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1. 发明公开

US20230312476A1 COMPOUNDS WITH SEMIOCHEMICAL PROPERTIES AND BIOSENSORS 审中-公开
公开(公告)号：US20230312476A1
公开(公告)日：2023-10-05
申请号：US18018964
申请日：2021-07-30
申请人： ROTHAMSTED RESEARCH LIMITED
发明人： Cassie Marie SIMS , Mike BIRKETT , David WITHALL , Alistair POXON
IPC分类号： C07D221/02 , C07C49/303 , C07C35/23 , C07D335/04 , A01N31/06 , A01N43/18 , A01N43/42
CPC分类号： C07D221/02 , C07C49/303 , C07C35/23 , C07D335/04 , A01N31/06 , A01N43/18 , A01N43/42 , C07B2200/05
摘要： Provided are a compound of Formula I or Formula IA, a composition comprising a compound of Formula I or Formula IA, uses of the compounds and compositions to modulate insect behaviour and methods for modulating insect behaviour. Also provided are biosensors for detecting an analyte in a sample, uses of the biosensor, and methods for detecting an analyte in a sample.

2. 发明申请

US20100209372A1 PATCHOULOL ODORANT 有权
标题翻译： PATCHOULOL气味
公开(公告)号：US20100209372A1
公开(公告)日：2010-08-19
申请号：US12738737
申请日：2008-10-29
申请人： Robert Moretti , Olivier Etter
发明人： Robert Moretti , Olivier Etter
IPC分类号： C07C35/23 , A61K8/33 , C11D3/50 , A61L9/01
CPC分类号： C07C35/36 , C07C69/013 , C07C2602/10 , C07C2602/28 , C11B9/0053
摘要： The invention relates to the use as perfuming ingredients of 8a-alkyl-perhydro-naphthalenol derivatives, to impart odor notes of the woody-earthy type.
摘要翻译：本发明涉及作为8a-烷基 - 全氢 - 萘酚衍生物的加香成分的用途，以赋予木质土类型的气味。

3. 发明申请

US20090075859A1 FRAGRANCE COMPOSITION 有权
标题翻译： FRAGRANCE组成
公开(公告)号：US20090075859A1
公开(公告)日：2009-03-19
申请号：US11911751
申请日：2006-06-29
申请人： Naotoshi Toki , Kosaku Ishida , Kazuyuki Fukuda
发明人： Naotoshi Toki , Kosaku Ishida , Kazuyuki Fukuda
IPC分类号： A61K8/34 , A61K8/49 , C07C35/23 , A61Q11/00
CPC分类号： C11D3/50 , A61K8/34 , A61Q13/00 , C07B2200/07 , C07C29/00 , C07C2602/28 , C11B9/0053 , C11B9/0076 , C07C35/36
摘要： A fragrance composition containing 0.0005 to 10% by mass of a decalin alcohol as component (a) represented by formula (1a) and 90 to 99.9995% by mass of one or more polycyclic woody-amber fragrances as component (b) selected from the group consisting of 7-acetyl-1,2,3,4,5,6,7,8-octahydro-1,1,6,7-tetramethylnaphthalene, 1,2,3,4,4a,5,6,7-octahydro-2,5,5-trimethyl-2-naphthalenol, 1,2,3,4,4a,7,8,8a-octahydro-2,4a,5,8a-tetramethyl-1-naphthyl formate, 3a-ethyldodecahydro-6,6,9a-trimethylnaphtho[2,1-b]furan, and racemic or optically active dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan; and a cosmetic product, a household product and an environmental/sanitary product containing the fragrance composition. The fragrance composition of the present invention is a highly versatile fragrance composition that brings about an odor of natural ambergris and can attain effects to enhance warmth and an odor quality even in a small amount.
摘要翻译：作为组分（b）的含有0.0005至10质量％的作为组分（a）的十氢化萘作为组分（1a）和90至99.9995质量％的一种或多种多环琥珀香料的香料组合物，选自组由7-乙酰基-1,2,3,4,5,6,7,8-八氢-1,1,6,7-四甲基萘，1,2,3,4,4a，5,6,7- 八氢-2,5,5-三甲基-2-萘酚，1,2,3,4,4a，7,8,8a-八氢-2,4a，5,8a-四甲基-1-萘基甲酸酯，3a-乙基十二氢 -6,6,9a-三甲基萘并[2,1-b]呋喃，和外消旋或光学活性十二氢-3a,6,6,9a-四甲基萘并[2,1-b]呋喃; 和化妆品，家用产品和含有香料组合物的环保/卫生产品。本发明的香料组合物是高度通用的香料组合物，其具有天然琥珀酸的气味，并且即使少量也可获得增强温度和气味质量的效果。

4. 发明授权

US6133286A Tetrahydronaphthalene and tetrahydroquinoline compounds, their preparation and their use as leukotriene B.sub.4 (LTB.sub.4) antagonists 失效
标题翻译：四氢萘和四氢喹啉化合物，它们的制备及其作为白三烯B4（LTB4）拮抗剂的用途
公开(公告)号：US6133286A
公开(公告)日：2000-10-17
申请号：US493707
申请日：2000-01-28
申请人： Mark A. Dombroski , Kevin Koch , Anthony D. Piscopio
发明人： Mark A. Dombroski , Kevin Koch , Anthony D. Piscopio
IPC分类号： C07D263/14 , A61K31/00 , A61K31/35 , A61K31/352 , A61K31/353 , A61P11/00 , A61P11/06 , A61P29/00 , A61P37/00 , A61P37/06 , C07C35/23 , C07C35/52 , C07C39/14 , C07C39/17 , C07C39/38 , C07C65/17 , C07C65/26 , C07C65/36 , C07D311/04 , C07D311/22 , C07D311/24 , C07D311/48 , C07D311/58 , C07D413/04 , C07D215/233 , A61K31/045
CPC分类号： C07D311/22 , C07D311/58
摘要： This invention relates to novel benzopyran and other benzo-fused leukotriene B.sub.4 (LTB.sub.4) antagonists and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing such compounds or a pharmaceutically acceptable salt thereof, and to methods of using such compounds as LTB.sub.4 antagonists. The compounds and the pharmaceutically acceptable salts of this invention inhibit the action of LTB.sub.4 and are therefore useful in the treatment of LTB.sub.4 induced illnesses such as inflammatory disorders including rheumatoid arthritis, osteoarthritis, inflammatory bowel disease, psoriasis and other skin disorders such as eczema, erythema, pruritus and acne, stroke and other forms of reperfusion injury, graft rejection, autoimmune diseases, asthma, and other conditions where marked neutrophil infiltration occurs.
摘要翻译：本发明涉及新颖的苯并吡喃和其它苯并稠合白三烯B4（LTB4）拮抗剂及其药学上可接受的盐，含有这些化合物或其药学上可接受的盐的药物组合物，以及使用这些化合物如LTB4拮抗剂的方法。本发明的化合物和药学上可接受的盐抑制LTB4的作用，因此可用于治疗LTB4诱导的疾病，例如炎症性疾病，包括类风湿性关节炎，骨关节炎，炎性肠病，牛皮癣和其它皮肤疾病如湿疹，红斑，瘙痒和痤疮，中风和其他形式的再灌注损伤，移植排斥反应，自身免疫性疾病，哮喘和其他明显的嗜中性粒细胞浸润发生的病症。

5. 发明授权

US5731464A Process for preparation of indenol 失效
标题翻译：茚诺酮的制备方法
公开(公告)号：US5731464A
公开(公告)日：1998-03-24
申请号：US647854
申请日：1996-05-15
申请人： Kunio Ogasawara
发明人： Kunio Ogasawara
IPC分类号： C12P41/00 , C07C27/02 , C07C35/23 , C07C67/333 , C07C69/157 , C07C69/24 , C07C213/02 , C07C215/44 , C07C243/42 , C07C247/14 , C07C309/66 , C07C309/73 , C07D303/36 , C12R1/38 , C07C211/38 , C07D303/06
CPC分类号： C07C213/02 , C07C247/14 , C07D303/36 , C07B2200/07 , C07C2102/08
摘要： The invention relates to the preparation of (1S,2R)-cis-1-aminoindan-2-ol represented by formula (IX): ##STR1## and intermediates derived therein.
摘要翻译：本发明涉及由式（IX）表示的（1S，2R） - 顺式-1-氨基茚满-2-醇：其中衍生的中间体。

6. 发明授权

US4535192A Tertiary pentamethylindanol derivatives and organoleptic uses thereof 失效
公开(公告)号：US4535192A
公开(公告)日：1985-08-13
申请号：US671330
申请日：1984-11-14
申请人： John B. Hall , Takao Yoshida
发明人： John B. Hall , Takao Yoshida
IPC分类号： A24B15/34 , C07C35/23 , C07C35/32 , C11B9/00 , C11D3/50
CPC分类号： C11D3/50 , A24B15/345 , C07C35/23 , C07C35/32 , C11B9/0049
摘要： Described are tertiary pentamethylindanol derivatives defined according to the structure: ##STR1## wherein the dashed line represents a carbon-carbon single bond or a carbon-carbon double bond and uses thereof in augmenting or enhancing the aroma or taste of consumable materials selected from the group consisting of perfume compositions, colognes, perfumed articles, foodstuffs, smoking tobaccos and smoking tobacco compositions.

7. 发明授权

US4341908A Ambrinol and its homologues 失效
标题翻译：安珠瑞诺及其同系物
公开(公告)号：US4341908A
公开(公告)日：1982-07-27
申请号：US161329
申请日：1980-06-20
申请人： Brian J. Willis , Philip A. Christenson , Robert A. Mack
发明人： Brian J. Willis , Philip A. Christenson , Robert A. Mack
IPC分类号： C07C43/18 , C07C27/00 , C07C29/00 , C07C29/10 , C07C29/58 , C07C35/22 , C07C35/23 , C07C35/27 , C07C35/36 , C07C35/46 , C07C41/00 , C07C41/32 , C07C43/188 , C07C45/00 , C07C45/63 , C07C49/23 , C07C67/00 , C07C67/04 , C07C67/14 , C07C67/307 , C07C69/025 , C07C69/65 , C07C69/76 , C07F3/02 , C07F3/04 , C07F3/06 , C07F7/18 , C11B9/00
CPC分类号： C11B9/0053 , C07C29/00 , C07C29/58 , C07C35/36 , C07C35/46 , C07C403/16 , C07C43/188 , C07C45/63 , C07C49/23 , C07F7/1856 , C07C2101/14 , C07C2102/26
摘要： Compounds useful as fragrance materials having the structure ##STR1## wherein each of R.sub.1, R.sub.2, and R.sub.3 are hydrogen or methyl can be prepared by reacting a halogen-containing cyclohexane, having the structure ##STR2## wherein each of R.sub.1, R.sub.2, and R.sub.3 are hydrogen or methyl and X is a halogen, with a reagent capable of effecting intramolecular cyclization.
摘要翻译：可用作具有结构的芳香剂材料的化合物，其中R 1，R 2和R 3各自为氢或甲基，可以通过使具有结构“IMAGE”的含卤素的环己烷与R1，R2和R3各自反应是氢或甲基，X是卤素，具有能够进行分子内环化的试剂。

8. 发明授权

US3439102A Preventing influenza infection with aminobicyclo(3.2.2)nonanes 失效
标题翻译：用氨基胆碱（3.2.2）预防流感病毒感染
公开(公告)号：US3439102A
公开(公告)日：1969-04-15
申请号：US3439102D
申请日：1966-08-10
申请人： SMITHKLINE CORP
发明人： CHOW ALFRED W
IPC分类号： A61K31/13 , C07C29/09 , C07C29/147 , C07C35/23 , C07C51/09 , C07C51/15 , C07C51/305 , C07C51/38 , C07C51/60 , A61K27/00 , C07C87/40
CPC分类号： A61K31/13 , C07C29/09 , C07C29/147 , C07C35/23 , C07C211/19 , C07C211/25 , C07C211/38 , C07C2602/46 , C07C33/14
摘要： 1,104,058. Antiviral compositions. SMITH KLINE & FRENCH LABORATORIES. 2 Nov., 1966 [9 Nov., 1965; 20 Dec., 1965; 12 May, 1965; 10 Aug., 1366], No. 49224/66. Heading ASB. [Also in Division C2] Antiviral compositions comprise novel bicycloamines of the formulµ (where n is zero or 1; one A is NH 2 , CH 2 NH 2 , CH(CH 3 )NH 2 or NHCH 3 and the others are H; one B is NH 2 , CH(CH 3 )NH 2 or NHCH 3 and the others are H; and one C is CH 2 NH 2 and the others are H) or the known 6-aminomethylbicyclo [3.2.2] nonane, or acid-addition salts thereof and carriers. They are administered orally or intranasally. A specified ingredient is 3-aminobicyclo [3.3.1] nonane hydrochloride.

9. 发明授权

US3427353A Bicyclo(3.3.2)decane amines 失效
标题翻译： BICYCLO（3.3.2）DECANE AMINES
公开(公告)号：US3427353A
公开(公告)日：1969-02-11
申请号：US3427353D
申请日：1966-05-12
申请人： SMITHKLINE CORP
发明人： CHOW ALFRED W
IPC分类号： A61K31/13 , C07C29/09 , C07C29/147 , C07C35/23 , C07C51/09 , C07C51/15 , C07C51/305 , C07C51/38 , C07C51/60 , C07C87/40 , C07C85/00
CPC分类号： A61K31/13 , C07C29/09 , C07C29/147 , C07C35/23 , C07C211/19 , C07C211/25 , C07C211/38 , C07C2602/46 , C07C33/14
摘要： 1,104,058. Antiviral compositions. SMITH KLINE & FRENCH LABORATORIES. 2 Nov., 1966 [9 Nov., 1965; 20 Dec., 1965; 12 May, 1965; 10 Aug., 1366], No. 49224/66. Heading ASB. [Also in Division C2] Antiviral compositions comprise novel bicycloamines of the formulµ (where n is zero or 1; one A is NH 2 , CH 2 NH 2 , CH(CH 3 )NH 2 or NHCH 3 and the others are H; one B is NH 2 , CH(CH 3 )NH 2 or NHCH 3 and the others are H; and one C is CH 2 NH 2 and the others are H) or the known 6-aminomethylbicyclo [3.2.2] nonane, or acid-addition salts thereof and carriers. They are administered orally or intranasally. A specified ingredient is 3-aminobicyclo [3.3.1] nonane hydrochloride.
摘要翻译： 1,104,058。抗病毒组合物。史密斯与法国实验室。 1966年11月2日[1965年11月9日; 1965年12月20日; 1965年5月12日; 1366年8月10日，第49224/66号。标题ASB。 [也在C2部分]抗病毒组合物包含式（2）的新型双环胺，其中n为0或1;一个为NH 2，CH 2 NH 2，CH（CH 3）NH 2或NHCH 3，其余为H;一 B为NH 2，CH（CH 3）NH 2或NHCH 3，其余为H;一个C为CH 2 NH 2，其余为H）或已知的6-氨基甲基双环[3.2.2]壬烷或酸其加成盐和载体。它们口服或鼻内给药。特定成分是3-氨基双环[3.3.1]壬烷盐酸盐。

10. 发明授权

US09403777B2 Inhibitors of the influenza A virus M2 proton channel 有权
公开(公告)号：US09403777B2
公开(公告)日：2016-08-02
申请号：US14036813
申请日：2013-09-25
申请人： The Trustees Of The University Of Pennsylvania
发明人： William F. DeGrado , Jun Wang
IPC分类号： C07C255/47 , C07C61/13 , C07C211/38 , C07D223/32 , C07C49/447 , C07C49/427 , A61K31/045 , A61K31/122 , A61K31/13 , A61K31/19 , A61K31/277 , A61K31/55 , C07C35/23 , C07C49/323 , C07C49/623 , C07C211/19
CPC分类号： C07D223/32 , A61K31/045 , A61K31/122 , A61K31/13 , A61K31/19 , A61K31/277 , A61K31/55 , C07C35/23 , C07C49/323 , C07C49/427 , C07C49/447 , C07C49/623 , C07C61/13 , C07C211/19 , C07C211/38 , C07C255/47 , C07C2602/50
摘要： Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.

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