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31. 发明授权

US06764710B2 Light emitting markers for use with substrates 失效
标题翻译：用于衬底的发光标记
公开(公告)号：US06764710B2
公开(公告)日：2004-07-20
申请号：US09908530
申请日：2001-07-18
申请人： Kenneth M. Merdan , Dachuan Yang , Lixiao Wang
发明人： Kenneth M. Merdan , Dachuan Yang , Lixiao Wang
IPC分类号： A61L2700
CPC分类号： B29C66/91218 , A61L29/14 , A61L31/14 , A61M25/0009 , B29C65/02 , B29C65/14 , B29C65/1403 , B29C65/1406 , B29C65/1409 , B29C65/1412 , B29C65/1416 , B29C65/1425 , B29C65/16 , B29C65/1606 , B29C65/1616 , B29C65/1619 , B29C66/1142 , B29C66/43 , B29C66/43121 , B29C66/534 , B29C66/65 , B29C66/71 , B29C66/742 , B29C66/91221 , B29C66/91411 , B29C2035/0822 , B29C2035/0827 , B29C2035/0844 , B29C2035/085 , B29C2035/0855 , B29K2023/00 , B29K2023/06 , B29K2023/12 , B29K2027/06 , B29K2067/00 , B29K2067/006 , B29K2075/00 , B29K2077/00 , B29K2079/08 , B29K2995/0049 , B29K2995/0056 , B29L2031/7542 , Y10T156/10 , B29K2071/00 , B29K2067/003 , B29K2027/18 , B29K2021/003
摘要： A method of determining whether a substrate has been subjected to an energy source. In one embodiment, the method includes the steps of providing a polymeric surface, providing a light emitting material having a specified emission spectrum that changes upon exposure to an energy source on the surface or embedded in said substrate and applying said energy source to said surface with said light emitting material. This method can be particularly useful for detecting the bond quality in medical devices.
摘要翻译：一种确定衬底是否已经经过能量源的方法。在一个实施方案中，该方法包括以下步骤：提供聚合物表面，提供具有特定发射光谱的发光材料，该特定发射光谱在暴露于表面上的能量源或嵌入在所述衬底中并且将所述能量源施加到所述表面上时，所述发光材料。该方法对于检测医疗器械中的结合质量特别有用。

32. 发明授权

US06685718B1 Expandable ablation burr 失效
标题翻译：可扩展消融毛刺
公开(公告)号：US06685718B1
公开(公告)日：2004-02-03
申请号：US09629771
申请日：2000-07-31
申请人： Mark H. Wyzgala , Eric B. Hamilton , Thomas J. Hiblar , Lixiao Wang , John J. Chen , Irina Nazarova , Nancy L. Haig , Sheng-Ping Zhong
发明人： Mark H. Wyzgala , Eric B. Hamilton , Thomas J. Hiblar , Lixiao Wang , John J. Chen , Irina Nazarova , Nancy L. Haig , Sheng-Ping Zhong
IPC分类号： A61B1732
CPC分类号： A61B17/320725 , A61B17/320758 , A61B2017/00557 , A61B2017/00867 , A61B2017/320004 , A61B2017/320733
摘要： An atherectomy burr has an operating diameter that is larger than the diameter of a catheter in which the burr is routed. The burr may include a polymeric balloon that is coated with an abrasive and that expands when the burr is rotated. When the burr is rotated, the polymeric tube expands by centrifugal force. The maximum expansion of the burr is controlled by an expansion mechanism. Various mechanisms are disclosed for controlling the maximum diameter of the burr thus preventing the burr from over expanding. In addition, the present invention includes a system for preventing the loose ablated particulate from reembolizing in the distal vasculature. The system includes an ablation burr that has abrasive disposed on the proximal end that is pulled back toward the guide catheter to ablate the lesion. The burr creates a seal when expanded to block the ablated particulate so that the aspiration system can remove the particulate from the patient vessel or stent. Alternatively, the burr system may include a self expanding seal that is deployed out of the aspiration sheath so that a slight vacuum can remove the large loose particulate form, the patient's vessel or stent.
摘要翻译：粥样斑块切除术毛刺的操作直径大于其中布置毛刺的导管的直径。毛刺可以包括涂覆有磨料的聚合物气球，并且当毛刺旋转时膨胀。当毛刺旋转时，聚合物管通过离心力膨胀。毛刺的最大膨胀由膨胀机构控制。公开了用于控制毛刺的最大直径的各种机构，从而防止毛刺过度膨胀。此外，本发明还包括一种用于防止松散的消融颗粒在远端脉管系统中再栓塞的系统。该系统包括消融毛刺，其具有设置在近端上的磨料，其被拉回导向导管以烧蚀病变。当膨胀时，毛刺产生密封以阻挡消融的颗粒，使得吸气系统可以从患者的血管或支架中移除颗粒。或者，毛刺系统可以包括从抽吸鞘部署出来的自膨胀密封，使得轻微的真空可以从患者的血管或支架中移除大的松散颗粒。

33. 发明授权

US06652575B2 Stent with smooth ends 有权
公开(公告)号：US06652575B2
公开(公告)日：2003-11-25
申请号：US10017004
申请日：2001-12-14
申请人： Lixiao Wang
发明人： Lixiao Wang
IPC分类号： A61F206
CPC分类号： A61F2/82 , A61F2/88 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/92 , A61F2002/91541 , A61F2002/91558 , A61F2220/005 , A61F2250/0018 , A61K9/0024 , A61L31/10 , A61L31/16 , A61L2300/25 , A61L2300/416 , A61L2300/606 , A61L2300/608 , A61L2420/08
摘要： A stent having at least one smooth end is disclosed. The stent may include a coating or coatings on one or both end portions to provide a smooth finish to reduce possible damage to body passages when the stent is deployed and delivered. The stent may also contain drugs or surgical adhesives or a combination thereof in or on the coated portion of the stent. The stent may also be of the type where the materials of the stent may be treated to have a smooth flexible end or ends. The stent may also be of a configuration such that at least one end is more flexible than the middle portion of the stent.

34. 发明授权

US06575168B2 System and method for percutaneous coronary artery bypass 有权
标题翻译：经皮冠状动脉旁路的系统和方法
公开(公告)号：US06575168B2
公开(公告)日：2003-06-10
申请号：US09759996
申请日：2001-01-12
申请人： Daniel M. LaFontaine , Kent D. Harrison , Charles L. Euteneuer , Roger N. Hastings , Lixiao Wang
发明人： Daniel M. LaFontaine , Kent D. Harrison , Charles L. Euteneuer , Roger N. Hastings , Lixiao Wang
IPC分类号： A61B1900
CPC分类号： A61F2/82 , A61B17/32053 , A61B2017/00243 , A61B2017/00252 , A61B2017/1135 , A61B2017/306 , A61B2090/3929 , A61B2090/3945 , A61B2090/3958 , A61F2/06 , A61F2/064 , A61F2/90 , A61F2/958 , A61F2250/0098 , Y10S623/902
摘要： A percutaneous system for bypassing a restriction in a native vessel of a mammal having an aorta includes providing a graft having a body portion with a first end, a second end and a lumen therebetween. An aperture is formed in the aorta. The graft is inserted into the aorta and the first end of the graft is connected to the aorta about the aperture in the aorta. An aperture is then formed in the native vessel distal of the restriction. The second end of the graft is connected to the native vessel about the aperture therein such that the lumen in the graft communicates with the aorta and the native vessel.
摘要翻译：用于绕过具有主动脉的哺乳动物的天然血管中的限制的经皮系统包括提供具有主体部分的移植物，其具有第一端，第二端和其间的内腔。在主动脉中形成孔。将移植物插入主动脉，并且移植物的第一端围绕主动脉的孔连接到主动脉。然后在限制器的远端的天然血管中形成孔。移植物的第二端围绕其中的孔连接到天然血管，使得移植物中的内腔与主动脉和天然血管连通。

35. 发明授权

US06562061B1 Stent delivery balloon with securement structure 有权
标题翻译：支架结构固定支架
公开(公告)号：US06562061B1
公开(公告)日：2003-05-13
申请号：US09510033
申请日：2000-02-22
申请人： Lixiao Wang , John Jianhua Chen
发明人： Lixiao Wang , John Jianhua Chen
IPC分类号： A61F206
CPC分类号： A61M25/1029 , A61F2002/9583
摘要： A stent delivery balloon structure is formed by molding at a desired pressure, temperature and tension a medical balloon with a tube disposed thereabout and subsequently removing one or more layers of material from the body portion of the thus formed medical balloon structure.
摘要翻译：通过在期望的压力，温度下模制塑料制成支架输送球囊结构，并且在其周围设置管并且随后从如此形成的医疗气囊结构的主体部分移除一层或多层材料的医疗气囊。

36. 发明授权

US06517575B1 Multilayer liquid absorption and deformation devices 失效
标题翻译：多层液体吸收和变形装置
公开(公告)号：US06517575B1
公开(公告)日：2003-02-11
申请号：US09609584
申请日：2000-06-30
申请人： Dachuan Yang , Lixiao Wang
发明人： Dachuan Yang , Lixiao Wang
IPC分类号： A61F206
CPC分类号： A61F2/82 , A61F2/88 , A61F2/92 , A61F2210/0061 , A61F2210/0076 , A61L31/10 , A61L31/145 , A61L31/148 , A61L31/16 , A61L2300/00
摘要： A multilayer device comprised of at least one layer of material which is capable of absorbing liquid to thereby increase the volume of the layer, i.e., liquid swellable, and when bound to at least one non-absorbing or lesser absorbing layer of material causes deformation of the device upon liquid absorption.
摘要翻译：一种多层器件，由至少一层材料组成，能够吸收液体从而增加该层的体积，即液体可膨胀，并且当与至少一种不吸收或较小的吸收层材料结合时，会导致变形该装置在液体吸收时。

37. 发明授权

US06419692B1 Surface protection method for stents and balloon catheters for drug delivery 有权
标题翻译：用于药物输送的支架和球囊导管的表面保护方法
公开(公告)号：US06419692B1
公开(公告)日：2002-07-16
申请号：US09243580
申请日：1999-02-03
申请人： Duchuan Yang , Joel Stanslaski , Lixiao Wang
发明人： Duchuan Yang , Joel Stanslaski , Lixiao Wang
IPC分类号： A61F206
CPC分类号： A61L31/16 , A61F2/0077 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/91541 , A61F2002/91558 , A61F2250/0067 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/416 , A61L2300/608 , A61L2420/08
摘要： A medical device, such as a stent or balloon of a balloon catheter which includes a body portion which has an exterior surface which contacts, at least in part, a vessel wall during treatment. The body portion is expandable from a first position, wherein the body portion is sized for insertion into the vessel lumen, to a second position, wherein at least a portion of the exterior surface is in contact with the lumen wall. The medical device includes a first coating disposed over at least a portion of the exterior surface of the body portion with the first coating including a drug or therapeutic substance which is intended for controlled release from the surface. The medical device further includes a second coating overlying at least a substantial portion of the first coating. The second coating includes a material that is generally impervious to elution of the drug or therapeutic substance therethrough when the body portion is in a first position when inserted into the vessel lumen. The material of the second coating is relatively inelastic so that the second coating fractures during expansion of the body portion to the second position to allow elution of therapeutic substance through a multiplicity of fissures formed through the second coating.
摘要翻译：一种医疗装置，例如球囊导管的支架或球囊，其包括主体部分，该主体部分具有在治疗期间至少部分地与血管壁接触的外表面。主体部分从第一位置可膨胀，其中主体部分的尺寸适于插入血管腔，到达第二位置，其中外表面的至少一部分与内腔壁接触。医疗装置包括设置在主体部分的外表面的至少一部分上的第一涂层，第一涂层包括用于从表面受控释放的药物或治疗物质。医疗装置还包括覆盖第一涂层的至少大部分的第二涂层。第二涂层包括当插入血管内腔时主体部分处于第一位置时通常不透过药物或治疗物质的洗脱的材料。第二涂层的材料相对无弹性，使得第二涂层在主体部分膨胀到第二位置期间断裂，以允许通过穿过第二涂层形成的多个裂缝洗脱治疗物质。

38. 发明授权

US06387124B1 Biodegradable drug delivery vascular stent 失效
标题翻译：生物降解药物输送血管支架
公开(公告)号：US06387124B1
公开(公告)日：2002-05-14
申请号：US09420079
申请日：1999-10-18
申请人： Paul J. Buscemi , Elizabeth A. Stejskal , Donald F. Palme, II , Lixiao Wang
发明人： Paul J. Buscemi , Elizabeth A. Stejskal , Donald F. Palme, II , Lixiao Wang
IPC分类号： A61F206
CPC分类号： A61F2/82 , A61F2/88 , A61F2/958 , A61F2210/0004 , A61F2210/0023 , A61F2250/0067 , A61F2250/0068 , A61L31/041 , A61L31/044 , A61L31/047 , A61L31/148 , A61L31/16 , A61L2300/42 , A61L2300/604 , A61L2300/606 , A61L2300/622 , Y10S623/901 , C08L67/04
摘要： A stent includes a main body of a generally tubular shape for insertion into a lumen of a vessel of a living being. The tubular main body includes a substantially biodegradable matrix having collagen IV and laminin that enclose voids within the matrix. The tubular main body also includes a biodegradable strengthening material in contact with the matrix to strengthen the matrix. The tubular main body is essentially saturated with drugs.
摘要翻译：支架包括用于插入活体血管内腔的大体管状形状的主体。管状主体包括基本上可生物降解的基质，其具有包围基质内的空隙的胶原IV和层粘连蛋白。管状主体还包括与基质接触以增强基质的可生物降解的强化材料。管状主体基本上被药物饱和。

39. 发明授权

US06328710B1 Process improvements for preparing catheter balloons 失效
标题翻译：制备导管球囊的工艺改进
公开(公告)号：US06328710B1
公开(公告)日：2001-12-11
申请号：US08955984
申请日：1997-10-22
申请人： Lixiao Wang , Paul J. Miller , Daniel J. Horn , Deborah A. Frank
发明人： Lixiao Wang , Paul J. Miller , Daniel J. Horn , Deborah A. Frank
IPC分类号： A61M2900
CPC分类号： A61M25/1029 , A61M25/0045 , A61M25/1002 , A61M25/104 , A61M2025/1075 , A61M2025/1088 , B29C35/041 , B29C49/04 , B29C49/18 , B29C49/783 , B29C2049/0089 , B29K2067/00 , B29K2105/258 , B29K2905/12 , B29L2031/7542 , Y10T428/1331 , Y10T428/1352 , Y10T428/139
摘要： A method for forming a balloon for a dilatation catheter may utilize the steps of extruding a tubing preform of a polyester resin and then blowing the tubing into an oriented balloon, wherein the tubing preform is dried prior to blowing into the balloon form. Other process steps by which balloon cone and waist thicknesses may be reduced involve varying the axial tension and blowing pressure at several stages as a mold containing the balloon preform is dipped into a heating medium. Specifically, tubing of a thermoplastic material is placed in a mold and blown by pressurizing and tensioning the tubing and gradually dipping the mold into a heated heat transfer media so as to sequentially blow a first waist, a body and a second waist portion. The tubing is subjected to a relatively lower pressure while the body portion is blown than while the first and second waist portions are blown.
摘要翻译：用于形成用于扩张导管的球囊的方法可以采用以下步骤：挤出聚酯树脂的管坯预成型件，然后将管道吹入定向气囊中，其中将管坯预先吹入气囊形式之前进行干燥。球囊和腰部厚度可能减小的其他工艺步骤包括在将包含球囊预制件的模具浸入加热介质中时，在几个阶段改变轴向张力和吹塑压力。具体地说，将热塑性材料的管材放置在模具中，并通过加压和张紧管子并将模具逐渐浸入加热的传热介质中，以便顺序地吹动第一腰部，身体和第二腰部部分而吹塑。当吹塑本体部分时，管道相对于第一和第二腰部部分被吹送而受到相对较低的压力。

40. 发明授权

US6117168A Multilayer liquid absorption and deformation devices 失效
公开(公告)号：US6117168A
公开(公告)日：2000-09-12
申请号：US775741
申请日：1996-12-31
申请人： Dachuan Yang , Lixiao Wang
发明人： Dachuan Yang , Lixiao Wang
IPC分类号： A61L31/00 , A61F2/82 , A61F2/88 , A61F2/92 , A61L31/10 , A61L31/14 , A61L31/16 , A61F2/06
CPC分类号： A61F2/82 , A61F2/88 , A61F2/92 , A61L31/10 , A61L31/145 , A61L31/148 , A61L31/16 , A61F2210/0061 , A61F2210/0076 , A61L2300/00
摘要： A multilayer device comprised of at least one layer of material which is capable of absorbing liquid to thereby increase the volume of the layer, i.e., liquid swellable, and when bound to at least one non-absorbing or lesser absorbing layer of material causes deformation of the device upon liquid absorption.

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