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21. 发明授权

US5416023A System for benzodiazepine detection 失效
标题翻译：苯二氮卓检测系统
公开(公告)号：US5416023A
公开(公告)日：1995-05-16
申请号：US271390
申请日：1994-07-06
申请人： Steven R. Binder , David L. King
发明人： Steven R. Binder , David L. King
IPC分类号： G01N30/02 , G01N30/06 , G01N30/08 , G01N30/14 , G01N30/34 , G01N30/46 , G01N30/74 , G01N30/86 , G01N30/88
CPC分类号： G01N30/461 , G01N30/88 , G01N2030/027 , G01N2030/085 , G01N2030/8804 , G01N2030/8813 , G01N2030/8831 , G01N30/02 , G01N30/06 , G01N30/14 , G01N30/34 , G01N30/468 , G01N30/74 , G01N30/8606 , G01N30/8679 , Y10S436/901 , Y10T436/14 , Y10T436/145555 , Y10T436/17 , Y10T436/25 , Y10T436/25125 , Y10T436/255
摘要： Biological samples are analyzed for benzodiazepines in a single isocratic analysis using a chromatographic column system containing an immobilized enzyme reactor which cleaves glucuronic acid-conjugated benzodiazepines, an anion exchange column, a hydrophobic cation exchange column and a reverse-phase analytical column. Preferred methods of performing the analysis further involve the use of a hydrophobic cation exchange precolumn prior to the anion exchange column. The system readily lends itself to automation, automatic periodic sampling and benzodiazepine identification and quantification. The system is particularly well adapted to the determination and identification of benzodiazepines in urine samples.
摘要翻译：在使用含有固定化酶反应器的色谱柱系统的单一等度分析中分析生物样品中的苯并二氮杂，所述固定化酶反应器切割葡糖醛酸 - 共轭苯并二氮杂，阴离子交换柱，疏水性阳离子交换柱和反相分析柱。执行分析的优选方法还涉及在阴离子交换柱之前使用疏水性阳离子交换预柱。该系统易于自动化，自动定期取样和苯二氮卓鉴定和定量。该系统特别适用于尿液样品中苯二氮卓类的测定和鉴定。

22. 发明授权

US4338811A Method and apparatus for diagnosis of disease 失效
标题翻译：疾病诊断方法和装置
公开(公告)号：US4338811A
公开(公告)日：1982-07-13
申请号：US201723
申请日：1980-10-29
申请人： Hiroyuki Miyagi , Yoshinori Takata , Junkichi Miura , Mamoru Taki
发明人： Hiroyuki Miyagi , Yoshinori Takata , Junkichi Miura , Mamoru Taki
IPC分类号： G01N30/86 , G01N33/50 , G06F17/00
CPC分类号： G01N33/50 , G01N30/8606 , G01N30/8675
摘要： A disease diagnostic method and apparatus in which a two-dimensional pattern diagram representing the relation between integrated values of peaks and the retention times in a chromatogram of substances in a body fluid of a subject is obtained to be geographically compared, for disease diagnostic purpose, with a two-dimensional pattern diagram representing the relation between integrated values of peaks and the retention times in a chromatogram obtained through separating and detecting substances in a body fluid of a normal person, and also with two-dimensional pattern diagrams representing the relation between integrated values of peaks and the retention times in chromatograms obtained through separating and detecting substances in a body fluid of abnormal patients classified by diseases.
摘要翻译：疾病诊断方法和装置，其中获得代表对象的体液中的物质的色谱图中的峰的积分值与保留时间之间的关系的二维图案图，以进行地理上的比较，用于疾病诊断目的，具有表示通过分离和检测正常人的体液中的物质而获得的色谱图中峰的积分值与保留时间之间的关系的二维图案图，以及表示正常人的体液中的物质的二维图案图通过分离和检测通过疾病分类的异常患者的体液中的物质获得的色谱图中的峰值和保留时间。

23. 发明授权

US3563083A Automatic interface for gas chromatograph-mass spectrometer system 失效
标题翻译：气相色谱 - 质谱仪系统的自动界面
公开(公告)号：US3563083A
公开(公告)日：1971-02-16
申请号：US3563083D
申请日：1968-01-15
申请人： VARIAN ASSOCIATES
发明人： BENZ HANSPETER
IPC分类号： G01N30/86 , H01J49/02 , G01N31/08
CPC分类号： G01N30/7206 , G01N30/82 , G01N30/8606 , H01J49/022
摘要： AN ANALYTICAL SYSTEM IS DESCRIBED INCLUDING A COMBINATION OF A GAS CHROMATOGRAPH AND A MASS SPECTROMETER ALONG WITH AN AUTOMATIC INTERFACE APPARATUS FOR RENDERING THE TWO DISSIMILAR COMPONENTS HIGHLY COMPATIBLE IN A CONTINUOUS FLOW QUANTITATIVE-QUALITATIVE ANALYZING SYSTEM. THE INTERFACE INCLUDES AN AUTOMATIC CONTROL CIRCUIT FOR DETECTING THE OUTPUT OF THE GAS CHROMATOGRAPH AND SELECTING FROM EACH GC PEAK A PREDETERMINED QUANTITY OF SAMPLE FOR PRESENTATION TO THE ION SOURCE OF THE MASS SPECTOMETER.

24. 发明授权

US3500028A Automatic chromatography system 失效
标题翻译：自动色谱系统
公开(公告)号：US3500028A
公开(公告)日：1970-03-10
申请号：US3500028D
申请日：1965-03-10
申请人： FOSTER GRANT CO INC
发明人： KILLIAN CHARLES R
IPC分类号： G01N3/08 , B65H67/04 , G01N30/86 , G06G7/75 , G06G7/18 , G06F15/20 , G06G7/48
CPC分类号： G01N30/8651 , B65H67/0434 , B65H2701/31 , G01N30/8603 , G01N30/8606 , G06G7/75

25. 发明授权

US3026502A Peak signal summation system 失效
标题翻译：峰值信号求和系统
公开(公告)号：US3026502A
公开(公告)日：1962-03-20
申请号：US7403560
申请日：1960-12-06
申请人： UNION CARBIDE CORP
发明人： ROGERS LOUIS J , WEISS MARVIN D
IPC分类号： G01N30/86 , G05D3/14
CPC分类号： G01N30/8603 , G01N30/8606 , G05D3/14

26. 发明公开

US20240345046A1 WAVEFORM-ANALYZING METHOD, WAVEFORM-ANALYZING DEVICE, AND ANALYZING SYSTEM 审中-公开
公开(公告)号：US20240345046A1
公开(公告)日：2024-10-17
申请号：US18631581
申请日：2024-04-10
申请人： SHIMADZU CORPORATION
发明人： Hitomi YOSHIYAMA-KITAJIMA , Shinji KANAZAWA
IPC分类号： G01N30/86 , G01N30/72
CPC分类号： G01N30/8637 , G01N30/8606 , G01N30/72
摘要： A model for locating a peak portion in a chromatogram or similar waveform is trained by machine learning using multiple sets of partial waveforms prepared by dividing each reference waveform having a known peak position. An analysis-target waveform is divided into partial waveforms, and whether or not a partial waveform is a peak portion is determined for each partial waveform by the trained model, to estimate different kinds of regions in the analysis-target waveform, including an overlap-peak region. For an overlap peak within a region estimated to be an overlap-peak region, whether or not that peak is a multimodal peak originating from one component is determined, using at least the height of a peak in the overlap peak, the depth of the trough between two neighboring peaks, or the horizontal width of the portion between the bottom of the trough and the top of one of the neighboring peaks.

27. 发明授权

US11879880B2 Integrated machines and methods for performing fully-automated biological evaluation and chemical analysis 有权
公开(公告)号：US11879880B2
公开(公告)日：2024-01-23
申请号：US17276447
申请日：2019-07-17
申请人： RESEARCH CENTER FOR ECO-ENVIRONMENTAL SCIENCES, CHINESE ACADEMY OF SCIENCES
发明人： Guangbo Qu , Qianchi Ma , Yanna Liu , Jianbo Shi , Guibin Jiang
IPC分类号： G01N30/88 , G01N30/72 , G01N30/86 , G01N30/02 , H01J49/40 , B01J20/291
CPC分类号： G01N30/88 , G01N30/72 , G01N30/8606 , B01J20/291 , G01N2030/027 , H01J49/40
摘要： Machines and methods are for performing fully-automated biological evaluation and chemical analysis. A pretreatment module is used in treatments of enriching, concentrating and purifying a sample to be analyzed. A component separation module is used for carrying out separation of multiple compounds in mother liquor to be analyzed. A monitoring and identifying module is for monitoring and collecting chromatographic signals of the separated liquid effluent in real time, as well as quantitative detection of suspicious compounds. A component collection module is used in operations of collecting, transferring and dissolving, redissolving, and pipetting the separated liquid effluent. A biological evaluation module is for cell culture and detection of cytotoxic effect and toxic targets. A data processing and automated control module is for acquisition, arrangement and analysis of the integrated data. The machines and methods provide an efficient, stable and normalized standard operation condition for the screening of toxicity of compounds.

28. 发明授权

US07043406B1 Apparatus and methods for reduction of coherent noise in a digital signal averager 有权
标题翻译：用于减少数字信号平均器中相干噪声的装置和方法
公开(公告)号：US07043406B1
公开(公告)日：2006-05-09
申请号：US10421590
申请日：2003-04-23
申请人： David G. Welkie , Craig M. Whitehouse
发明人： David G. Welkie , Craig M. Whitehouse
IPC分类号： H04B15/00
CPC分类号： G01R13/0272 , G01N30/8606
摘要： Apparatus and methods are provided for reducing coherent noise in measurements of repetitive analog signal waveforms by digital signal averagers. Coherent noise is repetitive and synchronous with the signal waveform and is therefore undiminished by conventional signal averaging techniques. A major source of coherent noise is the repetitive voltage transitions that occur within the digital signal averager itself. The apparatus and methods of the present invention introduce a known and variable phase offset during the signal averaging process between the signal waveform being measured and the internally generated coherent noise, thereby allowing such coherent noise to be averaged, and therefore reduced, during the signal averaging process. Consequently, the apparatus and methods of the present invention allow greater signal-to-noise ratio and signal dynamic range than with the prior art.
摘要翻译：提供了设备和方法，用于通过数字信号平均器来减少重复模拟信号波形测量中的相干噪声。相干噪声与信号波形重复并同步，因此通过传统的信号平均技术不会受到影响。相干噪声的主要来源是在数字信号平均器本身内发生的重复电压转换。本发明的装置和方法在正被测量的信号波形与内部产生的相干噪声之间的信号平均过程期间引入已知和可变的相位偏移，从而允许在信号平均期间使这种相干噪声平均，因此减小处理。因此，与现有技术相比，本发明的装置和方法允许更大的信噪比和信号动态范围。

29. 发明授权

US06952945B2 Method and apparatus for concentrating samples for analysis 有权
标题翻译：用于浓缩样品进行分析的方法和装置
公开(公告)号：US06952945B2
公开(公告)日：2005-10-11
申请号：US09770942
申请日：2001-01-25
申请人： Robert O'Brien
发明人： Robert O'Brien
IPC分类号： G01N33/497 , G01N1/00 , G01N1/02 , G01N1/22 , G01N1/24 , G01N1/36 , G01N1/40 , G01N15/00 , G01N21/27 , G01N21/33 , G01N21/35 , G01N30/02 , G01N30/04 , G01N30/06 , G01N30/08 , G01N30/20 , G01N30/22 , G01N30/32 , G01N30/34 , G01N30/46 , G01N30/62 , G01N30/64 , G01N30/68 , G01N30/70 , G01N30/74 , G01N30/78 , G01N30/86 , G01N30/88 , G01N33/00 , G01W1/17 , G01N30/90
CPC分类号： G01N1/2202 , G01N1/24 , G01N1/40 , G01N30/06 , G01N30/22 , G01N30/78 , G01N30/8606 , G01N30/8641 , G01N2001/2223 , G01N2001/4027 , G01N2015/0046 , G01N2015/0092 , G01N2030/025 , G01N2030/328 , G01N2030/625 , G01N2030/626 , G01N30/32
摘要： A method for analyzing a gas sample is described. The method comprises providing a gas sample, increasing pressure applied to the gas sample to compress the sample to a smaller volume and provide a pneumatically focused gas sample, and analyzing the pneumatically focused gas sample using any of a variety of analytical techniques. Pneumatic Focusing generally means increasing the pressure of the sample, column or cell to a pressure of from about 100 psi to about 15,000 psi, more typically from about 200 psi to about 2,000 psi. Examples including gas chromatography and absorption spectroscopy are illustrated herein. Numerous other examples could be given. The method is well suited for analyzing gaseous samples, such as ambient air samples, both continuously, and remotely, using computer control. Continuously sampling ambient air provides a method for real-time monitoring of air quality. Continuous monitoring allows for pollutant exposure and allows for the identification of emission sources. The method is also well suited for analysis of breath exhalations from respiring organisms useful in metabolic studies or disease diagnosis.
摘要翻译：对气体样品的分析方法进行说明。该方法包括提供气体样品，增加施加到气体样品的压力以将样品压缩到更小的体积并提供气动聚焦的气体样品，以及使用各种分析技术中的任何一种来分析气动聚焦的气体样品。气动聚焦通常意味着将样品，柱或细胞的压力提高到约100psi至约15,000psi，更典型地约200psi至约2,000psi的压力。本文说明了包括气相色谱和吸收光谱的实例。可以给出很多其他例子。该方法非常适用于使用计算机控制连续和远程分析气态样品，如环境空气样品。连续采样环境空气提供了一种实时监测空气质量的方法。连续监测允许污染物暴露并允许识别排放源。该方法也非常适用于分析代谢研究或疾病诊断中有用的呼吸生物的呼吸呼气。

30. 发明授权

US5311444A Absorbance analyzer and data processing method for chromatograph 失效
标题翻译：吸光度分析仪和色谱数据处理方法
公开(公告)号：US5311444A
公开(公告)日：1994-05-10
申请号：US906972
申请日：1992-06-30
申请人： Hiroshi Ohta
发明人： Hiroshi Ohta
IPC分类号： G01N21/17 , G01J3/28 , G01N21/27 , G01N21/31 , G01N30/74 , G01N30/86 , G01N21/72 , G06K9/46
CPC分类号： G01N30/8624 , G01N21/27 , G01J2003/2863 , G01N2021/3595 , G01N30/74 , G01N30/8606 , G01N30/8641
摘要： A measuring part measures the absorbance spectrum of an effluent fluid sample from a chromatograph in a constant cycle, and a base line calculating part calculates a base line including absorbance values on both ends of a designated wave number range with respect to every absorbance spectrum data as measured. A peak area calculating part calculates the peak area of the absorbance spectrum in the designated wave number range on the basis of the decided base line. A chromatogram is obtained by time change of the calculated peak area. Thus, it is possible to eliminate influences by other functional groups and fluctuation of the base line in an absorbance analyzer.
摘要翻译：测量部分以恒定周期测量来自色谱仪的流出液样品的吸收光谱，基线计算部分计算包括相对于每个吸光度光谱数据指定波数范围的两端的吸光度值的基线，作为测量。峰值区域计算部分基于所确定的基线计算指定波数范围内的吸收光谱的峰面积。通过计算的峰面积的时间变化获得色谱图。因此，可以消除吸光度分析仪中其他官能团的影响和基线的波动。

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