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21. 发明授权

US09210925B2 Multipotent postnatal stem cells from human periodontal ligament and uses thereof 有权
标题翻译：来自人牙周膜的多能产后干细胞及其用途
公开(公告)号：US09210925B2
公开(公告)日：2015-12-15
申请号：US11433627
申请日：2006-05-12
申请人： Songtao Shi , Byoung-Moo Seo , Masako Miura
发明人： Songtao Shi , Byoung-Moo Seo , Masako Miura
IPC分类号： A61K35/32 , A61C5/00 , A01N1/02 , A61C8/02 , C12N5/0775
CPC分类号： A61K35/32 , A01N1/02 , A01N1/0205 , A01N1/0221 , A61C8/0006 , A61K9/0063 , A61L27/3834 , A61L27/3865 , A61L27/3895 , A61L2300/412 , A61L2300/64 , C12N5/0664
摘要： The invention generally relates to postnatal periodontal ligament stem cells and methods for their use. More specifically, the invention relates in one aspect to postnatal periodontal ligament multipotent stem cells, use of the cells to generate periodontium, differentiation of the cells and methods of tissue cryopreservation.
摘要翻译：本发明一般涉及产后牙周韧带干细胞及其使用方法。更具体地，本发明在一个方面涉及产后牙周韧带多能干细胞，使用细胞产生牙周膜，细胞分化和组织冷冻保存方法。

22. 发明授权

US09161528B2 Method for dental pulp cryopreservation 有权
标题翻译：牙髓冷冻保存方法
公开(公告)号：US09161528B2
公开(公告)日：2015-10-20
申请号：US13697244
申请日：2011-05-06
申请人： Silvia Gioventù , Stefania Frasca , Elisa Giovanna Angela Montelatici , Paolo Rebulla , Gabriella Andriolo , Lorenza Lazzari , Ferruccio Bonino
发明人： Silvia Gioventù , Stefania Frasca , Elisa Giovanna Angela Montelatici , Paolo Rebulla , Gabriella Andriolo , Lorenza Lazzari , Ferruccio Bonino
IPC分类号： C12N5/00 , A01N1/02 , A61K35/32 , C12N5/0775 , C12N5/077
CPC分类号： A01N1/0284 , A01N1/02 , A61K35/32 , C12N5/0653 , C12N5/0654 , C12N5/0655 , C12N5/0664
摘要： The present invention relates to a method for cryopreserving the pulp of a non-exfoliated deciduous tooth, comprising a step of making with a laser a hole into the tooth removed from its physiological seat on the tooth neck. After making the hole, the tooth is contacted with a cryopreserving agent and then cryofrozen. An object of the invention further consists in mesenchymal stem cells isolated from the pulp of a cryopreserved tooth according to the method of the invention.
摘要翻译：本发明涉及一种冷冻保存非脱落落叶牙的纸浆的方法，其特征在于，包括使用激光将孔从其从颈部的生理座位移除的牙齿制作的步骤。制作孔后，将牙齿与冷冻保存剂接触，然后冷冻。本发明的目的还包括根据本发明的方法从冷冻保存的牙髓的纸浆分离的间充质干细胞。

23. 发明授权

US09119391B1 Polymer coated ceria nanoparticles for selective cytoprotection 有权
标题翻译：用于选择性细胞保护的聚合物包被的二氧化铈纳米颗粒
公开(公告)号：US09119391B1
公开(公告)日：2015-09-01
申请号：US12169179
申请日：2008-07-08
申请人： Jesus Manuel Perez , Atul Asati , Sudip Nath , Charalambos Kaittanis
发明人： Jesus Manuel Perez , Atul Asati , Sudip Nath , Charalambos Kaittanis
IPC分类号： A01N59/16 , A61K9/14 , A01N1/02
CPC分类号： A01N1/02 , A61K9/5161 , A61K33/00
摘要： Methods, systems and compositions are disclosed wherein normal, non-transformed, healthy biological cells are protected from oxidative stress, radiation therapy and chemotherapy while diseased, transformed cells, such as, cancer cells, are provided no protection by the biocompatible, polymer coated nanoceria composition of the present invention. The polymer-coated nanoceria preparation herein exhibits no toxicity to normal cells and exhibits pH-dependent antioxidant properties at neutral or physiological pH values, between approximately 6.5 to approximately 11.0 and is inactive as an antioxidant at acidic pH values between approximately 2.0 to approximately 6.4. Improved therapeutic agents and cytoprotecting devices are based on the newly discovered, pH dependent properties of polymer-coated nanoceria that provide selective cytoprotection.
摘要翻译：公开了方法，系统和组合物，其中正常的，未转化的，健康的生物细胞免受氧化应激，放射疗法和化学疗法，而患病的转化细胞，例如癌细胞，不提供生物相容的聚合物包被的纳米囊的保护本发明的组合物。本文所述的聚合物包被的纳米制品在正常细胞中没有毒性，并且在中性或生理学pH值（约6.5至约11.0之间）具有pH依赖性抗氧化剂性质，并且在约2.0至约6.4之间的酸性pH值下作为抗氧化剂无活性。改进的治疗剂和细胞保护装置基于提供选择性细胞保护的聚合物包被的纳米囊的新发现的pH依赖性质。

24. 发明授权

US09078426B2 Integration of sample storage and sample management for life science 有权
标题翻译：将样品储存和样品管理整合到生命科学中
公开(公告)号：US09078426B2
公开(公告)日：2015-07-14
申请号：US12182926
申请日：2008-07-30
申请人： Judy Muller-Cohn , Rolf Muller
发明人： Judy Muller-Cohn , Rolf Muller
IPC分类号： C12M1/00 , C12M3/00 , A01N1/00 , A01N1/02 , B01L3/00 , B82Y30/00 , G01N35/00 , G01N35/02
CPC分类号： A01N1/00 , A01N1/02 , A01N1/0263 , B01L3/50255 , B01L3/5085 , B01L3/50853 , B01L3/50855 , B01L3/545 , B01L2300/022 , B01L2300/023 , B01L2300/043 , B01L2300/069 , B01L2300/0829 , B01L2400/0487 , B82Y30/00 , G01N35/00871 , G01N35/028 , G01N2035/00108 , G01N2035/00782
摘要： Compositions and methods are disclosed for automated storing, tracking, retrieving and analyzing biological samples, including dry storage at ambient temperatures of nucleic acids, proteins (including enzymes), and cells using a dry storage matrix that permits recovery of biologically active materials. RFID-tagged biological sample storage devices featuring dissolvable or dissociable matrices are described for use as supports of biological samples, which matrices can be dried and subsequently rehydrated for sample recovery. Also disclosed are computer-implemented systems and methods for managing sample data.
摘要翻译：公开了用于自动存储，跟踪，检索和分析生物样品的组合物和方法，包括在环境温度下的核酸，蛋白质（包括酶）的干燥储存和使用允许回收生物活性物质的干燥储存基质的细胞。描述了具有可溶解或可解离基质的RFID标记的生物样品储存装置，用作生物样品的支持物，该基质可以被干燥并随后再水化以进行样品回收。还公开了用于管理样本数据的计算机实现的系统和方法。

25. 发明申请

US20150140650A1 SYSTEMS AND METHODS FOR CRYOPRESERVATION OF CELLS 有权
标题翻译：用于细胞再生的系统和方法
公开(公告)号：US20150140650A1
公开(公告)日：2015-05-21
申请号：US14592184
申请日：2015-01-08
申请人： Cook General Biotechnology LLC
发明人： Erik John Woods , John K. Critser
IPC分类号： A01N1/02
CPC分类号： A01N1/0231 , A01N1/02 , A01N1/0268
摘要： An auto-nucleating device includes a tube containing a crystalline cholesterol matrix. The ends of the tube are closed by a membrane that is impermeable to the cholesterol but permeable to liquids contained in a cryopreservation vessel. The auto-nucleating device provides a site for ice nucleation during freezing of the liquid within the vessel. One such cryopreservation vessel is a flexible vial having a closed port at one adapted to be pierced by a needle to withdraw the liquid within, and an opposite end that is initially open to receive the liquid. Another vessel includes an adaptor mounted to liquid container with a tubular branch closed by a needle septum and another tubular branch provided with a barbed fitting for engaging a flexible tube that terminates in a needle septum. In another embodiment, the vessel includes an inlet and vent branch at the top of the container and an outlet septum at a bottom opening.
摘要翻译：自动成核装置包括含有结晶胆固醇基质的管。管的端部由对胆固醇不渗透但对包含在冷冻保存容器中的液体可渗透的膜封闭。自动成核装置在容器内的液体冷冻期间提供冰成核的部位。一个这样的冷冻保存容器是柔性小瓶，其具有适于被针刺穿的一个封闭端口，以将液体抽出，并且最初打开以接收液体的相对端。另一个容器包括一个安装到液体容器上的适配器，其中一个管状分支被一个针隔膜封闭，另一个管状分支设有一个带倒钩的配件，用于接合终止于针间隔的柔性管。在另一个实施例中，容器在容器的顶部包括入口和通气分支以及底部开口处的出口隔膜。

26. 发明授权

US09017700B2 Production of a viable, storable worm egg suspension 有权
标题翻译：生产可存储的蠕虫卵悬浮液
公开(公告)号：US09017700B2
公开(公告)日：2015-04-28
申请号：US12594074
申请日：2008-03-31
申请人： Rudolf Wilhelm , Allan Kund Roepstorff , Christian Moliin Outzen Kapel
发明人： Rudolf Wilhelm , Allan Kund Roepstorff , Christian Moliin Outzen Kapel
IPC分类号： A61K39/002 , A01N1/02 , A61K35/62
CPC分类号： A01N1/02 , A01N1/0205 , A01N1/0215 , A61K35/62
摘要： The present application describes a novel, advantageous purification method which guarantees the embryonation capability and the viability of a worm egg suspension. The T. suis worm eggs are first treated in a non-embryonated condition in a sulfuric acid solution at about =ph 2. Bacteria and viruses are thereby killed successfully. The germination number of yeasts and fungi is reduced. In a second step, the pH-value is increased and an orally tolerated preservative is added. Yeasts and fungi are thereby killed successfully. The suspension medium used in the second purification step can then be used as a culture medium for additional production (embryonation) and storage.
摘要翻译：本申请描述了一种新颖的有利的纯化方法，其保证蠕虫卵悬液的胚胎能力和活力。首先在大约= ph 2的硫酸溶液中以非含胚胎状态处理猪蛔虫卵。因此细菌和病毒被成功杀死。酵母和真菌的发芽数量减少。在第二步中，增加pH值并加入口服耐受性防腐剂。因此，酵母和真菌被成功杀死。然后可以将用于第二纯化步骤的悬浮介质用作用于额外生产（胚胎化）和储存的培养基。

27. 发明申请

US20150079254A1 POLYPEPTIDES COMPRISING AN ICE-BINDING ACTIVITY 有权
标题翻译：包含冰结合活性的多糖
公开(公告)号：US20150079254A1
公开(公告)日：2015-03-19
申请号：US14481056
申请日：2014-09-09
申请人： Roskilde Universitet
发明人： Hans Ramløv , Casper Wilkens , Anders Løbner-Olesen
IPC分类号： A23L3/375 , A23L3/3526 , C07K14/435
CPC分类号： C07K14/43563 , A01N1/02 , A01N1/0221 , A01N3/00 , A23B7/055 , A23B7/154 , A23G9/38 , A23L3/3526 , A23L3/375 , A23V2002/00 , A61K8/64 , A61Q19/00 , C07K2319/23 , C12N9/1088 , C12Y205/01018 , F16L58/00
摘要： The present invention relates to novel polypeptides comprising an ice-binding capability resulting in an ice crystal formation and/or growth reducing or inhibiting activity. The present invention also relates to an edible product and to a solid support comprising the novel polypeptide. Furthermore, the present invention also relates to a method for producing the novel polypeptide and to different uses of the novel polypeptide.
摘要翻译：本发明涉及包含冰结合能力的新型多肽，其导致冰晶形成和/或生长降低或抑制活性。本发明还涉及可食用产品和包含该新型多肽的固体支持物。此外，本发明还涉及新型多肽的制备方法和新型多肽的不同用途。

28. 发明授权

US08962303B2 Apparatus and method for maintaining and/or restoring viability of organs 有权
标题翻译：用于维持和/或恢复器官活力的装置和方法
公开(公告)号：US08962303B2
公开(公告)日：2015-02-24
申请号：US13137385
申请日：2011-08-10
申请人： Donald R. Owen , David C. Kravitz , John Brassil , Kelvin G. M. Brockbank , Andrew Burroughs , Dickon Isaacs , Douglas Schein
发明人： Donald R. Owen , David C. Kravitz , John Brassil , Kelvin G. M. Brockbank , Andrew Burroughs , Dickon Isaacs , Douglas Schein
IPC分类号： A01N1/02
CPC分类号： G06F17/30876 , A01N1/02 , A01N1/0247 , A01N1/0273 , H04L67/02
摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.
摘要翻译：器官灌注装置和方法监测，维持和/或恢复器官的活力并保存器官用于储存和/或运输。其他装置包括器官输送器，器官盒和器官诊断装置。在灌注中，器官灌注压力优选地响应于设置在置于器官中的管的末端中的传感器，通过气动加压的医用液体储存器进行控制，提供灌注压力微调，超压预防和紧急流量截止。在低体温模式中，器官用液体灌注，优选地是含有抗氧化剂的简单晶体溶液，间歇地或以缓慢的连续流动。可以从具有低压头的中间容器将药液输送到器官中，以避免器官过压。可以自动监测器官的活力，优选通过监测医用流体灌注液的特性。可以使用控制程序自动控制灌注过程。

29. 发明授权

US08945611B2 Artificial oxygen carriers and use thereof 有权
标题翻译：人造氧气载体及其用途
公开(公告)号：US08945611B2
公开(公告)日：2015-02-03
申请号：US13003400
申请日：2009-07-08
申请人： Herbert De Groot , Christian Mayer , Frank Petrat , Michael Kirsch
发明人： Herbert De Groot , Christian Mayer , Frank Petrat , Michael Kirsch
IPC分类号： A01N1/02 , A61K9/00 , A61K9/16 , A61K9/50 , A61K9/51 , A61K31/755
CPC分类号： A61K9/0026 , A01N1/02 , A01N1/0226 , A61K9/1647 , A61K9/5031 , A61K9/5153 , A61K31/755
摘要： The invention relates to dispersions of artificial oxygen carriers, wherein the dispersions contain capsules with reversible oxygen storage capacity, the capsules comprising an oxygen-permeable capsule material, that contains and/or encloses fluorinated, particularly perfluorinated hydrocarbons, preferably perfluorocarbons. The dispersions are particularly suitable as a blood substitute, preferably for the purpose of transfusion, e.g. in states of blood loss of the human or animal body, in particular following surgical interventions, accidents, injuries etc, or for the prophylactic treatment and/or treatment by therapy of ischaemic states or states following a reperfusion.
摘要翻译：本发明涉及人造氧载体的分散体，其中分散体含有具有可逆储氧能力的胶囊，所述胶囊包含透氧胶囊材料，其含有和/或包围氟化的，特别是全氟化烃，优选全氟化碳。分散体特别适合作为血液替代物，优选用于输血的目的，例如，在人或动物身体的失血状态下，特别是在手术干预，事故，损伤等之后，或通过再灌注后缺血状态或状态的治疗进行预防性治疗和/或治疗。

30. 发明授权

US08932641B2 Dried amnion and method for drying treatment of amnion 有权
标题翻译：干羊草干燥处理方法
公开(公告)号：US08932641B2
公开(公告)日：2015-01-13
申请号：US11990904
申请日：2006-08-18
申请人： Toshio Nikaido , Toshiko Yoshida , Motonori Okabe , Ayaka Toda , Kiyotaka Kitagawa , Masahiko Arakawa
发明人： Toshio Nikaido , Toshiko Yoshida , Motonori Okabe , Ayaka Toda , Kiyotaka Kitagawa , Masahiko Arakawa
IPC分类号： A61K35/50 , A61L27/36 , A01N1/02 , C12N5/00
CPC分类号： A61L27/3641 , A01N1/02 , A01N1/0205 , A01N1/0231 , A01N1/0289 , A61K35/50 , A61L27/3604 , A61L27/3683 , A61L2430/40 , C12N5/0068 , C12N2533/92
摘要： The present invention provides a dried amnion which is dried with maintaining tissues of a raw amnion and can be easily stored for a prolonged period of time. An amnion which is dried with maintaining cells and tissues of a raw amnion can be produced by repeating a pressure-reducing operation and a pressure-recovery operation several times, the pressure-reducing operation comprising continuously heating a raw amnion placed in a treatment vessel by a far-infrared heater provided in the treatment vessel and reducing the pressure of the inside of the treatment vessel, and the pressure-recovery operation comprising recovering the reduced pressure of the inside of the treatment vessel with heating the amnion by microwaves irradiated from a microwave heating apparatus provided outside of the treatment vessel, and the amnion is characterized by retaining basement membranes and connective tissues which are constituents of the raw amnion.
摘要翻译：本发明提供一种干燥的羊膜，其干燥并保持生羊膜的组织，并且可以容易地长时间储存。通过重复进行减压操作和压力恢复操作多次，可以通过重复进行多次的生产羊膜的维持细胞和组织而干燥的羊膜，减压操作包括：将放置在处理容器中的原料羊膜连续加热设置在处理容器中的远红外加热器，并且降低处理容器内部的压力，以及压力恢复操作，包括通过从微波照射的微波加热羊膜来回收处理容器内部的减压加热装置设置在处理容器的外部，羊膜的特征在于保留作为原料羊膜成分的基底膜和结缔组织。

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