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1. 发明授权

US08100979B2 Method and system for mammalian joint resurfacing 有权
标题翻译：哺乳动物关节表面置换的方法和系统
公开(公告)号：US08100979B2
公开(公告)日：2012-01-24
申请号：US12479402
申请日：2009-06-05
申请人： Jeffrey C Felt , Mark A. Rydell , Paul J. Buscemi , Alexander Arsenyev , Christopher H. Porter
发明人： Jeffrey C Felt , Mark A. Rydell , Paul J. Buscemi , Alexander Arsenyev , Christopher H. Porter
IPC分类号： A61F2/44
CPC分类号： A61B17/562 , A61F2/30721 , A61F2/34 , A61F2/38 , A61F2/3872 , A61F2/3877 , A61F2/389 , A61F2002/30535 , A61F2250/0058 , A61L27/18 , A61L2430/24 , C08G18/10 , C08G18/4854 , C08G18/61 , C08G18/69 , C08L75/04 , C08G18/32
摘要： A method and system for the creation or modification of the wear surface of orthopedic joints, involving the preparation and use of one or more partially or fully preformed and procured components, adapted for insertion and placement into the body and at the joint site. In a preferred embodiment, component(s) can be partially cured and generally formed ex vivo and further and further formed in vivo at the joint site to enhance conformance and improve long term performance. In another embodiment, a preformed balloon or composite material can be inserted into the joint site and filled with a flowable biomaterial in situ to conform to the joint site. In yet another embodiment, the preformed component(s) can be fully cured and formed ex vivo and optionally further fitted and secured at the joint site. Preformed components can be sufficiently pliant to permit insertion through a minimally invasive portal, yet resilient enough to substantially assume, or tend towards, the desired form in vivo with additional forming there as needed.
摘要翻译：一种用于创建或修改整形外科关节磨损表面的方法和系统，涉及准备和使用一种或多种部分或完全预成型和采购的部件，适于插入和放置在身体和关节部位。在一个优选的实施方案中，组分可以部分固化，并且通常在体外形式离体进一步形成并且在接合部位进一步形成，以增强一致性并改善长期性能。在另一个实施方案中，预先形成的球囊或复合材料可以插入到关节部位中并且在原位填充可流动的生物材料以符合关节部位。在另一个实施方案中，预成型组分可以完全固化并离体形成，并任选地进一步装配并固定在接头部位。预成型组件可以足够柔顺以允许通过微创入口插入，但足够弹性足以基本上假设或倾向于体内所需的形式，并根据需要进一步形成。

2. 发明申请

US20110308530A1 SYSTEMS AND METHODS FOR TREATMENT OF SLEEP APNEA 有权
标题翻译：用于治疗睡眠APNEA的系统和方法
公开(公告)号：US20110308530A1
公开(公告)日：2011-12-22
申请号：US13113946
申请日：2011-05-23
申请人： Edward M. Gillis , John H. Shadduck , Csaba Truckai , Andrew Poutiatine , Paul J. Buscemi
发明人： Edward M. Gillis , John H. Shadduck , Csaba Truckai , Andrew Poutiatine , Paul J. Buscemi
IPC分类号： A61F5/56
CPC分类号： A61F2/00 , A61F5/566 , A61F2210/0004
摘要： A system for treating an airway disorder is provided with an implant body configured to conform to an airway-interface tissue site in a manner compatible with normal physiological function of the site. In some embodiments, the implant body has first and second end portions and a medial portion. The implant body also includes a coupler configured to couple the end portions to one another such that the medial portion encircles targeted tissue. Methods of using such systems are also provided.
摘要翻译：一种用于治疗气道障碍的系统设置有植入体，其构造成以与该部位的正常生理功能相适应的方式与气道界面组织部位一致。在一些实施例中，植入体具有第一和第二端部和中间部分。植入体还包括耦合器，其被配置为将端部部分彼此耦合，使得内侧部分围绕目标组织。还提供了使用这种系统的方法。

3. 发明申请

US20100059066A1 Tongue implant 有权
标题翻译：舌植入
公开(公告)号：US20100059066A1
公开(公告)日：2010-03-11
申请号：US12586170
申请日：2009-09-16
申请人： Paul J. Buscemi , Kurt D. Krueger , Paula Bushendorf
发明人： Paul J. Buscemi , Kurt D. Krueger , Paula Bushendorf
IPC分类号： A61F5/56
CPC分类号： A61F5/566 , A61B2017/248
摘要： A patient's obstructive sleep apnea is treated by identifying a patient with sleep apnea attributable at least in part to movement of a base of a tongue of the patient toward a pharyngeal wall of the patient. The tongue is stiffened by an implant sized to be placed within the tongue. A distal portion of the implant is sized to extend within the tongue from a first end near a mandibular-geniohyoid interface to a second end near a base of the tongue. A proximal portion is attached to the first end and adapted to be secured to a jaw bone of the patient following a period of healing after placement of the implant in the tongue.
摘要翻译：患者的阻塞性睡眠呼吸暂停通过识别至少部分地归因于患者的舌头的基部朝向患者的咽壁的移动而患有睡眠呼吸暂停的患者来治疗。舌头由被放置在舌头内的植入物硬化。植入物的远端部分的尺寸被设计成在舌下从第一端附近的下颌骨 - 基底膜界面延伸到靠近舌头基部的第二端。近端部分附接到第一端并且适于在将植入物放置在舌头中之后经过愈合期后固定到患者的颚骨上。

4. 发明申请

US20100059065A1 Tongue Implant for Sleep Apnea 有权
标题翻译：舌植入物睡眠呼吸暂停
公开(公告)号：US20100059065A1
公开(公告)日：2010-03-11
申请号：US12553262
申请日：2009-09-03
申请人： Paul J. Buscemi , Kurt D. Krueger
发明人： Paul J. Buscemi , Kurt D. Krueger
IPC分类号： A61F5/56
CPC分类号： A61F5/566
摘要： A patient's obstructive sleep apnea is treated by identifying a patient with sleep apnea attributable at least in part to movement of a base of a tongue of said patient toward a pharyngeal wall of said patient. The method includes identifying a region in the tongue extending from a mandibular-geniohyoid interface to the base of the tongue and stiffening a tissue of the tongue throughout the identified region.
摘要翻译：患者的阻塞性睡眠呼吸暂停通过识别至少部分地归因于所述患者的舌头的基部朝向所述患者的咽壁的移动而患有睡眠呼吸暂停的患者来治疗。该方法包括识别从下颌骨 - 基底膜界面延伸到舌头基部的舌头中的区域，并且在整个识别的区域中加强舌头的组织。

5. 发明授权

US07491230B2 Endovascular apparatus 失效
公开(公告)号：US07491230B2
公开(公告)日：2009-02-17
申请号：US10288185
申请日：2002-11-05
申请人： Thomas J. Holman , Darlene A. Thometz , Fertac Bilge , Paul J. Buscemi , David H. Donabedian
发明人： Thomas J. Holman , Darlene A. Thometz , Fertac Bilge , Paul J. Buscemi , David H. Donabedian
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61B17/12045 , A61B17/12118 , A61B2017/00004 , A61B2017/00535 , A61B2017/1205 , A61B2017/12127 , A61F2/89 , A61F2/94 , A61F2/95 , A61F2/954 , A61F2002/065 , A61F2002/072 , A61F2002/075 , A61F2250/0003
摘要： Percutaneous treatment of aortic aneurysms and like vascular anomalies by an apparatus and method wherein the apparatus is delivered via catheter and comprises a sleeve with at least one peripheral conduit which is caused to assume an expanded, rigid configuration by the introduction of a chemical or mechanical hardening means, whereby the sleeve is caused to assume an open cylindrical configuration for fluid flow therethrough.

6. 发明申请

US20070295340A1 Stiffening Procedure for Sleep Apnea 有权
标题翻译：睡眠呼吸暂停的加强程序
公开(公告)号：US20070295340A1
公开(公告)日：2007-12-27
申请号：US11426133
申请日：2006-06-23
申请人： Paul J. Buscemi
发明人： Paul J. Buscemi
IPC分类号： A61F5/56
CPC分类号： A61F5/566
摘要： A patient's obstructive sleep apnea is treated by placing a fibrosis-inducing agent is placed within the tongue in a region extending substantially from a hyoid bone rearward toward a back surface of the tongue and upwardly along the back wall toward a free end of a soft palate of the patient.
摘要翻译：患者的阻塞性睡眠呼吸暂停通过将纤维化诱导剂放置在舌头内的区域中进行治疗，所述纤维化诱导剂基本上从舌骨向后延伸到舌的后表面并沿着后壁向上延伸到软腭的自由端的病人。

7. 发明授权

US06869443B2 Biodegradable drug delivery vascular stent 失效
标题翻译：生物降解药物输送血管支架
公开(公告)号：US06869443B2
公开(公告)日：2005-03-22
申请号：US10108904
申请日：2002-03-28
申请人： Paul J. Buscemi , Elizabeth A. Stejskal , Donald F. Palme, II , Lixiao Wang
发明人： Paul J. Buscemi , Elizabeth A. Stejskal , Donald F. Palme, II , Lixiao Wang
IPC分类号： A61F2/00 , A61F2/02 , A61F2/82 , A61F2/88 , A61L31/14 , A61L31/16 , A61F2/06
CPC分类号： A61F2/82 , A61F2/88 , A61F2/958 , A61F2210/0004 , A61F2210/0023 , A61F2250/0067 , A61F2250/0068 , A61L31/041 , A61L31/044 , A61L31/047 , A61L31/148 , A61L31/16 , A61L2300/42 , A61L2300/604 , A61L2300/606 , A61L2300/622 , Y10S623/901 , C08L67/04
摘要： A stent includes a main body of a generally tubular shape for insertion into a lumen of a vessel of a living being. The tubular main body includes a substantially biodegradable matrix having collagen IV and laminin that enclose voids within the matrix. The tubular main body also includes a biodegradable strengthening material in contact with the matrix to strengthen the matrix. The tubular main body is essentially saturated with drugs.
摘要翻译：支架包括用于插入活体血管内腔的大体管状形状的主体。管状主体包括基本上可生物降解的基质，其具有包围基质内的空隙的胶原IV和层粘连蛋白。管状主体还包括与基质接触以增强基质的可生物降解的强化材料。管状主体基本上被药物饱和。

8. 发明授权

US06692523B2 Endovascular apparatus 有权
标题翻译：血管内装置
公开(公告)号：US06692523B2
公开(公告)日：2004-02-17
申请号：US10003218
申请日：2001-10-30
申请人： Thomas J. Holman , Darlene A. Thometz , Fertac Bilge , Paul J. Buscemi , David H. Donabedian
发明人： Thomas J. Holman , Darlene A. Thometz , Fertac Bilge , Paul J. Buscemi , David H. Donabedian
IPC分类号： B23K2702
CPC分类号： A61F2/07 , A61B17/12045 , A61B17/12118 , A61B2017/00004 , A61B2017/00535 , A61B2017/1205 , A61B2017/12127 , A61F2/89 , A61F2/94 , A61F2/95 , A61F2/954 , A61F2002/065 , A61F2002/072 , A61F2002/075 , A61F2250/0003
摘要： Percutaneous treatment of aortic aneurysms and like vascular anomalies by an apparatus and method wherein the apparatus is delivered via catheter and comprises a sleeve with at least one peripheral conduit which is caused to assume an expanded, rigid configuration by the introduction of a chemical or mechanical hardening means, whereby the sleeve is caused to assume an open cylindrical configuration for fluid flow therethrough.
摘要翻译：通过一种装置和方法经皮治疗主动脉瘤和类似的血管异常，其中该装置通过导管输送并且包括具有至少一个周边导管的套筒，其通过引入化学或机械硬化而被引入膨胀的刚性构型意味着使套筒呈现开口的圆柱形结构，用于流过其中的流体。

9. 发明授权

US06387124B1 Biodegradable drug delivery vascular stent 失效
标题翻译：生物降解药物输送血管支架
公开(公告)号：US06387124B1
公开(公告)日：2002-05-14
申请号：US09420079
申请日：1999-10-18
申请人： Paul J. Buscemi , Elizabeth A. Stejskal , Donald F. Palme, II , Lixiao Wang
发明人： Paul J. Buscemi , Elizabeth A. Stejskal , Donald F. Palme, II , Lixiao Wang
IPC分类号： A61F206
CPC分类号： A61F2/82 , A61F2/88 , A61F2/958 , A61F2210/0004 , A61F2210/0023 , A61F2250/0067 , A61F2250/0068 , A61L31/041 , A61L31/044 , A61L31/047 , A61L31/148 , A61L31/16 , A61L2300/42 , A61L2300/604 , A61L2300/606 , A61L2300/622 , Y10S623/901 , C08L67/04
摘要： A stent includes a main body of a generally tubular shape for insertion into a lumen of a vessel of a living being. The tubular main body includes a substantially biodegradable matrix having collagen IV and laminin that enclose voids within the matrix. The tubular main body also includes a biodegradable strengthening material in contact with the matrix to strengthen the matrix. The tubular main body is essentially saturated with drugs.
摘要翻译：支架包括用于插入活体血管内腔的大体管状形状的主体。管状主体包括基本上可生物降解的基质，其具有包围基质内的空隙的胶原IV和层粘连蛋白。管状主体还包括与基质接触以增强基质的可生物降解的强化材料。管状主体基本上被药物饱和。

10. 发明授权

US06312446B1 Apparatus and method for closing a septal defect 有权
标题翻译：闭合中隔缺损的装置和方法
公开(公告)号：US06312446B1
公开(公告)日：2001-11-06
申请号：US09659346
申请日：2000-09-12
申请人： Joseph Huebsch , Paul J. Buscemi , Thomas J. Holman , Danney Langanki
发明人： Joseph Huebsch , Paul J. Buscemi , Thomas J. Holman , Danney Langanki
IPC分类号： A61B1708
CPC分类号： A61B17/0057 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00606 , A61B2017/00619 , A61B2017/00623
摘要： A catheter delivered device to close a septal defect, the device comprising a cylindrical shaft of metal or polymeric material with concentric parallel cuts through the wall of the device which create flattened support struts. The center of the support struts move radially away from the axis in a hinge like fashion in response to the movement of the device's proximal and distal ends toward the center of the device. This movement is reversibly effected through mechanical means. The device can be coated with growth factors, mitogenic factors or other determinants which can improve tissue growth such that tissue ingrowth can occur over a period of time. The catheter itself may be an ultrasonic imaging catheter.
摘要翻译：导管输送装置以闭合隔膜缺损，该装置包括金属或聚合材料的圆柱形轴，穿过穿过该装置的壁的同心平行切口，其形成平坦的支撑支柱。响应于装置的近端和远端朝向装置的中心的移动，支撑支柱的中心以铰链相似的方式径向地远离轴线移动。这种运动通过机械手段可逆地实现。该装置可以涂覆生长因子，促有丝分裂因子或其它决定因素，其可以改善组织生长，使得组织向内生长可以在一段时间内发生。导管本身可以是超声成像导管。

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