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1. 发明授权

US07655766B2 Compositions comprising positional isomers of PEGylated G-CSF 失效
标题翻译：包含聚乙二醇化G-CSF的位置异构体的组合物
公开(公告)号：US07655766B2
公开(公告)日：2010-02-02
申请号：US11742445
申请日：2007-04-30
申请人： Carsten Germansen , Bobby Soni , Grethe Rasmussen
发明人： Carsten Germansen , Bobby Soni , Grethe Rasmussen
IPC分类号： C07K14/53 , A61K47/36 , A61K38/24
CPC分类号： C07K14/535 , A61K38/193 , A61K47/60 , C12P21/02
摘要： A method for increasing the stability and uniformity of a PEGylated G-CSF polypeptide having at least one PEG moiety attached to the epsilon amino group of a lysine residue or the N-terminal amino group and at least one PEG moiety attached to a hydroxyl group, comprising subjecting the polypeptide to an elevated pH of above 8.0 for a period of time suitable to remove PEG moieties attached to a hydroxyl group, and reducing the pH to about 8.0 or lower; as well as PEGylated G-CSF polypeptides and compositions produced according to the method and methods for increasing neutrophil levels in a patient using the PEGylated G-CSF polypeptides and compositions.
摘要翻译：增加具有连接到赖氨酸残基或N-末端氨基的ε氨基上的至少一个PEG部分和与羟基连接的至少一个PEG部分的聚乙二醇化G-CSF多肽的稳定性和均匀性的方法，包括使多肽经历高于8.0的升高的pH适合于除去连接到羟基上的PEG部分并将pH降低至约8.0或更低的时间; 以及聚乙二醇化G-CSF多肽和根据使用聚乙二醇化G-CSF多肽和组合物在患者中增加嗜中性粒细胞水平的方法和方法产生的组合物。

2. 发明申请

US20090030183A1 Interferon Beta-Like Molecules 审中-公开
标题翻译：干扰素β样分子
公开(公告)号：US20090030183A1
公开(公告)日：2009-01-29
申请号：US12206275
申请日：2008-09-08
申请人： Poul Baad Rasmussen , Joern Drustrup , Grethe Rasmussen , Anders Hjelholt Pedersen , Hans Thalsgard Schambye , Kim Vilbour Andersen , Claus Bornaes
发明人： Poul Baad Rasmussen , Joern Drustrup , Grethe Rasmussen , Anders Hjelholt Pedersen , Hans Thalsgard Schambye , Kim Vilbour Andersen , Claus Bornaes
IPC分类号： C07K14/565 , C12P21/02 , C12N15/19 , C12N5/10 , C12N15/85
CPC分类号： A61K9/0019 , A61K9/0073 , A61K31/724 , A61K38/21 , A61K38/215 , A61K47/40 , A61K47/60 , A61K47/6951 , B82Y5/00 , C07K14/565 , A61K2300/00
摘要： The invention relates to a conjugate exhibiting interferon β (IFNB) activity and comprising at least one first non-polypeptide moiety covalently attached to an IFNB polypeptide, the amino acid sequence of which differs from that of wildtype human IFNB in at least one introduced and at least one removed amino acid residue comprising an attachment group for said first non-polypeptide moiety. The first non-polypeptide moiety is e.g. a polymer molecule or a sugar moiety. The conjugate finds particular use in therapy. The invention also relates to a glycosylated variant of a parent IFNB polypeptide comprising at least one in vivo glycosylation site, wherein an amino acid residue of said parent polypeptide located close to said glycosylation site has been modified to obtain the variant polypeptide having an increased glycosylation as compared to the glycosylation of the parent polypeptide.
摘要翻译：本发明涉及一种表现出干扰素β（IFNB）活性的缀合物，其包含共价连接到IFNB多肽的至少一个第一非多肽部分，所述第一非多肽部分与至少一个引入的和在至少一个除去的氨基酸残基，其包含所述第一非多肽部分的连接基团。第一非多肽部分是例如。聚合物分子或糖部分。该缀合物在治疗中特别有用。本发明还涉及包含至少一个体内糖基化位点的母体IFNB多肽的糖基化变体，其中位于所述糖基化位点附近的所述亲本多肽的氨基酸残基已被修饰以获得具有增加的糖基化的变体多肽作为与母体多肽的糖基化相比。

3. 发明申请

US20080090764A1 PEGYLATED G-CSF POLYPEPTIDES AND METHODS OF PRODUCING SAME 失效
标题翻译：聚乙二醇化G-CSF多肽及其生产方法
公开(公告)号：US20080090764A1
公开(公告)日：2008-04-17
申请号：US11742445
申请日：2007-04-30
申请人： Carsten GERMANSEN , Bobby SONI , Grethe RASMUSSEN
发明人： Carsten GERMANSEN , Bobby SONI , Grethe RASMUSSEN
IPC分类号： A61K38/19 , C07K14/53 , C12N15/09
CPC分类号： C07K14/535 , A61K38/193 , A61K47/60 , C12P21/02
摘要： A method for increasing the stability and uniformity of a PEGylated G-CSF polypeptide having at least one PEG moiety attached to the epsilon amino group of a lysine residue or the N-terminal amino group and at least one PEG moiety attached to a hydroxyl group, comprising subjecting the polypeptide to an elevated pH of above 8.0 for a period of time suitable to remove PEG moieties attached to a hydroxyl group, and reducing the pH to about 8.0 or lower; as well as PEGylated G-CSF polypeptides and compositions produced according to the method and methods for increasing neutrophil levels in a patient using the PEGylated G-CSF polypeptides and compositions.
摘要翻译：增加具有连接到赖氨酸残基或N-末端氨基的ε氨基上的至少一个PEG部分和与羟基连接的至少一个PEG部分的聚乙二醇化G-CSF多肽的稳定性和均匀性的方法，包括使多肽经历高于8.0的升高的pH适合于除去连接到羟基上的PEG部分并将pH降低至约8.0或更低的时间; 以及聚乙二醇化G-CSF多肽和根据使用聚乙二醇化G-CSF多肽和组合物在患者中增加嗜中性粒细胞水平的方法和方法产生的组合物。

4. 发明授权

US07381805B2 Compositions comprising mixtures of positional PEG isomers of PEGylated G-CSF 失效
标题翻译：包含聚乙二醇化G-CSF的位置PEG异构体的混合物的组合物
公开(公告)号：US07381805B2
公开(公告)日：2008-06-03
申请号：US11420546
申请日：2006-05-26
申请人： Carsten Germansen , Bobby Soni , Grethe Rasmussen
发明人： Carsten Germansen , Bobby Soni , Grethe Rasmussen
IPC分类号： C07K14/53 , A61K47/36 , A61K38/24
CPC分类号： C07K14/535 , A61K38/193 , A61K47/60 , C12P21/02
摘要： A method for increasing the stability and uniformity of a PEGylated G-CSF polypeptide having at least one PEG moiety attached to the epsilon amino group of a lysine residue or the N-terminal amino group and at least one PEG moiety attached to a hydroxyl group, comprising subjecting the polypeptide to an elevated pH of above 8.0 for a period of time suitable to remove PEG moieties attached to a hydroxyl group, and reducing the pH to about 8.0 or lower; as well as PEGylated G-CSF polypeptides and compositions produced according to the method and methods for increasing neutrophil levels in a patient using the PEGylated G-CSF polypeptides and compositions.
摘要翻译：增加具有连接到赖氨酸残基或N-末端氨基的ε氨基上的至少一个PEG部分和与羟基连接的至少一个PEG部分的聚乙二醇化G-CSF多肽的稳定性和均匀性的方法，包括使多肽经历高于8.0的升高的pH适合于除去连接到羟基上的PEG部分并将pH降低至约8.0或更低的时间; 以及聚乙二醇化G-CSF多肽和根据使用聚乙二醇化G-CSF多肽和组合物在患者中增加嗜中性粒细胞水平的方法和方法产生的组合物。

5. 发明申请

US20070014762A1 PEGYLATED G-CSF POLYPEPTIDES AND METHODS OF PRODUCING SAME 审中-公开
公开(公告)号：US20070014762A1
公开(公告)日：2007-01-18
申请号：US11532808
申请日：2006-09-18
申请人： Carsten GERMANSEN , Bobby SONI , Grethe RASMUSSEN
发明人： Carsten GERMANSEN , Bobby SONI , Grethe RASMUSSEN
IPC分类号： A61K38/19 , C07K14/535
CPC分类号： C07K14/535 , A61K38/193 , A61K47/60 , C12P21/02
摘要： A method for increasing the stability and uniformity of a PEGylated G-CSF polypeptide having at least one PEG moiety attached to the epsilon amino group of a lysine residue or the N-terminal amino group and at least one PEG moiety attached to a hydroxyl group, comprising subjecting the polypeptide to an elevated pH of above 8.0 for a period of time suitable to remove PEG moieties attached to a hydroxyl group, and reducing the pH to about 8.0 or lower; as well as PEGylated G-CSF polypeptides and compositions produced according to the method and methods for increasing neutrophil levels in a patient using the PEGylated G-CSF polypeptides and compositions.

6. 发明授权

US07144574B2 Interferon β variants and conjugates 失效
标题翻译：干扰素β变体和缀合物
公开(公告)号：US07144574B2
公开(公告)日：2006-12-05
申请号：US10084706
申请日：2002-02-26
申请人： Poul Baad Rasmussen , Grethe Rasmussen , Kim Vilbour Andersen , Claus Bornaes
发明人： Poul Baad Rasmussen , Grethe Rasmussen , Kim Vilbour Andersen , Claus Bornaes
IPC分类号： A61K38/21 , A61K88/00 , C07K17/00
CPC分类号： B82Y5/00 , A61K9/0019 , A61K31/724 , A61K38/21 , A61K38/215 , A61K47/40 , A61K47/6951 , C07K14/565 , A61K2300/00
摘要： The invention relates to a conjugate exhibiting interferon β (IFNB) activity and comprising at least one first non-polypeptide moiety covalently attached to an IFNB polypeptide, the amino acid sequence of which differs from that of wildtype human IFNB in at least one introduced and at least one removed amino acid residue comprising an attachment group for said first non-polypeptide moiety. The first non-polypeptide moiety is e.g. a polymer molecule or a sugar moiety. The conjugate finds particular use in therapy. The invention also relates to a glycosylated variant of a parent IFNB polypeptide comprising at least one in vivo glycosylation site, wherein an amino acid residue of said parent polypeptide located close to said glycosylation site has been modified to obtain the variant polypeptide having an increased glycosylation as compared to the glycosylation of the parent polypeptide.
摘要翻译：本发明涉及一种表现出干扰素β（IFNB）活性的缀合物，其包含共价连接到IFNB多肽的至少一个第一非多肽部分，所述第一非多肽部分与至少一个引入的和在至少一个除去的氨基酸残基，其包含所述第一非多肽部分的连接基团。第一非多肽部分是例如。聚合物分子或糖部分。该缀合物在治疗中特别有用。本发明还涉及包含至少一个体内糖基化位点的母体IFNB多肽的糖基化变体，其中位于所述糖基化位点附近的所述亲本多肽的氨基酸残基已被修饰以获得具有增加的糖基化的变体多肽作为与母体多肽的糖基化相比。

7. 发明授权

US06667167B1 Storage-stable liquid formulation comprising a laccase 失效
标题翻译：包含漆酶的储存稳定的液体制剂
公开(公告)号：US06667167B1
公开(公告)日：2003-12-23
申请号：US09605319
申请日：2000-06-28
申请人： Niels Henrik Sorensen , Grethe Rasmussen , Lotte Rugholm Henriksen
发明人： Niels Henrik Sorensen , Grethe Rasmussen , Lotte Rugholm Henriksen
IPC分类号： C12N996
CPC分类号： C12N9/0061 , C12N9/96
摘要： The present invention relates to a storage-stable liquid formulation comprising a laccase comprising (i) a laccase, (ii) at least one polyalcohol, which formulation has a pH which is more alkaline than the pH optimum of the laccase. It is also an object of the invention to provide a method for improving the storage-stability of liquid formulations comprising a laccase and the use of said liquid formulations for a personal care application or for bleaching or for textile applications such as dyeing of fabrics.
摘要翻译：本发明涉及一种储存稳定液体制剂，其包含漆酶，其包含（i）漆酶，（ii）至少一种多元醇，该制剂的pH比漆酶的pH最佳值更碱性。本发明的另一个目的是提供一种用于改善包含漆酶的液体制剂的储存稳定性的方法，以及使用所述液体制剂用于个人护理应用或用于漂白或织物应用如织物染色的方法。

8. 发明授权

US6110884A Protease variants 有权
标题翻译：蛋白酶变体
公开(公告)号：US6110884A
公开(公告)日：2000-08-29
申请号：US460658
申请日：1999-12-13
申请人： Grethe Rasmussen , Egon Nielsen , Torben Halkier
发明人： Grethe Rasmussen , Egon Nielsen , Torben Halkier
IPC分类号： C12N9/54 , C11D3/396 , C12N15/00
CPC分类号： C12N9/54
摘要： This invention is a protease mutant wherein said mutant substitutes the naturally occurring tyrosine amino acids for other amino acids at positions 91, 167, 171, 192, 209, 214, and 263. The protease mutants are used in detergent compositions.
摘要翻译：本发明是一种蛋白酶突变体，其中所述突变体将天然存在的酪氨酸氨基酸替代于91,37,171,192,209,214和263的其它氨基酸。蛋白酶突变体用于洗涤剂组合物中。

9. 发明授权

US06428993B1 Transglutaminase from oomycetes 失效
标题翻译：来自卵菌的转谷氨酰胺酶
公开(公告)号：US06428993B1
公开(公告)日：2002-08-06
申请号：US08881742
申请日：1997-06-24
申请人： Lisbeth Bech , Grethe Rasmussen , Torben Halkier , Mariko Okada , Lene Nonboe Andersen , Markus Sakari Kauppinen , Thomas Sandal
发明人： Lisbeth Bech , Grethe Rasmussen , Torben Halkier , Mariko Okada , Lene Nonboe Andersen , Markus Sakari Kauppinen , Thomas Sandal
IPC分类号： C12N910
CPC分类号： C12Y203/02013 , A21D8/042 , C12N9/1044 , C14C11/00 , Y10S435/911
摘要： The present invention relates to transglutaminases and transglutaminase preparations obtained from lower fungi belonging to the class Oomycetes. Unprecedented high-level expression is achievable by growing these coenocytium forming organisms, especially the strains Pythium sp., Pythium irregulare, Pythium dissotocum, Pythium periilum (or P. periplocum), Pythium torulosum, Pythium ultimum, Pythium aphanidermatum, Phytophthora cactorum, Phytophthora palmivora, Phytophthora porri, Phytophthora infestans, Phytoph-thora megasperma, Phytophthora cinnamomi and Phytophthora cryptogea. Arecombinant transglutaminase has been cloned and expressed, the enzyme and enzyme preparations being useful for cross-linking proteins, e.g. in flour, baked products, meat products, fish products, cosmetics, cheese, milk products, gelled food products and leather finishing, or as a glutaminase, e.g. in bread and other baked glutein-containing food products.
摘要翻译：本发明涉及从属于卵菌纲的较低真菌获得的转谷氨酰胺酶和转谷氨酰胺酶制剂。通过生长这些细胞形成的细菌，特别是菌株腐霉菌，不锈钢腐霉，腐霉腐霉（P. periplocum），腐皮腐，腐霉，腐霉，腐皮疫霉，致病疫霉（Phytophthora palmivora），可以实现前所未有的高水平表达，疫霉疫霉（Phytophthora porri），致病疫霉（Phytophthora infestans），致病疫霉（Phytoph-thora megasperma），肉桂疫霉（Phytophthora cinnamomi）和疫霉疫霉（Phytophthora cryptogea）。克隆和表达重组转谷氨酰胺酶，酶和酶制剂可用于交联蛋白质，例如，在面粉，烘焙食品，肉制品，鱼制品，化妆品，奶酪，乳制品，凝胶食品和皮革整理中，或作为谷氨酰胺酶。在面包和其他烘烤含麸质的食品中。

10. 发明授权

US06190879B1 Microbial transglutaminases, their production and use 失效
标题翻译：微生物转谷氨酰胺酶，其生产和使用
公开(公告)号：US06190879B1
公开(公告)日：2001-02-20
申请号：US09294565
申请日：1999-04-20
申请人： Lisbeth Bech , Iben Angelica Nørrevang , Torben Halkier , Grethe Rasmussen , Thomas Schäfer , Jens Tønne Andersen
发明人： Lisbeth Bech , Iben Angelica Nørrevang , Torben Halkier , Grethe Rasmussen , Thomas Schäfer , Jens Tønne Andersen
IPC分类号： C12P2106
CPC分类号： C12Y203/02013 , A23C9/1216 , C12N9/1044
摘要： A method for identifying a transglutaminase-producing microorganism based on a selective assay is disclosed.
摘要翻译：公开了一种基于选择性测定来鉴定产生转谷氨酰胺酶的微生物的方法。

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