酮：其中R是直链或支链的C 1 -C 5烷基和饱和类似物。这些化合物表现出花香和木质气味和/或期望的风味特性，并且可用作香料和/或香料材料。通过与烷基金属乙酰乙酸酯进行迈克尔加成，随后加成的脱羧环化，方便地由亚烷基环戊酮制备化合物。然后可以通过氢化制备饱和类似物。

8. 发明授权

US3701800A Cis 1-methyl-2-isopropenyl-cyclobutyl acetic acid 失效
标题翻译： CIS 1-甲基-2-异丙基 - 环丙基乙酸
公开(公告)号：US3701800A
公开(公告)日：1972-10-31
申请号：US3701800D
申请日：1971-06-25
申请人： ZOECON CORP
发明人： ZURFLUH RENE C , SIDDALL JOHN B
IPC分类号： C07C45/59 , C07C45/63 , C07C45/65 , C07C49/477 , C07C49/633 , C07C61/16 , C07C69/74
CPC分类号： C07C49/477 , C07C45/59 , C07C45/63 , C07C45/65 , C07C49/633
摘要： STEREOSPECIFIC SYNTHESIS OF SEX ATTRACTANT COMPONENT OF THE BOLL WEEVIL BY HALOGENATION OF 6-METHYLBICYCLO (4,2,0)OCTAN-2-ON OR KETAL THEREOF, DEHYDROHALOGENATION, METHYLATION OF KETONE, MILD OXIDATIVE CLEAVAGE TO DESIRED CIS ISOMER, WITTIG CONVERSION OF KETON TO METHYLENE AND REDUCTON OF ACID OR ESTER THEREOF TO CIS 2-(1''-METHYL-2''ISOPROPENYL-CYCLOBUTYL) ETHANOL.

9. 发明申请

US20050222274A1 Hyperforin halogenated derivatives, the use thereof and formulations containing them 失效
标题翻译： Hyperforin卤化衍生物，其使用和含有它们的制剂
公开(公告)号：US20050222274A1
公开(公告)日：2005-10-06
申请号：US10511894
申请日：2003-04-15
申请人： Ezio Bombardelli , Paolo Morazzoni , Antonella Riva , Nicola Fuzzati
发明人： Ezio Bombardelli , Paolo Morazzoni , Antonella Riva , Nicola Fuzzati
IPC分类号： A61K36/18 , A61K31/122 , A61P25/24 , A61P25/28 , C07C45/51 , C07C45/62 , C07C45/63 , C07C45/78 , C07C49/477 , C07C49/507 , C07C49/513 , C07C49/693 , C07C49/713 , C07C49/743 , C07C49/293 , A61K31/12
CPC分类号： C07C49/743 , C07C45/512 , C07C45/62 , C07C45/63 , C07C45/78 , C07C49/477 , C07C49/513 , C07C49/693 , C07C49/713
摘要： Hyperforin and adhyperforin halogenated derivatives of general formula (I) in which X, R and R1 have the meanings as defined in the disclosure, the process for the preparation thereof and the use thereof in the pharmaceutical and/or nutritional field, in particular in the treatment of depression, and Alzheimer's disease.
摘要翻译：其中X，R和R 1具有如本公开内容中所定义的含义的通式（I）的高效蛋白和高效皂化衍生物，其制备方法及其在药物和/ 或营养场，特别是治疗抑郁症和阿尔茨海默病。

10. 发明授权

US4855322A Oxygenated alkyl substituted bicyclo alkanes 失效
标题翻译：氧化烷基取代的双环烷烃
公开(公告)号：US4855322A
公开(公告)日：1989-08-08
申请号：US56467
申请日：1987-06-01
申请人： Walter J. Kasha , Chantal S. Burnison
发明人： Walter J. Kasha , Chantal S. Burnison
IPC分类号： C07C43/18 , A61K20060101 , A61K8/00 , A61K8/04 , A61K8/34 , A61K8/35 , A61K8/36 , A61K8/368 , A61K8/37 , A61K31/12 , A61K31/19 , A61K31/21 , A61P17/00 , A61Q5/02 , C07C20060101 , C07C35/02 , C07C35/23 , C07C43/12 , C07C43/13 , C07C43/162 , C07C43/178 , C07C45/29 , C07C45/30 , C07C45/45 , C07C45/63 , C07C45/65 , C07C45/67 , C07C45/68 , C07C47/28 , C07C47/38 , C07C49/385 , C07C49/443 , C07C49/477 , C07C49/493 , C07C49/497 , C07C49/503 , C07C49/513 , C07C49/517 , C07C49/523 , C07C49/587 , C07C49/743 , C07C59/00 , C07C59/205 , C07C59/76 , C07C59/82 , C07C59/88 , C07C59/90 , C07C59/92 , C07C61/00 , C07C62/00 , C07C69/14 , C07C69/24 , C07C69/716 , C07C69/74 , C07D317/72 , C07F1/02 , C11D3/48
CPC分类号： C07C43/13 , C07C43/12 , C07C43/162 , C07C43/1781 , C07C45/292 , C07C45/305 , C07C45/45 , C07C45/63 , C07C45/65 , C07C45/67 , C07C45/673 , C07C45/68 , C07C49/443 , C07C49/493 , C07C49/497 , C07C49/503 , C07C49/513 , C07C49/523 , C07C49/743 , C07C59/82 , C07C59/88 , C07C59/90 , C07C59/92 , C07D317/72 , C07F1/02 , C07C2102/44
摘要： A compound of the formula ##STR1## wherein Q is CO, CH(OR), CR(OH), or CR (OC)-lower alkyl); R is H, or C.sup.1-2 -alkyl;X is hydroxyalkyl,methoxy-C.sup.2-11 -alkyl, ethoxy-C.sup.2-11 -alkyl or oxo-C.sup.2-11 -alkyl, formyl-C.sup.2-11 -alkyl,carboxy-C.sup.2-11 -alkyl or (C.sub.1-2 -alkyl) oxycarbonyl-C.sup.2-11 -alkyl;c is 1 or 2;p or w are 0, 1 or 2 and the sum of p and w is 1 to 4;and a pharmaceutically acceptable salt thereof.
摘要翻译：其中Q是CO，CH（OR），CR（OH）或CR（OC） - 低级烷基）的式（I）化合物; R为H或C 1-2 - 烷基; X是羟基烷基，甲氧基-C2-11 - 烷基，乙氧基-C2-11 - 烷基或氧代-C2-11-烷基，甲酰基-C2-11 - 烷基，羧基-C2-11 - 烷基或（C1-2 - 烷基）氧羰基-C2-11烷基; c为1或2; p或w为0,1或2，p和w的和为1〜4; 及其药学上可接受的盐。

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