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1. 发明申请

US20090227949A1 BALLOON CATHETER DEVICES WITH FOLDED BALLOONS 有权
标题翻译：具有折叠气球的气缸导管装置
公开(公告)号：US20090227949A1
公开(公告)日：2009-09-10
申请号：US12399548
申请日：2009-03-06
申请人： David Knapp , Timothy J. Mickley , John Chen , Derek Sutermeister , Toby Freyman , Gordon Kocur , Daniel Horn , Jim Anderson , Ben Arcand , Jay Rassat , Raed Rizq , Irina Nazarova , Dan Quillin , Jan Weber , Torsten Scheuermann
发明人： David Knapp , Timothy J. Mickley , John Chen , Derek Sutermeister , Toby Freyman , Gordon Kocur , Daniel Horn , Jim Anderson , Ben Arcand , Jay Rassat , Raed Rizq , Irina Nazarova , Dan Quillin , Jan Weber , Torsten Scheuermann
IPC分类号： A61M25/10
CPC分类号： A61M25/1029 , A61L29/085 , A61L29/16 , A61L2300/416 , A61M25/0045 , A61M25/10 , A61M2025/0056 , A61M2025/1031 , A61M2025/105 , B29L2009/005 , C08L53/02
摘要： Catheter devices having an expandable balloon for delivering a therapeutic agent to a body site. The balloon has one or more folds which serve as a reservoir for containing the therapeutic agent. The fold may have any of various configurations to hold the therapeutic agent. In some cases, the balloon comprises one or more lobes that forms the fold(s). The therapeutic agent may be provided in various ways. For example, the therapeutic agent may be contained in packets that rupture upon expansion of the balloon, or as a plurality of discrete bulk masses, or sealed within compartments.
摘要翻译：具有用于将治疗剂递送到身体部位的可膨胀气囊的导管装置。气囊具有一个或多个折叠，其用作容纳治疗剂的储存器。折叠可以具有保持治疗剂的各种构造中的任何一种。在一些情况下，气囊包括形成褶皱的一个或多个凸起。治疗剂可以以各种方式提供。例如，治疗剂可以包含在囊膨胀时破裂的包装中，或者作为多个离散的体积块，或者密封在隔室内。

2. 发明授权

US07252674B2 Expandable ablation burr 失效
标题翻译：可扩展消融毛刺
公开(公告)号：US07252674B2
公开(公告)日：2007-08-07
申请号：US10770336
申请日：2004-02-02
申请人： Mark H. Wyzgala , Eric B. Hamilton , Tom J. Hiblar , Lixiao Wang , John J. Chen , Irina Nazarova , Nancy L. Haig , Sheng-Ping Zhong
发明人： Mark H. Wyzgala , Eric B. Hamilton , Tom J. Hiblar , Lixiao Wang , John J. Chen , Irina Nazarova , Nancy L. Haig , Sheng-Ping Zhong
IPC分类号： A61B17/32
CPC分类号： A61B17/320725 , A61B17/320758 , A61B2017/00557 , A61B2017/00867 , A61B2017/320004 , A61B2017/320733
摘要： An atherectomy burr has an operating diameter that is larger than the diameter of a catheter in which the burr is routed. The burr may include an expandable polymeric balloon having a partially abrasive exterior surface. The maximum expansion of the burr is controlled by an expansion mechanism. Various mechanisms are disclosed for controlling the maximum diameter of the burr thus preventing the burr from over expanding. In addition, the present invention includes systems that are pulled proximally to remove portions of a lesion located in a patient's vasculature. The system includes an ablation burr that has abrasive disposed on the proximal end. The burr may create a seal when expanded to block the ablated particulate so that an aspiration system can remove the particulate from the vasculature. Alternatively, the burr system may include a self expanding seal that is deployed out of the aspiration sheath.
摘要翻译：粥样斑块切除术毛刺的操作直径大于其中布置毛刺的导管的直径。毛刺可以包括具有部分研磨外表面的可膨胀聚合气囊。毛刺的最大膨胀由膨胀机构控制。公开了用于控制毛刺的最大直径的各种机构，从而防止毛刺过度膨胀。另外，本发明还包括向近侧拉动以去除位于病人脉管系统中的病变部分的系统。该系统包括具有设置在近端的磨料的消融毛刺。当膨胀时，毛刺可以产生密封，以阻止消融的颗粒，使得吸气系统可以从脉管系统中除去颗粒。或者，毛刺系统可以包括从抽吸鞘部署出来的自膨胀密封件。

3. 发明授权

US06685718B1 Expandable ablation burr 失效
标题翻译：可扩展消融毛刺
公开(公告)号：US06685718B1
公开(公告)日：2004-02-03
申请号：US09629771
申请日：2000-07-31
申请人： Mark H. Wyzgala , Eric B. Hamilton , Thomas J. Hiblar , Lixiao Wang , John J. Chen , Irina Nazarova , Nancy L. Haig , Sheng-Ping Zhong
发明人： Mark H. Wyzgala , Eric B. Hamilton , Thomas J. Hiblar , Lixiao Wang , John J. Chen , Irina Nazarova , Nancy L. Haig , Sheng-Ping Zhong
IPC分类号： A61B1732
CPC分类号： A61B17/320725 , A61B17/320758 , A61B2017/00557 , A61B2017/00867 , A61B2017/320004 , A61B2017/320733
摘要： An atherectomy burr has an operating diameter that is larger than the diameter of a catheter in which the burr is routed. The burr may include a polymeric balloon that is coated with an abrasive and that expands when the burr is rotated. When the burr is rotated, the polymeric tube expands by centrifugal force. The maximum expansion of the burr is controlled by an expansion mechanism. Various mechanisms are disclosed for controlling the maximum diameter of the burr thus preventing the burr from over expanding. In addition, the present invention includes a system for preventing the loose ablated particulate from reembolizing in the distal vasculature. The system includes an ablation burr that has abrasive disposed on the proximal end that is pulled back toward the guide catheter to ablate the lesion. The burr creates a seal when expanded to block the ablated particulate so that the aspiration system can remove the particulate from the patient vessel or stent. Alternatively, the burr system may include a self expanding seal that is deployed out of the aspiration sheath so that a slight vacuum can remove the large loose particulate form, the patient's vessel or stent.
摘要翻译：粥样斑块切除术毛刺的操作直径大于其中布置毛刺的导管的直径。毛刺可以包括涂覆有磨料的聚合物气球，并且当毛刺旋转时膨胀。当毛刺旋转时，聚合物管通过离心力膨胀。毛刺的最大膨胀由膨胀机构控制。公开了用于控制毛刺的最大直径的各种机构，从而防止毛刺过度膨胀。此外，本发明还包括一种用于防止松散的消融颗粒在远端脉管系统中再栓塞的系统。该系统包括消融毛刺，其具有设置在近端上的磨料，其被拉回导向导管以烧蚀病变。当膨胀时，毛刺产生密封以阻挡消融的颗粒，使得吸气系统可以从患者的血管或支架中移除颗粒。或者，毛刺系统可以包括从抽吸鞘部署出来的自膨胀密封，使得轻微的真空可以从患者的血管或支架中移除大的松散颗粒。

4. 发明授权

US08617586B2 Hydrophilic coating that reduces particle development on ester-linked poly(ester-block-amide) 有权
标题翻译：亲水性涂料，可降低酯基聚（酯 - 嵌段 - 酰胺）上的颗粒发育
公开(公告)号：US08617586B2
公开(公告)日：2013-12-31
申请号：US12704390
申请日：2010-02-11
申请人： Irina Nazarova , Jeffrey S. Lindquist , Daniel J. Horn
发明人： Irina Nazarova , Jeffrey S. Lindquist , Daniel J. Horn
IPC分类号： A61M25/10
CPC分类号： A61L29/085 , A61L29/14 , A61L29/145 , Y10T428/265 , Y10T428/31786
摘要： Articles such as catheters or balloons that have an ester-linked poly(ester-block-amide) substrate have a lubricious hydrogel coating which suppresses particle development under accelerated aging conditions. A polymerizable coating composition is applied to the substrate without application of an intervening primer layer and cured. The coating composition comprises an uncrosslinked polyvinylpyrrolidone polymer that is free of attached photoinitiator groups and at least one polyfunctional ethylenically unsaturated monomer.
摘要翻译：具有酯交联聚（酯 - 嵌段 - 酰胺）基材的导管或气囊的制品具有润滑的水凝胶涂层，其抑制在加速老化条件下的颗粒发育。将可聚合涂层组合物施加到基材上，而不施加中间底漆层并固化。涂料组合物包含不含附着的光引发剂基团和至少一种多官能烯属不饱和单体的未交联的聚乙烯吡咯烷酮聚合物。

5. 发明申请

US20100217186A1 Hydrophilic Coating that Reduces Particle Development on Ester-linked Poly(ester-block-amide) 有权
标题翻译：酯交联聚（酯 - 嵌段 - 酰胺）上减少颗粒发展的亲水性涂层
公开(公告)号：US20100217186A1
公开(公告)日：2010-08-26
申请号：US12704390
申请日：2010-02-11
申请人： Irina Nazarova , Jeffrey S. Lindquist , Daniel J. Horn
发明人： Irina Nazarova , Jeffrey S. Lindquist , Daniel J. Horn
IPC分类号： A61M25/10 , B32B27/36 , B32B27/06 , B32B5/00 , B05D3/02 , B05D3/06 , B05D3/04 , A61M25/00
CPC分类号： A61L29/085 , A61L29/14 , A61L29/145 , Y10T428/265 , Y10T428/31786
摘要： Articles such as catheters or balloons that have an ester-linked poly(ester-block-amide) substrate have a lubricious hydrogel coating which suppresses particle development under accelerated aging conditions. A polymerizable coating composition is applied to the substrate without application of an intervening primer layer and cured. The coating composition comprises an uncrosslinked polyvinylpyrrolidone polymer that is free of attached photoinitiator groups and at least one polyfunctional ethylenically unsaturated monomer.
摘要翻译：具有酯交联聚（酯 - 嵌段 - 酰胺）基材的导管或气囊的制品具有润滑的水凝胶涂层，其抑制在加速老化条件下的颗粒发育。将可聚合涂层组合物施加到基材上，而不施加中间底漆层并固化。涂料组合物包含不含附着的光引发剂基团和至少一种多官能烯属不饱和单体的未交联的聚乙烯吡咯烷酮聚合物。

6. 发明授权

US07694810B1 Carrier tube assembly for packaging a medical device 有权
标题翻译：用于包装医疗装置的载体管组件
公开(公告)号：US07694810B1
公开(公告)日：2010-04-13
申请号：US12393943
申请日：2009-02-26
申请人： Kevin Barry , Robert N. Squire , Jeff Lindquist , Irina Nazarova
发明人： Kevin Barry , Robert N. Squire , Jeff Lindquist , Irina Nazarova
IPC分类号： B65D85/20
CPC分类号： A61M25/002
摘要： A carrier tube assembly for packaging a medical catheter is disclosed. The carrier tube assembly includes an elongate tube, a medical catheter, and a plug. At least a distal portion of the elongate shaft of the medical catheter is positioned in the lumen of the elongate tube such that the proximal end of the elongate tube is hermetically sealed around a portion of the hub assembly of the medical catheter. The plug is inserted into the lumen of the elongate tube at the distal end of the elongate tube, hermetically sealing the distal end of the elongate tube. Thus, a hermetically sealed environment is established within the elongate tube. The plug includes a moisture and/or oxygen absorbing agent to absorb moisture and/or oxygen in the hermetically sealed environment.
摘要翻译：公开了一种用于包装医疗导管的载体管组件。载体管组件包括细长管，医疗导管和塞子。医疗导管的细长轴的至少远端部分定位在细长管的内腔中，使得细长管的近端围绕医疗导管的毂组件的一部分气密密封。该插头在细长管的远端插入细长管的内腔中，气密地密封细长管的远端。因此，在细长管内建立密封的环境。塞子包括用于吸收密封环境中的水分和/或氧气的水分和/或氧吸收剂。

7. 发明授权

US5902631A Lubricity gradient for medical devices 失效
标题翻译：医疗器械的润滑梯度
公开(公告)号：US5902631A
公开(公告)日：1999-05-11
申请号：US868301
申请日：1997-06-03
申请人： Lixiao Wang , Irina Nazarova
发明人： Lixiao Wang , Irina Nazarova
IPC分类号： A61M25/00 , A61L29/08 , A61L29/14 , A61L31/10 , A61L31/18 , A61M25/01 , B05D3/10
CPC分类号： A61L31/18 , A61L29/085 , A61L29/14 , A61L31/10 , A61M2025/0062 , A61M25/0045 , B29L2031/7542 , Y10T428/24942 , Y10T428/31511 , Y10T428/31725 , Y10T428/31935
摘要： A medical device for partial insertion into a patient and navigating passageways, channels, canals, cavities, and other interior parts of said patient, said medical device comprising an elongate body having an in the body segment which, in normal use, is inserted in the body of a patient. At least a portion of the in-the-body segment is provided with a lubricious coating. The coating displays a gradient of lubricity along the length of thereof.
摘要翻译：一种医疗装置，用于部分地插入到患者体内并且导航所述患者的通道，通道，运河，空腔和其它内部部分，所述医疗装置包括细长体，其具有在正常使用中插入病人的身体身体部分的至少一部分设置有光滑的涂层。该涂层沿其长度显示出润滑性的梯度。

8. 发明授权

US08481139B2 High performance balloon catheter/component 有权
公开(公告)号：US08481139B2
公开(公告)日：2013-07-09
申请号：US12637490
申请日：2009-12-14
申请人： Daniel J. Horn , Jeffrey S. Lindquist , Irina Nazarova , Scott Schewe , David W. Meister , John J. Chen
发明人： Daniel J. Horn , Jeffrey S. Lindquist , Irina Nazarova , Scott Schewe , David W. Meister , John J. Chen
IPC分类号： B32B23/00 , B32B1/08
CPC分类号： A61M25/1029 , A61L29/126 , Y10T156/103 , Y10T428/13 , Y10T428/1303 , Y10T428/1352 , Y10T428/1359 , Y10T428/1362 , Y10T428/1369 , Y10T428/139
摘要： Composite fiber reinforced balloons for medical devices prepared by applying a web of fibers to the exterior of a preformed underlying balloon and encasing the web with a matrix material to form a composite balloon. The fiber web is applied to at least the cone portion of the underlying balloon form. Either the cone portion of the underlying balloon form, or the web fibers applied to said cone portion, or both, have a friction-enhancing material coated thereon.

9. 发明授权

US06261630B1 Coating gradient for lubricious coatings on balloon catheters 有权
标题翻译：球囊导管上润滑涂层的涂层梯度
公开(公告)号：US06261630B1
公开(公告)日：2001-07-17
申请号：US09764180
申请日：2001-01-17
申请人： Irina Nazarova , Lixiao Wang
发明人： Irina Nazarova , Lixiao Wang
IPC分类号： A61L2904
CPC分类号： A61M25/1029 , A61L29/085 , A61L29/14 , A61L31/10 , A61L31/18 , A61M25/0045 , A61M25/10 , A61M2025/0046 , A61M2025/0062 , A61M2025/1031 , A61M2025/1075 , A61M2025/1088 , B29C49/10 , B29C49/22 , B29L2031/7542 , Y10T428/24942 , Y10T428/2495 , Y10T428/31511 , Y10T428/31725 , Y10T428/31935 , A61L31/148 , C08L83/04 , C08L71/02 , C08L35/00 , A61L29/148
摘要： This invention relates to a dilatation balloon formed from an extruded tubular preform by blowing, said balloon having a body, at least one cone and at least one waist portion wherein said balloon has a lubricity coating gradient from the body portion which has the lowest coat thickness to the waist portion which has the highest coat thickness said coating applied to said extruded tubular preform prior to forming said balloon by blowing.
摘要翻译：本发明涉及一种由挤出的管状预成型件通过吹塑形成的膨胀气囊，所述气囊具有主体，至少一个锥体和至少一个腰部部分，其中所述球囊具有从具有最低涂层厚度的主体部分的润滑性涂层梯度在通过吹塑形成所述气囊之前，将具有最高涂层厚度的所述涂层施加到所述挤出的管状预成型件的腰部。

10. 发明申请

US20100094213A1 HIGH PERFORMANCE BALLOON CATHETER/COMPONENT 有权
标题翻译：高性能气球吸管/组件
公开(公告)号：US20100094213A1
公开(公告)日：2010-04-15
申请号：US12637490
申请日：2009-12-14
申请人： Daniel J. Horn , Jeffrey S. Lindquist , Irina Nazarova , Scott Schewe , David W. Meister , John J. Chen
发明人： Daniel J. Horn , Jeffrey S. Lindquist , Irina Nazarova , Scott Schewe , David W. Meister , John J. Chen
IPC分类号： A61M25/10
CPC分类号： A61M25/1029 , A61L29/126 , Y10T156/103 , Y10T428/13 , Y10T428/1303 , Y10T428/1352 , Y10T428/1359 , Y10T428/1362 , Y10T428/1369 , Y10T428/139
摘要： Composite fiber reinforced balloons for medical devices prepared by applying a web of fibers to the exterior of a preformed underlying balloon and encasing the web with a matrix material to form a composite balloon. The fiber web is applied to at least the cone portion of the underlying balloon form. Either the cone portion of the underlying balloon form, or the web fibers applied to said cone portion, or both, have a friction-enhancing material coated thereon.
摘要翻译：用于医疗装置的复合纤维增强气囊通过将纤维网施加到预先形成的下面的气球的外部并且用基质材料包裹纤维网以形成复合气囊而制备。至少将纤维网应用于下面的气球形式的锥形部分。下面的球囊形成的锥形部分或施加到所述锥形部分的纤维网或两者都具有涂覆在其上的摩擦增强材料。

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