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1. 发明授权

US5515367A Method and system for planning and installing communication networks 失效
标题翻译：规划和安装通信网络的方法和系统
公开(公告)号：US5515367A
公开(公告)日：1996-05-07
申请号：US130350
申请日：1993-10-01
申请人： Louis A. Cox, Jr. , Yuping Qiu , George E. Tegan , Lu Lu
发明人： Louis A. Cox, Jr. , Yuping Qiu , George E. Tegan , Lu Lu
IPC分类号： H04L12/24 , H04Q3/00 , H04Q11/04 , H04L12/43 , H04L12/46
CPC分类号： H04Q3/0083 , H04L41/145 , H04L41/22 , H04Q3/002 , H04J2203/0057 , H04L41/0823 , H04L41/0826
摘要： A method is disclosed for use in cooperation with a computer having memory in a Synchronous Optical Network (SONET) for generating an optimized transition plan for the placement of Self-Healing Rings (SHR) and the routing of point-to-point demand in accordance with projected customer demand over a selected multi-period time interval. By determining the number of nodes within a SONET, the demand therebetween over selected time interval as well as the discounted add-drop cost for a plurality of selected Add-Drop Multiplexers (ADMs), a set of logical rings as well as a set of physical rings and detailed routing information may be obtained and graphically illustrated. Logical rings may be determined by optimizing discounted fixed and interconnection costs for the plurality of ADMs in accordance with a selected mixed integer program to generate a corresponding electrical signal for receipt by the computer memory. Thereafter, the placement of physical self-healing rings, the cash flow out and optimal traffic routing may be determined in accordance with a second selected mixed integer program whereupon a second electrical signal may be generated corresponding thereto. Utilizing a heuristic approach, where the number of nodes under study is high, logical rings may be determined through an iterative process of randomly generating new proposed rings or, in the alternative, randomly expanding existing proposed rings until all demand has been satisfied.
摘要翻译：公开了一种用于与在同步光网络（SONET）中具有存储器的计算机配合使用的方法，用于产生用于放置自愈环（SHR）的优化过渡计划以及根据点对点需求的路由预计客户需求超过选定的多周期时间间隔。通过确定SONET内的节点数量，在所选择的时间间隔之间的需求以及多个选择的分插复用器（ADM）的折扣加成成本，一组逻辑环以及一组物理环和详细路由信息可以获得并以图形方式示出。可以通过根据所选择的混合整数程序来优化多个ADM的折扣固定和互连成本来确定逻辑环，以产生相应的电信号以供计算机存储器接收。此后，可以根据第二选择的混合整数程序确定物理自愈环的放置，现金流出和最佳交通路由，从而可以相应地产生第二电信号。利用启发式方法，其中正在研究的节点数量高，可以通过随机生成新的提议环的迭代过程来确定逻辑环，或者替代地，随机扩展现有的建议环，直到满足所有需求。

2. 发明授权

US5450317A Method and system for optimized logistics planning 失效
标题翻译：优化物流规划方法与系统
公开(公告)号：US5450317A
公开(公告)日：1995-09-12
申请号：US158128
申请日：1993-11-24
申请人： Lu Lu , Yuping Qiu , Louis A. Cox, Jr.
发明人： Lu Lu , Yuping Qiu , Louis A. Cox, Jr.
IPC分类号： G06Q10/06 , G06Q10/08 , G06Q30/02 , G06F15/20 , G06G7/418
CPC分类号： G06Q10/06 , G06Q10/06314 , G06Q10/06315 , G06Q10/06316 , G06Q10/087 , G06Q30/0202
摘要： An improved logistics planning method and system for recommending optimal order quantities and timing, choice of vendor locations and storage locations, and transportation modes, for individual items and for product families. The system is designed for use in cooperation with the computer having memory and incorporates item, customer, supplier, and routing information databases. In operation, the item, customer and supplier databases are accessed in order to provide customer and warehouse demand forecasts. The routing and customer databases are similarly accessed to provide transportation cost forecasts necessary to determine optimized routing modes for selected items, customers and suppliers. The demand and transportation costs are processed in accordance with a dynamic programming model to determine stock and non-stock order/shipment solutions for the selected items and customers, including optimized supplier and routing selection, order timing and quantity.
摘要翻译：改进的物流计划方法和系统，用于为个别物品和产品系列推荐最佳订单数量和时间，供应商位置和仓储位置的选择以及运输方式。该系统设计用于与具有存储器的计算机配合使用，并结合了项目，客户，供应商和路由信息数据库。在操作中，访问项目，客户和供应商数据库，以提供客户和仓库需求预测。类似地访问路由和客户数据库，以提供确定所选项目，客户和供应商的优化路由模式所必需的运输成本预测。根据动态规划模型处理需求和运输成本，以确定所选项目和客户的库存和非库存订单/运输解决方案，包括优化的供应商和路由选择，订单时间和数量。

3. 发明授权

US5508999A Method and system for designing least cost local access networks 失效
标题翻译：用于设计最低成本的本地接入网络的方法和系统
公开(公告)号：US5508999A
公开(公告)日：1996-04-16
申请号：US131045
申请日：1993-10-01
申请人： Louis A. Cox, Jr. , Yuping Qiu , George E. Tegan , Xiaorong Sun
发明人： Louis A. Cox, Jr. , Yuping Qiu , George E. Tegan , Xiaorong Sun
IPC分类号： H04L12/24 , H04Q3/00 , H04Q11/04 , H04L12/28
CPC分类号： H04L41/22 , H04L41/0826 , H04L41/145 , H04Q3/002 , H04Q3/0083 , H04J2203/0057 , H04L41/0823
摘要： A method and system is provided for use in cooperation with a computer having a memory for generating an optimized transition plan for the placement and interconnection of carrier hubs in a local access network having a plurality of Central Offices (COs), Serving Wire Centers (SWCs) and Point-of-Presence (POP) exchange carriers such that calls may be routed at least cost. In operation, the total number and location of existing SWCs within the network must be determined along with the total switched and special access demand. Thereafter, known tariff rates for selected channel terminals, transport channels and multiplexers must be determined along with the total number of DS3 lines from each SWC to its corresponding POP. By expressing determined network demand as selected mixed-integer program decision variables and determining a corresponding set of logical constraints consistent with these decision variables, the optimized placement of hubs within the local access network may be determined. In addition, the corresponding location and type of channel terminals, transport channels and multiplexers may be implemented all accordance with the mixed-integer program and an electrical signal corresponding thereto may be generated for receipt by the computer memory. This information may thereafter be retrieved from computer memory and graphically displayed on a user-friendly interface.
摘要翻译：提供了一种与具有存储器的计算机配合使用的方法和系统，所述存储器用于生成用于在具有多个中心局（CO），服务线中心（SWC）的本地接入网络中的载波集线器的放置和互连的优化转换计划）和点对点（POP）交换运营商，使得呼叫可以以至少成本路由。在运营中，网络中现有的SWC的总数和位置必须与总的交换和特殊访问需求一起确定。此后，必须确定所选频道终端，运输频道和多路复用器的已知电费率，以及每个SWC到其相应POP的DS3线路总数。通过将确定的网络需求表示为选定的混合整数程序决策变量并确定与这些决策变量一致的对应的一组逻辑约束，可以确定集线器在本地接入网络内的优化布局。此外，可以根据混合整数程序来实现信道终端，传输信道和多路复用器的相应位置和类型，并且可以生成与之对应的电信号以供计算机存储器接收。此后可以从计算机存储器检索该信息，并以图形方式显示在用户友好界面上。

4. 发明申请

US20100080772A1 Hepatitis C Virus Inhibitors 有权
公开(公告)号：US20100080772A1
公开(公告)日：2010-04-01
申请号：US12569466
申请日：2009-09-29
申请人： Makonen Belema , Van N. Nguyen , Michael Serrano-Wu , Denis R. St. Laurent , Yuping Qiu , Min Ding , Nicholas A. Meanwell , Lawrence B. Snyder
发明人： Makonen Belema , Van N. Nguyen , Michael Serrano-Wu , Denis R. St. Laurent , Yuping Qiu , Min Ding , Nicholas A. Meanwell , Lawrence B. Snyder
IPC分类号： A61K38/20 , A61K38/21 , A61K31/70 , A61K31/7088 , A61K31/5377 , A61K31/47 , C07D413/04 , C07D217/00 , C07D215/00
CPC分类号： C07D207/16 , A61K31/401 , A61K31/4015 , A61K31/47 , A61K31/5377 , A61K31/70 , A61K31/7088 , C07C233/62 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/12 , C07D409/14 , C07D487/08
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

5. 发明申请

US20060217412A1 Imidazo-fused oxazolo[4,5-b]pyridine and imidazo-fused thiazolo[4,5-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same 审中-公开
标题翻译：咪唑并恶唑并[4,5-b]吡啶和咪唑并稠合的噻唑并[4,5-b]吡啶三环化合物和包含它们的药物组合物
公开(公告)号：US20060217412A1
公开(公告)日：2006-09-28
申请号：US11444856
申请日：2006-06-01
申请人： William Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude Quesnelle , Steven Spergel , Fred Zusi
发明人： William Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude Quesnelle , Steven Spergel , Fred Zusi
IPC分类号： A61K31/4745 , C07D498/14 , C07D491/14
CPC分类号： C07D513/14
摘要： The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
摘要翻译：本发明提供具有式（I）的吡唑并嘌呤类三环化合物，其中R 1，R 2，R 3，R 3， SUP> 4，R 5和R 6如本文所述。本发明还提供包含这些化合物的药物组合物，以及这些化合物用于治疗炎症和免疫疾病的用途。

6. 发明申请

US20060106051A1 Imidazo-fused oxazolo[4,5-b]pyridine and imidazo-fused thiazolo[4,5-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same 有权
标题翻译：咪唑并恶唑并[4,5-b]吡啶和咪唑并稠合的噻唑并[4,5-b]吡啶三环化合物和包含它们的药物组合物
公开(公告)号：US20060106051A1
公开(公告)日：2006-05-18
申请号：US11272401
申请日：2005-11-10
申请人： Alaric Dyckman , William Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude Quesnelle , Steven Spergel , F. Zusi
发明人： Alaric Dyckman , William Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude Quesnelle , Steven Spergel , F. Zusi
IPC分类号： A61K31/4745 , C07D498/14
CPC分类号： C07D513/14
摘要： The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
摘要翻译：本发明提供具有式（I）的吡唑并嘌呤类三环化合物，其中R 1，R 2，R 3和R 3，R 如本文所述。本发明还提供包含这些化合物的药物组合物，以及这些化合物用于治疗炎症和免疫疾病的用途。

7. 发明授权

US06869956B2 Methods of treating inflammatory and immune diseases using inhibitors of IκB kinase (IKK) 失效
标题翻译：使用IkappaB激酶抑制剂（IKK）治疗炎症和免疫疾病的方法
公开(公告)号：US06869956B2
公开(公告)日：2005-03-22
申请号：US10062847
申请日：2002-02-01
申请人： James R. Burke , Robert M. Townsend , Yuping Qiu , Fred Christopher Zusi , Steven G. Nadler
发明人： James R. Burke , Robert M. Townsend , Yuping Qiu , Fred Christopher Zusi , Steven G. Nadler
IPC分类号： A61K31/4985 , A61K31/519 , A61P1/00 , A61P11/06 , A61P19/02 , A61P37/06 , C07D471/04 , C07D487/04 , C07D513/04
CPC分类号： C07D471/04 , A61K31/4985 , A61K31/519 , C07D487/04 , C07D513/04
摘要： The present invention describes methods of preventing and treating inflammatory and immune-related diseases or disorders using inhibitors of IκB kinase (IKK). Also described are IKK inhibitors effective for the prevention and treatment of inflammatory and immune-related diseases or disorders, as demonstrated in vivo. Further embodiments of the present invention relate to a specific IKK inhibitors, 4(2′-aminoethyl)amino-1,8-dimethylimidazo(1,2-a) quinoxaline and compounds of formula (I), salts thereof, and pharmaceutical compositions.
摘要翻译：本发明描述了使用IkappaB激酶（IKK）抑制剂预防和治疗炎性和免疫相关疾病或病症的方法。还描述了如体内所证明的有效预防和治疗炎性和免疫相关疾病或病症的IKK抑制剂。本发明的其它实施方案涉及特定的IKK抑制剂，4（2'-氨基乙基）氨基-1,8-二甲基咪唑（1,2-a）喹喔啉和式（I）化合物，其盐和药物组合物。

8. 发明申请

US20110294819A1 Hepatitis C Virus Inhibitors 有权
标题翻译：丙型肝炎病毒抑制剂
公开(公告)号：US20110294819A1
公开(公告)日：2011-12-01
申请号：US12974069
申请日：2010-12-21
申请人： Omar D. Lopez , Denis R. St. Laurent , Jason Goodrich , Jeffrey Lee Romine , Michael Serrano-Wu , Fukang Yang , Ramesh Kakarla , Xuejie Yang , Yuping Qiu , Lawrence B. Snyder
发明人： Omar D. Lopez , Denis R. St. Laurent , Jason Goodrich , Jeffrey Lee Romine , Michael Serrano-Wu , Fukang Yang , Ramesh Kakarla , Xuejie Yang , Yuping Qiu , Lawrence B. Snyder
IPC分类号： A61K31/421 , C07D413/14 , C07D471/04 , C07D403/14 , C07D417/14 , C07D401/14 , C07D231/12 , C07D249/08 , C07D249/12 , C07D249/06 , C07D409/14 , C07D405/14 , A61K31/422 , A61K31/496 , A61K31/427 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/4178 , A61K31/4725 , A61P31/14 , C07D263/32
CPC分类号： A61K31/415 , A61K31/4196 , A61K31/4245 , C07D231/12 , C07D233/58 , C07D233/64 , C07D249/06 , C07D249/08 , C07D249/12 , C07D263/32 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the function of the NS5A protein.
摘要翻译：本公开一般涉及抗病毒化合物，更具体地涉及可以抑制由丙型肝炎病毒（HCV）编码的NS5A蛋白的功能的化合物，包含这些化合物的组合物，以及用于抑制NS5A蛋白功能的方法。

9. 发明授权

US07968718B2 Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein 有权
标题翻译：制备三唑取代的亚氮杂双氧乙酸哌嗪衍生物的方法及其中生成的新型盐形式
公开(公告)号：US07968718B2
公开(公告)日：2011-06-28
申请号：US12548809
申请日：2009-08-27
申请人： Nachimuthu Soundararajan , Yuping Qiu , Wenhao Hu , David R. Kronenthal , Pierre Sirard , Jean Lajeunesse , Robert Droghini , Ramakrishnan Chidambaram , Xinhua Qian , Kenneth J. Natalie , Shawn K. Pack , Nathan Reising , Erqing Tang , Michael G. Fakes , Qi Gao , Feng Qian , Blisse J. Vakkalagadda , Chiajen Lai , Shan-Ming Kuang
发明人： Nachimuthu Soundararajan , Yuping Qiu , Wenhao Hu , David R. Kronenthal , Pierre Sirard , Jean Lajeunesse , Robert Droghini , Ramakrishnan Chidambaram , Xinhua Qian , Kenneth J. Natalie , Shawn K. Pack , Nathan Reising , Erqing Tang , Michael G. Fakes , Qi Gao , Feng Qian , Blisse J. Vakkalagadda , Chiajen Lai , Shan-Ming Kuang
IPC分类号： C07D471/02
CPC分类号： C07D471/04 , C07C311/49 , C07D213/26
摘要： A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoloxoacetic piperazine derivatives and processes for producing such novel forms are also provided.
摘要翻译：提供制备三唑取代的氮杂糊精乙酸哌嗪衍生物的方法。还提供了在上述方法中制备的新型中间体和新的N-1和无定形形式的1,2,3-三唑取代的氮杂寡脱氧乙酸哌嗪衍生物及其制备方法。

10. 发明申请

US20100068176A1 HEPATITIS C VIRUS INHIBITORS 有权
标题翻译： HEPATITIS C病毒抑制剂
公开(公告)号：US20100068176A1
公开(公告)日：2010-03-18
申请号：US12536362
申请日：2009-08-05
申请人： Makonen Belema , Andrew C. Good , Jason Goodrich , Ramesh Kakarla , Guo Li , Omar D. Lopez , Van N. Nguyen , Jayne Kapur , Yuping Qiu , Jeffrey Lee Romine , Denis R. St. Laurent , Michael Serrano-Wu , Lawrence B. Snyder , Fukang Yang
发明人： Makonen Belema , Andrew C. Good , Jason Goodrich , Ramesh Kakarla , Guo Li , Omar D. Lopez , Van N. Nguyen , Jayne Kapur , Yuping Qiu , Jeffrey Lee Romine , Denis R. St. Laurent , Michael Serrano-Wu , Lawrence B. Snyder , Fukang Yang
IPC分类号： A61K38/20 , C07D403/14 , A61K31/4184 , A61K31/497 , A61K38/21 , A61K31/7088 , A61P31/12
CPC分类号： C07D235/20 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
摘要翻译：本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

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