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1. 发明授权

US06419692B1 Surface protection method for stents and balloon catheters for drug delivery 有权
标题翻译：用于药物输送的支架和球囊导管的表面保护方法
公开(公告)号：US06419692B1
公开(公告)日：2002-07-16
申请号：US09243580
申请日：1999-02-03
申请人： Duchuan Yang , Joel Stanslaski , Lixiao Wang
发明人： Duchuan Yang , Joel Stanslaski , Lixiao Wang
IPC分类号： A61F206
CPC分类号： A61L31/16 , A61F2/0077 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/91541 , A61F2002/91558 , A61F2250/0067 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/416 , A61L2300/608 , A61L2420/08
摘要： A medical device, such as a stent or balloon of a balloon catheter which includes a body portion which has an exterior surface which contacts, at least in part, a vessel wall during treatment. The body portion is expandable from a first position, wherein the body portion is sized for insertion into the vessel lumen, to a second position, wherein at least a portion of the exterior surface is in contact with the lumen wall. The medical device includes a first coating disposed over at least a portion of the exterior surface of the body portion with the first coating including a drug or therapeutic substance which is intended for controlled release from the surface. The medical device further includes a second coating overlying at least a substantial portion of the first coating. The second coating includes a material that is generally impervious to elution of the drug or therapeutic substance therethrough when the body portion is in a first position when inserted into the vessel lumen. The material of the second coating is relatively inelastic so that the second coating fractures during expansion of the body portion to the second position to allow elution of therapeutic substance through a multiplicity of fissures formed through the second coating.
摘要翻译：一种医疗装置，例如球囊导管的支架或球囊，其包括主体部分，该主体部分具有在治疗期间至少部分地与血管壁接触的外表面。主体部分从第一位置可膨胀，其中主体部分的尺寸适于插入血管腔，到达第二位置，其中外表面的至少一部分与内腔壁接触。医疗装置包括设置在主体部分的外表面的至少一部分上的第一涂层，第一涂层包括用于从表面受控释放的药物或治疗物质。医疗装置还包括覆盖第一涂层的至少大部分的第二涂层。第二涂层包括当插入血管内腔时主体部分处于第一位置时通常不透过药物或治疗物质的洗脱的材料。第二涂层的材料相对无弹性，使得第二涂层在主体部分膨胀到第二位置期间断裂，以允许通过穿过第二涂层形成的多个裂缝洗脱治疗物质。

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