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1. 发明申请

US20050222389A1 Method for preparing modified polypeptides 审中-公开
标题翻译：制备修饰多肽的方法
公开(公告)号：US20050222389A1
公开(公告)日：2005-10-06
申请号：US10756813
申请日：2004-01-12
申请人： Torben Halkier , Anders Pedersen , Jens Okkels , Kim Anderson
发明人： Torben Halkier , Anders Pedersen , Jens Okkels , Kim Anderson
IPC分类号： C07H21/04 , C07K1/107 , C07K14/31 , C07K14/47 , C07K19/00 , C12N15/10 , C12Q1/68 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： C12N15/1058 , C07K1/107 , C07K14/31 , C07K19/00 , C12N15/1034
摘要： Methods for producing polypeptide with altered immunogenicity or improved stability properties are disclosed. The methods involve a) expressing a diversified population of nucleotide sequences encoding a polypeptide of interest, b) screening the polypeptides expressed in step a) for function, immunogenicity and/or stability, c) selecting functional polypeptides having altered immunogenicity and/or increased stability, e.g. functional in vivo half-life as compared to the polypeptide of interest, and d) optionally subjecting the nucleotide sequence encoding the polypeptide selected in step c) to one or more repeated cycles of steps a)-c). In a further step the expressed polypeptides of step a) or c) can be conjugated to at least one non-polypeptide moiety.
摘要翻译：公开了产生具有改变的免疫原性或改善的稳定性的多肽的方法。所述方法包括：a）表达编码感兴趣多肽的核苷酸序列的多样化群体，b）筛选功能，免疫原性和/或稳定性在步骤a）中表达的多肽，c）选择具有改变的免疫原性和/或增加稳定性的功能性多肽，例如与目的多肽相比具有功能的体内半衰期，和d）任选地将编码步骤c）中选择的多肽的核苷酸序列经历步骤a）-c）的一个或多个重复循环。在另一步骤中，步骤a）或c）的表达多肽可以与至少一个非多肽部分缀合。

2. 发明授权

US5676536A Raw gas burner and process for burning oxygenic constituents in process gas 失效
公开(公告)号：US5676536A
公开(公告)日：1997-10-14
申请号：US532209
申请日：1995-11-13
申请人： Andreas Ruhl , Patrick McGehee , Kim Anderson , Serguei Charamko
发明人： Andreas Ruhl , Patrick McGehee , Kim Anderson , Serguei Charamko
IPC分类号： F23D14/00 , F23D14/62 , F23G7/06
CPC分类号： F23G7/065 , F23D14/62 , F23G2207/102 , F23G2207/20
摘要： Raw gas burner that maximizes fuel efficiency of the burner, minimizes residence time, and reduces or eliminates flame contact with the process air or gas in order to minimize NOx formation. Process air flow such as from the cold side of a heat exchanger associated with thermal oxidizer apparatus is directed into and around the burner. The amount of process air flowing into the burner is regulated based upon the pressure drop created by the burner assembly. The pressure drop is, in turn, regulated by one or more of an external damper assembly, an internal damper assembly, and movement of the burner relative to the apparatus in which it is mounted. To ensure thorough mixing of the fuel and process air, process air entering the burner is caused to spin by the use of a swirl generator. The fuel/process air mixture proceeds into the combustion section of the burner, where the swirling flow is caused to recirculate to ensure complete combustion of the fuel in the combustion chamber. The mixture of burned fuel and process gas transfers its energy flamelessly to the process gas circulating outside the burner combustion chamber, and is hot enough to ignite the process gas there, which then burns separately from the burner combustion chamber, such as in the main combustion enclosure of the thermal post-combustion device.

3. 发明申请

US20080058210A1 Method of isolating shikimic acid from a plant 失效
标题翻译：从植物中分离莽草酸的方法
公开(公告)号：US20080058210A1
公开(公告)日：2008-03-06
申请号：US11897970
申请日：2007-08-30
申请人： Kim Anderson
发明人： Kim Anderson
IPC分类号： A01N25/32 , C07C61/00
CPC分类号： C07C51/42 , C07C2601/16 , C07C62/32
摘要： The present invention provides a method of isolating shikimic acid from a plant. First, a plant is provided. Next, the plant is grown in the absence of glyphosate for a first time period. The plant is then treated with glyphosate for a second time period. This second time period is sufficient for the glyphosate to increase the amount of shikimic acid in the plant. The plant with increased amounts of shikimic acid is then harvested and the shikimic acid is isolated from the plant.
摘要翻译：本发明提供了从植物中分离莽草酸的方法。首先，提供一个植物。接下来，植物在第一次没有草甘膦的情况下生长。然后用草甘膦处理植物第二次。该第二时间段足以使草甘膦增加植物中莽草酸的量。然后收获具有增加量的莽草酸的植物，并从植物中分离莽草酸。

4. 发明授权

US5618173A Apparatus for burning oxygenic constituents in process gas 失效
标题翻译：用于在工艺气体中燃烧含氧成分的装置
公开(公告)号：US5618173A
公开(公告)日：1997-04-08
申请号：US356600
申请日：1994-12-15
申请人： Andreas Ruhl , Gert Rentzel , Patrick McGehee , Serguei Charamko , Kim Anderson
发明人： Andreas Ruhl , Gert Rentzel , Patrick McGehee , Serguei Charamko , Kim Anderson
IPC分类号： F23D11/44 , F23D14/02 , F23G7/06 , F23M9/00
CPC分类号： F23G7/065 , F23D14/02 , F23G7/066
摘要： Process and apparatus for burning combustible constituents in process gas in a main combustion enclosure, preferably a thermal post-combustion device, whereby the main combustion enclosure is separated from a combustion chamber, into which oxygenic gas and gaseous fuel are fed, mixed and burnt. The fuel for the apparatus is fed through a lance which opens into a mixing chamber supplied with oxygenic gas, which is either itself the combustion chamber or merges with it, and the outer surface of the combustion chamber is exposed at least partially to the process gas. The fuel is burned completely or nearly completely in the burner combustion chamber and the mixture of burned fuel and gas leaving the combustion chamber oxidizes the combustible constitutes in the process gas flowing outside of the combustion chamber by yielding flameless heat energy to them.
摘要翻译：用于燃烧主燃烧外壳中的工艺气体中的可燃组分的方法和装置，优选热后燃烧装置，由此主燃烧外壳与燃气室分离，氧气和气体燃料进入燃烧室，混合燃烧。用于该设备的燃料通过喷枪进入，该喷枪通向供应有氧气的混合室，该混合室本身是燃烧室或与其合并，并且燃烧室的外表面至少部分暴露于工艺气体。燃料在燃烧器燃烧室中被完全燃烧或几乎完全燃烧，并且燃烧的燃料和离开燃烧室的气体的混合物氧化了在燃烧室外面流动的工艺气体中构成的可燃物通过向它们产生无焰的热能。

5. 发明申请

US20140255607A1 Method And Apparatus For Coating Discrete Patches 审中-公开
标题翻译：涂布离散补丁的方法和装置
公开(公告)号：US20140255607A1
公开(公告)日：2014-09-11
申请号：US14008103
申请日：2012-04-13
申请人： Eric Maki , George Glenn , Kim Anderson
发明人： Eric Maki , George Glenn , Kim Anderson
IPC分类号： B05B15/04 , B05D5/00
CPC分类号： B05C5/0258 , B05B12/16 , B05C5/0254 , B05C11/1015 , B05C11/1021 , B05C11/1023 , B05C11/1026 , H01M4/0404
摘要： An improved system for applying a coating to a sheet is disclosed. The system allows precise control of the actuation of the valves and movement of the nozzle to create a plurality of coating profiles. The system includes a controller, which is used to actuate the valves to begin and terminate the flow of material onto the sheet through a nozzle. In addition, the controller may move the nozzle from its operative position to an inoperative position away from the sheet. In some embodiments, a fluid displacement mechanism is used. The controller is also able to coat the opposite side of the sheet. Registration of the coating can be programmed to be in exact alignment, or advanced or delayed by a specific amount.
摘要翻译：公开了一种用于将涂层施加到片材的改进的系统。该系统允许精确地控制阀的致动和喷嘴的运动以产生多个涂层轮廓。该系统包括控制器，该控制器用于致动阀门以通过喷嘴开始和终止材料流入片材。此外，控制器可以将喷嘴从其工作位置移动到远离纸张的不工作位置。在一些实施例中，使用流体移动机构。控制器还可以涂覆在纸张的相对面上。涂层的注册可以被编程为精确对准，或者高级或延迟特定量。

6. 发明申请

US20050201982A1 Polynucleotides encoding interferon gamma peptide variants 失效
标题翻译：编码干扰素γ肽变体的多核苷酸
公开(公告)号：US20050201982A1
公开(公告)日：2005-09-15
申请号：US11115906
申请日：2005-04-27
申请人： Bart Hazel , Anne Jensen , Frank Nygaard , Kim Anderson
发明人： Bart Hazel , Anne Jensen , Frank Nygaard , Kim Anderson
IPC分类号： A61K38/00 , C07K14/57 , A61K38/21 , C12P21/04
CPC分类号： C07K14/57 , A61K38/00
摘要： When interferon gamma (IFNG) is produced in mammalian cell lines a heterogenous population of IFNG polypeptides is obtained due to C-terminal processing of the IFNG polypeptide. Clearly, this constitutes a severe problem in that valuable polypeptide material is lost and, further, it is necessary to carry out time-consuming and cumbersome purification in order to obtain a homogenous population of active IFNG polypeptides having the desired length. It has now been found that an IFNG fragment containing 132 amino acid residues (truncated at the nucleotide level by introducing a stop-codon after the codon encoding amino acid residue no. 132) does not undergo C-terminal truncation or, at least, is not significantly C-terminally truncated. Furthermore, as the IFNG fragment containing 132 amino acid residues is active, this opens up the possibility of producing a homogenous active IFNG polypeptide in eukaryotic host cells, such as CHO cells. More particularly, the present invention relates to an IFNG polypeptide variant exhibiting IFNG activity and having the amino acid sequence shown in SEQ ID NO:12. In a highly preferred embodiment of the invention, the variant comprises at least one further modification, such as 1-10 further modifications, relative to the amino acid sequence shown in SEQ ID NO:12. A particular preferred further modification is E38N+S40T.
摘要翻译：当在哺乳动物细胞系中产生干扰素γ（IFNG）时，由于IFNG多肽的C末端加工，获得IFNG多肽的异源群体。显然，这构成了一个严重的问题，即有价值的多肽材料丢失，而且还需要进行耗时且繁琐的纯化，以获得具有所需长度的活性IFNG多肽的均质群体。现在已经发现，含有132个氨基酸残基的IFNG片段（在编码氨基酸残基132号的密码子后通过引入终止密码子在核苷酸水平被截短）不经历C-末端截短，或至少是不显着C末端截断。此外，由于含有132个氨基酸残基的IFNG片段是有活性的，因此可以在真核宿主细胞如CHO细胞中产生均一的活性IFNG多肽。更具体地，本发明涉及表现出IFNG活性且具有SEQ ID NO：12所示氨基酸序列的IFNG多肽变体。在本发明的一个非常优选的实施方案中，相对于SEQ ID NO：12所示的氨基酸序列，变体包含至少一个其它修饰，例如1-10个其它修饰。特别优选的进一步修改是E38N + S40T。

7. 发明授权

US10265719B2 Method and apparatus for coating discrete patches 有权
公开(公告)号：US10265719B2
公开(公告)日：2019-04-23
申请号：US14008103
申请日：2012-04-13
申请人： Eric Maki , George Glenn , Kim Anderson
发明人： Eric Maki , George Glenn , Kim Anderson
IPC分类号： B05B15/00 , B05C5/02 , B05C11/10 , B05B12/16 , H01M4/04
摘要： An improved system for applying a coating to a sheet is disclosed. The system allows precise control of the actuation of the valves and movement of the nozzle to create a plurality of coating profiles. The system includes a controller, which is used to actuate the valves to begin and terminate the flow of material onto the sheet through a nozzle. In addition, the controller may move the nozzle from its operative position to an inoperative position away from the sheet. In some embodiments, a fluid displacement mechanism is used. The controller is also able to coat the opposite side of the sheet. Registration of the coating can be programmed to be in exact alignment, or advanced or delayed by a specific amount.

8. 发明授权

US5609833A Process and apparatus for burning oxygenic constituents in process gas 失效
标题翻译：在工艺气体中燃烧含氧成分的方法和装置
公开(公告)号：US5609833A
公开(公告)日：1997-03-11
申请号：US532210
申请日：1995-09-22
申请人： Andreas R uhl , Gert Rentzel , Patrick McGehee , Serguei Charamko , Kim Anderson
发明人： Andreas R uhl , Gert Rentzel , Patrick McGehee , Serguei Charamko , Kim Anderson
IPC分类号： F23D11/44 , F23D14/02 , F23G7/06 , F01N3/10
CPC分类号： F23G7/065 , F23D14/02 , F23G7/066
摘要： Process and apparatus for burning combustible constituents in process gas in a main combustion enclosure, preferably a thermal post-combustion device, whereby the main combustion enclosure is separated from a combustion chamber, into which oxygenic gas and gaseous fuel are fed, mixed and burnt. The fuel for the apparatus is fed through a lance which opens into a mixing chamber supplied with oxygenic gas, which is either itself the combustion chamber or merges with it, and the outer surface of the combustion chamber is exposed at least partially to the process gas. The fuel is burned completely or nearly completely in the burner combustion chamber and the mixture of burned fuel and gas leaving the combustion chamber oxidizes the combustible constitutes in the process gas flowing outside of the combustion chamber by yielding flameless heat energy to them.
摘要翻译：用于燃烧主燃烧外壳中的工艺气体中的可燃组分的方法和装置，优选热后燃烧装置，由此主燃烧外壳与燃气室分离，氧气和气体燃料进入燃烧室，混合燃烧。用于该设备的燃料通过喷枪进入，该喷枪通向供应有氧气的混合室，该混合室本身是燃烧室或与其合并，并且燃烧室的外表面至少部分暴露于工艺气体。燃料在燃烧器燃烧室中被完全燃烧或几乎完全燃烧，并且燃烧的燃料和离开燃烧室的气体的混合物氧化了在燃烧室外面流动的工艺气体中构成的可燃物通过向它们产生无焰的热能。

9. 发明授权

US5601789A Raw gas burner and process for burning oxygenic constituents in process gas 失效
标题翻译：原燃气燃烧器和燃烧过程气体中含氧成分的方法
公开(公告)号：US5601789A
公开(公告)日：1997-02-11
申请号：US356601
申请日：1994-12-15
申请人： Andreas Ruhl , Patrick McGehee , Kim Anderson , Serguei Charamko
发明人： Andreas Ruhl , Patrick McGehee , Kim Anderson , Serguei Charamko
IPC分类号： F23D14/00 , F23D14/62 , F23G7/06 , B01D50/00 , B01D53/34
CPC分类号： F23G7/065 , F23D14/62 , F23G2207/102 , F23G2207/20
摘要： Raw gas burner that maximizes fuel efficiency of the burner, minimizes residence time, and reduces or eliminates flame contact with the process air or gas in order to minimize NOx formation. Process air flow such as from the cold side of a heat exchanger associated with thermal oxidizer apparatus is directed into and around the burner. The amount of process air flowing into the burner is regulated based upon the pressure drop created by the burner assembly. The pressure drop is, in turn, regulated by one or more of an external damper assembly, an internal damper assembly, and movement of the burner relative to the apparatus in which it is mounted. To ensure thorough mixing of the fuel and process air, process air entering the burner is caused to spin by the use of a swirl generator. The fuel/process air mixture proceeds into the combustion section of the burner, where the swirling flow is caused to recirculate to ensure complete combustion of the fuel in the combustion chamber. The mixture of burned fuel and process gas transfers its energy flamelessly to the process gas circulating outside the burner combustion chamber, and is hot enough to ignite the process gas there, which then burns separately from the burner combustion chamber, such as in the main combustion enclosure of the thermal post-combustion device.
摘要翻译：原燃气燃烧器使燃烧器的燃油效率最大化，最小化停留时间，并减少或消除与过程空气或气体的火焰接触，以最小化NOx的形成。来自与热氧化装置相关联的热交换器的冷侧的处理空气流被引导到燃烧器中和周围。基于由燃烧器组件产生的压降来调节流入燃烧器的过程空气量。压降又由一个或多个外部阻尼器组件，内部阻尼器组件和燃烧器相对于其安装的装置的运动来调节。为了确保燃料和处理空气的充分混合，通过使用涡流发生器使进入燃烧器的进程空气旋转。燃料/过程空气混合物进入燃烧器的燃烧部分，在该燃烧器的燃烧部分中，使涡旋流再循环以确保燃料在燃烧室中完全燃烧。燃烧燃料和处理气体的混合物将其能量无火焰地转移到在燃烧器燃烧室外循环的过程气体，并且足够高以点燃那里的工艺气体，然后该燃烧器与燃烧器燃烧室分开燃烧，例如主燃烧热后燃烧装置的外壳。

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