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31. 发明申请

US20140148603A1 Method for preparing a fluorinated organic compound 有权
标题翻译：氟化有机化合物的制备方法
公开(公告)号：US20140148603A1
公开(公告)日：2014-05-29
申请号：US14119470
申请日：2012-05-29
申请人： RHODIA OPERATIONS
发明人： Olivier Buisine , Michael Dejoux
IPC分类号： C07D231/14 , C07C67/307 , C07C231/12 , C07C51/363
CPC分类号： C07D231/14 , C07B39/00 , C07C29/62 , C07C45/63 , C07C51/363 , C07C67/307 , C07C231/12 , C07C303/22 , C07C233/05 , C07C309/06 , C07C53/18 , C07C69/63 , C07C49/167 , C07C31/38
摘要： A method for preparing a fluorinated organic compound (II) from an organic compound (I) comprising at least one nucleofugal group Nu, and also a preparation of different specific organic compounds, in particular a fluoro-methylpyrazole compound. The method comprises: a reaction, in the presence of water, of the organic compound (I) and at least one salt providing at least one fluoride anion; and a replacement of at least one nucleofugal group Nu of the compound (I) with a fluorine atom, in order to obtain the fluorinated organic compound (II).
摘要翻译：从含有至少一个核原子核Nu的有机化合物（I）制备含氟有机化合物（II）的方法，以及不同特定有机化合物，特别是氟 - 甲基吡唑化合物的制备方法。该方法包括：在水的存在下，有机化合物（I）和提供至少一种氟化物阴离子的至少一种盐的反应; 并且用氟原子代替化合物（I）的至少一个核末数基团Nu，以获得氟化有机化合物（II）。

32. 发明申请

US20130315822A1 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS 有权
公开(公告)号：US20130315822A1
公开(公告)日：2013-11-28
申请号：US13723333
申请日：2012-12-21
申请人： Lantheus Medical Imaging, Inc.
发明人： Richard R. Cesati , Thomas D. Harris , Simon P. Robinson , Richard J. Looby , Edward H. Cheesman , Padmaja Yalamanchili , David S. Casebier
IPC分类号： A61K49/10 , A61K51/04
CPC分类号： C07D257/02 , A61K49/103 , A61K49/106 , A61K51/04 , C07C53/18 , C07C259/06 , C07C259/14 , C07C271/22 , C07C2601/14 , C07D209/20 , C07D213/56 , C07D403/12
摘要： The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.

33. 发明申请

US20130261101A1 BICYCLIC AZAHETEROCYCLOBENZYLAMINES AS PI3K INHIBITORS 有权
标题翻译：作为PI3K抑制剂的双酚A亚胺基环硼酰胺
公开(公告)号：US20130261101A1
公开(公告)日：2013-10-03
申请号：US13854789
申请日：2013-04-01
申请人： INCYTE CORPORATION
发明人： Andrew P. Combs , Richard B. Sparks , Thomas P. Maduskuie, Jr.
IPC分类号： C07D487/04 , A61K31/519 , A61K31/553
CPC分类号： C07D487/04 , A61K31/519 , A61K31/553 , C07C53/18
摘要： The present invention provides bicyclic azaheterocyclobenzylamines of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.
摘要翻译：本发明提供了式I的双环氮杂环丁烷基胺：其中变量在本文中定义，其调节磷酸肌醇3-激酶（PI3K）的活性，并且可用于治疗与PI3Ks的活性相关的疾病，包括例如炎症性疾病，基于免疫的疾病，癌症和其他疾病。

34. 发明申请

US20110218197A1 SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS 有权
标题翻译：作为TRPM8受体调节剂有用的取代的AZA-双环咪唑衍生物
公开(公告)号：US20110218197A1
公开(公告)日：2011-09-08
申请号：US13034922
申请日：2011-02-25
申请人： Mark R. PLAYER , Raul Calvo , Jinsheng Chen , Sanath Meegalla , Daniel Parks , William Parsons , Scott Ballentine , Shawn Branum
发明人： Mark R. PLAYER , Raul Calvo , Jinsheng Chen , Sanath Meegalla , Daniel Parks , William Parsons , Scott Ballentine , Shawn Branum
IPC分类号： A61K31/5377 , C07D471/04 , A61K31/437 , A61P29/00 , A61P9/00 , C07D473/00 , A61K31/52 , C07D487/04 , A61K31/4985
CPC分类号： C07D471/04 , C07B2200/13 , C07C53/18 , C07C309/04 , C07D473/00 , C07D487/04
摘要： The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.
摘要翻译：本发明涉及取代的氮杂 - 双环咪唑衍生物，含有它们的药物组合物及其用于治疗由TRP M8调节的病症和状况的用途，包括例如炎症性疼痛，炎性痛觉过敏，炎症性超敏反应性病症，神经性疼痛，神经性冷异常性疼痛，炎性体痛痛觉过敏，炎性内脏痛觉过敏，由寒冷和肺部疾病加重的心血管疾病加重。

35. 发明申请

US20110005915A1 METHOD FOR RECOVERING FLUOROCARBOXYLIC ACIDS 审中-公开
标题翻译：回收氟代羧酸的方法
公开(公告)号：US20110005915A1
公开(公告)日：2011-01-13
申请号：US12680496
申请日：2008-09-25
申请人： Claude Mercier , Francois Metz
发明人： Claude Mercier , Francois Metz
IPC分类号： C07C51/46 , C07C51/44 , B01D3/36 , C07C53/18
CPC分类号： B01D3/36 , C07C51/44 , C07C53/18 , C07C53/21
摘要： The invention relates to a method for recovering fluorocarboxylic acids from aqueous compositions containing said acids. The invention more particularly relates to the recovery of flourocarboxylic acids forming an azeotrope with water by contact with a strong acid.
摘要翻译：本发明涉及从含有所述酸的含水组合物中回收氟代羧酸的方法。本发明更具体地涉及通过与强酸接触而与水形成共沸物的三氟羧酸的回收。

36. 发明申请

US20090253905A1 PROCESS FOR THE PREPARATION OF ONIUM SALTS WITH ALKYL- OR ARYLSULFONATE ANIONS OR ALKYL- OR ARYLCARBOXYLATE ANIONS HAVING A LOW HALIDE CONTENT 审中-公开
标题翻译：用碱金属离子或芳基磺酸盐阴离子或碱金属或芳香族羧酸盐阴离子制备低盐含量的方法
公开(公告)号：US20090253905A1
公开(公告)日：2009-10-08
申请号：US11721617
申请日：2005-11-18
申请人： Nikolai (Mykola) Ignatyev , Urs Weiz-Biermann , Andriy Kucheryna , Helge Willner
发明人： Nikolai (Mykola) Ignatyev , Urs Weiz-Biermann , Andriy Kucheryna , Helge Willner
IPC分类号： C07D265/30 , C07D233/54 , C07D213/20 , C07D295/02 , C07F7/02 , C07D249/04 , C07D239/02 , C07D237/02 , C07D241/02 , C07D277/20 , C07D263/02 , C07D231/02 , C07D249/08
CPC分类号： C07D295/023 , C07C51/412 , C07C51/60 , C07C279/04 , C07C303/32 , C07D207/04 , C07D213/06 , C07D213/20 , C07D213/74 , C07D233/54 , C07D295/037 , C07F9/5407 , C07C53/18 , C07C53/48 , C07C309/04 , C07C309/06 , C07C309/29 , C07C309/30
摘要： The invention relates to a method for producing onium salts comprising alkyl anions or aryl sulfonate anions or alkyl carboxylate anions or acryl carboxylate anions by reacting an onium halide with an alkyl silyl ester or trialkyl silyl ester of an alkyl sulfonic acid or aryl sulfonic acid or an alkyl carboxylic acid or aryl carboxylic acid or the anhydrides thereof.
摘要翻译：本发明涉及一种通过使卤鎓鎓与烷基磺酸或芳基磺酸的烷基甲硅烷基酯或三烷基甲硅烷基酯反应来制备包含烷基阴离子或芳基磺酸根阴离子或羧酸烷基酯阴离子或羧酸烷基酯阴离子的方法，烷基羧酸或芳基羧酸或其酸酐。

37. 发明申请

US20090198070A1 Condensation Reaction by Metal Catalyst 有权
标题翻译：金属催化剂的缩合反应
公开(公告)号：US20090198070A1
公开(公告)日：2009-08-06
申请号：US12085988
申请日：2006-12-04
申请人： Kazushi Mashima , Takashi Ohshima , Takanori Iwasaki , Hironori Maeda , Kenya Ishida
发明人： Kazushi Mashima , Takashi Ohshima , Takanori Iwasaki , Hironori Maeda , Kenya Ishida
IPC分类号： C07F15/00 , C07D263/08 , C07D263/52
CPC分类号： C07D263/12 , B01J31/2226 , B01J2531/26 , C07C53/18 , C07C231/02 , C07C253/30 , C07D263/10 , C07D263/14 , C07D263/52 , C07D413/06 , C07F3/003 , C07F7/1892 , C07F9/5022 , C07K1/088 , C07K1/10
摘要： The invention relates to a method for producing an azoline compound represented by the general formula (3): wherein R1 represents an optionally substituted hydrocarbon group, an optionally substituted alkoxy group, an optionally substituted alkoxycarbonyl group, a halogen atom, a substituted amino group, a substituted carbamoyl group or an optionally substituted heterocyclic group; R3, R4, R5 and R6 may be the same or different and each represents a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted alkoxy group, an optionally substituted alkoxycarbonyl group, a halogen atom, a substituted amino group, a substituted carbamoyl group or an optionally substituted heterocyclic group; two arbitrary groups selected from R3, R4, R5 and R6 may bond to each other to form a ring; and Z1 represents an oxygen atom, a sulfur atom or a selenium atom; comprising reacting a carboxylic acid or a carboxylic acid derivative represented by the general formula (1): R1CO2R2 (1) wherein R1 is as defined above; R2 represents a hydrogen atom, an optionally substituted alkyl group or an optionally substituted aryl group; and R1 and R2 may bond to each other to form a ring; with an aminochalcogenide represented by the general formula (2): wherein R3, R4, R5, R6 and Z1 are as defined above; in the presence of a compound containing a group 12 metal element in the periodic table.
摘要翻译：本发明涉及一种制备由通式（3）表示的唑啉化合物的方法：其中R1表示任选取代的烃基，任选取代的烷氧基，任选取代的烷氧基羰基，卤素原子，取代的氨基，取代的氨基甲酰基或任选取代的杂环基; R3，R4，R5和R6可以相同或不同，各自表示氢原子，任选取代的烃基，任选取代的烷氧基，任选取代的烷氧基羰基，卤素原子，取代的氨基，取代的氨基甲酰基基团或任选取代的杂环基团; 选自R3，R4，R5和R6中的两个任意基团可以彼此键合形成环; Z1表示氧原子，硫原子或硒原子; 包括使由通式（1）表示的羧酸或羧酸衍生物反应：<？in-line-formula description =“In-line formula”end =“lead”？> R1CO2R2（1）<？ -formulae description =“In-line Formulas”end =“tail”？>其中R1如上定义; R2表示氢原子，任选取代的烷基或任选取代的芳基; 并且R 1和R 2可以彼此键合形成环; 与通式（2）表示的氨基硫族化物：其中R3，R4，R5，R6和Z1如上定义; 在含有元素周期表中第12族金属元素的化合物存在下进行。

38. 发明授权

US5478486A Composition and method for treating substrates to reduce electrostatic charge and resultant article 失效
标题翻译：用于处理底物以减少静电荷和所得物品的组合物和方法
公开(公告)号：US5478486A
公开(公告)日：1995-12-26
申请号：US154665
申请日：1993-11-18
申请人： Michael J. Incorvia
发明人： Michael J. Incorvia
IPC分类号： C07C53/18 , C07C53/21 , C07C217/50 , C08J7/04 , C08L101/00 , C09K3/16 , D06M13/17 , D06M13/236 , D06M13/33 , D06M13/463 , H01B1/12 , D06M13/213
CPC分类号： H01B1/122 , C07C217/50 , C07C53/18 , C07C53/21 , C08J7/047 , C08L101/00 , C09K3/16 , D06M13/17 , D06M13/236 , D06M13/33 , D06M13/463 , C08J2471/00 , C08L2201/04 , D06M2200/00 , Y10S524/91 , Y10S524/911 , Y10S57/901 , Y10T428/2967 , Y10T428/2969 , Y10T442/2459
摘要： Antistatic agents and their use in processing textiles or formed plastic substrates. The antistatic agent comprises a compound having a fluorocarbon moiety and an ethoxylated quaternary ammonium moiety. The antistatic composition increases the electrolytic conductivity of treated textile or plastic materials, thereby increasing the rate of electrostatic charge dissipation thereof. The antistatic agents remain effective after exposure of the treated substrate to an aqueous environment.
摘要翻译：抗静电剂及其在加工纺织品或成型塑料基材中的应用。抗静电剂包括具有氟烃部分和乙氧基化季铵部分的化合物。抗静电组合物提高了处理的纺织品或塑料材料的电解电导率，从而增加了其静电电荷耗散速率。抗静电剂在经处理的底物暴露于水性环境之后仍然有效。

39. 发明授权

US3894082A Process of making trifluoroacetic acid 失效
标题翻译：制备三氟乙酸的方法
公开(公告)号：US3894082A
公开(公告)日：1975-07-08
申请号：US32152173
申请日：1973-01-05
申请人： KALI CHEMIE AG
发明人： FERNSCHILD GUNTER , PAUCKSCH HEINRICH , MASSONNE JOACHIM
IPC分类号： C07C51/04
CPC分类号： C07C51/04 , C07C53/18
摘要： Substantially anhydrous and chlorine-free trifluoroacetic acid is made in a continuous process by hydrolysis of trifluoroacetyl chloride with water and distillation in a manner wherein the distillation is carried out in a distillation column and attached reflux condenser and gaseous trifluoroacetyl chloride is introduced in the still of the apparatus into a boiling mixture of trifluoroacetic acid, water and hydrogen chloride which mixture has a boiling point between the boiling point of the azeotropic mixture and 72*C/760 Torr. The major portion of the trifluoroacetic acid which condenses at the head of the column is continuously withdrawn from the rising gas mixture at a place ahead of the condenser while the gas mixture which passes through the condenser and includes hydrogen chloride and residual acid is passed into an aqueous solution where it is absorbed while simultaneously an amount of water is added to the still as is necessary for the hydrolysis.
摘要翻译：基本上无水和无氯的三氟乙酸通过用水的三氟乙酰氯水解并以蒸馏在蒸馏塔和附着的回流冷凝器中进行蒸馏的方式在连续方法中制备，并将气态三氟乙酰氯引入到该装置成三氟乙酸，水和氯化氢的沸腾混合物，该混合物的沸点在共沸混合物的沸点和72℃/ 760乇之间。在塔顶部冷凝的三氟乙酸的主要部分在冷凝器前面的一个地方从上升气体混合物中连续排出，而通过冷凝器并包括氯化氢和残留酸的气体混合物被传入水溶液中，同时一定量的水加入到静止物中，这是水解所必需的。

40. 发明授权

US3759743A Method of applying coarings of tin oxide upon transparent substrates 失效
标题翻译：在透明基材上涂覆氧化锡的方法
公开(公告)号：US3759743A
公开(公告)日：1973-09-18
申请号：US3759743D
申请日：1971-09-17
申请人： LIBBEY OWENS FORD CO
发明人： MENKE A
IPC分类号： C01G19/02 , C01F11/46 , C01G19/00 , C03C17/25 , C07C51/41 , C07F7/22 , C23C16/40 , C23C18/12 , H01B13/00 , C23C11/08 , H05K3/00
CPC分类号： C07F7/2256 , C01F11/46 , C03C17/253 , C03C2217/211 , C03C2218/112 , C07C51/412 , C07F7/2244 , C07C53/18
摘要： AN IMPROVED TECHNIQUE FOR PRODUCING ELECTRICALLY CONDUCTING TIN OXIDE FILMS ON THE SURFACE OF A CERAMIC SUBSTRATE BY APPLYING A SOLUTION OF AN ORGANOTIN SALT OF TRIFLUOROACETIC ACID TO THE SUBSTRATE WHILE IT IS AT A TEMPERATURE ABOVE 800*F.

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