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1. 发明授权

US11078456B2 Fusarium solani and use of same in prevention and treatment of southern blight of Dendrobium officinale Kimura et Migo 有权
公开(公告)号：US11078456B2
公开(公告)日：2021-08-03
申请号：US16650975
申请日：2018-08-13
申请人： JIANGSU VOCATIONAL COLLEGE OF AGRICULTURE AND FORESTRY
发明人： Chao Xu , Hongyan Zhang , Hetong Yang , Gangjun Xi , Kai Zheng , Jun Shi
IPC分类号： C12N1/14 , A01N63/30 , C12R1/77
摘要： A Fusarium solani strain and a use thereof in the control of southern blight disease of Dendrobium officinale Kimura et Migo, and the strain JSNL007-2 has been identified as Fusarium solani and has been deposited in China Center for Type Culture Collection on Mar. 10, 2017 with a deposit number of CGMCC NO. 13687. The Fusarium solani JSNL007-2 of the present invention has a significant effect on the disease resistance of Dendrobium officinale Kimura et Migo, especially for improving the ability of Dendrobium officinale Kimura et Migo to resist southern blight disease, and has a certain effect on reducing the use of chemical pesticides, which is an important means to ensure food safety.

2. 发明申请

US20200281214A1 FUSARIUM SOLANI AND USE OF SAME IN PREVENTION AND TREATMENT OF SOUTHERN BLIGHT OF DENDROBIUM OFFICINALE KIMURA ET MIGO 审中-公开
公开(公告)号：US20200281214A1
公开(公告)日：2020-09-10
申请号：US16650975
申请日：2018-08-13
申请人： JlANGSU VOCATIONAL COLLEGE OF AGRICULTURE AND FORESTRY
发明人： Chao XU , Hongyan ZHANG , Hetong YANG , Gangjun XI , Kai ZHENG , Jun SHI
IPC分类号： A01N63/30 , C12R1/77 , C12N1/14
摘要： A Fusarium solani strain and a use thereof in the control of southern blight disease of Dendrobium officinale Kimura et Migo, and the strain JSNL007-2 has been identified as Fusarium solani and has been deposited in China Center for Type Culture Collection on Mar. 10, 2017 with a deposit number of CGMCC NO. 13687. The Fusarium solani JSNL007-2 of the present invention has a significant effect on the disease resistance of Dendrobium officinale Kimura et Migo, especially for improving the ability of Dendrobium officinale Kimura et Migo to resist southern blight disease, and has a certain effect on reducing the use of chemical pesticides, which is an important means to ensure food safety.

3. 发明授权

US09145442B2 Cyclic pentadepsipeptides and microorganism of Fusarium strain producing the same 有权
标题翻译：环戊五肽和镰刀菌菌株的微生物产生相同
公开(公告)号：US09145442B2
公开(公告)日：2015-09-29
申请号：US14502520
申请日：2014-09-30
申请人： Chung-Ang University Industry-Academy Cooperation Foundation
发明人： Chan Lee , Hyuk-Hwan Song , Hee-Seok Lee
IPC分类号： A61K38/12 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , C07K11/02 , C12P21/02 , C12R1/77 , A61K38/15 , A61K38/00
CPC分类号： C07K11/02 , A61K38/00 , A61K38/15 , C12P21/02 , C12R1/77
摘要： Disclosed is a Fusarium strain producing novel cyclic pentadepsipeptides which are of excellent multidrug resistance-reversing activity and inhibitory activity against cancer cells. Also, novel cyclic pentadepsipeptides are provided as active ingredients of the compositions useful in the treatment of cancer and diseases associated with multidrug resistance.
摘要翻译：公开了一种产生新型环戊五肽的镰刀菌菌株，其具有优异的多药耐药逆转活性和对癌细胞的抑制活性。另外，提供新的环状五缩水甘油肽作为可用于治疗癌症和与多药耐药相关的疾病的组合物的活性成分。

4. 发明授权

US09057080B1 Biosynthesis of styrene and 7-methyl-1,3,5-cyclooctatriene 有权
标题翻译：苯乙烯和7-甲基-1,3,5-环辛三烯的生物合成
公开(公告)号：US09057080B1
公开(公告)日：2015-06-16
申请号：US12265264
申请日：2008-11-05
申请人： John J. Beck , Glory B. Merrill , Jeffrey D. Palumbo , Teresa L. O'Keeffe
发明人： John J. Beck , Glory B. Merrill , Jeffrey D. Palumbo , Teresa L. O'Keeffe
IPC分类号： C12P7/00 , C12N1/14 , C12P5/00 , C12R1/77
CPC分类号： C12P5/005 , C12P5/002 , C12R1/77
摘要： The present invention relates to microorganisms capable of producing isolable amounts of styrene and/or 7-methyl-1,3,5-cyclooctatriene (MCOT) and uses thereof. The present invention also relates to methods for biosynthetically preparing styrene and/or 7-methyl-1,3,5-cyclooctatriene (MCOT) utilizing microorganisms capable of producing isolable amounts of styrene and/or 7-methyl-1,3,5-cyclooctatriene (MCOT).
摘要翻译：本发明涉及能够产生可分离量的苯乙烯和/或7-甲基-1,3,5-环辛三烯（MCOT）的微生物及其应用。本发明还涉及利用能够产生可分离量的苯乙烯和/或7-甲基-1,3,5-环辛三烯（MCOT）的生物合成制备苯乙烯和/或7-甲基-1,3,5-环辛三烯（MCOT）的方法，环辛三烯（MCOT）。

5. 发明授权

US5980958A Fungal food 失效
标题翻译：真菌食品
公开(公告)号：US5980958A
公开(公告)日：1999-11-09
申请号：US91105
申请日：1998-06-12
申请人： Thomas William Naylor , Trevor Williamson , Anthony Peter Joseph Trinci , Geoffrey David Robson , Marilyn Gail Wiebe
发明人： Thomas William Naylor , Trevor Williamson , Anthony Peter Joseph Trinci , Geoffrey David Robson , Marilyn Gail Wiebe
IPC分类号： A23J1/00 , A23J3/00 , A23J3/20 , A23L1/00 , A23L1/28 , C12N1/08 , C12N1/14 , C12N15/01 , C12R1/77 , A23J1/18
CPC分类号： C12R1/645 , A23J1/008 , A23L31/00
摘要： A human food product comprises a higher ploidy strain of Fungi imperfecti of which each parent has a genetic growth constraint not shared by the other parent. One parent is for example auxotrophic for two compounds selected from histidine, arginine, leucine and adenine and the other for the other two. The nucleic acid content of the strain is preferably less than 2% by weight. The strain may be made by killing a higher ploidy strain of Fungi imperfecti and simultaneously reducing its nucleic acid content to below 2% by weight by treatment with water. The process may include preparing a higher ploidy strain of edible Fusarium by culturing two auxotrophs thereof together in a medium containing nutrients permitting both to grow and then culturing organisms derived from such culture in minimal medium. The invention is applicable to the production of human food by culturing the strain in conditions such that reversion or partial reversion to the haploid form(s) is minimised.
摘要翻译： PCT No.PCT / GB96 / 03046 Sec。 371日期：1998年6月12日 102（e）1998年6月12日PCT PCT 1996年12月9日PCT公布。出版物WO97 / 22686 日期1997年6月26日人类食品包括更高倍性的真菌菌株，其中每个亲本具有不由另一方父母共享的遗传增长限制。一个亲本是例如两种选自组氨酸，精氨酸，亮氨酸和腺嘌呤的化合物的营养缺陷型，另一种是另外两种。菌株的核酸含量优选小于2重量％。可以通过杀死更高倍性的真菌菌株并同时通过用水处理将其核酸含量降低到低于2重量％来制备菌株。该方法可以包括通过在包含营养物质的培养基中培养两种营养缺陷型营养素来制备较高倍性的可食镰刀菌菌株，所述培养基允许生长，然后在基本培养基中培养来自这种培养物的生物。本发明适用于通过在使单倍体形式的逆转或部分逆转最小化的条件下培养菌株来生产人类食物。

6. 发明授权

US5879664A Fungal protein disulfide isomerase 失效
标题翻译：真菌蛋白二硫键异构酶
公开(公告)号：US5879664A
公开(公告)日：1999-03-09
申请号：US557122
申请日：1995-12-11
申请人： Carsten Mailand Hjort
发明人： Carsten Mailand Hjort
IPC分类号： C12N1/15 , A21D8/04 , A23B5/03 , A23K10/14 , A23L29/00 , A61K8/66 , A61K38/00 , A61Q5/00 , C12N1/19 , C12N9/90 , C12N15/61 , C12R1/66 , C12R1/77 , C12R1/85 , D06M16/00 , A61K7/09 , A45D7/00 , A61K38/51
CPC分类号： D06M16/003 , A21D8/042 , A23K10/14 , A23L29/06 , A61K8/66 , A61Q5/00 , C12N9/90 , C12Y503/04001 , A61K38/00
摘要： A fungal protein disulfide isomerase obtainable from fungal species belonging to Aspergillus, especially A. oryzae, or A. niger, is disclosed. Furthermore sequences for recombinant production of the protein disulfide isomerase are disclosed.
摘要翻译： PCT No.PCT / DK94 / 00266 Sec。 371 1995年12月11日第 102（e）日期1995年12月11日PCT提交1994年6月28日PCT公布。出版物WO95 / 00636 日期1995年1月5日公开了一种从属于曲霉属（Aspergillus），特别是米曲霉（A. oryzae）或黑曲霉（A.niger）的真菌种获得的真菌蛋白质二硫键异构酶。此外公开了重组生产蛋白质二硫键异构酶的序列。

7. 发明授权

US5853702A Penicillium purpurogenum mutanases and nucleic acids encoding same 失效
标题翻译：青霉黄假单胞菌和编码相同的核酸
公开(公告)号：US5853702A
公开(公告)日：1998-12-29
申请号：US797366
申请日：1997-02-07
申请人： Randy M. Berka , Stephan Christgau , Torben Halkier , Jeff Shuster , Claus Crone Fuglsang
发明人： Randy M. Berka , Stephan Christgau , Torben Halkier , Jeff Shuster , Claus Crone Fuglsang
IPC分类号： C12N15/09 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N9/24 , C12N15/00 , C12N15/55 , C12R1/07 , C12R1/46 , C12R1/465 , C12R1/645 , C12R1/66 , C12R1/72 , C12R1/77 , C12R1/785 , C12R1/80 , C12R1/84 , C12R1/85 , A61K7/28 , C07H21/04 , C07K1/00
CPC分类号： C12Y302/01084 , C12N9/2402 , Y10S435/933 , Y10S435/935
摘要： The present invention relates to polypeptides having mutanase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides. The present invention further relates to oral cavity compositions and methods for degrading mutan.
摘要翻译：本发明涉及具有衍生葡聚糖酶活性的多肽和分离的编码多肽的核酸序列。本发明还涉及包含核酸序列的核酸构建体，载体和宿主细胞以及用于产生多肽的方法。本发明还涉及口腔组合物和降解变应原的方法。

8. 发明授权

US5759543A Application of a cell culture of a fusarium fungus strain producer for medical uses 失效
标题翻译：应用镰刀菌菌株生产者的细胞培养用于医疗用途
公开(公告)号：US5759543A
公开(公告)日：1998-06-02
申请号：US507376
申请日：1995-08-21
申请人： Galina Rostislavovna Morozova , Alexandr Lvovich Morozov
发明人： Galina Rostislavovna Morozova , Alexandr Lvovich Morozov
IPC分类号： A23L1/28 , A61K9/14 , A61K9/20 , A61K35/74 , A61K36/06 , A61P3/06 , A61P9/00 , A61P9/08 , A61P9/10 , A61P35/02 , A61P37/00 , A61P43/00 , C12N1/14 , C12R1/77 , A61K35/72
CPC分类号： A61K36/06
摘要： The invention describes utilization of a cell culture of the strain of fungus Fusarium sambucinum Fuckel var. ossicolum (Berk. et Curt.) Bulai VSB-917 (All-Union Collection of Industrial Microorganisms of the VNIIgenetika Institute, collection code VKPM F-168) for application in the capacity of a producer of physiologically active substances for prophylactic and curative purposes.
摘要翻译： PCT No.PCT / RU94 / 00260 Sec。 371日期1995年8月21日 102（e）1995年8月21日PCT PCT 1994年11月23日PCT公布。公开号WO95 / 17902 日期1995年7月6日本发明描述了真菌镰刀菌Fuckel变种菌株的细胞培养物的利用。（Berk。et Curt。）Bulai VSB-917（VNIIgenetika研究所的All-Union Collection of Industrial Microorganisms of the VNIIgenetika Institute，collection code VKPM F-168），用于以生理活性物质的生产者的能力用于预防和治疗目的。

9. 发明授权

US5620953A Antiprotozoal cyclic tetrapeptides 失效
标题翻译：抗原生动物四环素
公开(公告)号：US5620953A
公开(公告)日：1997-04-15
申请号：US447664
申请日：1995-05-23
申请人： Christine L. Cannova , Michael A. Goetz , Anne W. Dombrowski , Sandra J. Rattray , Sheo B. Singh , Gerald F. Bills , Jon Polishook , Joyce A. Greene , Gary K. Darland
发明人： Christine L. Cannova , Michael A. Goetz , Anne W. Dombrowski , Sandra J. Rattray , Sheo B. Singh , Gerald F. Bills , Jon Polishook , Joyce A. Greene , Gary K. Darland
IPC分类号： A61K38/00 , A61P29/00 , A61P33/02 , C07K5/12 , C12N1/14 , C12P21/04 , C12R1/77 , A61K38/12 , A61K31/445 , C07D471/04
CPC分类号： C12R1/77 , C07K5/126 , A61K38/00
摘要： The present invention provides novel cyclic tetrapeptides useful in the treatment or prevention of protozoal diseases; in particular, the novel compounds are active against the causative pathogens in malaria, toxoplasmosis, and coccidiosis.
摘要翻译：本发明提供了可用于治疗或预防原生动物疾病的新型环状四肽; 特别是新型化合物对疟疾，弓形虫病和球虫病引起的病原体具有抗性。

10. 发明授权

US5344994A Process for the preparation of coniferyl aldehyde 失效
标题翻译：制备松柏醛的方法
公开(公告)号：US5344994A
公开(公告)日：1994-09-06
申请号：US76296
申请日：1993-06-11
申请人： Wolf-Rainer Abraham , Hans-Adolf Arfmann
发明人： Wolf-Rainer Abraham , Hans-Adolf Arfmann
IPC分类号： C07C47/277 , C12P7/24 , C12P7/26 , C12R1/645 , C12R1/77 , C07C45/00
CPC分类号： C12P7/24
摘要： Coniferyl aldehyde can be prepared from eugenol with the aid of fungi or their constituents.
摘要翻译：松果醛可以通过真菌或其成分从丁香酚制备。

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