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31. 发明授权

US5919690A .alpha.-galactosidase enzyme 失效
标题翻译： α-半乳糖苷酶
公开(公告)号：US5919690A
公开(公告)日：1999-07-06
申请号：US522269
申请日：1995-09-12
申请人： Inge Helmer Knap , Carsten M. Hjort , Torben Halkier , Lene Venke Kofod
发明人： Inge Helmer Knap , Carsten M. Hjort , Torben Halkier , Lene Venke Kofod
IPC分类号： A23L11/00 , A23L29/00 , A61K38/46 , A61P1/14 , C07H21/04 , C12N1/15 , C12N1/21 , C12N9/40 , C12N15/09 , C12N15/56 , C12P19/02 , C12R1/685 , C12R1/69 , C12N1/14 , C12N1/20
CPC分类号： C12N9/2465
摘要： A DNA construct comprising a DNA sequence encoding a polypeptide having .alpha.-galactosidase activity, having the amino acid sequence of SEQ ID NO:3.
摘要翻译： PCT No.PCT / DK94 / 00138 Sec。 371 1995年9月12日第 102（e）日期1995年9月12日PCT 1994年3月30日PCT PCT。第WO94 / 23022号公报日期1994年10月13日包含编码具有α-半乳糖苷酶活性的多肽的DNA序列的DNA构建体，其具有SEQ ID NO：3的氨基酸序列。

32. 发明授权

US5879921A Recombinant expression of a glucose oxidase from a cladosporium strain 失效
标题翻译：葡萄糖氧化酶从枝孢菌菌株的重组表达
公开(公告)号：US5879921A
公开(公告)日：1999-03-09
申请号：US746257
申请日：1996-11-07
申请人： Joel R. Cherry , Randy M. Berka , Torben Halkier
发明人： Joel R. Cherry , Randy M. Berka , Torben Halkier
IPC分类号： C12N9/04 , C12N15/53 , C12N15/09
CPC分类号： C12N9/0006
摘要： The invention is directed to alkaline glucose oxidases comprising novel peptide sequences. Furthermore, the invention relates to methods for producing and using said glucose oxidases.
摘要翻译：本发明涉及包含新肽序列的碱性葡萄糖氧化酶。此外，本发明涉及生产和使用所述葡萄糖氧化酶的方法。

33. 发明授权

US5874275A Polypeptides having mutanase activity and nucleic acids encoding same 失效
标题翻译：具有转录酶活性的多肽和编码相同的核酸
公开(公告)号：US5874275A
公开(公告)日：1999-02-23
申请号：US956268
申请日：1997-10-22
申请人： Randy M Berka , Stephan Christgau , Torben Halkier , Jeff Shuster , Claus Crone Fuglsang
发明人： Randy M Berka , Stephan Christgau , Torben Halkier , Jeff Shuster , Claus Crone Fuglsang
IPC分类号： C12N15/09 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N9/24 , C12N15/00 , C12N15/55 , C12R1/07 , C12R1/46 , C12R1/465 , C12R1/645 , C12R1/66 , C12R1/72 , C12R1/77 , C12R1/785 , C12R1/80 , C12R1/84 , C12R1/85 , C07H21/04 , C12N1/20
CPC分类号： C12Y302/01084 , C12N9/2402 , Y10S435/933 , Y10S435/935
摘要： The present invention relates to polypeptides having mutanase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides. The present invention further relates to oral cavity compositions and methods for degrading mutan.
摘要翻译：本发明涉及具有衍生葡聚糖酶活性的多肽和分离的编码多肽的核酸序列。本发明还涉及包含核酸序列的核酸构建体，载体和宿主细胞以及用于产生多肽的方法。本发明还涉及口腔组合物和降解变应原的方法。

34. 发明授权

US5866393A Haloperoxidases from curvularia verruculosa and nucleic acids encoding same 失效
标题翻译：来自疣状弧菌的卤素过氧化物酶和编码相同的核酸
公开(公告)号：US5866393A
公开(公告)日：1999-02-02
申请号：US679405
申请日：1996-07-09
申请人： Claus Fuglsang , Karen Oxenb.o slashed.ll , Torben Halkier , Randy M. Berka , Joel Cherry
发明人： Claus Fuglsang , Karen Oxenb.o slashed.ll , Torben Halkier , Randy M. Berka , Joel Cherry
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N9/08 , C12N15/52 , C12N15/53 , C12N15/80 , C12P21/02 , C12R1/645
CPC分类号： C12N9/0065 , Y10S435/911
摘要： The present invention relates to Curvularia verruculosa haloperoxidases and isolated nucleic acid fragments comprising nucleic acid sequences encoding the haloperoxidases as well as nucleic acid constructs, vectors, and recombinant host cells comprising the nucleic acid sequences. The invention also relates to methods for recombinant production of the haloperoxidase. The invention further relates to compositions comprising the haloperoxidases and methods of using the compositions for killing microbial cells or inhibiting growth of microbial cells.
摘要翻译：本发明涉及疣状弧菌弧菌过氧化物酶和包含编码卤代过氧化物酶的核酸序列以及包含核酸序列的核酸构建体，载体和重组宿主细胞的分离的核酸片段。本发明还涉及用于重组生产卤代过氧化物酶的方法。本发明还涉及包含卤代过氧化物酶的组合物和使用该组合物杀死微生物细胞或抑制微生物细胞生长的方法。

35. 发明授权

US5821104A Tripeptidyl aminopeptidase 失效
标题翻译：三肽基氨基肽酶
公开(公告)号：US5821104A
公开(公告)日：1998-10-13
申请号：US821119
申请日：1997-03-19
申请人： Kaj Andre Holm , Grethe Rasmussen , Torben Halkier , Jan Lehmbeck
发明人： Kaj Andre Holm , Grethe Rasmussen , Torben Halkier , Jan Lehmbeck
IPC分类号： C12N15/09 , C12N1/15 , C12N1/21 , C12N9/48 , C12N9/62 , C12N15/57 , C12R1/19 , C12R1/66 , C12R1/77 , C12N15/11 , C12N15/80
CPC分类号： C12N9/48
摘要： The present invention relates to a tripeptidyl aminopeptidase, a DNA construct encoding the tripeptidyl aminopeptidase, a method of producing tripeptidyl aminopeptidase and methods of reducing the tripeptidyl aminopeptidase production in cells in which tripeptidyl aminopeptidase activity is undesirable.
摘要翻译：本发明涉及三肽基氨基肽酶，编码三肽基氨基肽酶的DNA构建体，产生三肽基氨基肽酶的方法和减少三肽基氨基肽酶活性不希望的细胞中三肽基氨基肽酶产生的方法。

36. 发明授权

US5610048A Xylanase, DNA sequences, coding for the xylanases and methods of use thereof 失效
标题翻译：木聚糖酶，编码木聚糖酶的DNA序列及其使用方法
公开(公告)号：US5610048A
公开(公告)日：1997-03-11
申请号：US119169
申请日：1993-09-21
申请人： Martin Schulein , Torben Halkier , Hans P. Heldt-Hansen , Henrik Dalb.o slashed.ge , Lars S. Pedersen
发明人： Martin Schulein , Torben Halkier , Hans P. Heldt-Hansen , Henrik Dalb.o slashed.ge , Lars S. Pedersen
IPC分类号： C07K14/37 , A21D8/04 , A23K20/189 , C07K14/00 , C07K14/41 , C12N20060101 , C12N1/15 , C12N1/19 , C12N1/21 , C12N9/24 , C12N9/42 , C12N15/09 , C12N15/56 , C12R1/07 , C12R1/645 , C12R1/66 , C12R1/685 , C12R1/69 , C12S3/08 , D21C5/00 , D21C9/10 , C12N15/80
CPC分类号： C12Y302/01032 , A21D8/042 , A23K20/189 , C12N9/248 , C12Y302/01008 , D21C5/005
摘要： The xylanase is characterized by several partial amino acid sequences and is immunoreactive with an antibody raised against a purified xylanase derived from Humicola insolens, DSM 1800. This xylanase preparation is practically free of cellulase xylanase and is well suited for treatment of paper pulp, as a baking agent and as an additive to fodder.
摘要翻译： PCT No.PCT / DK92 / 00099 Sec。 371日期：1993年9月21日 102（e）日期1993年9月21日PCT 1992年3月27日PCT公布。 WO92 / 17573 PCT公开日期1992年10月15日木聚糖酶的特征在于几个部分氨基酸序列，并且与针对源自Humicola insolens，DSM 1800的纯化的木聚糖酶产生的抗体具有免疫反应性。该木聚糖酶制剂实际上不含纤维素酶木聚糖酶，并且非常适合于纸浆，作为烘焙剂和饲料添加剂。

37. 发明授权

US07098017B2 Protease variants and compositions 有权
公开(公告)号：US07098017B2
公开(公告)日：2006-08-29
申请号：US09948080
申请日：2001-09-06
申请人： Claus von der Osten , Torben Halkier , Carsten Andersen , Peter Bauditz , Peter Kamp Hansen
发明人： Claus von der Osten , Torben Halkier , Carsten Andersen , Peter Bauditz , Peter Kamp Hansen
IPC分类号： C12N9/52 , C12N9/56 , C12N15/57 , C12N15/74 , C11D3/386
CPC分类号： C11D3/386 , C12N9/54
摘要： The present invention relates to enzymes produced by mutating the genes for a number of subtilases and expressing the mutated genes in suitable hosts are presented. The enzymes exhibit improved autoproteolytic stability in comparison to their wild type parent enzymes.

38. 发明申请

US20050222389A1 Method for preparing modified polypeptides 审中-公开
标题翻译：制备修饰多肽的方法
公开(公告)号：US20050222389A1
公开(公告)日：2005-10-06
申请号：US10756813
申请日：2004-01-12
申请人： Torben Halkier , Anders Pedersen , Jens Okkels , Kim Anderson
发明人： Torben Halkier , Anders Pedersen , Jens Okkels , Kim Anderson
IPC分类号： C07H21/04 , C07K1/107 , C07K14/31 , C07K14/47 , C07K19/00 , C12N15/10 , C12Q1/68 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： C12N15/1058 , C07K1/107 , C07K14/31 , C07K19/00 , C12N15/1034
摘要： Methods for producing polypeptide with altered immunogenicity or improved stability properties are disclosed. The methods involve a) expressing a diversified population of nucleotide sequences encoding a polypeptide of interest, b) screening the polypeptides expressed in step a) for function, immunogenicity and/or stability, c) selecting functional polypeptides having altered immunogenicity and/or increased stability, e.g. functional in vivo half-life as compared to the polypeptide of interest, and d) optionally subjecting the nucleotide sequence encoding the polypeptide selected in step c) to one or more repeated cycles of steps a)-c). In a further step the expressed polypeptides of step a) or c) can be conjugated to at least one non-polypeptide moiety.
摘要翻译：公开了产生具有改变的免疫原性或改善的稳定性的多肽的方法。所述方法包括：a）表达编码感兴趣多肽的核苷酸序列的多样化群体，b）筛选功能，免疫原性和/或稳定性在步骤a）中表达的多肽，c）选择具有改变的免疫原性和/或增加稳定性的功能性多肽，例如与目的多肽相比具有功能的体内半衰期，和d）任选地将编码步骤c）中选择的多肽的核苷酸序列经历步骤a）-c）的一个或多个重复循环。在另一步骤中，步骤a）或c）的表达多肽可以与至少一个非多肽部分缀合。

39. 发明授权

US06645500B1 Method for down-regulating osteoprotegerin ligand activity 失效
标题翻译：降低骨保护素配体活性的方法
公开(公告)号：US06645500B1
公开(公告)日：2003-11-11
申请号：US09396937
申请日：1999-09-15
申请人： Torben Halkier , Jesper Haaning
发明人： Torben Halkier , Jesper Haaning
IPC分类号： A61K3900
CPC分类号： C07K14/70575 , A61K39/00 , A61K2039/51 , C07K2319/02 , C12N2799/021 , Y02A50/412
摘要： The invention provides a novel method for down-regulating the biological activity of osteoprotegerin ligand (OPGL, TRANCE) thereby rendering possible the treatment/amelioration of diseases characterized by excessive loss of bone mass, e.g. osteoporosis. Down-regulation is effected by inducing an immune response against OPGL in an individual in need thereof. Immune responses can be raised by classical immunization with immunogenic variants of OPGL or by nucleic acid immunization where the nucleic acids encode the OPGL variant. The invention also pertains to compositions, polypeptides and nucleic acids useful in the invention, as well as to vectors and transformed host cells useful in the preparation thereof.
摘要翻译：本发明提供了一种用于下调骨保护蛋白配体（OPGL，TRANCE）的生物学活性的新方法，从而使得治疗/改善以骨量过量损失为特征的疾病，例如，骨质疏松症通过在有需要的个体中诱导针对OPGL的免疫应答来实现下调。免疫反应可以通过用OPGL的免疫原性变体进行的经典免疫或通过核酸免疫进行，其中核酸编码OPGL变体。本发明还涉及可用于本发明的组合物，多肽和核酸，以及可用于其制备的载体和转化的宿主细胞。

40. 发明授权

US06428993B1 Transglutaminase from oomycetes 失效
标题翻译：来自卵菌的转谷氨酰胺酶
公开(公告)号：US06428993B1
公开(公告)日：2002-08-06
申请号：US08881742
申请日：1997-06-24
申请人： Lisbeth Bech , Grethe Rasmussen , Torben Halkier , Mariko Okada , Lene Nonboe Andersen , Markus Sakari Kauppinen , Thomas Sandal
发明人： Lisbeth Bech , Grethe Rasmussen , Torben Halkier , Mariko Okada , Lene Nonboe Andersen , Markus Sakari Kauppinen , Thomas Sandal
IPC分类号： C12N910
CPC分类号： C12Y203/02013 , A21D8/042 , C12N9/1044 , C14C11/00 , Y10S435/911
摘要： The present invention relates to transglutaminases and transglutaminase preparations obtained from lower fungi belonging to the class Oomycetes. Unprecedented high-level expression is achievable by growing these coenocytium forming organisms, especially the strains Pythium sp., Pythium irregulare, Pythium dissotocum, Pythium periilum (or P. periplocum), Pythium torulosum, Pythium ultimum, Pythium aphanidermatum, Phytophthora cactorum, Phytophthora palmivora, Phytophthora porri, Phytophthora infestans, Phytoph-thora megasperma, Phytophthora cinnamomi and Phytophthora cryptogea. Arecombinant transglutaminase has been cloned and expressed, the enzyme and enzyme preparations being useful for cross-linking proteins, e.g. in flour, baked products, meat products, fish products, cosmetics, cheese, milk products, gelled food products and leather finishing, or as a glutaminase, e.g. in bread and other baked glutein-containing food products.
摘要翻译：本发明涉及从属于卵菌纲的较低真菌获得的转谷氨酰胺酶和转谷氨酰胺酶制剂。通过生长这些细胞形成的细菌，特别是菌株腐霉菌，不锈钢腐霉，腐霉腐霉（P. periplocum），腐皮腐，腐霉，腐霉，腐皮疫霉，致病疫霉（Phytophthora palmivora），可以实现前所未有的高水平表达，疫霉疫霉（Phytophthora porri），致病疫霉（Phytophthora infestans），致病疫霉（Phytoph-thora megasperma），肉桂疫霉（Phytophthora cinnamomi）和疫霉疫霉（Phytophthora cryptogea）。克隆和表达重组转谷氨酰胺酶，酶和酶制剂可用于交联蛋白质，例如，在面粉，烘焙食品，肉制品，鱼制品，化妆品，奶酪，乳制品，凝胶食品和皮革整理中，或作为谷氨酰胺酶。在面包和其他烘烤含麸质的食品中。

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