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1. 发明授权

US11944718B1 Compositions and manufacture of allograft tissue 有权
公开(公告)号：US11944718B1
公开(公告)日：2024-04-02
申请号：US18083019
申请日：2022-12-16
申请人： Healthtech Solutions, Inc.
发明人： Bradley Robinson , Douglas Ivins Schmid , Thayne Sherman Ekness
IPC分类号： A61L27/36 , A01N1/02 , A61K35/50 , A61L27/22 , A61L27/60
CPC分类号： A61L27/3604 , A01N1/0284 , A01N1/0289 , A61K35/50 , A61L27/227 , A61L27/60
摘要： The disclosure herein relates to isolated and purified mammalian fetal allografts and kits and compositions containing these. Also disclosed are methods of preparing isolated and purified mammalian fetal allografts; methods of contacting a wound of a subject with these, and methods of treating a disease or condition with these.

2. 发明授权

US11903383B2 Cryopreservation method and apparatus 有权
公开(公告)号：US11903383B2
公开(公告)日：2024-02-20
申请号：US16652831
申请日：2018-10-12
申请人： Asymptote Ltd.
发明人： Peter Kilbride , George John Morris
IPC分类号： A01N1/02
CPC分类号： A01N1/0257 , A01N1/0268 , A01N1/0284 , A01N1/0289
摘要： The present invention relates to methods and apparatus for the cryopreservation of biological samples involving a density assisted vitrification wherein a sample of biological material in a cryopreservation agent is cooled from its top surface, causing an ice layer to form thereon. As cooling continues the ice layer grows downwards through the sample to provide a cryoprotectant and biological material rich layer below the ice layer that undergoes vitrification as cooling continues to below the glass transition temperature.

3. 发明公开

US20230380413A1 METHOD AND DEVICE TO PRESERVE ORGANS AND TISSUE FOR TRANSPLANTATION 审中-公开
公开(公告)号：US20230380413A1
公开(公告)日：2023-11-30
申请号：US17825179
申请日：2022-05-26
申请人： SoftWave Tissue Regeneration Technologies, Inc.
发明人： John F. Warlick , John Mullins , David Dean
IPC分类号： A01N1/02
CPC分类号： A01N1/0215 , A01N1/021 , A01N1/0278 , A01N1/0289 , A01N1/0284 , A01N1/0226
摘要： A method of treating a harvested organ or tissue for preservation for implantation into a patient has the steps of, harvesting an organ or tissue from a donor; placing the harvested organ or tissue into a container; filling the container with a fluid for preservation; sealing the container once filled; directing one or more sound wave treatments into the container to destroy bacteria or molds or fungi or virus and to stimulate the organ or tissue; and storing the container at a hypothermic temperature of about 4 degrees C. for storage prior to implantation.

4. 发明公开

US20230232820A1 PERMEATION OF WHOLE VERTEBRAL BODIES WITH A CRYOPROTECTANT USING VACUUM ASSISTED DIFFUSION 审中-公开
公开(公告)号：US20230232820A1
公开(公告)日：2023-07-27
申请号：US18155657
申请日：2023-01-17
申请人： Ossium Health, Inc.
发明人： Erik J. WOODS , Brian H. JOHNSTONE
IPC分类号： A01N1/02 , C12N5/0775 , C12N5/0789
CPC分类号： A01N1/0284 , A01N1/0289 , A01N1/0221 , C12N5/0663 , C12N5/0647 , C12N2509/10 , C12N2501/734 , C12N2523/00
摘要： The present disclosure relates to, at least, a vacuum-assisted method for infiltrating cadaver bone with a cryoprotectant and a method for rapidly warming the cryopreserved cadaver bone for bone marrow processing.

5. 发明授权

US09974814B2 Gas filled decellularized matrix 有权
公开(公告)号：US09974814B2
公开(公告)日：2018-05-22
申请号：US15079985
申请日：2016-03-24
申请人： Miromatrix Medical Inc.
发明人： Aleksandr Katane , Dominique Seetapun , Jeffrey Ross
IPC分类号： A61N1/02 , A61K35/42 , A61K35/22 , A61K35/30 , A61K35/34 , A61K35/38 , A61K35/39 , A61K35/407 , A61K45/06 , A61K47/02 , A01N1/02 , A61L27/36 , A61L27/38 , A61L27/54
CPC分类号： A61K35/42 , A01N1/021 , A01N1/0289 , A61K35/22 , A61K35/30 , A61K35/34 , A61K35/38 , A61K35/39 , A61K35/407 , A61K45/06 , A61K47/02 , A61L27/3633 , A61L27/3683 , A61L27/3691 , A61L27/38 , A61L27/54 , A61L2300/414 , A61L2300/426
摘要： A method to provide an inflated decellularized extracellular matrix of a mammalian organ or a vascularized portion thereof, or a mammalian vascularized tissue or a vascularized portion thereof, an inflated decellularized extracellular matrix of a mammalian organ or a vascularized portion thereof, or a mammalian vascularized tissue or a vascularized portion thereof, and uses thereof, are provided.

6. 发明申请

US20170369845A1 METHODS FOR ISOLATION OF PLATELETS 审中-公开
公开(公告)号：US20170369845A1
公开(公告)日：2017-12-28
申请号：US15541354
申请日：2015-12-30
申请人： Manoochehr KHORSHIDI , ANTHROGENESIS CORPORATION
发明人： Manoochehr KHORSHIDI
IPC分类号： C12N5/078 , A01N1/02 , A61K35/19 , C12N5/00
CPC分类号： C12N5/0644 , A01N1/0284 , A01N1/0289 , A61K35/19 , A61M1/0272 , A61M1/3693 , A61M2202/0427 , A61M2202/0462 , C12N5/0087
摘要： Provided herein are methods for the isolation of platelets, for example, isolation of platelets from umbilical cord blood. In certain embodiments, presented herein are methods for preparation of platelet rich plasma. In one aspect, provided herein are methods for isolation of platelets from blood. In certain embodiments, presented herein are methods for isolation of platelets from cord blood, e.g., human cord blood. The isolated platelets can be used for a variety of applications, including, for example, methods of wound healing, organ repair and/or regeneration, and/or tissue repair and/or regeneration, in either autologous or allogenic settings.

7. 发明申请

US20160227762A1 Method and Apparatus for Prevention of Thermo-Mechanical Fracturing in Vitrified Tissue Using Rapid Cooling and Warming by Persufflation 审中-公开
标题翻译：用于通过吹泡快速冷却和变暖来预防玻璃化组织中热机械压裂的方法和装置
公开(公告)号：US20160227762A1
公开(公告)日：2016-08-11
申请号：US15131771
申请日：2016-04-18
申请人： Arigos Biomedical, Inc.
发明人： Stephen Van Sickle , Tanya Jones
IPC分类号： A01N1/02
CPC分类号： A01N1/021 , A01N1/0247 , A01N1/0257 , A01N1/0284 , A01N1/0289
摘要： A method and apparatus are disclosed for avoiding fracturing, e.g., thermo-mechanical fracturing, in vitrified biological systems via rapid cooling and/or warming persufflation techniques, by reducing the domain size of fracturing and by reducing thermal gradients. Also disclosed is a system adapted to rapidly cool and warm vitrifiable vascular biological tissue by persufflation, significantly reducing cryoprotectant toxicity from that of surface cooled tissue, in which the system is constructed and configured to use one or more of helium gas, hydrogen gas, neon gas, argon gas, krypton gas, xenon gas, oxygen gas, or various gaseous compounds. The system can he operated under pressure to increase the density and heat capacity of the gas relative to its density and heat capacity at atmospheric pressure and to cool the gas by one or more of mechanical action and by the phase change of a material such as a cryogenic gas or solid.
摘要翻译：公开了一种方法和装置，用于通过快速冷却和/或升温渗透技术，通过减小压裂的畴尺寸和减少热梯度来避免玻璃化生物系统中的压裂，例如热机械压裂。还公开了一种适于通过透气快速冷却和温暖玻璃化血管生物组织的系统，显着降低来自表面冷却组织的冷冻保护剂毒性，其中系统被构造和配置为使用氦气，氢气，氖中的一种或多种气体，氩气，氪气，氙气，氧气或各种气态化合物。该系统可以在压力下操作，以增加气体的密度和热容量相对于其在大气压下的密度和热容量，并通过一种或多种机械作用和相变材料来冷却气体，例如低温气体或固体。

8. 发明申请

US20150352235A1 TISSUE ALLOGRAFT STERILIZATION METHOD 有权
标题翻译：组织洗脱灭菌方法
公开(公告)号：US20150352235A1
公开(公告)日：2015-12-10
申请号：US14300462
申请日：2014-06-10
申请人： Theodore I. Malinin
发明人： Theodore I. Malinin
IPC分类号： A61L2/00 , A61L27/36
CPC分类号： A61L2/0088 , A01N1/0215 , A01N1/0289 , A01N47/44 , A01N59/00 , A61L27/3687 , A61L27/3691 , A61L2202/21 , A61L2430/02 , A61L2430/06 , A61L2430/34 , Y10T83/04
摘要： The invention is a novel method of sterilizing bone and soft tissues intended for human transplantation. In one embodiment the process includes steps of subjecting transplants to high hydrostatic pressures of aqueous fluid to which chlorhexidine gluconate or similar sterilizing chemicals have been added.
摘要翻译：本发明是用于人类移植的骨和软组织的消毒方法。在一个实施方案中，该方法包括以下步骤：将移植物施加到水性流体的高静水压下，向其中添加了氯己定葡萄糖酸盐或类似的灭菌化学品。

9. 发明授权

US08932641B2 Dried amnion and method for drying treatment of amnion 有权
标题翻译：干羊草干燥处理方法
公开(公告)号：US08932641B2
公开(公告)日：2015-01-13
申请号：US11990904
申请日：2006-08-18
申请人： Toshio Nikaido , Toshiko Yoshida , Motonori Okabe , Ayaka Toda , Kiyotaka Kitagawa , Masahiko Arakawa
发明人： Toshio Nikaido , Toshiko Yoshida , Motonori Okabe , Ayaka Toda , Kiyotaka Kitagawa , Masahiko Arakawa
IPC分类号： A61K35/50 , A61L27/36 , A01N1/02 , C12N5/00
CPC分类号： A61L27/3641 , A01N1/02 , A01N1/0205 , A01N1/0231 , A01N1/0289 , A61K35/50 , A61L27/3604 , A61L27/3683 , A61L2430/40 , C12N5/0068 , C12N2533/92
摘要： The present invention provides a dried amnion which is dried with maintaining tissues of a raw amnion and can be easily stored for a prolonged period of time. An amnion which is dried with maintaining cells and tissues of a raw amnion can be produced by repeating a pressure-reducing operation and a pressure-recovery operation several times, the pressure-reducing operation comprising continuously heating a raw amnion placed in a treatment vessel by a far-infrared heater provided in the treatment vessel and reducing the pressure of the inside of the treatment vessel, and the pressure-recovery operation comprising recovering the reduced pressure of the inside of the treatment vessel with heating the amnion by microwaves irradiated from a microwave heating apparatus provided outside of the treatment vessel, and the amnion is characterized by retaining basement membranes and connective tissues which are constituents of the raw amnion.
摘要翻译：本发明提供一种干燥的羊膜，其干燥并保持生羊膜的组织，并且可以容易地长时间储存。通过重复进行减压操作和压力恢复操作多次，可以通过重复进行多次的生产羊膜的维持细胞和组织而干燥的羊膜，减压操作包括：将放置在处理容器中的原料羊膜连续加热设置在处理容器中的远红外加热器，并且降低处理容器内部的压力，以及压力恢复操作，包括通过从微波照射的微波加热羊膜来回收处理容器内部的减压加热装置设置在处理容器的外部，羊膜的特征在于保留作为原料羊膜成分的基底膜和结缔组织。

10. 发明申请

US20140007961A1 APPARATUS FOR MAINTAINING A HARVESTED ORGAN VIABLE AND TRANSPORTABLE 审中-公开
标题翻译：维护受影响的有机体和运输的装置
公开(公告)号：US20140007961A1
公开(公告)日：2014-01-09
申请号：US14006324
申请日：2012-03-23
申请人： Stig Steen , Audrius Paskevicius , Benjamin King
发明人： Stig Steen , Audrius Paskevicius , Benjamin King
IPC分类号： A01N1/02
CPC分类号： A01N1/0289 , A01N1/0247 , Y10T137/86035
摘要： An apparatus for enclosing an organ after harvesting and before implantation, having; a vessel enclosing a fluid, a connection tube for connecting a circulation hose to the organ for passing a fluid to the organ by a pump, and a degassing hose extending from the connection tube to the vessel. A pinch valve is arranged in the degassing hose. During a degassing phase, the pinch valve is opened to allow fluid flow from the pump, via the circulation hose to the connection tube and via the degassing hose to the vessel for expelling air entrapped in the fluid flow system. A balloon is arranged to prevent fluid flow via the connection tube to the organ during the degassing phase. A sterility arrangement closes the vessel at the top and may be replaced by further sterility arrangements without compromising the sterility.
摘要翻译：用于在收获后和植入前封闭器官的装置，具有：封闭流体的容器，用于将循环软管连接到器官的连接管，用于将流体通过泵传递到器官;以及从连接管延伸到容器的脱气软管。排气软管中设有夹管阀。在脱气阶段期间，夹管阀被打开以允许流体从泵通过循环软管流到连接管，并且经由脱气软管流到容器，以排出被截留在流体流动系统中的空气。布置气囊以防止在脱气阶段期间流体经由连接管流到器官。无菌布置使顶部的容器封闭，并且可以通过进一步的不育布置来替代，而不损害无菌性。

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