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1. 发明授权

US4338811A Method and apparatus for diagnosis of disease 失效
标题翻译：疾病诊断方法和装置
公开(公告)号：US4338811A
公开(公告)日：1982-07-13
申请号：US201723
申请日：1980-10-29
申请人： Hiroyuki Miyagi , Yoshinori Takata , Junkichi Miura , Mamoru Taki
发明人： Hiroyuki Miyagi , Yoshinori Takata , Junkichi Miura , Mamoru Taki
IPC分类号： G01N30/86 , G01N33/50 , G06F17/00
CPC分类号： G01N33/50 , G01N30/8606 , G01N30/8675
摘要： A disease diagnostic method and apparatus in which a two-dimensional pattern diagram representing the relation between integrated values of peaks and the retention times in a chromatogram of substances in a body fluid of a subject is obtained to be geographically compared, for disease diagnostic purpose, with a two-dimensional pattern diagram representing the relation between integrated values of peaks and the retention times in a chromatogram obtained through separating and detecting substances in a body fluid of a normal person, and also with two-dimensional pattern diagrams representing the relation between integrated values of peaks and the retention times in chromatograms obtained through separating and detecting substances in a body fluid of abnormal patients classified by diseases.
摘要翻译：疾病诊断方法和装置，其中获得代表对象的体液中的物质的色谱图中的峰的积分值与保留时间之间的关系的二维图案图，以进行地理上的比较，用于疾病诊断目的，具有表示通过分离和检测正常人的体液中的物质而获得的色谱图中峰的积分值与保留时间之间的关系的二维图案图，以及表示正常人的体液中的物质的二维图案图通过分离和检测通过疾病分类的异常患者的体液中的物质获得的色谱图中的峰值和保留时间。

2. 发明授权

US4823168A Flow-through cell for a photometer formed using a pair of cell body members 失效
标题翻译：用于使用一对电池体构件形成的光度计的流通池
公开(公告)号：US4823168A
公开(公告)日：1989-04-18
申请号：US116543
申请日：1987-11-04
申请人： Masao Kamahori , Yoshio Watanabe , Junkichi Miura , Mamoru Taki , Hiroyuki Miyagi
发明人： Masao Kamahori , Yoshio Watanabe , Junkichi Miura , Mamoru Taki , Hiroyuki Miyagi
IPC分类号： G01N21/05 , G01N30/74
CPC分类号： G01N21/05 , G01N2021/0346 , G01N2021/054 , G01N2030/746 , G01N30/74
摘要： A flow cell for a photometer, which comprises a cell body integrated from a pair of cell body members by joining, at least one of which is provided with a linear groove on the joining surface of the cell body member from one end to another to the full length, as exposed to the joining surface, the groove playing both roles of a liquid sample passage and a detecting light path by the integration of the cell body members, and is further provided with a liquid sample inlet passage at a position near one end of the groove and a liquid sample outlet passage at a position near the other end of the groove, both passages being communicated with the grooves, the linear groove being provided with a light reflecting layer to the full length of the linear groove, and a pair of light transmission window members joined with the flow cell body at both ends on the groove-open sides thereof is provided, where polishing of the grooves is readily carried out and random reflection of light or absorption of light due to poor reflection is reduced, and the turbulent flow of a liquid sample and generation of noise are suppressed.
摘要翻译：一种用于光度计的流动池，其包括通过接合从一对电池主体部件集成的电池体，其中至少一个在电池体部件的接合表面上从一端到另一端设置有线性槽全长，暴露于接合表面，沟槽通过集成电池主体部件而兼容液体样品通道和检测光路两者，并且在靠近一端的位置处进一步设置有液体样品入口通道的槽和在槽的另一端附近的位置处的液体样品出口通道，两个通道与槽连通，所述直线槽在直线槽的整个长度上设置有光反射层，以及一对提供了在其开槽侧的两端与流通池本体连接的透光窗构件，其中容易进行槽的抛光和光或吸收的随机反射o 由于反射不良导致的光衰减，液体试样的紊流和噪声的产生被抑制。

3. 发明授权

US5093267A Method for biochemical assay and an analyzer for the method 失效
标题翻译：生物化学测定方法和方法分析仪
公开(公告)号：US5093267A
公开(公告)日：1992-03-03
申请号：US267293
申请日：1988-11-04
申请人： Junkichi Miura , Mamoru Taki , Yoshio Watanabe , Masao Kamahori , Hiroyuki Miyagi
发明人： Junkichi Miura , Mamoru Taki , Yoshio Watanabe , Masao Kamahori , Hiroyuki Miyagi
IPC分类号： G01N30/06 , G01N30/88 , G01N33/94
CPC分类号： G01N33/9406 , G01N30/88 , Y10T436/142222 , Y10T436/173845 , Y10T436/203332 , Y10T436/255
摘要： Catecholamines can be detected with high sensitivity in a shortened time period, by introducing a sample containing catecholamines into an adsorption column packed with an adsorbent to adsorb catecholamines to the column, then introducing a reagent for derivatization to effect pre-column labeling and then analyzing the pre-column labeled catecholamines by means of high performance liquid chromatography. Connection of the adsorption column and a separation column of high performance liquid chromatography via a fluid path changeover valve enables to automated analysis of catecholamines.
摘要翻译：可以在缩短的时间内以高灵敏度检测儿茶酚胺，通过将含有儿茶酚胺的样品引入填充有吸附剂的吸附塔中将儿茶酚胺吸附到塔中，然后引入用于衍生化的试剂进行预柱标记，然后分析通过高效液相色谱法预柱标记的儿茶酚胺。通过流体路径切换阀连接吸附塔和高效液相色谱分离柱，可以自动分析儿茶酚胺。

4. 发明授权

US5005434A Autosampler with a means for detecting air bubble in specimen 失效
标题翻译：自动进样器，用于检测样品中的气泡
公开(公告)号：US5005434A
公开(公告)日：1991-04-09
申请号：US390720
申请日：1989-08-08
申请人： Yoshio Watanabe , Mamoru Taki , Junkichi Miura , Masao Kamahori , Hiroyuki Miyagi , Yasuhide Matsumura , Masafumi Kanetomo
发明人： Yoshio Watanabe , Mamoru Taki , Junkichi Miura , Masao Kamahori , Hiroyuki Miyagi , Yasuhide Matsumura , Masafumi Kanetomo
IPC分类号： G01N35/10 , G01N1/00 , G01N1/14 , G01N15/00 , G01N30/16 , G01N30/24 , G01N30/34
CPC分类号： G01N35/1097 , G01N1/14 , G01N2015/0011 , G01N2021/4735 , G01N2201/08 , G01N30/34
摘要： An autosampler consists of a needle to draw specimen from a specimen container into a passage therein; a block having a passage that follows the passge in the needle; a suction mechanism for drawing in the specimen by suction through the passages in the needle and the block; a discharge mechanism for discarding the specimen drawn in by the suction mechanism; and a detecting device for detecting air bubble in the specimen, the detecting device being embedded in the block in such a manner as to face the passage in the block. The detecting device detects the air bubbles in the specimen according to changes in physical or chemical properties of the specimen passing through the passage in the block. The discharge mechanism is activated by the detecting device to discharge air-mixed specimen. When even a small amount of air is drawn into the passage from the specimen container, in which only a small amount of specimen is contained, the air specimen can reliably be distinguished from normal specimen by this autosampler. Therefore the reliability of the system using the autosampler can be significantly improved.
摘要翻译：自动进样器由将样本从样本容器拉入其中的通道的针头组成; 具有跟随针头中的传递的通道的块; 抽吸机构，用于通过抽吸通过针和块中的通道抽吸样品; 用于废弃由抽吸机构吸入的试样的排出机构; 以及用于检测样本中的气泡的检测装置，所述检测装置以面对块中的通道的方式嵌入块中。检测装置根据通过块体中的通道的试样的物理或化学特性的变化来检测样品中的气泡。排出机构由检测装置启动，以排出空气混合样品。即使少量的空气从容纳少量试样的试样容器的通道中吸入，也可以通过该自动进样器将空气样本与正常试样区分开。因此，可以显着提高使用自动进样器的系统的可靠性。

5. 发明授权

US5294336A Apparatus for liquid chromatography for separating AIC components from hemoglobin in blood 失效
标题翻译：用于液体色谱法分离血液中血红蛋白的AIC成分的装置
公开(公告)号：US5294336A
公开(公告)日：1994-03-15
申请号：US896784
申请日：1992-06-09
申请人： Masako Mizuno , Kenji Tochigi , Yutaka Misawa , Hiroyuki Miyagi , Yoshio Watanabe , Taro Nogami , Junkichi Miura , Yoshinori Takata
发明人： Masako Mizuno , Kenji Tochigi , Yutaka Misawa , Hiroyuki Miyagi , Yoshio Watanabe , Taro Nogami , Junkichi Miura , Yoshinori Takata
IPC分类号： G01N30/32 , B01D15/08 , B01J20/281 , G01N30/02 , G01N30/86 , G01N30/88 , G01N33/487 , G01N33/72
CPC分类号： G01N33/723 , B01D15/08 , G01N2030/027
摘要： Stable hemoglobin A.sub.lc (s-A.sub.lc) can be separated from other hemoglobin components and quantitated in a short time by means of a liquid-chromatographic apparatus comprising a separation column packed with a packing material consisting essentially of a porous substance having a carboxyalkyl group combined thereinto, as ion exchanger, a means for injecting a sample into the separation column, a means for passing one or more eluents through the separation column, and a means for detecting hemoglobin, hemoglobin derivatives or glycosylated hemoglobin, the average particle size of the packing material in dry state being 4 .mu.m or less.
摘要翻译：稳定的血红蛋白Alc（s-Alc）可以与其他血红蛋白成分分离，并通过液相色谱装置在短时间内定量，该液相色谱装置包括一个分离柱，该分离柱填充有基本上由其中组合有羧基烷基的多孔物质组成的包装材料作为离子交换剂，将样品注入分离塔的方法，使一个或多个洗脱液通过分离塔的装置和用于检测血红蛋白，血红蛋白衍生物或糖基化血红蛋白的装置，包装材料的平均粒径在干燥状态下为4（my）m或更小。

6. 发明授权

US5132012A Liquid chromatograph 失效
标题翻译：液相色谱仪
公开(公告)号：US5132012A
公开(公告)日：1992-07-21
申请号：US369853
申请日：1989-06-22
申请人： Junkichi Miura , Andreas Manz , Yoshio Watanabe , Yuji Miyahara , Hiroyuki Miyagi , Keiji Tsukada
发明人： Junkichi Miura , Andreas Manz , Yoshio Watanabe , Yuji Miyahara , Hiroyuki Miyagi , Keiji Tsukada
IPC分类号： G01N30/18 , G01N30/32 , G01N30/38 , G01N30/60 , G01N30/64 , G01N35/00
CPC分类号： G01N30/6095 , G01N2030/385 , G01N2035/00237 , G01N30/18 , G01N30/32 , G01N30/64
摘要： A liquid chromatograph comprises an analyzing chip in which a capillary is formed in a substrate and a detector section is disposed downstream of the capillary. The capillary is covered so that an inlet opening end and an outlet opening end of said capillary flow path is opened. A frame member has a sample introduction path, a carrier liquid introduction path and a liquid discharge path. The analyzing chip is movably disposed in the frame member so that the inlet opening end and the outlet opening end of the capillary are selectively in communication with and/or under interruption against said sample introduction path, the carrier liquid introduction path and the liquid discharge path. The liquid chromatograph is very small in size but is easy to handle. Incidentally, there is disclosed also a sample introduction apparatus and method for the chromatograph, and an FET type detector suitable for the chromatograph.
摘要翻译：液相色谱仪包括分析芯片，其中在基板中形成毛细管，并且检测器部分设置在毛细管的下游。毛细管被覆盖，使得所述毛细管流路的入口开口端和出口开口端被打开。框架构件具有样品引入路径，载液引入路径和液体排出路径。分析芯片可移动地设置在框架构件中，使得毛细管的入口开口端和出口开口端选择性地与所述样品引入路径，载液引入路径和液体排出路径。液相色谱仪尺寸非常小，易于处理。顺便提及，还公开了用于色谱仪的样品引入装置和方法，以及适用于色谱仪的FET型检测器。

7. 发明授权

US4452682A Apparatus for measuring clinical emergency check items of blood 失效
标题翻译：用于测量血液临床紧急检查项目的装置
公开(公告)号：US4452682A
公开(公告)日：1984-06-05
申请号：US200264
申请日：1980-10-24
申请人： Yoshinori Takata , Hiroyuki Miyagi , Kunio Hirota , Yasuhisa Shibata , Kazuo Nidaira , Fusao Shirato
发明人： Yoshinori Takata , Hiroyuki Miyagi , Kunio Hirota , Yasuhisa Shibata , Kazuo Nidaira , Fusao Shirato
IPC分类号： G01N27/403 , G01N27/416 , G01N27/46
CPC分类号： G01N33/4915 , G01N33/492
摘要： An apparatus for electrochemically measuring clinical emergency check items of blood for a short time by flowthrough system, using a small amount of whole blood as a blood sample, which comprises a blood pH/gas component sensor unit, an electrolyte component sensor unit, and/or a biochemical component sensor unit, arranged in series in this order, a sampler and these sensor units being communicated with one another through a blood sample flow passage or channel, each of the sensor units being provided with sensor electrodes and at least one reference electrode as electrochemical sensor means.Detected values from each of the sensor units are transmitted to a computer or calculator through a current amplifier and/or a differential amplifier for a differential voltage from the voltage of the reference electrode to compute pH, pressure, or concentrations from the detected values, and numerically displayed on a display device connected to the computer.
摘要翻译：一种用于使用少量全血作为血液样品的流过系统电化学测量血液临时紧急检查项目的装置，其包括血液pH /气体成分传感器单元，电解质成分传感器单元和/ 或生物化学成分传感器单元，其依次排列成一个采样器，并且这些传感器单元通过血液样本流动通道或通道彼此连通，每个传感器单元设置有传感器电极和至少一个参考电极作为电化学传感器装置。来自每个传感器单元的检测值通过电流放大器和/或差分放大器传输到计算机或计算器，用于与参考电极的电压的差分电压，以从检测值计算pH，压力或浓度，以及数字显示在连接到计算机的显示设备上。

8. 发明授权

US5112471A Ion selective electrode 失效
标题翻译：离子选择电极
公开(公告)号：US5112471A
公开(公告)日：1992-05-12
申请号：US526782
申请日：1990-05-18
申请人： Yasuhisa Shibata , Naoto Oki , Satoshi Ozawa , Hiroyuki Miyagi
发明人： Yasuhisa Shibata , Naoto Oki , Satoshi Ozawa , Hiroyuki Miyagi
IPC分类号： G01N27/333
CPC分类号： G01N27/3335
摘要： The present invention provides an ion selective electrode for anions such as Cl.sup.- and cations such as Ca.sup.2+ which has a sensitive membrane comprising a polymer material and containing an ion sensitive material and a plasticizer. In thins ion selective electrode, the ion sensitive material is an ion exchanger such as a quaternary ammonium salt, a quaternary phosphonium salt or an organic phosphate and the plasticizer is a compound having the formula (1): ##STR1## wherein X represents an alkyl group, a phenyl group or a phenyl group to which a functional group bonds. As the plasticizer there may also be used a mixture of the compound of the formula (1) with an alcohol compound such as an alcohol having a dielectric constant of 10 or less and containing 10 or more carbon atoms or an ester compound.

9. 发明授权

US4112297A Interface for use in a combined liquid chromatography - mass spectrometry system 失效
标题翻译：用于组合液相色谱 - 质谱系统的界面
公开(公告)号：US4112297A
公开(公告)日：1978-09-05
申请号：US811720
申请日：1977-06-30
申请人： Hiroyuki Miyagi , Fumito Nakajima , Yoshijiro Arikawa
发明人： Hiroyuki Miyagi , Fumito Nakajima , Yoshijiro Arikawa
IPC分类号： G01N1/00 , G01N27/62 , G01N30/72 , G01N30/78 , H01J49/04 , B01D59/44
CPC分类号： H01J49/0468 , G01N30/7246 , G01N30/728 , H01J49/0445 , G01N1/22
摘要： A new interface is interposed between a liquid chromatograph and a mass spectrometer, and it consists of a nebulizer, an evaporator and a cooler. An effluent from the liquid chromatograph is nebulized by the nebulizer. The nebulized effluent is heated by the evaporator, and has only its solvent evaporated. A mixed fluid which consists of the evaporated solvent and the nebulized sample is guided to the cooler, and is cooled therein. At this time, the evaporated solvent is condensed again and is separated from the nebulized sample as a liquid. The nebulized sample left behind is guided to an ion source of the mass spectrometer.
摘要翻译：在液相色谱仪和质谱仪之间插入一个新的界面，它由雾化器，蒸发器和冷却器组成。来自液相色谱仪的流出液被喷雾器雾化。雾化的流出物通过蒸发器加热，仅溶剂蒸发。由蒸发的溶剂和雾化样品组成的混合流体被引导到冷却器中并在其中冷却。此时，蒸发的溶剂再次冷凝，并作为液体与雾化样品分离。留下的雾化样品被引导到质谱仪的离子源。

10. 发明授权

US4936975A Chloride ion-selective electrode 失效
标题翻译：氯离子选择电极
公开(公告)号：US4936975A
公开(公告)日：1990-06-26
申请号：US221219
申请日：1988-07-19
申请人： Yasuhisa Shibata , Satoshi Ozawa , Naoto Oki , Hiroyuki Miyagi
发明人： Yasuhisa Shibata , Satoshi Ozawa , Naoto Oki , Hiroyuki Miyagi
IPC分类号： G01N27/30 , G01N27/333
CPC分类号： G01N27/3335
摘要： A liquid film type, chloride ion-selective electrode is provided with the present invention, which comprises a sensitive film containing a polymeric material as a support film material, a tetraalkyl ammonium salt with four alkyl group each having 10-24 carbon atoms as a chloride ion-sensitive substance, and a mixture of a linear alcohol having a low dielectric constant with at leastg 10 carbon atoms and an organic compound having a dielectric constant higher than that of said linear alcohol as plasticizer. This electrode has a high selectivity over lipophilic anions and hydrophilic anions, high accuracy ion measurements, and a long life.

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