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21. 发明授权

US07071333B2 Triazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same 有权
标题翻译：基于三唑基嘌呤的三环化合物和包含它们的药物组合物
公开(公告)号：US07071333B2
公开(公告)日：2006-07-04
申请号：US10901677
申请日：2004-07-29
申请人： Donald Combs , Charles M. Langevine , Yuping Qiu , Fred Christopher Zusi
发明人： Donald Combs , Charles M. Langevine , Yuping Qiu , Fred Christopher Zusi
IPC分类号： C07D487/14 , A61K31/519 , A61P11/06 , A61P19/02
CPC分类号： C07D487/14
摘要： The present invention provides for triazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, R4, and R5 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
摘要翻译：本发明提供具有式（I）的三唑并嘌呤类三环化合物，其中R 1，R 2，R 3，R 3， SUP＆gt; 4＆gt;和＆lt; 5＆gt;如本文所述。本发明还提供包含这些化合物的药物组合物，以及这些化合物用于治疗炎症和免疫疾病的用途。

22. 发明授权

US06933294B2 Thiophene-based tricyclic compounds and pharmaceutical compositions comprising same 有权
标题翻译：基于噻吩的三环化合物和包含它们的药物组合物
公开(公告)号：US06933294B2
公开(公告)日：2005-08-23
申请号：US10400387
申请日：2003-03-27
申请人： Makonen Belema , Amy Bunker , Van Nguyen , Francis Beaulieu , Carl Ouellet , Anne Marinier , Stephan Roy , Xuejie Yang , Yuping Qiu , Yunhui Zhang , Alain Martel , Christopher Zusi
发明人： Makonen Belema , Amy Bunker , Van Nguyen , Francis Beaulieu , Carl Ouellet , Anne Marinier , Stephan Roy , Xuejie Yang , Yuping Qiu , Yunhui Zhang , Alain Martel , Christopher Zusi
IPC分类号： C07D495/14 , A61K31/4985 , A61P11/06 , A61P17/06 , A61P19/02
CPC分类号： C07D495/14
摘要： Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates and prodrugs thereof, are useful as anti-inflammatory agents, in which R1, R2, and R3 are hydrogen, halogen, alkyl, or perfluoroalkyl; R4 is an optionally substituted alkyl or cycloalkyl group; X is a linker; A is an aryl, heteroaryl, heterocycle, cycloalkyl, or is absent; and R7 is a substituent on A as defined in the specification.
摘要翻译：具有式（I）的化合物及其药学上可接受的盐，水合物和前药可用作抗炎剂，其中R 1，R 2，和 R 3是氢，卤素，烷基或全氟烷基; R 4是任选取代的烷基或环烷基; X是一个连接子; A是芳基，杂芳基，杂环，环烷基或不存在; 并且R 7是在说明书中定义的A上的取代基。

23. 发明授权

US5515367A Method and system for planning and installing communication networks 失效
标题翻译：规划和安装通信网络的方法和系统
公开(公告)号：US5515367A
公开(公告)日：1996-05-07
申请号：US130350
申请日：1993-10-01
申请人： Louis A. Cox, Jr. , Yuping Qiu , George E. Tegan , Lu Lu
发明人： Louis A. Cox, Jr. , Yuping Qiu , George E. Tegan , Lu Lu
IPC分类号： H04L12/24 , H04Q3/00 , H04Q11/04 , H04L12/43 , H04L12/46
CPC分类号： H04Q3/0083 , H04L41/145 , H04L41/22 , H04Q3/002 , H04J2203/0057 , H04L41/0823 , H04L41/0826
摘要： A method is disclosed for use in cooperation with a computer having memory in a Synchronous Optical Network (SONET) for generating an optimized transition plan for the placement of Self-Healing Rings (SHR) and the routing of point-to-point demand in accordance with projected customer demand over a selected multi-period time interval. By determining the number of nodes within a SONET, the demand therebetween over selected time interval as well as the discounted add-drop cost for a plurality of selected Add-Drop Multiplexers (ADMs), a set of logical rings as well as a set of physical rings and detailed routing information may be obtained and graphically illustrated. Logical rings may be determined by optimizing discounted fixed and interconnection costs for the plurality of ADMs in accordance with a selected mixed integer program to generate a corresponding electrical signal for receipt by the computer memory. Thereafter, the placement of physical self-healing rings, the cash flow out and optimal traffic routing may be determined in accordance with a second selected mixed integer program whereupon a second electrical signal may be generated corresponding thereto. Utilizing a heuristic approach, where the number of nodes under study is high, logical rings may be determined through an iterative process of randomly generating new proposed rings or, in the alternative, randomly expanding existing proposed rings until all demand has been satisfied.
摘要翻译：公开了一种用于与在同步光网络（SONET）中具有存储器的计算机配合使用的方法，用于产生用于放置自愈环（SHR）的优化过渡计划以及根据点对点需求的路由预计客户需求超过选定的多周期时间间隔。通过确定SONET内的节点数量，在所选择的时间间隔之间的需求以及多个选择的分插复用器（ADM）的折扣加成成本，一组逻辑环以及一组物理环和详细路由信息可以获得并以图形方式示出。可以通过根据所选择的混合整数程序来优化多个ADM的折扣固定和互连成本来确定逻辑环，以产生相应的电信号以供计算机存储器接收。此后，可以根据第二选择的混合整数程序确定物理自愈环的放置，现金流出和最佳交通路由，从而可以相应地产生第二电信号。利用启发式方法，其中正在研究的节点数量高，可以通过随机生成新的提议环的迭代过程来确定逻辑环，或者替代地，随机扩展现有的建议环，直到满足所有需求。

24. 发明授权

US08143288B2 Inhibitors of HCV replication 有权
标题翻译： HCV复制抑制剂
公开(公告)号：US08143288B2
公开(公告)日：2012-03-27
申请号：US11446788
申请日：2006-06-05
申请人： Michael Serrano-Wu , Makonen Belema , Lawrence B. Snyder , Nicholas A. Meanwell , Denis R. St. Laurent , Ramesh Kakarla , Van N. Nguyen , Yuping Qiu , Xuejie Yang , John E. Leet , Min Gao , Donald R. O'Boyle, II , Julie A. Lemm , Fukang Yang
发明人： Michael Serrano-Wu , Makonen Belema , Lawrence B. Snyder , Nicholas A. Meanwell , Denis R. St. Laurent , Ramesh Kakarla , Van N. Nguyen , Yuping Qiu , Xuejie Yang , John E. Leet , Min Gao , Donald R. O'Boyle, II , Julie A. Lemm , Fukang Yang
IPC分类号： A61K31/444 , A61K31/4439 , A61K31/42 , A61K31/416 , A61K31/4025 , C07D413/14 , C07D403/14 , C07D409/14
CPC分类号： C07D207/16 , C07D207/22 , C07D207/277 , C07D209/42 , C07D211/60 , C07D263/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Compounds having the structure of formula I are described. The compounds can inhibit hepatitis C virus (HCV) replication, and in particular can inhibit the function of the HCV NS5A protein.
摘要翻译：描述具有式I结构的化合物。该化合物可以抑制丙型肝炎病毒（HCV）复制，特别是可以抑制HCV NS5A蛋白的功能。

25. 发明授权

US06960585B2 Amino-substituted tetracyclic compounds useful as anti-inflammatory agents and pharmaceutical compositions comprising same 有权
标题翻译：可用作抗炎剂的氨基取代的四环化合物和包含其的药物组合物
公开(公告)号：US06960585B2
公开(公告)日：2005-11-01
申请号：US09965977
申请日：2001-09-27
申请人： Francis Beaulieu , Carl Quellet , Makonen Belema , Yuping Qiu , Xuejie Yang , Fred C. Zusi
发明人： Francis Beaulieu , Carl Quellet , Makonen Belema , Yuping Qiu , Xuejie Yang , Fred C. Zusi
IPC分类号： A61K31/4745 , A61K31/4985 , A61K31/519 , A61P1/04 , A61P11/00 , A61P11/06 , A61P17/06 , A61P29/00 , A61P31/18 , A61P31/22 , A61P35/00 , A61P37/00 , C07D471/04 , C07D487/04 , C07D513/04
CPC分类号： C07D471/04 , A61K31/519 , C07D487/04 , C07D513/04 , Y02A50/411
摘要： Compounds of formula (I), or pharmaceutically-acceptable salts thereof, are useful in treating inflammatory and immune diseases and disorders, wherein X, Y1, Y2, and R2-4 are as defined in the specification.
摘要翻译：式（I）化合物或其药学上可接受的盐可用于治疗炎症和免疫疾病和病症，其中X，Y 1，Y 2和R 本说明书中所定义的。

26. 发明授权

US6031133A Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof 失效
标题翻译：多羟基，二烯基内酯及其模拟物的合成技术和中间体
公开(公告)号：US6031133A
公开(公告)日：2000-02-29
申请号：US21878
申请日：1998-02-11
申请人： Amos B. Smith, III , Yuping Qiu , Michael Kaufman , Hirokaza Arimoto , David R. Jones , Kaoru Kobayashi
发明人： Amos B. Smith, III , Yuping Qiu , Michael Kaufman , Hirokaza Arimoto , David R. Jones , Kaoru Kobayashi
IPC分类号： C07D303/16 , A61K31/047 , A61K31/12 , A61K31/27 , A61K31/336 , A61K31/351 , A61K31/366 , A61K31/422 , A61K31/427 , A61K31/5355 , A61K31/7028 , A61P35/00 , A61P37/06 , C07C239/06 , C07D263/22 , C07D309/10 , C07D309/30 , C07D309/32 , C07D319/06 , C07D413/06 , C07D413/12 , C07D417/06 , C07F7/18 , C07H23/00 , C07C233/04
CPC分类号： C07D413/12 , C07C239/06 , C07D263/22 , C07D309/30 , C07D319/06 , C07F7/1892
摘要： Synthetic methods for lactone-containing compounds such as the discodermolides are provided, as are compounds which mimic the chemical and/or biological activity thereof, and methods and intermediates useful in their preparation.
摘要翻译：提供了含内酯化合物如脱氧胆甾醇的合成方法，以及模拟其化学和/或生物活性的化合物，以及可用于其制备的方法和中间体。

27. 发明授权

US5649113A Method and system for translating an optimization problem for use in efficient resource allocation 失效
标题翻译：用于翻译优化问题以用于高效资源分配的方法和系统
公开(公告)号：US5649113A
公开(公告)日：1997-07-15
申请号：US321950
申请日：1994-10-12
申请人： Jianhua Zhu , Yuping Qiu
发明人： Jianhua Zhu , Yuping Qiu
IPC分类号： G06Q10/06 , G06F17/60
CPC分类号： G06Q10/06 , G06Q10/0631
摘要： An improved method and system for translating an optimization problem for use in efficient resource allocation. The improved method of the present invention includes the step of generating an index link record for each of the index variables in the optimization problem so as to eliminate the need for a symbol table and a plurality of temporary data records. The method also includes the step of linking the index link records of the index variables requiring expansion in a reverse order of the order listed in the optimization problem so as to reduce the number of traversals performed during expansion processing. The index link records have a pointer for identifying the next index variable requiring expansion.
摘要翻译：一种改进的方法和系统，用于翻译优化问题以用于有效的资源分配。本发明的改进方法包括在优化问题中为每个索引变量生成索引链接记录的步骤，以消除对符号表和多个临时数据记录的需要。该方法还包括以优化问题中列出的顺序的相反顺序链接需要扩展的索引变量的索引链接记录的步骤，以减少在扩展处理期间执行的遍历次数。索引链接记录具有用于标识需要扩展的下一个索引变量的指针。

28. 发明授权

US5564021A Method for assigning inter-nodal traffic loads to channels in sonet rings 失效
标题翻译：将节点间流量负载分配给sonet环中的通道的方法
公开(公告)号：US5564021A
公开(公告)日：1996-10-08
申请号：US252035
申请日：1994-05-31
申请人： Yuping Qiu , Jennifer Ryan , Xiaorong Sun , Youngho Lee
发明人： Yuping Qiu , Jennifer Ryan , Xiaorong Sun , Youngho Lee
IPC分类号： G06F17/50 , H04J3/08 , H04L12/24 , H04Q3/00 , H04Q11/04 , G06F15/20 , G06F9/312
CPC分类号： H04Q3/0083 , G06F17/509 , H04J3/085 , H04L41/0826 , H04L41/145 , H04J2203/0057 , H04L41/0803
摘要： A method for generating an optimized solution for assigning traffic loads to channels in SONET rings in cooperation with a computer having sufficient memory. The method utilizes a Mixed Integer Program (MIP) having corresponding variables necessary to model the cost of Terminal Multiplexers, Add/Drop Multiplexers and corresponding interface ports necessary to route the desired traffic loads. By routing traffic loads to reduce computation time and imposing mathematical bounds on the MIP variables, the number of possible MIP solutions is reduced. The Mixed integer Program is minimized in accordance with the traffic routing and imposed mathematical bounds such that an electrical signal is generated which corresponds to the optimized traffic load assignment information. The signal is converted to digital format whereupon it may be retrieved from computer memory and displayed to the user.
摘要翻译：一种用于生成用于与具有足够存储器的计算机协作来向SONET环中的信道分配业务负载的优化解决方案。该方法利用具有相应变量的混合整数程序（MIP）来模拟终端多路复用器，分插复用器和路由所需业务负载所需的相应接口端口的成本。通过路由流量负载来减少计算时间并对MIP变量施加数学界限，减少了可能的MIP解决方案的数量。混合整数程序根据流量路由和施加的数学界限被最小化，使得生成对应于优化的业务负载分配信息的电信号。该信号被转换成数字格式，从而可以从计算机存储器检索并显示给用户。

29. 发明授权

US5508999A Method and system for designing least cost local access networks 失效
标题翻译：用于设计最低成本的本地接入网络的方法和系统
公开(公告)号：US5508999A
公开(公告)日：1996-04-16
申请号：US131045
申请日：1993-10-01
申请人： Louis A. Cox, Jr. , Yuping Qiu , George E. Tegan , Xiaorong Sun
发明人： Louis A. Cox, Jr. , Yuping Qiu , George E. Tegan , Xiaorong Sun
IPC分类号： H04L12/24 , H04Q3/00 , H04Q11/04 , H04L12/28
CPC分类号： H04L41/22 , H04L41/0826 , H04L41/145 , H04Q3/002 , H04Q3/0083 , H04J2203/0057 , H04L41/0823
摘要： A method and system is provided for use in cooperation with a computer having a memory for generating an optimized transition plan for the placement and interconnection of carrier hubs in a local access network having a plurality of Central Offices (COs), Serving Wire Centers (SWCs) and Point-of-Presence (POP) exchange carriers such that calls may be routed at least cost. In operation, the total number and location of existing SWCs within the network must be determined along with the total switched and special access demand. Thereafter, known tariff rates for selected channel terminals, transport channels and multiplexers must be determined along with the total number of DS3 lines from each SWC to its corresponding POP. By expressing determined network demand as selected mixed-integer program decision variables and determining a corresponding set of logical constraints consistent with these decision variables, the optimized placement of hubs within the local access network may be determined. In addition, the corresponding location and type of channel terminals, transport channels and multiplexers may be implemented all accordance with the mixed-integer program and an electrical signal corresponding thereto may be generated for receipt by the computer memory. This information may thereafter be retrieved from computer memory and graphically displayed on a user-friendly interface.
摘要翻译：提供了一种与具有存储器的计算机配合使用的方法和系统，所述存储器用于生成用于在具有多个中心局（CO），服务线中心（SWC）的本地接入网络中的载波集线器的放置和互连的优化转换计划）和点对点（POP）交换运营商，使得呼叫可以以至少成本路由。在运营中，网络中现有的SWC的总数和位置必须与总的交换和特殊访问需求一起确定。此后，必须确定所选频道终端，运输频道和多路复用器的已知电费率，以及每个SWC到其相应POP的DS3线路总数。通过将确定的网络需求表示为选定的混合整数程序决策变量并确定与这些决策变量一致的对应的一组逻辑约束，可以确定集线器在本地接入网络内的优化布局。此外，可以根据混合整数程序来实现信道终端，传输信道和多路复用器的相应位置和类型，并且可以生成与之对应的电信号以供计算机存储器接收。此后可以从计算机存储器检索该信息，并以图形方式显示在用户友好界面上。

30. 发明授权

US5450317A Method and system for optimized logistics planning 失效
标题翻译：优化物流规划方法与系统
公开(公告)号：US5450317A
公开(公告)日：1995-09-12
申请号：US158128
申请日：1993-11-24
申请人： Lu Lu , Yuping Qiu , Louis A. Cox, Jr.
发明人： Lu Lu , Yuping Qiu , Louis A. Cox, Jr.
IPC分类号： G06Q10/06 , G06Q10/08 , G06Q30/02 , G06F15/20 , G06G7/418
CPC分类号： G06Q10/06 , G06Q10/06314 , G06Q10/06315 , G06Q10/06316 , G06Q10/087 , G06Q30/0202
摘要： An improved logistics planning method and system for recommending optimal order quantities and timing, choice of vendor locations and storage locations, and transportation modes, for individual items and for product families. The system is designed for use in cooperation with the computer having memory and incorporates item, customer, supplier, and routing information databases. In operation, the item, customer and supplier databases are accessed in order to provide customer and warehouse demand forecasts. The routing and customer databases are similarly accessed to provide transportation cost forecasts necessary to determine optimized routing modes for selected items, customers and suppliers. The demand and transportation costs are processed in accordance with a dynamic programming model to determine stock and non-stock order/shipment solutions for the selected items and customers, including optimized supplier and routing selection, order timing and quantity.
摘要翻译：改进的物流计划方法和系统，用于为个别物品和产品系列推荐最佳订单数量和时间，供应商位置和仓储位置的选择以及运输方式。该系统设计用于与具有存储器的计算机配合使用，并结合了项目，客户，供应商和路由信息数据库。在操作中，访问项目，客户和供应商数据库，以提供客户和仓库需求预测。类似地访问路由和客户数据库，以提供确定所选项目，客户和供应商的优化路由模式所必需的运输成本预测。根据动态规划模型处理需求和运输成本，以确定所选项目和客户的库存和非库存订单/运输解决方案，包括优化的供应商和路由选择，订单时间和数量。

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