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1. 发明授权

US5649113A Method and system for translating an optimization problem for use in efficient resource allocation 失效
标题翻译：用于翻译优化问题以用于高效资源分配的方法和系统
公开(公告)号：US5649113A
公开(公告)日：1997-07-15
申请号：US321950
申请日：1994-10-12
申请人： Jianhua Zhu , Yuping Qiu
发明人： Jianhua Zhu , Yuping Qiu
IPC分类号： G06Q10/06 , G06F17/60
CPC分类号： G06Q10/06 , G06Q10/0631
摘要： An improved method and system for translating an optimization problem for use in efficient resource allocation. The improved method of the present invention includes the step of generating an index link record for each of the index variables in the optimization problem so as to eliminate the need for a symbol table and a plurality of temporary data records. The method also includes the step of linking the index link records of the index variables requiring expansion in a reverse order of the order listed in the optimization problem so as to reduce the number of traversals performed during expansion processing. The index link records have a pointer for identifying the next index variable requiring expansion.
摘要翻译：一种改进的方法和系统，用于翻译优化问题以用于有效的资源分配。本发明的改进方法包括在优化问题中为每个索引变量生成索引链接记录的步骤，以消除对符号表和多个临时数据记录的需要。该方法还包括以优化问题中列出的顺序的相反顺序链接需要扩展的索引变量的索引链接记录的步骤，以减少在扩展处理期间执行的遍历次数。索引链接记录具有用于标识需要扩展的下一个索引变量的指针。

2. 发明申请

US20100080772A1 Hepatitis C Virus Inhibitors 有权
公开(公告)号：US20100080772A1
公开(公告)日：2010-04-01
申请号：US12569466
申请日：2009-09-29
申请人： Makonen Belema , Van N. Nguyen , Michael Serrano-Wu , Denis R. St. Laurent , Yuping Qiu , Min Ding , Nicholas A. Meanwell , Lawrence B. Snyder
发明人： Makonen Belema , Van N. Nguyen , Michael Serrano-Wu , Denis R. St. Laurent , Yuping Qiu , Min Ding , Nicholas A. Meanwell , Lawrence B. Snyder
IPC分类号： A61K38/20 , A61K38/21 , A61K31/70 , A61K31/7088 , A61K31/5377 , A61K31/47 , C07D413/04 , C07D217/00 , C07D215/00
CPC分类号： C07D207/16 , A61K31/401 , A61K31/4015 , A61K31/47 , A61K31/5377 , A61K31/70 , A61K31/7088 , C07C233/62 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/12 , C07D409/14 , C07D487/08
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

3. 发明申请

US20060217412A1 Imidazo-fused oxazolo[4,5-b]pyridine and imidazo-fused thiazolo[4,5-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same 审中-公开
标题翻译：咪唑并恶唑并[4,5-b]吡啶和咪唑并稠合的噻唑并[4,5-b]吡啶三环化合物和包含它们的药物组合物
公开(公告)号：US20060217412A1
公开(公告)日：2006-09-28
申请号：US11444856
申请日：2006-06-01
申请人： William Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude Quesnelle , Steven Spergel , Fred Zusi
发明人： William Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude Quesnelle , Steven Spergel , Fred Zusi
IPC分类号： A61K31/4745 , C07D498/14 , C07D491/14
CPC分类号： C07D513/14
摘要： The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
摘要翻译：本发明提供具有式（I）的吡唑并嘌呤类三环化合物，其中R 1，R 2，R 3，R 3， SUP> 4，R 5和R 6如本文所述。本发明还提供包含这些化合物的药物组合物，以及这些化合物用于治疗炎症和免疫疾病的用途。

4. 发明申请

US20060106051A1 Imidazo-fused oxazolo[4,5-b]pyridine and imidazo-fused thiazolo[4,5-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same 有权
标题翻译：咪唑并恶唑并[4,5-b]吡啶和咪唑并稠合的噻唑并[4,5-b]吡啶三环化合物和包含它们的药物组合物
公开(公告)号：US20060106051A1
公开(公告)日：2006-05-18
申请号：US11272401
申请日：2005-11-10
申请人： Alaric Dyckman , William Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude Quesnelle , Steven Spergel , F. Zusi
发明人： Alaric Dyckman , William Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude Quesnelle , Steven Spergel , F. Zusi
IPC分类号： A61K31/4745 , C07D498/14
CPC分类号： C07D513/14
摘要： The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
摘要翻译：本发明提供具有式（I）的吡唑并嘌呤类三环化合物，其中R 1，R 2，R 3和R 3，R 如本文所述。本发明还提供包含这些化合物的药物组合物，以及这些化合物用于治疗炎症和免疫疾病的用途。

5. 发明授权

US06869956B2 Methods of treating inflammatory and immune diseases using inhibitors of IκB kinase (IKK) 失效
标题翻译：使用IkappaB激酶抑制剂（IKK）治疗炎症和免疫疾病的方法
公开(公告)号：US06869956B2
公开(公告)日：2005-03-22
申请号：US10062847
申请日：2002-02-01
申请人： James R. Burke , Robert M. Townsend , Yuping Qiu , Fred Christopher Zusi , Steven G. Nadler
发明人： James R. Burke , Robert M. Townsend , Yuping Qiu , Fred Christopher Zusi , Steven G. Nadler
IPC分类号： A61K31/4985 , A61K31/519 , A61P1/00 , A61P11/06 , A61P19/02 , A61P37/06 , C07D471/04 , C07D487/04 , C07D513/04
CPC分类号： C07D471/04 , A61K31/4985 , A61K31/519 , C07D487/04 , C07D513/04
摘要： The present invention describes methods of preventing and treating inflammatory and immune-related diseases or disorders using inhibitors of IκB kinase (IKK). Also described are IKK inhibitors effective for the prevention and treatment of inflammatory and immune-related diseases or disorders, as demonstrated in vivo. Further embodiments of the present invention relate to a specific IKK inhibitors, 4(2′-aminoethyl)amino-1,8-dimethylimidazo(1,2-a) quinoxaline and compounds of formula (I), salts thereof, and pharmaceutical compositions.
摘要翻译：本发明描述了使用IkappaB激酶（IKK）抑制剂预防和治疗炎性和免疫相关疾病或病症的方法。还描述了如体内所证明的有效预防和治疗炎性和免疫相关疾病或病症的IKK抑制剂。本发明的其它实施方案涉及特定的IKK抑制剂，4（2'-氨基乙基）氨基-1,8-二甲基咪唑（1,2-a）喹喔啉和式（I）化合物，其盐和药物组合物。

6. 发明申请

US20110294819A1 Hepatitis C Virus Inhibitors 有权
标题翻译：丙型肝炎病毒抑制剂
公开(公告)号：US20110294819A1
公开(公告)日：2011-12-01
申请号：US12974069
申请日：2010-12-21
申请人： Omar D. Lopez , Denis R. St. Laurent , Jason Goodrich , Jeffrey Lee Romine , Michael Serrano-Wu , Fukang Yang , Ramesh Kakarla , Xuejie Yang , Yuping Qiu , Lawrence B. Snyder
发明人： Omar D. Lopez , Denis R. St. Laurent , Jason Goodrich , Jeffrey Lee Romine , Michael Serrano-Wu , Fukang Yang , Ramesh Kakarla , Xuejie Yang , Yuping Qiu , Lawrence B. Snyder
IPC分类号： A61K31/421 , C07D413/14 , C07D471/04 , C07D403/14 , C07D417/14 , C07D401/14 , C07D231/12 , C07D249/08 , C07D249/12 , C07D249/06 , C07D409/14 , C07D405/14 , A61K31/422 , A61K31/496 , A61K31/427 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/4178 , A61K31/4725 , A61P31/14 , C07D263/32
CPC分类号： A61K31/415 , A61K31/4196 , A61K31/4245 , C07D231/12 , C07D233/58 , C07D233/64 , C07D249/06 , C07D249/08 , C07D249/12 , C07D263/32 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the function of the NS5A protein.
摘要翻译：本公开一般涉及抗病毒化合物，更具体地涉及可以抑制由丙型肝炎病毒（HCV）编码的NS5A蛋白的功能的化合物，包含这些化合物的组合物，以及用于抑制NS5A蛋白功能的方法。

7. 发明授权

US07968718B2 Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein 有权
标题翻译：制备三唑取代的亚氮杂双氧乙酸哌嗪衍生物的方法及其中生成的新型盐形式
公开(公告)号：US07968718B2
公开(公告)日：2011-06-28
申请号：US12548809
申请日：2009-08-27
申请人： Nachimuthu Soundararajan , Yuping Qiu , Wenhao Hu , David R. Kronenthal , Pierre Sirard , Jean Lajeunesse , Robert Droghini , Ramakrishnan Chidambaram , Xinhua Qian , Kenneth J. Natalie , Shawn K. Pack , Nathan Reising , Erqing Tang , Michael G. Fakes , Qi Gao , Feng Qian , Blisse J. Vakkalagadda , Chiajen Lai , Shan-Ming Kuang
发明人： Nachimuthu Soundararajan , Yuping Qiu , Wenhao Hu , David R. Kronenthal , Pierre Sirard , Jean Lajeunesse , Robert Droghini , Ramakrishnan Chidambaram , Xinhua Qian , Kenneth J. Natalie , Shawn K. Pack , Nathan Reising , Erqing Tang , Michael G. Fakes , Qi Gao , Feng Qian , Blisse J. Vakkalagadda , Chiajen Lai , Shan-Ming Kuang
IPC分类号： C07D471/02
CPC分类号： C07D471/04 , C07C311/49 , C07D213/26
摘要： A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoloxoacetic piperazine derivatives and processes for producing such novel forms are also provided.
摘要翻译：提供制备三唑取代的氮杂糊精乙酸哌嗪衍生物的方法。还提供了在上述方法中制备的新型中间体和新的N-1和无定形形式的1,2,3-三唑取代的氮杂寡脱氧乙酸哌嗪衍生物及其制备方法。

8. 发明申请

US20100068176A1 HEPATITIS C VIRUS INHIBITORS 有权
标题翻译： HEPATITIS C病毒抑制剂
公开(公告)号：US20100068176A1
公开(公告)日：2010-03-18
申请号：US12536362
申请日：2009-08-05
申请人： Makonen Belema , Andrew C. Good , Jason Goodrich , Ramesh Kakarla , Guo Li , Omar D. Lopez , Van N. Nguyen , Jayne Kapur , Yuping Qiu , Jeffrey Lee Romine , Denis R. St. Laurent , Michael Serrano-Wu , Lawrence B. Snyder , Fukang Yang
发明人： Makonen Belema , Andrew C. Good , Jason Goodrich , Ramesh Kakarla , Guo Li , Omar D. Lopez , Van N. Nguyen , Jayne Kapur , Yuping Qiu , Jeffrey Lee Romine , Denis R. St. Laurent , Michael Serrano-Wu , Lawrence B. Snyder , Fukang Yang
IPC分类号： A61K38/20 , C07D403/14 , A61K31/4184 , A61K31/497 , A61K38/21 , A61K31/7088 , A61P31/12
CPC分类号： C07D235/20 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
摘要翻译：本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

9. 发明申请

US20050038054A1 Triazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same 有权
标题翻译：基于三唑基嘌呤的三环化合物和包含它们的药物组合物
公开(公告)号：US20050038054A1
公开(公告)日：2005-02-17
申请号：US10901677
申请日：2004-07-29
申请人： Donald Combs , Charles Langevine , Yuping Qiu , Fred Zusi
发明人： Donald Combs , Charles Langevine , Yuping Qiu , Fred Zusi
IPC分类号： A61K20060101 , A61K31/519 , C07D487/14
CPC分类号： C07D487/14
摘要： The present invention provides for triazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, R4, and R5 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
摘要翻译：本发明提供具有式（I）的三唑并嘌呤类三环化合物，其中R 1，R 2，R 3，R 4和R 5如本文所述。本发明还提供包含这些化合物的药物组合物，以及这些化合物用于治疗炎症和免疫疾病的用途。

10. 发明授权

US6096904A Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives 失效
标题翻译：多羟基，二烯基内酯衍生物的合成技术和中间体
公开(公告)号：US6096904A
公开(公告)日：2000-08-01
申请号：US121551
申请日：1998-07-23
申请人： Amos B. Smith, III , Yuping Qiu , Michael Kaufman , Hirokazu Arimoto , David R. Jones , Kaoru Kobayashi , Thomas J. Beauchamp
发明人： Amos B. Smith, III , Yuping Qiu , Michael Kaufman , Hirokazu Arimoto , David R. Jones , Kaoru Kobayashi , Thomas J. Beauchamp
IPC分类号： C07D263/22 , A61K31/047 , A61K31/12 , A61K31/27 , A61K31/336 , A61K31/351 , A61K31/366 , A61K31/422 , A61K31/427 , A61K31/5355 , A61K31/7028 , A61P35/00 , A61P37/06 , C07C29/38 , C07C33/02 , C07C33/42 , C07C239/06 , C07C271/12 , C07D303/16 , C07D309/10 , C07D309/30 , C07D309/32 , C07D319/06 , C07D413/06 , C07D413/12 , C07D417/06 , C07F7/18 , C07F9/54 , C07H23/00 , C07F9/02
CPC分类号： C07C239/06 , C07D263/22 , C07D309/30 , C07D319/06 , C07D407/06 , C07D413/06 , C07D413/12 , C07F7/1856 , C07F7/1892 , Y02P20/55
摘要： Synthetic methods for lactone-containing compounds such as the discodermolides are provided, as are compounds which mimic the chemical and/or biological activity thereof, and methods and intermediates useful in their preparation.
摘要翻译：提供了含内酯化合物如脱氧胆甾醇的合成方法，以及模拟其化学和/或生物活性的化合物，以及可用于其制备的方法和中间体。

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