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1. 发明授权

US08865191B2 Lipid composition and skin care formulation containing the same 有权
标题翻译：含有相同脂质组成和护肤配方
公开(公告)号：US08865191B2
公开(公告)日：2014-10-21
申请号：US10556183
申请日：2004-04-29
申请人： Kenya Ishida , Kenichiro Shiroyama
发明人： Kenya Ishida , Kenichiro Shiroyama
IPC分类号： A61K8/42 , A61K8/41 , A61K8/34 , A61K8/68 , A61Q5/00 , A61Q1/00 , A61Q19/10 , A61Q19/00 , A61K8/02 , A61Q5/12 , A61Q5/06 , A61Q5/02
CPC分类号： A61Q19/10 , A61K8/0295 , A61K8/342 , A61K8/68 , A61Q5/00 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q19/00
摘要： Bioavailability of a ceramide, which is a minimally soluble material of a skin care composition exhibiting an excellent effect is enhanced by combining at least one component selected from ceramides represented by Formula (1): and at least one component selected from aliphatic alcohol having 12 to 30 carbon atoms.
摘要翻译：通过将至少一种选自式（1）表示的神经酰胺和至少一种选自具有12个脂肪醇的组分的组分与至少一种选自具有12个的脂族醇的组分组合， 30个碳原子。

2. 发明授权

US08735446B2 Vanillin acetals and sensory stimulant composition containing the same 有权
标题翻译：香草醛缩醛和感官刺激剂组成含有相同的
公开(公告)号：US08735446B2
公开(公告)日：2014-05-27
申请号：US13467770
申请日：2012-05-09
申请人： Kenya Ishida , Takashi Aida
发明人： Kenya Ishida , Takashi Aida
IPC分类号： A61K31/335
CPC分类号： C07D317/22
摘要： The invention relates to a sensory stimulant composition containing one or more of vanillin acetals represented by the general formula (1), and a flavor and fragrance composition, a beverage or food product, a fragrance or cosmetic product, a daily utensil product, an oral composition, or a pharmaceutical product containing the sensory stimulant composition with a warming sensation agent or cooling sensation substance, if necessary. Vanillin acetals represented by the general formula (1) show an excellent pungent and/or warming sensation effect and a cooling sensation-emphasizing effect.
摘要翻译：本发明涉及含有一种或多种由通式（1）表示的香草醛缩醛的感官刺激剂组合物，以及香料和香料组合物，饮料或食品，香料或化妆品，日常用具产品，口服组合物或含有感觉刺激剂组合物的药物产品，如果需要，加热感觉剂或冷却感觉物质。由通式（1）表示的香草醛缩醛显示出极好的刺激性和/或加温感觉效果和冷却感觉强调效果。

3. 发明授权

US08632792B2 Cooling sensation agent composition and sensory stimulation agent composition 失效
标题翻译：冷却感觉剂组合物和感觉刺激剂组合物
公开(公告)号：US08632792B2
公开(公告)日：2014-01-21
申请号：US12936160
申请日：2009-04-01
申请人： Kenya Ishida , Takashi Aida , Tetsuya Yamamoto
发明人： Kenya Ishida , Takashi Aida , Tetsuya Yamamoto
IPC分类号： A61K8/02 , A61K31/335 , A61K31/265 , A61K31/22 , A61K31/23 , A01N25/34 , A23L1/22 , A23L1/221 , C07C69/96 , C07C69/00 , C07C69/52 , C07D317/00
CPC分类号： C07D317/36 , A23L27/203 , A23L27/2052 , A61K8/0208 , A61K8/37 , A61K8/4973 , A61K2800/244 , A61Q5/02 , A61Q11/00 , A61Q13/00 , A61Q15/00 , A61Q19/00 , A61Q19/10 , C07C69/24 , C07C69/96 , C07C2601/14
摘要： A cooling sensation agent composition with a prolonged cool sensation effect is provided comprising at least one compound selected from the group consisting of aceia or ketal derivatives of 3-(1-menthoxy)propan-1,2-diol represented by Formula (1), single or mixed carbonic esters ol one or two kinds ol alcohols represented by Formula (2), and carboxylic esters represented by Formula (4). A sensory stimulation agoni composition, a flavor or fragrance composition, a beverage or food product, a perfume or cosmetic product, a toiletry product, a daily utensil product or grocery, a fiber, a fiber product, a cloth or a medicine comprising the cooling sensation agent composition; a production method thereof; a cooling processing method of a fiber, fiber product or a cloth, comprising compounding the cooling sensation agent; and new compounds are also provided.
摘要翻译：提供具有延长的凉爽感觉效果的冷却感觉剂组合物，其包含至少一种选自由式（1）表示的3-（1-薄荷氧基）丙-1,2-二醇的乙酰亚胺或缩酮衍生物，由式（2）表示的一种或两种醇类的单一或混合碳酸酯和由式（4）表示的羧酸酯。感觉刺激激动剂组合物，风味剂或香料组合物，饮料或食品，香料或化妆品，化妆品，日用具产品或杂货，纤维，纤维制品，布或包含冷却感觉剂组成; 其制造方法; 纤维，纤维制品或布的冷却处理方法，包括配合冷却感觉剂; 并提供新的化合物。

4. 发明申请

US20130005807A1 ANTIMICROBIAL COMPOSITION 审中-公开
标题翻译：抗微生物组合物
公开(公告)号：US20130005807A1
公开(公告)日：2013-01-03
申请号：US13537971
申请日：2012-06-29
申请人： Kenya ISHIDA , Tomoko YAMAMOTO , Miho SUZUKI
发明人： Kenya ISHIDA , Tomoko YAMAMOTO , Miho SUZUKI
IPC分类号： A01N37/02 , A23F3/00 , A23F5/00 , A23L1/22 , A23L3/3481 , C07C43/196 , C07C69/67 , A01P1/00 , A23L3/3499 , A23L2/42 , A01N31/14 , C07C69/675
CPC分类号： A01N37/36 , A01N31/06 , A01N37/18 , A01N37/42 , A23F3/405 , A23G1/32 , A23G3/36 , A23G4/06 , A23L2/56 , A23L3/3463 , A23L3/3481 , A23L3/349 , A23L27/2028 , A23L27/203 , A61K8/34 , A61K8/345 , A61K8/37 , A61K2800/244 , A61Q11/00 , A61Q17/005
摘要： The objective of the present invention is to provide an antimicrobial composition that can be safely used with a broad range of foods and beverages, cosmetics, drugs, and other similar products while showing growth inhibition activity against a wide variety of microorganisms. The present invention relates to the antimicrobial composition comprising at least one cooling agent selected from the group consisting of menthyl 3-hydroxybutanoate, 2-methyl-3-(menthoxy)propane-1,2-diol, 2-(menthoxy)ethanol, 3-menthoxypropan-1-ol, 2-(2-menthoxyethoxy)ethanol, and menthyl glyoxylate.
摘要翻译：本发明的目的是提供一种抗微生物组合物，其能够广泛地用于广泛的食品和饮料，化妆品，药物和其它类似产品中，同时显示出对多种微生物的生长抑制活性。本发明涉及抗微生物组合物，其包含至少一种选自3-羟基丁酸薄荷酯，2-甲基-3-（薄荷氧基）丙烷-1,2-二醇，2-（薄荷氧基）乙醇，3 （2-乙氧基乙氧基）乙醇和乙醛酸薄荷酯。

5. 发明授权

US08236970B2 Vanillin acetals 有权
标题翻译：香草醛缩醛
公开(公告)号：US08236970B2
公开(公告)日：2012-08-07
申请号：US11988237
申请日：2006-07-05
申请人： Kenya Ishida , Takashi Aida
发明人： Kenya Ishida , Takashi Aida
IPC分类号： C07D317/00
CPC分类号： C07D317/22
摘要： The invention relates to a sensory stimulant composition containing one or more of vanillin acetals represented by the general formula (1), and a flavor and fragrance composition, a beverage or food product, a fragrance or cosmetic product, a daily utensil product, an oral composition, or a pharmaceutical product containing the sensory stimulant composition with a warming sensation agent or cooling sensation substance, if necessary. Vanillin acetals represented by the general formula (1) show an excellent pungent and/or warming sensation effect and a cooling sensation-emphasizing effect.
摘要翻译：本发明涉及含有一种或多种由通式（1）表示的香草醛缩醛的感官刺激剂组合物，以及香料和香料组合物，饮料或食品，香料或化妆品，日常用具产品，口服组合物或含有感觉刺激剂组合物的药物产品，如果需要，加热感觉剂或冷却感觉物质。由通式（1）表示的香草醛缩醛显示出极好的刺激性和/或加温感觉效果和冷却感觉强调效果。

6. 发明授权

US08217192B2 Production method of (2E,6Z,8E)-N-isobutyl-2,6,8-decatrienamide (spilanthol), and food or drink, fragrance or cosmetic, or pharmaceutical comprising the same 有权
标题翻译：（2E，6Z，8E）-N-异丁基-2,6,8-十一三烯酰胺（敏兰）和食品或饮料，香料或化妆品或包含其的药物的制备方法
公开(公告)号：US08217192B2
公开(公告)日：2012-07-10
申请号：US12673633
申请日：2009-01-16
申请人： Shigeru Tanaka , Kenji Yagi , Hideo Ujihara , Kenya Ishida
发明人： Shigeru Tanaka , Kenji Yagi , Hideo Ujihara , Kenya Ishida
IPC分类号： C07C231/00
CPC分类号： A61K8/42 , A23G1/32 , A23G3/36 , A23G4/06 , A23L27/202 , A61Q5/00 , A61Q11/00 , A61Q15/00 , C07C43/303 , C07C45/41 , C07C57/66 , C07C231/12 , C07C233/09 , C07C235/28 , C07C309/66 , C12P13/02 , C07C47/21
摘要： A problem as an object of the invention is to provide a production method of spilanthol in a large scale without using expensive reagents. The present invention provides a production method of N-isobutyl-2,6,8-decatrienamide, wherein a column chromatography purification step is not required in all processes.
摘要翻译：作为本发明的目的的一个问题是在不使用昂贵的试剂的情况下大规模地提供大量的生产方法。本发明提供N-异丁基-2,6,8-癸三酰胺的制备方法，其中在所有方法中不需要柱色谱纯化步骤。

7. 发明授权

US07728177B2 Optically active 3-methylcyclopentadecanone and method for producing intermediate thereof 有权
标题翻译：光学活性3-甲基环十五烷酮及其中间体的制备方法
公开(公告)号：US07728177B2
公开(公告)日：2010-06-01
申请号：US11920600
申请日：2006-05-17
申请人： Shigeru Tanaka , Kenya Ishida , Hiroyuki Matsuda
发明人： Shigeru Tanaka , Kenya Ishida , Hiroyuki Matsuda
IPC分类号： C07C45/00
CPC分类号： C07B53/00 , C07B2200/07 , C07C45/513 , C07C45/54 , C07C67/00 , C07C2601/18 , C07F9/657154 , C07C49/385 , C07C69/013 , C07C69/24
摘要： Disclosed is a method for producing an optically active 3-methylcyclopentadecan-1-one which is characterized in that 2-cyclopentadecen-1-one is subjected to a 1,4-conjugate addition reaction of a methyl group by using a methylated organic metal in the presence of a copper catalyst, an enol anion scavenger and a specific optically active phosphoramidite for obtaining an optically active 3-methyl-1-cyclopentadecene derivative, and then the thus-obtained 3-methyl-1-cyclopentadecene derivative is subjected to a solvolysis.
摘要翻译：公开了一种光学活性3-甲基环戊烷-1-酮的制备方法，其特征在于2-环戊烯-1-酮通过使用甲基化有机金属在甲基化有机金属中进行1,4-偶合物加成反应存在铜催化剂，烯醇阴离子清除剂和用于获得光学活性的3-甲基-1-环戊烯衍生物的特定光学活性亚磷酰胺，然后由此得到的3-甲基-1-环戊烯衍生物进行溶剂分解。

8. 发明申请

US20100093682A1 LIPID COMPOSITION HAVING EXCELLENT SHAPE RETENTION PROPERTY AND PRODUCT 有权
标题翻译：具有优异形状保持性能和产品的脂肪组合物
公开(公告)号：US20100093682A1
公开(公告)日：2010-04-15
申请号：US12529272
申请日：2008-02-27
申请人： Kenya Ishida , Chiyomi Birou , Tetsuya Yamamoto
发明人： Kenya Ishida , Chiyomi Birou , Tetsuya Yamamoto
IPC分类号： A61K31/568 , A61Q19/00 , A24B15/10 , A61K8/18 , C11D3/20 , C09K3/00
CPC分类号： A61K47/28 , A23L27/203 , A23L33/11 , A23V2002/00 , A24B15/30 , A61K8/34 , A61K8/63 , A61Q19/00 , A23V2200/208 , A23V2250/21 , A23V2250/18
摘要： It is to provide a technique for preventing aggregation or caking of menthol at the time of its keeping. In addition, it is to provide a lipid composition, which can show excellent thermal stability even in the case of high temperature at the time of keeping menthol and at the time of blending in a product, does not cause mutual aggregation of powders, particles, flakes, pellets, sticks and the like of menthol, and can maintain its shape retention property. From 10 to 50% by mass of sterols are added to and mixed with from 50 to 90% by mass of menthol, and the resultant is melted with heating. Paraffins may be further added and mixed in an amount of 20% by mass or less, based on the lipid composition.
摘要翻译：它是提供一种防止薄荷醇保留时聚集或结块的技术。此外，提供一种脂质组合物，即使在保持薄荷醇时的高温的情况下也能显示优异的热稳定性，并且在产品中混合时，不会引起粉末，颗粒，片，丸，棒等，并能保持其形状保持性。加入10〜50质量％的甾醇并与50〜90质量％的薄荷醇混合，加热熔融。基于脂质组成，石蜡可以进一步添加并混合20质量％以下。

9. 发明授权

US07576125B2 Melanogenesis inhibitor and skin preparation containing the same 失效
标题翻译：黑素生成抑制剂和含有相同的皮肤制剂
公开(公告)号：US07576125B2
公开(公告)日：2009-08-18
申请号：US10545006
申请日：2004-02-12
申请人： Kenya Ishida , Eiko Tamai
发明人： Kenya Ishida , Eiko Tamai
IPC分类号： A61K31/357
CPC分类号： A61Q19/02 , A61K8/4973
摘要： A melanogenesis inhibitor characterized by containing at least one kind of piperonyl alcohol represented by the following general formula (1) wherein R is a straight chain or branched chain alkyl group having 3 to 18 carbon atoms, a straight chain or branched chain alkenyl group having 3 to 18 carbon atoms, or an optionally substituted alicyclic alkyl group. The melanogenesis inhibitor is superior in stability and safety and has a high melanogenesis-inhibiting effect; and a skin preparation containing the melanogenesis inhibitor is very stable, safe, and has a sufficient fair skin effect and a sufficient effect for curing skin dyspigmentation.
摘要翻译：一种黑素生成抑制剂，其特征在于含有以下通式（1）表示的至少一种胡椒醇，其中R是具有3至18个碳原子的直链或支链烷基，具有3个碳原子的直链或支链烯基至18个碳原子，或任选取代的脂环族烷基。黑素生成抑制剂的稳定性和安全性优越，具有高的黑素生成抑制作用; 含有黑素生成抑制剂的皮肤制剂非常稳定，安全，具有足够的良好的皮肤效果和足够的治疗皮肤色素沉着的作用。

10. 发明授权

US07538081B2 Method and agent for enhancing diffusivity and long-lasting property of fragrance 有权
公开(公告)号：US07538081B2
公开(公告)日：2009-05-26
申请号：US09949718
申请日：2001-09-12
申请人： Kenya Ishida , Takashi Nishida , Hiroyuki Matsuda , Hisao Iwai , Toshimitsu Hagiwara
发明人： Kenya Ishida , Takashi Nishida , Hiroyuki Matsuda , Hisao Iwai , Toshimitsu Hagiwara
IPC分类号： A61K8/00
CPC分类号： A61Q13/00 , A23L2/56 , A61K8/34 , C11B9/0034
摘要： A fragrance composition having an excellent diffusivity and long-lasting property of fragrance and a cosmetic, toiletry, bath composition, food and drink and pharmaceutical having an excellent diffusivity and long-lasting property of fragrance by using a novel fixative. A compound represented by the following general formula (1) is incorporated in a fragrance composition or the foregoing products. The amount of the compound of the general formula (1) to be incorporated in the fragrance composition is preferably from 0.01 to 90% by weight. The amount of the compound of the general formula (1) to be incorporated directly in the foregoing products is preferably from 0.0001 to 2.0 times (by weight) the weight of the aroma composition and/or composition to be incorporated therein. In this arrangement, a fragrance composition or products having an enhanced diffusivity and long-lasting property of fragrance can be obtained without causing any safety problem on human being. wherein A represents H or OH group; B represents H or methyl group; and n represents an integer of from 0 to 2.

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