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1. 发明申请

US20190216913A1 VACCINE CONSTRUCTS AND USES THEREOF AGAINST STAPHYLOCOCCUS INFECTIONS 审中-公开
公开(公告)号：US20190216913A1
公开(公告)日：2019-07-18
申请号：US16337457
申请日：2017-10-20
申请人： SOCPRA SCIENCES ET GÉNIE S.E.C.
发明人： FRANÇOIS MALOUIN , CÉLINE STER , JULIE CÔTÉ-GRAVEL , ÉRIC BROUILLETTE
IPC分类号： A61K39/085 , A61P31/04 , A61P37/04 , C07K14/31 , C12N15/85 , C12N15/62
CPC分类号： A61K39/085 , A61K2039/522 , A61K2039/552 , A61P31/04 , A61P37/04 , C07K14/31 , C07K2319/00 , C12N15/62 , C12N15/85
摘要： There is provided a fusion construct of formula (I): X-A-linker-B-Z (I) wherein: (1) A and B are identical or different and are independently: (a) a polypeptide comprising a SACOL0029 polypeptide as set forth in any one of the sequences depicted in FIG. 24 (SEQ ID NOs: 5 and 121 to 131), a SACOL0264 polypeptide (SEQ ID NO: 185), a SACOL0442 polypeptide as set forth in any one of the sequences depicted in FIG. 22D (SEQ ID NOs: 29 and 82 to 92), a SACOL0718 polypeptide (SEQ ID NO: 186), a SACOL0720 polypeptide as set forth in any one of the sequences depicted in FIGS. 23I-J (SEQ ID NOs: 11 and 109 to 120), a SACOL1353 polypeptide (SEQ ID NO: 187), a SACOL1416 polypeptide (SEQ ID NO: 188), a SACOL1611 polypeptide (SEQ ID NO: 189), a SACOL1867 polypeptide as set forth in any one of the sequences depicted in FIG. 25D (SEQ ID NOs: 152 to 164), a SACOL1912 polypeptide (SEQ ID NO: 43), a SACOL1944 polypeptide (SEQ ID NO: 190), a SACOL2144 polypeptide (SEQ ID NO: 191), a SACOL2365 polypeptide (SEQ ID NO: 192), a SACOL2385 polypeptide (SEQ ID NO: 50) or a SACOL2599 polypeptide (SEQ ID NO: 193), based on the gene nomenclature from the Staphylococcus aureus COL (SACOL) genome set forth in NCBI Reference Sequence NC_002951.2; (b) a polypeptide encoded by a gene from a same operon as a gene encoding the polypeptide of (a); (c) a polypeptide comprising an immunogenic fragment of at least 13 consecutive amino acids of (a) or (b); (d) a polypeptide comprising an amino acid sequence at least 60% identical overall to the sequence of the polypeptide of any one of (a) to (c); or (e) a polypeptide comprising an immunogenic variant comprising at least 13 consecutive amino acids of any one of (a) to (c); (2) the linker is an amino acid sequence of at least one amino acid or is absent; (3) X is absent or is an amino acid sequence of at least one amino acid; and (4) Z is absent or is an amino acid sequence of at least one amino acid. Also provided are compositions and kits comprising the fusion and uses of these fusions, compositions and kits.

2. 发明申请

US20180312551A1 MODIFIED ALPHA HEMOLYSIN POLYPEPTIDES AND METHODS OF USE 审中-公开
公开(公告)号：US20180312551A1
公开(公告)日：2018-11-01
申请号：US16034115
申请日：2018-07-12
申请人： ELECTRONIC BIOSCIENCES, INC.
发明人： GEOFFREY A. BARRALL , ERIC N. ERVIN , PRITHWISH PAL
IPC分类号： C07K14/31 , C12Q1/6869
CPC分类号： C07K14/31 , C12Q1/6869 , Y10T436/143333
摘要： Provided herein are alpha hemolysin polypeptides comprising modified amino acid sequences that can reduce the rate of translocation of a polymer. Also provided herein are apparatuses and devices comprising modified hemolysin polypeptides. Also provided herein are methods of using modified alpha hemolysin proteins for use in characterizing and/or sequencing a polymer or for use as molecular sensors.

3. 发明授权

US10077471B2 Enzyme-pore constructs 有权
公开(公告)号：US10077471B2
公开(公告)日：2018-09-18
申请号：US14858138
申请日：2015-09-18
申请人： OXFORD NANOPORE TECHNOLOGIES LIMITED
发明人： Lakmal Jayasinghe , John Hagan Pryce Bayley , Stephen Cheley , Brian McKeown , James White , James Anthony Clarke
IPC分类号： C12Q1/68 , C12Q1/6869 , C12N9/12 , C12N9/22 , C12N9/52 , C07K14/31 , C12N9/16 , C12N9/90 , C12N9/96
CPC分类号： C12Q1/6869 , C07K14/31 , C12N9/1247 , C12N9/1252 , C12N9/127 , C12N9/1276 , C12N9/16 , C12N9/22 , C12N9/52 , C12N9/90 , C12N9/96 , C12Q2565/631
摘要： The invention relates to constructs comprising a transmembrane protein pore subunit and a nucleic acid handling enzyme. The pore subunit is covalently attached to the enzyme such that both the subunit and enzyme retain their activity. The constructs can be used to generate transmembrane protein pores having a nucleic acid handling enzyme attached thereto. Such pores are particularly useful for sequencing nucleic acids. The enzyme handles the nucleic acid in such a way that the pore can detect its component nucleotides by stochastic sensing.

4. 发明申请

US20180237481A1 POLYPEPTIDES AND IMMUNIZING COMPOSITIONS CONTAINING GRAM POSITIVE POLYPEPTIDES AND METHODS OF USE 审中-公开
公开(公告)号：US20180237481A1
公开(公告)日：2018-08-23
申请号：US15943214
申请日：2018-04-02
申请人： EPITOPIX, LLC
发明人： Lisa L. Herron-Olson , Drew M. Catron
IPC分类号： C07K14/31 , A61K39/085 , A61K38/00
CPC分类号： C07K14/31 , A61K38/00 , A61K39/085
摘要： The present invention provides isolated polypeptides isolatable from a Staphylococcus spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.

5. 发明申请

US20180215836A1 IMMUNOGLOBULIN-BINDING MODIFIED PROTEIN 审中-公开
公开(公告)号：US20180215836A1
公开(公告)日：2018-08-02
申请号：US15883569
申请日：2018-01-30
申请人： Kaneka Corporation
发明人： Masakatsu Nishihachijyo , Fuminori Konoike , Yoshiyuki Nakano , Masayuki Takano , Keita Yamashita
IPC分类号： C07K17/02 , C07K1/22 , B01D15/38 , C07K16/06 , B01J20/32
CPC分类号： C07K17/02 , B01D15/3809 , B01J20/286 , B01J20/3204 , B01J20/321 , B01J20/3274 , C07K1/22 , C07K14/31 , C07K16/065 , C07K16/42 , C07K2317/52 , C07K2317/92 , C12N15/09
摘要： A protein includes two or more amino acid sequences, wherein each amino acid sequence is derived from a sequence selected from the group consisting of SEQ ID NOs: 1 to 5. The amino acid sequence closest to the N-terminus includes more Lys residues than the other amino acid sequence(s), and in the amino acid sequence closest to the N-terminus, a total number of Lys in positions 1 to 38 is equal to or greater than a total number of Lys in position 39 and subsequent positions.

6. 发明申请

US20180215785A1 METHOD FOR PURIFYING ANTIBODY-LIKE PROTEIN 审中-公开
公开(公告)号：US20180215785A1
公开(公告)日：2018-08-02
申请号：US15876615
申请日：2018-01-22
申请人： Kaneka Corporation
发明人： Masakatsu Nishihachijyo , Yoshiyuki Nakano , Fuminori Konoike , Masayuki Takano , Shinichi Yoshida , Kazunobu Minakuchi
IPC分类号： C07K1/22 , C07K14/31
CPC分类号： C07K1/22 , B01D15/168 , B01D15/3809 , B01J20/286 , B01J20/3212 , B01J20/3219 , B01J20/3274 , C07K14/31 , C07K17/02
摘要： A method for purifying an antibody-like protein includes adsorbing an antibody-like protein onto an affinity separation matrix by bringing the antibody-like protein into contact with the affinity separation matrix; and eluting the antibody-like protein by bringing an eluent having a pH of 3.5 or higher into contact with the affinity separation matrix. The affinity separation matrix includes a carrier and a ligand immobilized on the carrier, and the ligand includes an amino acid sequence derived from a sequence selected from the group consisting of SEQ ID Nos: 1 to 5. Gln or Lys in an Fc-binding site of the amino acid sequence is substituted by Ala, Ser, or Thr, and the ligand has a lower antibody-binding capacity in an acidic pH range, as compared to a ligand including the amino acid sequence without the substitution.

7. 发明授权

US09943582B2 Cholera toxin chimera and its use as a staph vaccine 有权
公开(公告)号：US09943582B2
公开(公告)日：2018-04-17
申请号：US14456090
申请日：2014-08-11
申请人： BOISE STATE UNIVERSITY
发明人： Juliette Tinker
IPC分类号： A61K39/085 , A61K39/02 , C07K14/28 , C07K14/315 , C07K14/31 , A61K39/00
CPC分类号： A61K39/085 , A61K39/107 , A61K2039/55516 , A61K2039/575 , A61K2039/6037 , C07K14/28 , C07K14/31 , C07K14/315 , C07K2319/00
摘要： The present invention relates to chimeric protein vaccines and methods of use thereof in the treatment of Staphylococcus aureus. One embodiment of the present invention provides a method of generating an immune response in a mammal, that includes administering to the mammal, a composition having a chimeric protein having at least one of: a portion of a cholera toxin, a portion of a heat-labile toxin, and a portion of a shiga toxin; and an antigen having at least one of: an antigenic material from S. aureus and an antigenic material from a S. aureus-specific polypeptide.

8. 发明授权

US09932373B2 Polypeptides and immunizing compositions containing gram positive polypeptides and methods of use 有权
公开(公告)号：US09932373B2
公开(公告)日：2018-04-03
申请号：US13142524
申请日：2010-03-23
申请人： Lisa L. Herron-Olson , Drew M. Catron
发明人： Lisa L. Herron-Olson , Drew M. Catron
IPC分类号： A61K39/085 , A61P37/04 , C07K14/31 , A61K38/00
CPC分类号： C07K14/31 , A61K38/00 , A61K39/085
摘要： The present invention provides isolated polypeptides isolatable from a Staphylococcus spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.

9. 发明申请

US20180009853A1 CRYSTAL STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT FROM S. AUREUS 审中-公开
公开(公告)号：US20180009853A1
公开(公告)日：2018-01-11
申请号：US15547499
申请日：2016-01-26
申请人： Yeda Research And Development Co. Ltd.
发明人： Ada YONATH , Zohar EYAL , Donna MATZOV , Haim ROZENBERG , Ella ZIMMERMAN , Anat BASHAN
IPC分类号： C07K14/31 , C07H17/08 , C07D211/54 , C07D263/20 , G06F19/00 , G06F19/16
CPC分类号： C07K14/31 , C07D211/54 , C07D263/20 , C07H17/08 , C07K2299/00 , G16B15/00 , G16B30/00 , G16B35/00 , G16C20/50 , G16C20/60
摘要： A composition-of-matter comprising a crystallized form of a large ribosomal (50S) subunit of a pathogenic bacterium, and the atomic coordinates of the three-dimensional structure thereof are provided herein, as well as methods for crystallizing the same, and using the atomic coordinates of the same to design de novo ligands with high specificity thereto.

10. 发明申请

US20170348407A1 STAPHYLOCOCCUS AUREUS PROTEINS AND NUCLEIC ACIDS 审中-公开
公开(公告)号：US20170348407A1
公开(公告)日：2017-12-07
申请号：US15679910
申请日：2017-08-17
申请人： GLAXOSMITHKLINE BIOLOGICALS, SA
发明人： Vega MASIGNANI , Marirosa MORA , Maria SCARSELLI
IPC分类号： A61K39/085 , C07K14/31 , A61K39/00
CPC分类号： A61K39/085 , A61K2039/70 , C07K14/31
摘要： The invention provides proteins from Staphylococcus aureus including amino acid sequences and the corresponding nucleotide sequences. The proteins are useful for vaccines, immunogenic compositions, diagnostics, enzymatic studies and also as targets for antibiotics.

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