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1. 发明申请

US20190106799A1 ALUMINUM TRIHALIDE-NEUTRAL LIGAND IONIC LIQUIDS AND THEIR USE IN ALUMINUM DEPOSITION 审中-公开
公开(公告)号：US20190106799A1
公开(公告)日：2019-04-11
申请号：US16214436
申请日：2018-12-10
申请人： UT-Battelle, LLC
发明人： Sheng Dai , Xiao-Guang Sun
IPC分类号： C25D3/66 , C07C45/56 , C25D3/44 , C07C2/22
CPC分类号： C25D3/665 , C07C2/22 , C07C45/56 , C07C45/562 , C07C45/567 , C25D3/44 , C25D5/003
摘要： An ionic liquid composition comprising a complex of a trihalo aluminum (III) species with at least one organic uncharged ligand comprising a ring structure having at least three ring carbon atoms and at least one ring heteroatom selected from nitrogen and sulfur, wherein the complex is a liquid at a temperature of 100° C. or less. Methods of electroplating aluminum onto a metallic substrate using the above-described ionic liquid composition are also described.

2. 发明申请

US20150141656A1 METHODS FOR PRODUCING ORGANIC LIGHT EMITTING DIODE (OLED) MATERIALS 有权
标题翻译：用于生产有机发光二极管（OLED）材料的方法
公开(公告)号：US20150141656A1
公开(公告)日：2015-05-21
申请号：US14399285
申请日：2013-05-09
申请人： LOMOX LIMITED
发明人： Gene Carl Koch
IPC分类号： C07D277/64 , H01L51/00 , C07C1/207 , C07C69/616 , C07F7/08 , C07C45/56 , C07C45/68 , C07C57/50 , C09K11/06 , C07C5/03
CPC分类号： C07D417/08 , C07C1/2076 , C07C1/34 , C07C5/03 , C07C45/56 , C07C45/68 , C07C57/50 , C07C69/616 , C07C2601/08 , C07C2603/18 , C07C2603/78 , C07C2603/94 , C07D277/64 , C07F7/0827 , C09K11/06 , C09K2211/1011 , C09K2211/1018 , H01L51/0052 , H01L51/0058 , H01L51/0071 , H01L51/50 , H01L51/5012 , C07C13/72
摘要： Methods of producing OLED materials containing fluorene ring systems in which two alkyl substituents at the 9-position of fluorene ring are alkyl substituted through key intermediates generically represented by the formula: where X represents a substituent that increases the acidity of the hydrogen atoms on the adjoining methylene group (which is immediately adjacent the fluorene ring systems 9-position).
摘要翻译：制备含有芴环体系的OLED材料的方法，其中芴环9位上的两个烷基取代基是通过通式表示的关键中间体进行烷基取代：其中X表示增加邻位氢原子酸度的取代基亚甲基（其紧邻芴环系9位）。

3. 发明申请

US20010053852A1 Process for preparing alkyl- or aryloxyacetaldehydes 审中-公开
标题翻译：制备烷基或芳氧基乙醛的方法
公开(公告)号：US20010053852A1
公开(公告)日：2001-12-20
申请号：US09897390
申请日：2001-07-03
发明人： Karlheinz Giselbrecht , Rudolf Hermanseder
IPC分类号： C07D237/02 , C07C045/42
CPC分类号： C07C45/56 , C07C47/198 , C07C47/277
摘要： A process for preparing alkyl- or aryloxyacetaldehydes of the formula 1 where R can be an unsubstituted or mono- or polysubstituted alkyl, aryl, heteroaryl, alkaryl, alkylheteroaryl or aralkyl radical or an unsubstituted or mono- or polysubstituted heterocycle or alkyl heterocycle, which comprises reacting a compound of the formula RnullOMnullnull(II) where R is as defined above and M can be an alkali metal atom or an alkaline earth metal atom, with a compound of the formula 2 where R1 and R2 independently of one another are a C1-C6-alkyl radical or together are a C2-C6-alkylene radical and X is a halogen atom, to form the corresponding dialkylacetal of the formula 3 where R, R1 and R2 are as defined above, whereupon acetal cleavage is carried out to give the desired alkyl- or aryloxyacetaldehydes of the formula (I).
摘要翻译：制备下式的烷基 - 或芳氧基乙醛的方法，其中R可以是未取代的或单取代或多取代的烷基，芳基，杂芳基，烷芳基，烷基杂芳基或芳烷基或未取代或单取代或多取代的杂环或烷基杂环，式（I）所示的化合物，其中R如上定义，M可以是碱金属原子或碱土金属原子与下式的化合物反应，其中R 1和R 2彼此独立地为C 1 -C 6烷基或一起为C 2 -C 6亚烷基，X为卤素原子，形成相应的二烷基缩醛其中R，R 1和R 2如上所定义，由此进行缩醛裂解，得到所需的式（I）的烷基 - 或芳氧基乙醛，

4. 发明授权

US5874473A Substituted cycloalkanecarboxylic acid derivatives as matrix metalloprotease inhibitors 失效
标题翻译：取代的环烷烃羧酸衍生物作为基质金属蛋白酶抑制剂
公开(公告)号：US5874473A
公开(公告)日：1999-02-23
申请号：US864666
申请日：1997-05-28
申请人： Harold Clinton Eugene Kluender , Guenter Hans Herbert Heinz Benz , Kerry Jeanne Combs , Brian Richard Dixon , Michael Christopher VanZandt , Scott McClelland Wilhelm , Donald John Wolanin , Jill Elizabeth Wood , Stephan Schneider
发明人： Harold Clinton Eugene Kluender , Guenter Hans Herbert Heinz Benz , Kerry Jeanne Combs , Brian Richard Dixon , Michael Christopher VanZandt , Scott McClelland Wilhelm , Donald John Wolanin , Jill Elizabeth Wood , Stephan Schneider
IPC分类号： A61K31/19 , A61K31/215 , A61K31/275 , A61K31/4035 , A61K31/47 , A61P35/00 , A61P43/00 , C07C17/12 , C07C17/16 , C07C17/20 , C07C22/04 , C07C25/18 , C07C45/28 , C07C45/46 , C07C45/56 , C07C45/72 , C07C47/228 , C07C47/277 , C07C49/813 , C07C55/02 , C07C57/38 , C07C59/48 , C07C59/56 , C07C59/68 , C07C59/84 , C07C59/88 , C07C59/90 , C07C59/92 , C07C61/04 , C07C61/06 , C07C62/22 , C07C62/38 , C07C63/72 , C07C65/24 , C07C65/34 , C07C69/145 , C07C69/616 , C07C69/63 , C07C69/712 , C07C69/738 , C07C69/757 , C07C205/34 , C07C205/56 , C07C229/34 , C07C229/40 , C07C233/54 , C07C235/18 , C07C235/84 , C07C255/21 , C07C255/57 , C07C271/22 , C07C271/26 , C07C271/28 , C07C271/58 , C07C317/44 , C07C323/52 , C07C323/61 , C07C323/62 , C07C327/32 , C07D207/08 , C07D207/16 , C07D207/40 , C07D207/404 , C07D209/48 , C07D209/68 , C07D213/00 , C07D213/30 , C07D213/50 , C07D213/70 , C07D215/36 , C07D221/14 , C07D257/04 , C07D263/32 , C07D277/30 , C07D277/74 , C07D295/192 , C07D307/28 , C07D307/32 , C07D307/33 , C07D307/54 , C07D307/68 , C07D307/93 , C07D307/935 , C07D311/96 , C07D317/30 , C07D317/60 , C07D333/00 , C07D333/22 , C07D333/28 , C07D333/34 , C07D405/06 , C07D409/12 , C07D413/06 , C07D471/04 , C07D491/04 , C07D498/04 , C07F9/141 , C07F9/40 , C07C321/00
CPC分类号： C07D207/08 , A61K31/4035 , A61K31/47 , C07C17/12 , C07C17/16 , C07C17/208 , C07C205/34 , C07C205/56 , C07C22/04 , C07C229/34 , C07C229/40 , C07C233/54 , C07C235/84 , C07C25/18 , C07C255/21 , C07C255/57 , C07C271/22 , C07C271/26 , C07C271/28 , C07C271/58 , C07C317/44 , C07C323/52 , C07C323/61 , C07C323/62 , C07C327/32 , C07C45/28 , C07C45/46 , C07C45/56 , C07C45/72 , C07C47/228 , C07C47/277 , C07C49/813 , C07C55/02 , C07C59/56 , C07C59/84 , C07C59/88 , C07C59/90 , C07C59/92 , C07C61/04 , C07C61/06 , C07C62/22 , C07C62/38 , C07C63/72 , C07C65/24 , C07C65/34 , C07C69/616 , C07C69/712 , C07C69/738 , C07C69/757 , C07D207/16 , C07D207/404 , C07D209/48 , C07D209/68 , C07D213/30 , C07D213/50 , C07D213/70 , C07D215/36 , C07D221/14 , C07D257/04 , C07D263/32 , C07D277/30 , C07D277/74 , C07D295/192 , C07D307/28 , C07D307/32 , C07D307/33 , C07D307/54 , C07D307/68 , C07D307/93 , C07D307/935 , C07D311/96 , C07D317/30 , C07D317/60 , C07D333/22 , C07D333/28 , C07D333/34 , C07D405/06 , C07D409/12 , C07D413/06 , C07D471/04 , C07D491/04 , C07F9/1415 , C07F9/4059 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要： Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## wherein each T is a substituent group; x is 0, 1, or 2; the group D represents ##STR2## the subscript "e" is 2 or 3; the group R.sup.14 represents a variety of possible substituent groups on the cycloalkyl ring between D and G, and the group G represents M, ##STR3## in which M represents --CO.sub.2 H, --CON(R.sup.11).sub.2, or --CO.sub.2 R.sup.12 ; and R.sup.13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids.
摘要翻译：基质金属蛋白酶抑制剂，含有它们的药物组合物，以及使用它们治疗各种生理条件的方法。本发明的化合物具有通用化合物“IMAGE”，其中每个T是取代基; x为0,1或2; 组D表示，下标“e”为2或3; 基团R14表示D和G之间的环烷基环上各种可能的取代基，基团G表示M，其中M表示-CO 2 H，-CON（R 11）2或-CO 2 R 12; R13表示19个非环状天然氨基酸的任一侧链。

5. 发明授权

US5854277A Thiophenebutanoic acid derivatives as matrix metalloprotease inhibitors 失效
标题翻译：噻吩丁酸衍生物作为基质金属蛋白酶抑制剂
公开(公告)号：US5854277A
公开(公告)日：1998-12-29
申请号：US865639
申请日：1997-05-30
申请人： Harold Clinton Eugene Kluender , Guenter Hans Herbert Heinz Benz , William Harrison Bullock , Brian Richard Dixon , Michael Christopher VanZandt , Scott McClelland Wilhelm , Donald John Wolanin , Jill Elizabeth Wood , David Ross Brittelli
发明人： Harold Clinton Eugene Kluender , Guenter Hans Herbert Heinz Benz , William Harrison Bullock , Brian Richard Dixon , Michael Christopher VanZandt , Scott McClelland Wilhelm , Donald John Wolanin , Jill Elizabeth Wood , David Ross Brittelli
IPC分类号： A61K31/19 , A61K31/215 , A61K31/275 , A61K31/4035 , A61K31/47 , A61P35/00 , A61P43/00 , C07C17/12 , C07C17/16 , C07C17/20 , C07C22/04 , C07C25/18 , C07C45/28 , C07C45/46 , C07C45/56 , C07C45/72 , C07C47/228 , C07C47/277 , C07C49/813 , C07C55/02 , C07C57/38 , C07C59/48 , C07C59/56 , C07C59/68 , C07C59/84 , C07C59/88 , C07C59/90 , C07C59/92 , C07C61/04 , C07C61/06 , C07C62/22 , C07C62/38 , C07C63/72 , C07C65/24 , C07C65/34 , C07C69/145 , C07C69/616 , C07C69/63 , C07C69/712 , C07C69/738 , C07C69/757 , C07C205/34 , C07C205/56 , C07C229/34 , C07C229/40 , C07C233/54 , C07C235/18 , C07C235/84 , C07C255/21 , C07C255/57 , C07C271/22 , C07C271/26 , C07C271/28 , C07C271/58 , C07C317/44 , C07C323/52 , C07C323/61 , C07C323/62 , C07C327/32 , C07D207/08 , C07D207/16 , C07D207/40 , C07D207/404 , C07D209/48 , C07D209/68 , C07D213/00 , C07D213/30 , C07D213/50 , C07D213/70 , C07D215/36 , C07D221/14 , C07D257/04 , C07D263/32 , C07D277/30 , C07D277/74 , C07D295/192 , C07D307/28 , C07D307/32 , C07D307/33 , C07D307/54 , C07D307/68 , C07D307/93 , C07D307/935 , C07D311/96 , C07D317/30 , C07D317/60 , C07D333/00 , C07D333/22 , C07D333/28 , C07D333/34 , C07D405/06 , C07D409/12 , C07D413/06 , C07D471/04 , C07D491/04 , C07D498/04 , C07F9/141 , C07F9/40 , A61K31/38 , A61K31/41 , A61K31/415 , A61K31/435
CPC分类号： C07D207/08 , A61K31/4035 , A61K31/47 , C07C17/12 , C07C17/16 , C07C17/208 , C07C205/34 , C07C205/56 , C07C22/04 , C07C229/34 , C07C229/40 , C07C233/54 , C07C235/84 , C07C25/18 , C07C255/21 , C07C255/57 , C07C271/22 , C07C271/26 , C07C271/28 , C07C271/58 , C07C317/44 , C07C323/52 , C07C323/61 , C07C323/62 , C07C327/32 , C07C45/28 , C07C45/46 , C07C45/56 , C07C45/72 , C07C47/228 , C07C47/277 , C07C49/813 , C07C55/02 , C07C59/56 , C07C59/84 , C07C59/88 , C07C59/90 , C07C59/92 , C07C61/04 , C07C61/06 , C07C62/22 , C07C62/38 , C07C63/72 , C07C65/24 , C07C65/34 , C07C69/616 , C07C69/712 , C07C69/738 , C07C69/757 , C07D207/16 , C07D207/404 , C07D209/48 , C07D209/68 , C07D213/30 , C07D213/50 , C07D213/70 , C07D215/36 , C07D221/14 , C07D257/04 , C07D263/32 , C07D277/30 , C07D277/74 , C07D295/192 , C07D307/28 , C07D307/32 , C07D307/33 , C07D307/54 , C07D307/68 , C07D307/93 , C07D307/935 , C07D311/96 , C07D317/30 , C07D317/60 , C07D333/22 , C07D333/28 , C07D333/34 , C07D405/06 , C07D409/12 , C07D413/06 , C07D471/04 , C07D491/04 , C07F9/1415 , C07F9/4059 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要： Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## wherein each T is a substituent group; x is 0, 1, or 2; the group D represents ##STR2## the group R6 represents a variety of possible substituent groups on the carbon chain between D and G, and the group G represents M, ##STR3## in which M represents --CO.sub.2 H, --CON(R.sup.11).sub.2, or --CO.sub.2 R.sup.12 ; and R.sup.13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids.
摘要翻译：基质金属蛋白酶抑制剂，含有它们的药物组合物，以及使用它们治疗各种生理条件的方法。本发明的化合物具有通用化合物“IMAGE”，其中每个T是取代基; x为0,1或2; 基团D表示基团R6表示D和G之间的碳链上的各种可能的取代基，基团G表示M，其中M表示-CO 2 H，-CON（R 11）2，或-CO 2 R 12; R13表示19个非环状天然氨基酸的任一侧链。

6. 发明授权

US5220074A Optically active isoxazole derivatives and intermediates for preparation thereof as well as processes for producing the same 失效
标题翻译：光活性异恶唑衍生物及其制备中间体及其制备方法
公开(公告)号：US5220074A
公开(公告)日：1993-06-15
申请号：US906323
申请日：1992-06-30
申请人： Takashi Takahashi , Kazuhiko Sakaguchi
发明人： Takashi Takahashi , Kazuhiko Sakaguchi
IPC分类号： C07C43/178 , C07C43/315 , C07C45/29 , C07C45/51 , C07C45/56 , C07C45/66 , C07C47/277 , C07C49/255 , C07C49/753 , C07C69/734 , C07D261/20
CPC分类号： C07D261/20 , C07C43/1782 , C07C43/1787 , C07C43/315 , C07C45/29 , C07C45/296 , C07C45/515 , C07C45/56 , C07C45/66 , C07C47/277 , C07C49/255 , C07C49/753 , C07C69/734
摘要： The present invention relates to novel optically active isoxazole derivatives represented by general formula: ##STR1## which are useful as intermediates for synthesis of prostaglandin and a process for producing the same as well as novel aldehyde compounds represented by general formula: ##STR2## which are intermediates for preparing the compounds [XI] described above and a process for preparation thereof. In the compounds shown by these formulae, R.sup.1 represents an alkyl group or a cycloalkyl group which may have an alkoxy group or a group shown by -Ra-A-B (wherein Ra is an alkyl group; A is a hetero atom or an single bond; and B is an aromatic or hetero ring which may have a substituent(s)); and R.sup.2 and R.sup.3, which may be the same or different, each represents an aralkyl group, a silyl group or an acyl group.
摘要翻译：本发明涉及以通式表示的新颖的光学活性异恶唑衍生物：作为前列腺素合成的中间体及其制备方法，以及由通式表示的新型醛化合物：IMAGE > [IX]，它们是制备上述化合物[XI]的中间体及其制备方法。在这些化合物所示的化合物中，R 1表示可以具有烷氧基的环烷基或-R a-AB所示的基团（其中R a为烷基; A为杂原子或单键; 并且B是可以具有取代基的芳族或杂环）; 并且可以相同或不同的R 2和R 3各自表示芳烷基，甲硅烷基或酰基。

7. 发明授权

US5202497A Process for preparing unsaturated aldehydes 失效
标题翻译：制备不饱和脂肪酸的方法
公开(公告)号：US5202497A
公开(公告)日：1993-04-13
申请号：US863455
申请日：1992-04-01
申请人： Pierre Chabardes , Serge Henrot
发明人： Pierre Chabardes , Serge Henrot
IPC分类号： B01J23/22 , B01J31/12 , C07B61/00 , C07C45/27 , C07C45/51 , C07C45/53 , C07C45/56 , C07C47/21 , C07C209/68 , C07C211/21
CPC分类号： C07C209/68 , C07C45/27 , C07C45/516 , C07C45/56
摘要： The invention relates to a process for preparing unsaturated aldehydes and their enamines by the oxidation of allylic tertiary amines in the presence of an alkyl hydroperoxide and a vanadium-based catalyst.
摘要翻译：本发明涉及通过烯丙基叔胺在烷基氢过氧化物和钒基催化剂存在下氧化制备不饱和醛及其烯胺的方法。

8. 发明授权

US5089625A Substituted cyclic kentones, substituted cyclic enones 失效
标题翻译：替代循环赛，替代循环赛
公开(公告)号：US5089625A
公开(公告)日：1992-02-18
申请号：US627504
申请日：1990-12-14
申请人： Fumie Sato , Kazutaka Arai , Katsuaki Miyaji
发明人： Fumie Sato , Kazutaka Arai , Katsuaki Miyaji
IPC分类号： B01J23/40 , B01J25/00 , C07B61/00 , C07C45/00 , C07C45/56 , C07C45/59 , C07C45/67 , C07C49/395 , C07C49/403 , C07C49/487 , C07C49/493 , C07C49/497 , C07C49/517 , C07C49/703 , C07C49/707 , C07C49/753 , C07C67/00 , C07C69/66 , C07C221/00 , C07C225/14 , C07C253/10 , C07C255/31 , C07C323/52 , C07D261/20 , C07F7/18
CPC分类号： C07C49/493 , C07C45/56 , C07C45/673 , C07C49/497 , C07C49/707 , C07D261/20 , C07F7/1856 , Y02P20/55
摘要： The present invention relates to substituted cyclopentanone and cylohexanone derivatives and substituted cyclopentenone and cyclohexenone derivatives, which are useful as intermediates for pharmaceutical products and agricultural chemicals and especially useful for the synthesis of prostaglandins, and also to a process for producing the same.

9. 发明授权

US5034537A Leukotriene antagonists 失效
标题翻译：白三烯拮抗剂
公开(公告)号：US5034537A
公开(公告)日：1991-07-23
申请号：US476992
申请日：1990-02-08
申请人： James S. Frazee
发明人： James S. Frazee
IPC分类号： C07C45/44 , C07C45/56 , C07C45/62 , C07C45/68 , C07C47/542 , C07C47/546 , C07C47/548 , C07C47/55 , C07C255/33 , C07C323/56 , C07C323/60 , C07C323/66 , C07C323/67 , C07D233/84 , C07D257/04
CPC分类号： C07D257/04 , C07C255/33 , C07C323/56 , C07C323/60 , C07C323/66 , C07C323/67 , C07C45/44 , C07C45/56 , C07C45/62 , C07C45/68 , C07C47/542 , C07C47/546 , C07C47/548 , C07C47/55 , C07D233/84
摘要： This invention relates to (R)-.alpha.-methyl-4-halobenzenemethanamine salts of epimers of acids of the formula ##STR1## and the use of these salts to separate these epimers. These acids are leukotriene antagonists.
摘要翻译：本发明涉及式（α）的酸的差向异构体的（R）-α-甲基-4-卤代苯甲胺盐，以及这些盐用于分离这些差向异构体。这些酸是白三烯拮抗剂。

10. 发明授权

US4652559A 2-(Phenylmethylene)cycloalkyl-azetidines 失效
标题翻译： 2-（苯基亚甲基）环烷基 - 氮杂环丁烷
公开(公告)号：US4652559A
公开(公告)日：1987-03-24
申请号：US757819
申请日：1985-07-22
申请人： Jacob Szmuszkovicz
发明人： Jacob Szmuszkovicz
IPC分类号： C07C45/56 , C07C45/66 , C07C45/72 , C07C45/74 , C07D205/04 , C07D307/52 , C07D405/08 , A61K31/395
CPC分类号： C07D307/52 , C07C45/56 , C07C45/66 , C07C45/72 , C07C45/74 , C07D205/04
摘要： 2-(Phenylmethylene)cycloalkylamines and -azetidines of the formula ##STR1## and acid addition salts thereof, e.g., 1-[2-(phenylmethylene)cyclohexyl]azetidine, and related compounds, which have analgesic, antidepressant and mixed analgesic/antidepressant central nervous system (CNS) activities, and which are useful in treating pain and/or depression in mammals including humans. The invention provides processes for preparing the compounds as well as compositions containing the compounds and methods for using the compounds as analgesic and/or antidepressant drugs for humans and valuable mammalian animals.
摘要翻译：具有式（I）的2-（苯基亚甲基）环烷基胺和 - 氮杂环丁烷及其酸加成盐，例如1- [2-（苯基亚甲基）环己基]氮杂环丁烷和相关化合物，其具有止痛，抗抑郁和混合止痛 /抗抑郁中枢神经系统（CNS）活性，其可用于治疗包括人在内的哺乳动物的疼痛和/或抑郁。本发明提供了制备化合物的方法以及含有这些化合物的组合物和使用该化合物作为人类和有价值哺乳动物的镇痛药和/或抗抑郁药物的方法。

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