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1. 发明授权

US12111297B2 Liquid chromatograph and analysis method using liquid chromatograph 有权
公开(公告)号：US12111297B2
公开(公告)日：2024-10-08
申请号：US17962474
申请日：2022-10-08
申请人： SHIMADZU CORPORATION
发明人： Yuka Fujito , Logan Miller
IPC分类号： G01N30/38 , B01D15/18 , G01N30/02 , G01N30/22 , G01N30/24 , G01N30/26 , G01N30/86 , G01N30/16 , G01N30/20 , G01N30/88
CPC分类号： G01N30/38 , B01D15/18 , G01N30/22 , G01N30/8641 , G01N2030/027
摘要： A controller of a liquid chromatograph is configured to execute, as an analysis operation in an analysis unit, a sample injection step of bringing a high-pressure valve into a loading state, sucking a sample from a tip of a needle to hold a sample in a sampling channel, then connecting the sampling channel to an injection port and bringing the high-pressure valve into an injecting state, and supplying a mobile phase from a liquid supplier, thereby injecting a sample held in the sampling channel into an analysis channel, and an analysis step of separating components of a sample injected into the analysis channel in a separation column by bringing the high-pressure valve in the loading state and supplying the mobile phase from the liquid supplier after the sample injection step is ended. The controller is configured to execute, as the analysis operation, a system cleaning step of cleaning a liquid flowing route.

2. 发明授权

US12078619B2 Injector serving multiple sample separation apparatuses 有权
公开(公告)号：US12078619B2
公开(公告)日：2024-09-03
申请号：US17288478
申请日：2018-10-26
申请人： Agilent Technologies, Inc.
发明人： Thomas Ortmann
IPC分类号： G01N30/20 , B01D15/18 , G01N30/22 , G01N30/46 , G01N30/60
CPC分类号： G01N30/20 , B01D15/1885 , G01N30/22 , G01N30/466 , G01N30/6043 , G01N2030/202 , G01N2030/207
摘要： An injector, for injecting a fluidic sample in at least one selected one of a first sample separation apparatus and a second sample separation apparatus, includes a valve arrangement fluidically connectable to the first sample separation apparatus and the second sample separation apparatus, a sample accommodation volume for accommodating the fluidic sample, and a control unit configured for controlling the valve arrangement so that fluidic sample in the sample accommodation volume is selectively injectable into the selected first sample separation apparatus and/or second sample separation apparatus.

3. 发明公开

US20240272127A1 GAS CHROMATOGRAPHY ANALYTICAL METHOD 审中-公开
公开(公告)号：US20240272127A1
公开(公告)日：2024-08-15
申请号：US18568364
申请日：2022-03-16
申请人： ASAHI KASEI KABUSHIKI KAISHA
发明人： Masako YOKOYAMA
IPC分类号： G01N30/22 , B01D53/02 , G01N30/02
CPC分类号： G01N30/22 , B01D53/025 , G01N2030/025
摘要： It is an object of the present invention to provide a gas chromatography analytical method in which a purity of high-purity ethylene carbonate can be accurately analyzed by gas chromatography analysis, and the object can be achieved by a gas chromatography analytical method based on an ethylene carbonate split injection technique, comprising injecting ethylene carbonate to be analyzed into a gas chromatography analyzer; vaporizing the injected ethylene carbonate in a single taper liner not packed with wool; introducing a part of the vaporized ethylene carbonate into a capillary column with an inert gas flowing and allowing the ethylene carbonate to pass through the capillary column; and detecting the ethylene carbonate having passed through the capillary column with a detector.

4. 发明授权

US12031958B2 Impurity detection method of latamoxef sodium 有权
公开(公告)号：US12031958B2
公开(公告)日：2024-07-09
申请号：US17564242
申请日：2021-12-29
申请人： Hainan Hailing Chemipharma Corporation Ltd.
发明人： Youxing Huang , Yifeng Lu , Guorong Lu
IPC分类号： G01N30/06 , G01N30/22
CPC分类号： G01N30/22 , G01N30/06
摘要： A impurity detection method of latamoxef sodium is configured to detect the impurities in latamoxef sodium for injection by using high performance liquid chromatography. A chromatographic condition is as follows: taking Agilent ZORBAX SB-CN cyano bonded silica gel column as a stationary phase, taking 0.005˜0.015 mol/L ammonium acetate solution-methanol as a mobile phase A; taking 0.02˜0.03 mol/L ammonium acetate solution-acetonitrile as a mobile phase B; adjusting a pH value of the ammonium acetate solution to 5.8˜6.5; the present disclosure has advantages of a simple operation, high column efficiency, a moderate tailing factor and a retention time of a main peak, high detection accuracy of strong alkali damage, effective separation between the main peak and each impurity peak without interference, which is conducive to accurately controlling quality of lyophilized powder of latamoxef sodium for injection and ensuring quality of drugs.

5. 发明授权

US10613061B2 Systems, methods and devices addressing sample extraction and injection problems in chromatography 有权
公开(公告)号：US10613061B2
公开(公告)日：2020-04-07
申请号：US16070898
申请日：2017-01-19
申请人： Waters Technologies Corporation
发明人： Abhijit Tarafder
IPC分类号： B01D11/02 , B01D15/12 , G01N30/06 , G01N1/40 , G01N30/08 , G01N30/34 , B01D15/16 , G01N30/20 , G01N30/22 , G01N35/10 , B01D17/12 , G01N30/24 , G01N30/02 , G01N30/32 , G01N35/04 , G01N30/00 , B01D15/40
CPC分类号： G01N30/06 , B01D11/0203 , B01D11/028 , B01D11/0219 , B01D11/0288 , B01D15/12 , B01D15/166 , B01D17/12 , G01N1/4055 , G01N30/02 , G01N30/08 , G01N30/20 , G01N30/22 , G01N30/24 , G01N30/32 , G01N30/34 , G01N35/1097 , B01D15/40 , G01N2001/4061 , G01N2030/009 , G01N2030/062 , G01N2030/085 , G01N2030/201 , G01N2030/207 , G01N2030/328 , G01N2030/347 , G01N2035/0444
摘要： In a chromatography system, including within the system an extraction vessel which receives a mixture of mobile phase and co-solvent and provides a mixture of mobile phase and co-solvent with sample to a chromatography column to increase sample concentration within the mixture. In addition, adding a reservoir to the chromatography system to form an extraction-pressurization system, wherein the mixture with sample may be collected in the reservoir and may diffuse and equilibrate to an approximately uniform sample concentration before being provided to the chromatography column. Also in addition, providing a plurality of extraction-pressurization systems to allow near-simultaneous extraction of sample and loading of the column, or concurrent extraction and loading by the plurality of extraction-pressurization systems.

6. 发明申请

US20180093201A1 MODULAR-TYPE ANALYSIS SYSTEM 审中-公开
公开(公告)号：US20180093201A1
公开(公告)日：2018-04-05
申请号：US15563767
申请日：2015-04-03
申请人： Shimadzu Corporation
发明人： Yusuke YOKOI , Kazuya TAKAHASHI
IPC分类号： B01D15/22 , G01N30/22 , G01N30/60 , G01N35/00
CPC分类号： B01D15/22 , G01N30/22 , G01N30/6026 , G01N30/6039 , G01N30/8658 , G01N35/00 , G01N35/00594 , G01N2030/522 , G01N2030/8881
摘要： In the non-volatile storage unit (341) of the local control unit (34) of each unit (3 to 6) configuring an LC system, periodic inspection information, such as the installation date and the next inspection scheduled date, is stored at an appropriate time. When an analysis is carried out, in the system control unit (2) which controls each unit, a periodic inspection notification processing unit (211) collects periodic inspection information from each unit (3 to 7) upon power on or start up, compares the next inspection scheduled date with the current time by the real-time clock (212), and determines a unit for which a periodic inspection notification is required. If there is a unit that requires a periodic inspection notification, a notification request is sent to the unit, and the local control unit (34) of the unit outputs an indication prompting periodic inspection to the display unit (35). As a result, even if the installation times are different for each unit and even if each unit does not have a real-time clock, it is possible to notify a user when a predetermined age of service has passed from the installation time of a given unit.

7. 发明授权

US09671376B2 Flow path switching valve 有权
公开(公告)号：US09671376B2
公开(公告)日：2017-06-06
申请号：US14367147
申请日：2012-12-21
申请人： SHIMADZU CORPORATION
发明人： Kenichi Yasunaga , Yoshiaki Maeda
IPC分类号： F16K11/00 , G01N30/38 , F16K27/04 , F16K11/02 , G01N30/22 , G01N30/20
CPC分类号： G01N30/38 , F16K11/02 , F16K27/045 , G01N30/22 , G01N2030/202 , Y10T137/86863
摘要： A base and a stator forming a housing are joined by a stator position adjustment member. The adjustment member is a ring-shaped member having an inner diameter that is equal to the outer forms of the base and the stator, and threads opposite to each other are provided to an upper portion and a lower portion of the inner circumferential surface, along the circumferential direction. A thread for being screwed with the thread is provided, in the circumferential direction, to each of an upper portion of an outer circumferential surface of the base and a lower portion of an outer circumferential surface of an outer wall member of the stator. When the adjustment member is rotated, the base and the stator move in the direction of separating from each other or in the direction of coming close to each other.

8. 发明授权

US09624923B2 Control arrangement for controlling a piston pump unit for liquid chromatography 有权
公开(公告)号：US09624923B2
公开(公告)日：2017-04-18
申请号：US13917963
申请日：2013-06-14
申请人： Gervin Ruegenberg , Richard Schloderer , Werner Tuchan
发明人： Gervin Ruegenberg , Richard Schloderer , Werner Tuchan
IPC分类号： F04B41/06 , F04B49/22 , F04B49/20 , F04B23/06 , G01N30/32 , G01N30/22
CPC分类号： F04B49/22 , F04B23/06 , F04B49/20 , G01N30/22 , G01N30/32 , G01N2030/326
摘要： A control arrangement for controlling a piston pump unit for liquid chromatography, in particular high-performance liquid chromatography, is described. The piston pump unit has at least two piston-cylinder units which operate cyclically in a phase-offset manner and generate, at an outlet port, a predetermined flow of a liquid medium to be delivered. A system pressure is established at the outlet port, irrespective of an associated fluid load resistance. The control arrangement is configured to record the pressure in the cylinder volume of at least a first of the at least two piston-cylinder units. During a measurement phase of the compression phase of the first piston-cylinder unit or during a measurement phase of the decompression phase of the first piston-cylinder unit, the control arrangement stops the drive device for the first piston-cylinder unit for a predetermined time period and in the process records measurement data which characterize the time profile of the pressure.

9. 发明申请

US20140042351A1 SWITCHING VALVE FOR HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY 有权
标题翻译：用于高性能液相色谱的开关阀
公开(公告)号：US20140042351A1
公开(公告)日：2014-02-13
申请号：US13961637
申请日：2013-08-07
申请人： Joachim WIECHERS , Hermann HOCHGRAEBER
发明人： Joachim WIECHERS , Hermann HOCHGRAEBER
IPC分类号： G01N30/26
CPC分类号： G01N30/26 , F16K3/10 , F16K11/0743 , G01N30/22 , G01N2030/202
摘要： A switching valve is described that has a stator which is arranged in a housing and which has multiple connection ports. The switching valve also has a rotatable rotor which is arranged in the housing and which, in predetermined switching positions defined by associated angular positions, interacts with the stator for the fluidic connection or separation of predetermined connection ports. The rotor is rotatably mounted, and acted on with a predefined pressing force in the direction of the stator, by means of a bearing and pressing device arranged in the housing. The bearing and pressing device has a spring device which exerts a load on the rotor or on an element that is capable of performing a wobbling movement.
摘要翻译：描述了具有布置在壳体中并且具有多个连接端口的定子的切换阀。切换阀还具有可转动的转子，该转子布置在壳体中，并且在由关联的角位置限定的预定切换位置中与定子相互作用以进行流体连接或预定连接端口的分离。转子通过设置在壳体中的轴承和加压装置可旋转地安装并以预定的按压力在定子的方向上作用。轴承和加压装置具有弹簧装置，该弹簧装置对转子或能够进行摆动运动的元件施加负载。

10. 发明申请

US20130336803A1 CONTROL ARRANGEMENT FOR CONTROLLING A PISTON PUMP UNIT FOR LIQUID CHROMATOGRAPHY 有权
标题翻译：用于控制用于液相色谱的活塞泵单元的控制装置
公开(公告)号：US20130336803A1
公开(公告)日：2013-12-19
申请号：US13917963
申请日：2013-06-14
申请人： Gervin RUEGENBERG , Richard SCHLODERER , Werner TUCHAN
发明人： Gervin RUEGENBERG , Richard SCHLODERER , Werner TUCHAN
IPC分类号： F04B49/22
CPC分类号： F04B49/22 , F04B23/06 , F04B49/20 , G01N30/22 , G01N30/32 , G01N2030/326
摘要： A control arrangement for controlling a piston pump unit for liquid chromatography, in particular high-performance liquid chromatography, is described. The piston pump unit has at least two piston-cylinder units which operate cyclically in a phase-offset manner and generate, at an outlet port, a predetermined flow of a liquid medium to be delivered. A system pressure is established at the outlet port, irrespective of an associated fluid load resistance. The control arrangement is configured to record the pressure in the cylinder volume of at least a first of the at least two piston-cylinder units. During a measurement phase of the compression phase of the first piston-cylinder unit or during a measurement phase of the decompression phase of the first piston-cylinder unit, the control arrangement stops the drive device for the first piston-cylinder unit for a predetermined time period and in the process records measurement data which characterize the time profile of the pressure.
摘要翻译：描述了用于控制用于液相色谱的活塞泵单元，特别是高效液相色谱的控制装置。活塞泵单元具有至少两个活塞 - 气缸单元，其以相位偏移方式周期性地操作，并在出口处产生待输送的液体介质的预定流量。在出口处建立系统压力，不管相关的流体负载阻力如何。控制装置构造成记录至少两个活塞 - 气缸单元中的至少一个的气缸体积中的压力。在第一活塞 - 气缸单元的压缩阶段的测量阶段期间或在第一活塞 - 气缸单元的减压阶段的测量阶段期间，控制装置将用于第一活塞 - 气缸单元的驱动装置停止预定时间期间和过程记录表征压力时间曲线的测量数据。

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