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1. 发明申请

US20080257496A1 TEMPERATURE SETTING METHOD FOR THERMAL PROCESSING PLATE, TEMPERATURE SETTING APPARATUS FOR THERMAL PROCESSING PLATE, AND COMPUTER-READABLE STORAGE MEDIUM 有权
标题翻译：热处理板的温度设定方法，热处理板的温度设定装置和计算机可读存储介质
公开(公告)号：US20080257496A1
公开(公告)日：2008-10-23
申请号：US12103276
申请日：2008-04-15
申请人： Megumi JYOUSAKA , Masahide Tadokoro , Yoshitaka Konishi , Shinichi Shinozuka , Kunie Ogata
发明人： Megumi JYOUSAKA , Masahide Tadokoro , Yoshitaka Konishi , Shinichi Shinozuka , Kunie Ogata
IPC分类号： C23F1/00 , G06F19/00
CPC分类号： H01L21/67248
摘要： A temperature setting method of the present invention includes the steps of: measuring states of an etching pattern within the substrate for a substrate for which a series of photolithography processing including thermal processing and an etching treatment thereafter have been finished; calculating temperature correction values for regions of a thermal processing plate from measurement result of the states of the etching pattern within the substrate using a function between correction amounts for the states of the etching pattern and the temperature correction values for the thermal processing plate; and setting the temperature for each of the regions of the thermal processing plate by each of the calculated temperature correction values.
摘要翻译：本发明的温度设定方法包括以下步骤：测量用于其后完成了包括热处理和蚀刻处理的一系列光刻处理的基板的蚀刻图案的状态; 使用蚀刻图案的状态的校正量和热处理板的温度校正值之间的函数，从衬底内的蚀刻图案的状态的测量结果计算热处理板的区域的温度校正值; 并且通过计算的每个温度校正值来设定热处理板的每个区域的温度。

2. 发明申请

US20080257495A1 TEMPERATURE SETTING METHOD FOR THERMAL PROCESSING PLATE, TEMPERATURE SETTING APPARATUS FOR THERMAL PROCESSING PLATE, AND COMPUTER-READABLE STORAGE MEDIUM 有权
标题翻译：热处理板的温度设定方法，热处理板的温度设定装置和计算机可读存储介质
公开(公告)号：US20080257495A1
公开(公告)日：2008-10-23
申请号：US12099970
申请日：2008-04-09
申请人： Masahide Tadokoro , Megumi Jyousaka , Yoshitaka Konishi , Shinichi Shinozuka , Kunie Ogata
发明人： Masahide Tadokoro , Megumi Jyousaka , Yoshitaka Konishi , Shinichi Shinozuka , Kunie Ogata
IPC分类号： C23F1/00 , G06F19/00
CPC分类号： H01L21/67248 , G03F7/70483
摘要： In the present invention, the line widths within a substrate of an etching pattern are measured for a substrate for which photolithography processing and an etching treatment thereafter have been finished. The line width measurement results are converted into the line widths of a resist pattern using relational expressions which have been obtained in advance. From the converted line widths of the resist pattern, coefficients of a polynomial function indicating variations within the substrate are calculated. Next, a function between line width correction amounts for the resist pattern and temperature correction values is used to calculate temperature correction values for the regions of the thermal plate to bring the coefficients of the polynomial function close to zero. Based on each of the calculated temperature correction values, the temperature for each of the regions is set.
摘要翻译：在本发明中，对于其后的光刻处理和蚀刻处理结束的基板测量蚀刻图案的基板内的线宽。使用预先获得的关系式将线宽测量结果转换成抗蚀剂图案的线宽。根据抗蚀剂图案的转换线宽，计算表示衬底内的变化的多项式函数的系数。接下来，使用抗蚀剂图案的线宽校正量和温度校正值之间的函数来计算热板的区域的温度校正值，以使多项式函数的系数接近零。基于每个计算的温度校正值，设定每个区域的温度。

3. 发明申请

US20080116195A1 TEMPERATURE SETTING METHOD OF THERMAL PROCESSING PLATE, COMPUTER-READABLE RECORDING MEDIUM RECORDING PROGRAM THEREON, AND TEMPERATURE SETTING APPARATUS FOR THERMAL PROCESSING PLATE 有权
标题翻译：热处理板的温度设定方法，计算机可读记录介质记录程序及温度设定装置
公开(公告)号：US20080116195A1
公开(公告)日：2008-05-22
申请号：US11934303
申请日：2007-11-02
申请人： Megumi Jyousaka , Yoshitaka Konishi
发明人： Megumi Jyousaka , Yoshitaka Konishi
IPC分类号： H05B1/02
CPC分类号： G05D23/1932 , H01L21/67248
摘要： In the present invention, a thermal plate of a PEB unit is divided into a plurality of thermal plate regions, and a temperature is settable for each of the thermal plate regions. A temperature correction value for adjusting the temperature within the thermal plate is settable for each of the thermal plate regions of the thermal plate. The line widths within the substrate which has been subjected to the photolithography process are measured, and an improvement in-plane tendency Za improved by change of the temperature settings is subtracted from an in-plane tendency Z of the measured line widths within the substrate to calculate an in-plane tendency Zb of the line widths within the substrate after change of temperature settings. The improvement in-plane tendency Za is calculated using the following expression. Za=−1×α×MT (α: a resist heat sensitivity, M: a calculation model, and T: temperature correction values for thermal plate regions)
摘要翻译：在本发明中，将PEB单元的热板分割为多个热板区域，并且可以对每个热板区域设定温度。用于调节热板内的温度的温度校正值可针对热板的每个热板区域而设定。测量已进行了光刻处理的基板内的线宽，并从基板内的被测线宽度的面内倾向Z中减去由温度设定的变化而提高的面内倾向Za，在温度设置更改后，计算衬底内线宽的面内倾向Zb。使用以下表达式计算平面内倾向Za的改善。 <？in-line-formula description =“In-line Formulas”end =“lead”？> Za = -1xalphaxMT（α：抗蚀剂热敏性，M：计算模型，T：热板区域的温度校正值）<？in-line-formula description =“In-line Formulas”end =“tail”？>

4. 发明授权

US06914087B2 Process for producing powder coating composition, powder coating composition, and method of coating film formation 有权
标题翻译：粉末涂料组合物的制备方法，粉末涂料组合物和涂膜成膜方法
公开(公告)号：US06914087B2
公开(公告)日：2005-07-05
申请号：US09926632
申请日：2001-03-29
申请人： Katsuhiko Okada , Tetsuro Agawa , Kouji Shinohara , Yoshitaka Konishi
发明人： Katsuhiko Okada , Tetsuro Agawa , Kouji Shinohara , Yoshitaka Konishi
IPC分类号： B05D7/24 , C09D5/03 , C09D7/12 , C09D201/02 , C09D201/06 , B05D1/36 , C08L63/00
CPC分类号： C09D5/03
摘要： A powder coating is provided which does not require a long complicated production process, can be produced easily and with no danger of gelling occurring during production, and which forms a paint film with superior smoothness and with no film defects such as bubbles or pinholes. A powder coating raw materials solution comprising as essential constituents a room temperature solid main constituent resin (A) with a curable reactive group, a room temperature solid curing agent (B) which reacts with the curable reactive group of the main constituent resin (A), and an organic solvent (C), is spray dried at a temperature at which the main constituent resin (A) and the curing agent (B) undergo no substantial curing reaction.
摘要翻译：提供粉末涂料，其不需要长的复杂生产工艺，可以容易地制备，并且在生产过程中不会发生胶凝的危险，并且形成具有优异平滑度和没有膜缺陷如气泡或针孔的漆膜。一种粉末涂料原料溶液，其包含具有可固化反应性基团的室温固体主要构成树脂（A）和与主要构成树脂（A）的可固化反应性基团反应的室温固体固化剂（B）作为必要组分）和有机溶剂（C）在主要构成树脂（A）和固化剂（B）不发生实质固化反应的温度下进行喷雾干燥。

5. 发明授权

US6114338A Heterocyclic compounds 失效
标题翻译：杂环化合物
公开(公告)号：US6114338A
公开(公告)日：2000-09-05
申请号：US417910
申请日：1999-10-13
申请人： Sung Jai Lee , Yoshitaka Konishi , Orest Taras Macina , Kigen Kondo , Dingwei Tim Yu , Manton Rodgers Frierson , Masafumi Sugitani
发明人： Sung Jai Lee , Yoshitaka Konishi , Orest Taras Macina , Kigen Kondo , Dingwei Tim Yu , Manton Rodgers Frierson , Masafumi Sugitani
IPC分类号： A61K31/505 , A61P1/16 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/28 , A61P29/00 , A61P37/04 , A61P43/00 , C07D487/04 , C07D495/04 , C07D487/02
CPC分类号： C07D487/04 , C07D495/04
摘要： The compounds of the formula: ##STR1## wherein Y is bond or alkylene;Z is bond, alkylene or vinylene;E is(i) 4-15 membered, unsaturated, partially saturated or fully saturated, mono or bicyclic hetero ring containing as hetero atoms, one or two nitrogen atoms, one or two oxygen atoms or one sulfur atom,(ii) 4-15 membered, unsaturated or partially saturated, mono or bicyclic carbocyclic ring, or(iii) --OR.sup.4 (in which R.sup.4 is hydrogen atom, alkyl or alkyl substituted by a hydroxy group);Cyc is benzene, pyridine or imidazole;R.sup.1 is hydrogen or alkyl;R.sup.2 is hydrogen, alkyl, alkoxy or halogen atom;R.sup.3 is hydrogen, alkyl, alkoxy or --COOR.sup.5 (in which R.sup.5 is hydrogen or alkyl);with the proviso that(1) a Cyc ring should not bond to Z through a nitrogen atom in the Cyc ring when Z is vinylene and that(2) Y is not a single bond, when E is --OR.sup.4 ;or pharmaceutically acceptable acid addition salts thereof, pharmaceutically acceptable salts thereof, or hydrates thereof; have inhibitory effect on cGMP-PDE, or additionally on TXA.sub.2 synthetase.
摘要翻译：下式的化合物：其中Y是键或亚烷基; Z是键，亚烷基或亚乙烯基; E是（i）含有杂原子，一个或两个氮原子，一个或两个氧原子或一个硫原子的4-15元，不饱和，部分饱和或完全饱和的单或双环杂环，（ii）4-15 或（iii）-OR4（其中R4为氢原子，被羟基取代的烷基或烷基）;或（iii）-OR4（其中R4为氢原子，被羟基取代的烷基或烷基）; 环是苯，吡啶或咪唑; R1是氢或烷基; R2是氢，烷基，烷氧基或卤素原子; R3是氢，烷基，烷氧基或-COOR5（其中R5是氢或烷基）; 条件是（1）当Z是亚乙烯基时，环环不应通过环中的氮原子与Z键合，并且（2）Y不是单键，当E是-OR4时; 或其药学上可接受的酸加成盐，其药学上可接受的盐或其水合物; 对cGMP-PDE或另外在TXA2合成酶具有抑制作用。

6. 发明授权

US6001830A Heterocyclic compounds 失效
标题翻译：杂环化合物
公开(公告)号：US6001830A
公开(公告)日：1999-12-14
申请号：US189843
申请日：1998-11-12
申请人： Sung Jai Lee , Yoshitaka Konishi , Orest Taras Macina , Kigen Kondo , Dingwei Tim Yu , Manton Rodgers Frierson , Masafumi Sugitani
发明人： Sung Jai Lee , Yoshitaka Konishi , Orest Taras Macina , Kigen Kondo , Dingwei Tim Yu , Manton Rodgers Frierson , Masafumi Sugitani
IPC分类号： A61K31/505 , A61P1/16 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/28 , A61P29/00 , A61P37/04 , A61P43/00 , C07D487/04 , C07D495/04 , A61K31/50
CPC分类号： C07D487/04 , C07D495/04
摘要： The compounds of the formula: ##STR1## wherein ring ##STR2## is a hetero ring containing nitrogen atom, optionally selected from ##STR3## n is 0-2; Y is bond or alkylene;Z is bond, alkylene or vinylene;E is(i) 4-15 membered, unsaturated, partially saturated or fully saturated, mono or bicyclic hetero ring containing as hetero atoms, 1 or 2 N atoms, 1 or 2 O atoms or 1 S atom,(ii) 4-15 membered, unsaturated or partially saturated, mono or bicyclic carbocyclic ring, or(iii) --OR.sup.4 (in which R.sup.4 is hydrogen atom, alkyl or alkyl substituted by a hydroxy group);Cyc is 5-7 membered, unsaturated, partially saturated or fully saturated, monocyclic hetero ring containing as hetero atoms, 1 or 2 N atoms or 5-7 membered, unsaturated or partially saturated, monocyclic carbocyclic ring;R.sup.1 is H or alkyl;R.sup.2 is H, alkyl, alkoxy or halogen atom;R.sup.3 is H, alkyl, alkoxy or --COOR.sup.5 (in which R.sup.5 is H or alkyl);with the proviso that(1) a Cyc ring should not bond to Z through a nitrogen atom in the Cyc ring when Z is vinylene and that(2) Y is not a single bond, when E is --OR.sup.4 ;or pharmaceutically acceptable acid addition salts thereof, pharmaceutically acceptable salts thereof, or hydrates thereof; have inhibitory effect on cGMP-PDE, or additionally on TXA.sub.2 synthetase.
摘要翻译：下式的化合物：其中环是含氮原子的杂环，任选地选自n是0-2; Y是键或亚烷基; Z是键，亚烷基或亚乙烯基; E是（i）含有1或2个N原子，1或2个O原子或1个S原子的4-15元，不饱和，部分饱和或完全饱和的单或双环杂环，（ii）4-15 或（iii）-OR4（其中R4为氢原子，被羟基取代的烷基或烷基）;或（iii）-OR4（其中R4为氢原子，被羟基取代的烷基或烷基）; 环是含有杂原子，1或2个N原子或5-7元不饱和或部分饱和的单环碳环的5-7元，不饱和，部分饱和或完全饱和的单环杂环; R1是H或烷基; R2是H，烷基，烷氧基或卤素原子; R3是H，烷基，烷氧基或-COOR5（其中R5是H或烷基）; 条件是（1）当Z是亚乙烯基时，环环不应通过环中的氮原子与Z键合，并且（2）Y不是单键，当E是-OR4时; 或其药学上可接受的酸加成盐，其药学上可接受的盐或其水合物; 对cGMP-PDE或另外在TXA2合成酶具有抑制作用。

7. 发明授权

US5869486A Fused pyrimidines and pyriazines as pharmaceutical compounds 失效
标题翻译：融合的嘧啶和吡嗪作为药物化合物
公开(公告)号：US5869486A
公开(公告)日：1999-02-09
申请号：US393995
申请日：1995-02-24
申请人： Sung Jai Lee , Yoshitaka Konishi , Orest Taras Macina , Kigen Kondo , Dingwei Tim Yu , Manton Rodgers Frierson , Masafumi Sugitani
发明人： Sung Jai Lee , Yoshitaka Konishi , Orest Taras Macina , Kigen Kondo , Dingwei Tim Yu , Manton Rodgers Frierson , Masafumi Sugitani
IPC分类号： A61K31/505 , A61P1/16 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/28 , A61P29/00 , A61P37/04 , A61P43/00 , C07D487/04 , C07D495/04 , C07D409/02 , A61K31/38 , C07D409/14
CPC分类号： C07D487/04 , C07D495/04
摘要： The compounds of the formula: ##STR1## wherein ring ##STR2## is a hetero ring containing nitrogen atom, optionally selected from ##STR3## n is 0-2; Y is bond or alkylene;Z is bond, alkylene or vinylene;E is(i) 4-15 membered, unsaturated, partially saturated or fully saturated, mono or bicyclic hetero ring containing as hetero atoms, 1 or 2 N atoms, 1 or 2 O atoms or 1 S atom,(ii) 4-15 membered, unsaturated or partially saturated, mono or bicyclic carbocyclic ring, or(iii) --OR.sup.4 (in which R.sup.4 is hydrogen atom, alkyl or alkyl substituted by a hydroxy group);Cyc is 5-7 membered, unsaturated, partially saturated or fully saturated, monocyclic hetero ring containing as hetero atoms, 1 or 2 N atoms or 5-7 membered, unsaturated or partially saturated, monocyclic carbocyclic ring;R.sup.1 is H or alkyl;R.sup.2 is H, alkyl, alkoxy or halogen atom;R.sup.3 is H, alkyl, alkoxy or --COOR.sup.5 (in which R.sup.5 is H or alkyl);with the proviso that(1) a Cyc ring should not bond to Z through a nitrogen atom in the Cyc ring when Z is vinylene and that(2) Y is not a single bond, when E is --OR.sup.4 ;or pharmaceutically acceptable acid addition salts thereof, pharmaceutically acceptable salts thereof, or hydrates thereof; have inhibitory effect on cGMP-PDE, or additionally on TXA.sub.2 synthetase.
摘要翻译：下式的化合物：其中环是含有氮原子的杂环，任选地选自下式：亚烷基或亚乙烯基; E是（i）含有1或2个N原子，1或2个O原子或1个S原子的4-15元，不饱和，部分饱和或完全饱和的单或双环杂环，（ii）4-15 或（iii）-OR4（其中R4为氢原子，被羟基取代的烷基或烷基）;或（iii）-OR4（其中R4为氢原子，被羟基取代的烷基或烷基）; 环是含有杂原子，1或2个N原子或5-7元不饱和或部分饱和的单环碳环的5-7元，不饱和，部分饱和或完全饱和的单环杂环; R1是H或烷基; R2是H，烷基，烷氧基或卤素原子; R3是H，烷基，烷氧基或-COOR5（其中R5是H或烷基）; 条件是（1）当Z是亚乙烯基时，环环不应通过环中的氮原子与Z键合，并且（2）Y不是单键，当E是-OR4时; 或其药学上可接受的酸加成盐，其药学上可接受的盐或其水合物; 对cGMP-PDE或另外在TXA2合成酶具有抑制作用。

8. 发明授权

US4479966A 6,9-Methano-PGI2 analogues 失效
公开(公告)号：US4479966A
公开(公告)日：1984-10-30
申请号：US113502
申请日：1980-01-21
申请人： Masaki Hayashi , Yoshitaka Konishi , Yoshinobu Arai
发明人： Masaki Hayashi , Yoshitaka Konishi , Yoshinobu Arai
IPC分类号： A61K47/48 , C07C45/64 , C07C45/65 , C07C45/67 , C07C49/517 , C07C405/00 , C07D309/12 , C07C177/00 , C07C59/46
CPC分类号： B82Y5/00 , A61K47/48969 , C07C405/0083 , C07C45/64 , C07C45/65 , C07C45/673 , C07C49/517 , C07D309/12 , Y02P20/55
摘要： Prostaglandin I.sub.2 analogues of the formula: ##STR1## [wherein the symbol between the carbon atoms in positions 5 and 6 represents a single or double bond, Y represents ethylene or trans-vinylene, R.sup.1 represents hydrogen, alkyl of 1 to 12 carbon atoms, aralkyl of 7 to 12 carbon atoms, cycloalkyl of 4 to 7 carbon atoms optionally substituted by alkyl of 1 to 4 carbon atoms, phenyl optionally substituted by chlorine, trifluoromethyl, alkyl of 1 to 4 carbon atoms or phenyl, a --C.sub.m H.sub.2m COOR.sup.7 group (wherein m represents an integer of from 1 to 12 and R.sup.7 represents alkyl of 1 to 4 carbon atoms), a --C.sub.n H.sub.2n OR.sup.8 group (wherein n represents an integer of from 2 to 12 and R.sup.8 represents hydrogen or alkyl of 1 to 4 carbon atoms) or a ##STR2## group (wherein R.sup.9 and R.sup.10 each represent alkyl of 1 to 4 carbon atoms and n is as hereinbefore defined), R.sup.2 represents hydrogen or a hydroxy-protecting group, R.sup.3 represents hydrogen or a hydroxy-protecting group which is eliminated under acidic conditions, R.sup.4 represents hydrogen, methyl or ethyl, R.sup.5 represents a single bond or alkylene of 1 to 4 carbon atoms optionally substituted by a chlorine atom (provided that, when R.sup.5 is alkylene substituted by chlorine, R.sup.6 represents hydrogen or alkyl) R.sup.6 represents hydrogen, alkyl or 1 to 8 carbon atoms, cycloalkyl of 4 to 7 carbon atoms optionally substituted by alkyl of 1 to 8 carbon atoms, or phenyl or phenoxy optionally substituted by cholrine, trifluoromethyl or alkyl of 1 to 4 carbon atoms, and when represents a double bond that bond is E, Z or a mixture thereof and when, represents a single bond, the absolute configuration of C.sub.6 is R, S or a mixture thereof] and, when R.sup.2 and R.sup.3 represent hydrogen, cyclodextrin clathrates of such acids and esters and, when R.sup.1, R.sup.2 and R.sup.3 represent hydrogen, non-toxic salts thereof and, when R.sup.1 represents ##STR3## in which n, R.sup.9 and R.sup.10 are as hereinbefore defined, non-toxic acid addition salts thereof, are new compounds, possessing prostaglandin-like activity.

9. 发明授权

US4399147A Prostaglandin 12 analogues and their pharmaceutical compositions 失效
标题翻译：前列腺素12类似物及其药物组合物
公开(公告)号：US4399147A
公开(公告)日：1983-08-16
申请号：US872635
申请日：1978-01-26
申请人： Masaki Hayashi , Yoshinobu Arai , Yoshitaka Konishi , Katsuichi Shimoji , Shuichi Ohuchida , Hirohisa Wakatsuka , Hiroyuki Ito
发明人： Masaki Hayashi , Yoshinobu Arai , Yoshitaka Konishi , Katsuichi Shimoji , Shuichi Ohuchida , Hirohisa Wakatsuka , Hiroyuki Ito
IPC分类号： C07D307/935 , A61K31/34 , A61K31/343 , A61P43/00 , C07C405/00 , C07D307/937 , A61K31/557
CPC分类号： C07D307/937 , C07C405/00
摘要： Prostaglandin I.sub.2 analogues of the formula: ##STR1## [wherein X represents trans-vinylene or an ethylene group unsubstituted or substituted by a bromine atom at the C-5 position, Y represents trans-vinylene or ethylene, R.sup.1 represents hydrogen or an alkyl group containing from 1 to 12 carbon atoms, R.sup.2 represents hydrogen or methyl or ethyl, R.sup.3 represents a single bond or an alkylene group containing from 1 to 4 carbon atoms, R.sup.4 represents hydrogen, an alkyl group containing from 1 to 8 carbon atoms, a cycloalkyl group containing from 4 to 7 carbon atoms unsubstituted or substituted by at least one alkyl group containing from 1 to 8 carbon atoms, or a phenyl or phenoxy group unsubstituted or carrying at least one substituent selected from halogen atoms, the trifluoromethyl group and alkyl groups containing from 1 to 3 carbon atoms, and the wavy line attached to the carbon atoms in positions 6, 11 and 15 depicted in the formula represents .alpha.- or .beta.-configuration or mixtures thereof] are new compounds possessing pharmacological properties typical of prostaglandins, for example PGI.sub.2, and are more stable than PGI.sub.2.
摘要翻译：前列腺素I2类似物，具有下式：其中X表示反式亚乙烯基或未被取代或被C-5位上的溴原子取代的亚乙基，Y表示反式亚乙烯基或亚乙基，R 1表示氢或烷基含有1至12个碳原子，R 2表示氢或甲基或乙基，R 3表示单键或含有1至4个碳原子的亚烷基，R 4表示氢，含有1至8个碳原子的烷基，环烷基含有未取代或被至少一个含有1至8个碳原子的烷基取代的4至7个碳原子的基团，或未取代或携带至少一个选自卤素原子的取代基的苯基或苯氧基，三氟甲基和含有 1至3个碳原子，并且连接在式中描述的6,11和15位的碳原子上的波浪线代表α-或β-构型或其混合物] 是具有典型的前列腺素的药理学性质的新化合物，例如PGI 2，并且比PGI2更稳定。

10. 发明授权

US4207332A Prostaglandin I.sub.2 analogues 失效
标题翻译：前列腺素I2类似物
公开(公告)号：US4207332A
公开(公告)日：1980-06-10
申请号：US944164
申请日：1978-09-20
申请人： Masaki Hayashi , Yoshinobu Arai , Katsuichi Shimoji , Yoshitaka Konishi , Shuichi Ohuchida , Shinsuke Hashimoto
发明人： Masaki Hayashi , Yoshinobu Arai , Katsuichi Shimoji , Yoshitaka Konishi , Shuichi Ohuchida , Shinsuke Hashimoto
IPC分类号： C07D307/935 , A61K31/34 , A61K31/343 , A61P43/00 , C07C405/00 , C07D307/937 , C07D307/93
CPC分类号： C07D307/937 , C07C405/00
摘要： Prostaglandin analogues of the general formula: ##STR1## [wherein Y represents ethylene or trans-vinylene, R.sup.1 represents a group --C.sub.m H.sub.2m COOR.sup.5, --C.sub.n H.sub.2n OR.sup.6 or ##STR2## (wherein R.sup.5 represents an alkyl group containing from 1 to 4 carbon atoms, R.sup.6 represents a hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms, R.sup.7 and R.sup.8, which may be the same or different, each represents an alkyl group containing from 1 to 4 carbon atoms, m represents an integer of from 1 to 12 and n represents an integer of from 2 to 12), R.sup.2 represents a hydrogen atom or a methyl or ethyl group, R.sup.3 represents a single bond, or an alkylene group containing from 1 to 4 carbon atoms, R.sup.4 represents a hydrogen atom, an alkyl group containing from 1 to 8 carbon atoms, a cycloalkyl group containing from 4 to 7 carbon atoms in the ring, which may be unsubstituted or substituted by at least one alkyl group containing from 1 to 8 carbon atoms, or represents a phenyl or phenoxy group which may be unsubstituted or substituted by at least one chlorine atom, trifluoromethyl group or alkyl group containing from 1 to 3 carbon atoms, the wavy line attached to the carbon atoms in positions 11 and 15 represents .alpha.- or .beta.-configuration, or mixtures thereof, and the double bond between C.sub.5 -C.sub.6 is Z] and cyclodextrin clathrates thereof, and, when R.sup.1 represents a group ##STR3## in which n, R.sup.7 and R.sup.8 are as hereinbefore defined, non-toxic acid addition salts thereof, are new compounds and possess characteristic prostaglandin-like properties.
摘要翻译：前列腺素类似物具有以下通式：其中Y表示亚乙基或反式亚乙烯基，R1表示基团-CmH2mCOOR5，-CnH2nOR6或其中R5表示含有1至4个碳原子的烷基，R6表示含有1至4个碳原子的氢原子或烷基，可以相同或不同的R 7和R 8各自表示含有1至4个碳原子的烷基，m表示1至12的整数，m表示1至12的整数， n表示2〜12的整数），R2表示氢原子或甲基或乙基，R3表示单键或含有1〜4个碳原子的亚烷基，R4表示氢原子，烷基含有1至8个碳原子的环烷基，环中含有4至7个碳原子的环烷基，其可以是未取代的或被至少一个含有1至8个碳原子的烷基取代，或表示苯基或苯氧基，可以是未取代的或未取代的由至少一个氯原子，三氟甲基或含有1至3个碳原子的烷基取代，连接到位置11和15的碳原子的波浪线表示α或β构型，或其混合物，双键 C5-C6之间是Z]和环糊精包合物，当R1代表其中n，R7和R8如上所定义的基团“IMAGE”时，其无毒的酸加成盐是新的化合物，并且具有特征性的前列腺素 - 像属性。

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