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1. 发明申请

US20060052292A1 Adiponectin fragments and conjugates 审中-公开
公开(公告)号：US20060052292A1
公开(公告)日：2006-03-09
申请号：US10498665
申请日：2002-12-20
申请人： Poul Rasmussen , Kim Andersen , Anders Pedersen , Hans Schambye , Torben Halkier , Are Bogsnes
发明人： Poul Rasmussen , Kim Andersen , Anders Pedersen , Hans Schambye , Torben Halkier , Are Bogsnes
IPC分类号： A61K38/39 , C07K14/78
CPC分类号： C07K14/4702 , A61K38/00 , Y02A50/473
摘要： The invention relates to a conjugate comprising an adiponectin polypeptide, and a first non-polypeptide moiety covalently attached to the adiponectin polypeptide, wherein the adiponectin polypeptide comprises an amino acid residue having an attachment group for said first non-polypeptide moiety, wherein said amino acid residue has been introduced in a position that in the parent adiponectin is occupied by a surface exposed amino acid residue.

2. 发明授权

US06413559B1 Enzymes with aminopeptidase activity 失效
标题翻译：具有氨基肽酶活性的酶
公开(公告)号：US06413559B1
公开(公告)日：2002-07-02
申请号：US09718709
申请日：2000-11-22
申请人： Markus Sakari Kauppinen , Joan Qi Si , Tina Spendler , Claus Dambmann , Torben Halkier , Peter Rahbek Østergaard , Shamkant Anant Patkar , Kim Hansen
发明人： Markus Sakari Kauppinen , Joan Qi Si , Tina Spendler , Claus Dambmann , Torben Halkier , Peter Rahbek Østergaard , Shamkant Anant Patkar , Kim Hansen
IPC分类号： A21D200
CPC分类号： C12N9/48 , A21D8/042
摘要： The present invention relates to a 35 kDa enzyme exhibiting aminopeptidase activity which is derived from a fungal microorganism, a DNA construct comprising a DNA sequence encoding said enzyme, a recombinant expression vector comprising said DNA construct, and a cell comprising said DNA sequence. The present invention also provides a method for producing said enzyme exhibiting aminopeptidase activity, and an enzyme preparation comprising said enzyme, a bread-improving or dough-improving composition comprising the aminopeptidase of the invention. Finally the invention relates to the use of said enzyme exhibiting aminopeptidase activity or enzyme preparations or compositions thereof.
摘要翻译：本发明涉及一种表现出来自真菌微生物的氨基肽酶活性的35kDa酶，包含编码所述酶的DNA序列的DNA构建体，包含所述DNA构建体的重组表达载体和包含所述DNA序列的细胞。本发明还提供了生产表现出氨基肽酶活性的酶的方法，以及包含所述酶的酶制剂，包含本发明的氨基肽酶的面包改良组合物或面团改良组合物。最后，本发明涉及所述显示氨基肽酶活性的酶或酶制剂或其组合物的用途。

3. 发明授权

US06242232B1 Purified Coprinus laccases and nucleic acids encoding same 有权
标题翻译：纯化的鬼伞属漆酶和编码相同的核酸
公开(公告)号：US06242232B1
公开(公告)日：2001-06-05
申请号：US09181827
申请日：1998-10-28
申请人： Debbie Sue Yaver , Kimberley M. Brown , Sakari Kauppinen , Torben Halkier
发明人： Debbie Sue Yaver , Kimberley M. Brown , Sakari Kauppinen , Torben Halkier
IPC分类号： C12N902
CPC分类号： C12N9/0061 , C07K14/37
摘要： The present invention relates to polypeptides having laccase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides.
摘要翻译：本发明涉及具有漆酶活性的多肽和分离的编码该多肽的核酸序列。本发明还涉及包含核酸序列的核酸构建体，载体和宿主细胞以及用于产生多肽的方法。

4. 发明授权

US5538884A Rhamnogalacturonase, corresponding DNA sequence, rhamnogalacturonase containing enzyme preparation and use of the enzyme preparation 失效
标题翻译：鼠李半乳糖醛酸酶，相应的DNA序列，含鼠李糖半乳糖醛酸酶的酶制剂和使用酶制剂
公开(公告)号：US5538884A
公开(公告)日：1996-07-23
申请号：US140188
申请日：1993-12-15
申请人： Kurt D orreich , Henrik Dalb.o slashed.ge , Jan M. Mikkelsen , Flemming M. Christensen , Torben Halkier
发明人： Kurt D orreich , Henrik Dalb.o slashed.ge , Jan M. Mikkelsen , Flemming M. Christensen , Torben Halkier
IPC分类号： C12N1/06 , C12N9/24 , C12N15/09 , C12P19/14 , C12R1/07 , C12R1/19 , C12R1/66 , C12R1/865 , C07H19/00 , C07H21/00 , C12N9/40
CPC分类号： C12Y302/01171 , C12N9/2402 , C12P19/14
摘要： The present invention relates to rhamnogalacturonases derived from a strain of Aspergillus japonicus which (a) has a pH-optimum between 6.5 and 7.0; (b) retains at least 80% of the maximal activity throughout the pH range of 5.5-12; (c) has a temperature optimum of about 40.degree. C.; and (d) retains at least 80% of the maximal activity throughout the temperature range of 20.degree.-60.degree. C. The present invention relates to rhamnogalacturonases derived from a stain of Aspergillus aculeatus which (a) has a pH-optimum of about 5.0; (b) retains at least 80% of the maximal activity throughout the pH range of 3-6.5; (c) has a temperature optimum of about 40.degree. C.; and (d) retains at least 80% of the maximal activity throughout the temperature range of 5.degree.-50.degree. C.
摘要翻译： PCT No.PCT / DK92 / 00143 Sec。 371日期：1993年12月15日 102（e）日期1993年12月15日PCT提交1992年5月1日PCT公布。出版物WO92 / 19728 日期：1992年11月12日本发明涉及源自日本曲霉菌株的鼠李糖半乳糖醛酸酶，（a）pH最佳值在6.5-7.0之间; （b）在5.5-12的pH范围内保留至少80％的最大活性; （c）最适温度约为40℃。本发明涉及源自阿曲酸曲霉的染色体的鼠李糖半乳糖醛酸酶，其（a）的pH最佳值为约5.0 ; （b）在3-6.5的pH范围内保留至少80％的最大活性; （c）最适温度约为40℃。和（d）在5〜-50℃的温度范围内保持最大活性的至少80％。

5. 发明申请

US20090088559A1 Method for preparing modified polypeptides 审中-公开
标题翻译：制备修饰多肽的方法
公开(公告)号：US20090088559A1
公开(公告)日：2009-04-02
申请号：US12011979
申请日：2008-01-30
申请人： Torben Halkier , Anders Hjelholt Pedersen , Jens Sigurd Okkels , Kim Vilbour Andersen
发明人： Torben Halkier , Anders Hjelholt Pedersen , Jens Sigurd Okkels , Kim Vilbour Andersen
IPC分类号： C07K14/00
CPC分类号： C12N15/1058 , C07K1/107 , C07K14/31 , C07K19/00 , C12N15/1034
摘要： Methods for producing polypeptide with altered immunogenicity or improved stability properties are disclosed. The methods involve a) expressing a diversified population of nucleotide sequences encoding a polypeptide of interest, b) screening the polypeptides expressed in step a) for function, immunogenicity and/or stability, c) selecting functional polypeptides having altered immunogenicity and/or increased stability, e.g. functional in vivo half-life as compared to the polypeptide of interest, and d) optionally subjecting the nucleotide sequence encoding the polypeptide selected in step c) to one or more repeated cycles of steps a)-c). In a further step the expressed polypeptides of step a) or c) can be conjugated to at least one non-polypeptide moiety.
摘要翻译：公开了产生具有改变的免疫原性或改善的稳定性的多肽的方法。所述方法包括：a）表达编码感兴趣多肽的核苷酸序列的多样化群体，b）筛选功能，免疫原性和/或稳定性在步骤a）中表达的多肽，c）选择具有改变的免疫原性和/或增加稳定性的功能性多肽，例如与目的多肽相比具有功能的体内半衰期，和d）任选地将编码步骤c）中选择的多肽的核苷酸序列经历步骤a）-c）的一个或多个重复循环。在另一步骤中，步骤a）或c）的表达多肽可以与至少一个非多肽部分缀合。

6. 发明授权

US07056512B1 Method for down-regulating GDF-8 activity 失效
标题翻译：降低GDF-8活性的方法
公开(公告)号：US07056512B1
公开(公告)日：2006-06-06
申请号：US09620586
申请日：2000-07-20
申请人： Steen Klysner , Soren Mouritsen , Torben Halkier
发明人： Steen Klysner , Soren Mouritsen , Torben Halkier
IPC分类号： A61K39/00 , A61K39/38
CPC分类号： C07K14/475 , A61K38/00 , A61K39/00 , A61K39/0005 , A61K48/00 , A61K2039/523 , A61K2039/53 , A61K2039/55516 , A61K2039/55522 , C07K2319/00
摘要： Disclosed are novel methods for increasing muscle mass by means of immunization against Growth Differentiation Factor 8 (GDF-8, myostatin). Immunization is preferably effected by administration of analogues of GDF-8 which are capable of inducing antibody production against homologous GDF-8. Especially preferred as an immunogen is homologous GDF-8 which has been modified by introduction of one single or a few foreign, immunodominant and promiscuous T-cell epitopes while substantially preserving the tertiary structure of the homologous GDF-8. Also disclosed are nucleic acid vaccination against GDF-8 and vaccination using live vaccines as well as methods and means useful for the vaccination. Such methods and means include methods for identification of useful immunogenic GDF-8 analogues, methods for the preparation of analogues and pharmaceutical formulations, as well as nucleic acid fragments, vectors, transformed cells, polypeptides and pharmaceutical formulations.
摘要翻译：公开了通过免疫接种生长分化因子8（GDF-8，肌生成抑制素）来增加肌肉质量的新方法。免疫优选通过施用能够诱导针对同源GDF-8的抗体产生的GDF-8的类似物来实现。特别优选的是作为免疫原的同源GDF-8，其通过引入一个或多个外来的免疫显性和混杂的T细胞表位而被修饰，同时基本上保留了同源的GDF-8的三级结构。还公开了针对GDF-8的核酸疫苗接种和使用活疫苗的疫苗接种以及用于疫苗接种的方法和装置。这些方法和手段包括鉴定有用的免疫原性GDF-8类似物的方法，制备类似物和药物制剂的方法，以及核酸片段，载体，转化细胞，多肽和药物制剂。

7. 发明授权

US06350604B1 Alkaline lipolytic enzyme 失效
标题翻译：碱性脂解酶
公开(公告)号：US06350604B1
公开(公告)日：2002-02-26
申请号：US09177234
申请日：1998-10-22
申请人： Satoshi Hirayama , Rikako Taira , Kim Borch , Thomas Sandal , Torben Halkier , Karen Margrethe Oxenbøll , Bjarne Rønfeldt Nielsen
发明人： Satoshi Hirayama , Rikako Taira , Kim Borch , Thomas Sandal , Torben Halkier , Karen Margrethe Oxenbøll , Bjarne Rønfeldt Nielsen
IPC分类号： C12N920
CPC分类号： C11D3/38627 , C12N9/20
摘要： Lipolytic enzymes with high activity at alkaline pH in the absence of Ca++ can be obtained from filamentous fungi of the genera Gliocladium, Verticillium and Trichophaea and that the lipolytic enzymes are effective for improving the effect of detergents. The lipolytic enzymes have a good washing performance, as expressed by the hydrolysis of oil on textile swatches. The amino acid sequences of the lipolytic enzymes are highly homologous.
摘要翻译：在不含Ca ++的碱性pH下具有高活性的脂解酶可以从Gliocladium，轮枝孢属和Trichophaea属的丝状真菌获得，并且脂肪分解酶对于改善洗涤剂的效果是有效的。脂肪分解酶具有良好的洗涤性能，如织物样品上的油水解所表达的。脂肪分解酶的氨基酸序列是高度同源的。

8. 发明授权

US6110884A Protease variants 有权
标题翻译：蛋白酶变体
公开(公告)号：US6110884A
公开(公告)日：2000-08-29
申请号：US460658
申请日：1999-12-13
申请人： Grethe Rasmussen , Egon Nielsen , Torben Halkier
发明人： Grethe Rasmussen , Egon Nielsen , Torben Halkier
IPC分类号： C12N9/54 , C11D3/396 , C12N15/00
CPC分类号： C12N9/54
摘要： This invention is a protease mutant wherein said mutant substitutes the naturally occurring tyrosine amino acids for other amino acids at positions 91, 167, 171, 192, 209, 214, and 263. The protease mutants are used in detergent compositions.
摘要翻译：本发明是一种蛋白酶突变体，其中所述突变体将天然存在的酪氨酸氨基酸替代于91,37,171,192,209,214和263的其它氨基酸。蛋白酶突变体用于洗涤剂组合物中。

9. 发明授权

US6008029A Purified coprinus laccases and nucleic acids encoding the same 失效
标题翻译：纯化的古菌漆酶和编码相同的核酸
公开(公告)号：US6008029A
公开(公告)日：1999-12-28
申请号：US689421
申请日：1996-08-09
申请人： Debbie Sue Yaver , Kimberley M. Brown , Sakari Kauppinen , Torben Halkier
发明人： Debbie Sue Yaver , Kimberley M. Brown , Sakari Kauppinen , Torben Halkier
IPC分类号： C07K14/37 , C12N1/21 , C12N9/02 , C12N15/53 , C12N1/14 , C12N1/20 , C12N15/00
CPC分类号： C12N9/0061 , C07K14/37
摘要： The present invention relates to polypeptides having laccase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides.
摘要翻译：本发明涉及具有漆酶活性的多肽和分离的编码该多肽的核酸序列。本发明还涉及包含核酸序列的核酸构建体，载体和宿主细胞以及用于产生多肽的方法。

10. 发明授权

US5994113A Enzymes with aminopeptidase activity 失效
标题翻译：具有氨基肽酶活性的酶
公开(公告)号：US5994113A
公开(公告)日：1999-11-30
申请号：US929922
申请日：1997-09-15
申请人： Markus Sakari Kauppinen , Joan Qi Si , Tina Spendler , Claus Dambmann , Torben Halkier , Peter Rahbek stergaard , Shamkant Anant Patkar , Kim Hansen
发明人： Markus Sakari Kauppinen , Joan Qi Si , Tina Spendler , Claus Dambmann , Torben Halkier , Peter Rahbek stergaard , Shamkant Anant Patkar , Kim Hansen
IPC分类号： G02C13/00 , A21D8/04 , A23J3/34 , C07H21/04 , C11D3/386 , C11D7/42 , C12N1/16 , C12N1/19 , C12N9/48 , C12N15/00 , C12N15/09 , C12R1/19 , C12R1/69
CPC分类号： C12N9/48 , A21D8/042
摘要： The present invention relates to a enzyme exhibiting aminopeptidase activity, a method for producting said enzyme, and enzyme preparation containing said enzyme exhibithing aminopeptidase activity, and use of said enzyme for various industrial purposes.
摘要翻译：本发明涉及一种显示氨基肽酶活性的酶，一种产生所述酶的方法，以及含有展示氨基肽酶活性的酶的酶制剂，以及所述酶用于各种工业目的。

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