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1. 发明授权

US08278320B2 Azabicyclo[2.2.1]heptane compounds as alpha-7 nicotinic acetylcholine receptor ligands 有权
标题翻译：氮杂双环[2.2.1]庚烷化合物作为α-7烟碱乙酰胆碱受体配体
公开(公告)号：US08278320B2
公开(公告)日：2012-10-02
申请号：US12907122
申请日：2010-10-19
申请人： Ivar M. McDonald , Robert A. Mate , James H. Cook, II , Dalton King , Richard E. Olson , Nenghui Wang , Christiana I. Iwuagwu , F. Christopher Zusi , Matthew D. Hill , Haiquan Fang , John E. Macor
发明人： Ivar M. McDonald , Robert A. Mate , James H. Cook, II , Dalton King , Richard E. Olson , Nenghui Wang , Christiana I. Iwuagwu , F. Christopher Zusi , Matthew D. Hill , Haiquan Fang , John E. Macor
IPC分类号： A61K31/438 , A61K31/439 , C07D471/08
CPC分类号： C07D498/20 , C07D519/00
摘要： The disclosure provides compounds of formula I, including Ia, Ib, Ic, or Id, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
摘要翻译：本公开提供式I化合物，包括Ia，Ib，Ic或Id，包括其盐，以及使用该化合物的组合物和方法。这些化合物是烟碱型α7受体的配体，可用于治疗中枢神经系统的各种疾病，特别是情感和神经退行性疾病。

2. 发明申请

US20110269787A1 Azabicyclic Compounds as Alpha-7 Nicotinic Acetylcholine Receptor Ligands 有权
标题翻译： Azabicyclic化合物作为α-7烟碱乙酰胆碱受体配体
公开(公告)号：US20110269787A1
公开(公告)日：2011-11-03
申请号：US12911882
申请日：2010-10-26
申请人： Ivar M. McDonald , Robert A. Mate , James H. Cook, II , Dalton King , Richard E. Olson , Nenghui Wang , Christiana I. Iwuagwu , F. Christopher Zusi , John E. Macor
发明人： Ivar M. McDonald , Robert A. Mate , James H. Cook, II , Dalton King , Richard E. Olson , Nenghui Wang , Christiana I. Iwuagwu , F. Christopher Zusi , John E. Macor
IPC分类号： A61K31/438 , A61P25/18 , A61P3/10 , A61P19/02 , A61P1/02 , C07D498/20 , A61P25/28
CPC分类号： C07D498/20 , C07D519/00
摘要： The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
摘要翻译：本公开提供式I化合物，包括其盐，以及使用该化合物的组合物和方法。这些化合物是烟碱型α7受体的配体，可用于治疗中枢神经系统的各种疾病，特别是情感和神经退行性疾病。

3. 发明申请

US20050016235A1 Automated machine setup with modular tooling 有权
标题翻译：使用模块化工具自动化机床设置
公开(公告)号：US20050016235A1
公开(公告)日：2005-01-27
申请号：US10859899
申请日：2004-06-03
申请人： Christopher Zusi
发明人： Christopher Zusi
IPC分类号： B21D37/00 , G06F20060101
CPC分类号： G05B19/128 , G05B2219/49304 , G05B2219/49305 , H01R43/048 , Y02P90/86 , Y10S72/712 , Y10T29/49185 , Y10T29/49192 , Y10T29/53235
摘要： Apparatus and a method for establishing setup parameters for use in a machine. In one embodiment a tooling component is removably mountable to a host machine. The tooling component includes a memory that contains information defining setup parameters for the host machine for use with the tooling component. A controller associated with the host machine reads the information from the memory and configures the host machine based on the information read from the memory. In another embodiment, an information carrying tag, is associated with the tooling component. The information carrying tag is read and the identifying information obtained from the tag is used by a controller to select a set of setup parameters from one or more sets of setup parameters stored in a storage device accessible by the controller. A mechanism is provided to precisely position the adapter on the base plate for the host machine to minimize variations in production using the setup parameters derived from the stored information.
摘要翻译：用于建立在机器中使用的设置参数的装置和方法。在一个实施例中，工具部件可拆卸地安装到主机上。工具组件包括一个内存，其中包含定义主机的设置参数的信息，以供与工具组件一起使用。与主机相关联的控制器从存储器读取信息，并根据从存储器读取的信息配置主机。在另一个实施例中，信息携带标签与工具组件相关联。读取信息携带标签，并且从标签获得的识别信息由控制器用于由存储在可由控制器访问的存储设备中的一组或多组设置参数中选择一组设置参数。提供了一种机构，用于将适配器精确地定位在用于主机的基板上，以使用从存储的信息导出的设置参数来最小化生产变化。

4. 发明授权

US06319948B1 Retinoid antagonists and uses thereof 有权
公开(公告)号：US06319948B1
公开(公告)日：2001-11-20
申请号：US09732850
申请日：2000-12-08
申请人： Kenneth M. Tramposch , Xina Nair , Anne Marinier , Fred Christopher Zusi
发明人： Kenneth M. Tramposch , Xina Nair , Anne Marinier , Fred Christopher Zusi
IPC分类号： A61K31192
摘要： Retinoid antagonist compounds have been found to be useful in the prevention and/or minimization of surgical adhesion formation. Also provided by the invention are certain novel substituted (5,6)-dihydronaphthalenyl compounds which are retinoid antagonists and possess the above-mentioned property in addition to their use as antiinflammatory agents for chronic skin inflammatory diseases, as agents for the treatment of rheumatic diseases and as agents for the treatment of various tumors as well as non-malignant proliferative skin conditions.

5. 发明授权

US08481555B2 Aza-bicyclic amine N-oxide compounds as alpha-7 nicotinic acetylcholine receptor ligand pro-drugs 有权
标题翻译：氮杂双环胺N-氧化物作为α-7烟碱乙酰胆碱受体配体原药
公开(公告)号：US08481555B2
公开(公告)日：2013-07-09
申请号：US13097153
申请日：2011-04-29
申请人： Kimberley A. Lentz , Rex Denton , James H. Cook, II , Ivar M. McDonald , Dalton King , Richard E. Olson , Nenghui Wang , Robert A. Mate , Christiana I. Iwuagwu , F. Christopher Zusi , John E. Macor , Matthew D. Hill , Haiquan Fang
发明人： Kimberley A. Lentz , Rex Denton , James H. Cook, II , Ivar M. McDonald , Dalton King , Richard E. Olson , Nenghui Wang , Robert A. Mate , Christiana I. Iwuagwu , F. Christopher Zusi , John E. Macor , Matthew D. Hill , Haiquan Fang
IPC分类号： A01N43/42 , A61K31/44 , C07D491/10 , C07D491/20
CPC分类号： C07D498/10
摘要： The disclosure generally relates to compounds of the following formula, including their salts, as well as compositions and methods of using the compounds. The compounds are prodrugs for ligands, agonists, and partial agonists for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
摘要翻译：本公开一般涉及下式的化合物，包括其盐，以及使用该化合物的组合物和方法。这些化合物是配体，激动剂和烟碱型α7受体的部分激动剂的前药，并且可用于治疗中枢神经系统的各种疾病，特别是情感和神经退行性疾病。

6. 发明授权

US07176214B2 Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same 有权
标题翻译：咪唑并稠唑并[4,5-β]吡啶和咪唑并稠合的噻唑并[4,5-β]吡啶三环化合物和包含它们的药物组合物
公开(公告)号：US07176214B2
公开(公告)日：2007-02-13
申请号：US10848412
申请日：2004-05-18
申请人： William J. Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude A. Quesnelle , Steven H. Spergel , Fred Christopher Zusi
发明人： William J. Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude A. Quesnelle , Steven H. Spergel , Fred Christopher Zusi
IPC分类号： A61K31/4353 , C07D498/12
CPC分类号： C07D513/14
摘要： The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
摘要翻译：本发明提供具有式（I）的吡唑并嘌呤类三环化合物，其中R 1，R 2，R 3，R 3， SUP> 4，R 5和R 6如本文所述。本发明还提供包含这些化合物的药物组合物，以及这些化合物用于治疗炎症和免疫疾病的用途。

7. 发明授权

US06255496B1 Trifluoromethyl ketone analogs as selective cPLA2 inhibitors 失效
标题翻译：三氟甲基酮类似物作为选择性cPLA2抑制剂
公开(公告)号：US06255496B1
公开(公告)日：2001-07-03
申请号：US09300111
申请日：1999-04-27
申请人： Jacques Banville , Yonghua Gai , Graham Johnson , Fred Christopher Zusi , James R. Burke
发明人： Jacques Banville , Yonghua Gai , Graham Johnson , Fred Christopher Zusi , James R. Burke
IPC分类号： C07D20708
CPC分类号： C07D207/08 , C07C17/269 , C07C25/18 , C07C45/515 , C07C45/673 , C07C45/74 , C07C49/245 , C07C49/248 , C07C49/255 , C07C69/63 , C07C69/712 , C07C69/738 , C07C217/22 , C07C229/12 , C07C233/18 , C07C235/20 , C07C311/04 , C07C317/18 , C07C323/12 , C07D207/12 , C07D207/16 , C07D211/14 , C07D211/46 , C07D215/14 , C07D231/12 , C07D271/06 , C07D277/04 , C07D311/20 , C07D313/08 , C07D317/34 , C07F7/1804 , C07F9/113 , C07F9/2458
摘要： Selective inhibitors of the cPLA2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula
摘要翻译：提供cPLA2酶的选择性抑制剂，其可用于控制多种炎性疾病。本发明的抑制剂具有通式

8. 发明授权

US5164406A Method for enhancing transdermal penetration and compositions useful therein 失效
标题翻译：用于增强透气性和组合物的方法
公开(公告)号：US5164406A
公开(公告)日：1992-11-17
申请号：US353890
申请日：1989-05-22
申请人： Michael D. Helman , Alison B. Lukacsko , Thomas A. Re , F. Christopher Zusi
发明人： Michael D. Helman , Alison B. Lukacsko , Thomas A. Re , F. Christopher Zusi
IPC分类号： A61K31/415 , A61K47/18 , A61K47/22
CPC分类号： A61K9/0014 , A61K47/183 , A61K47/22 , Y10S514/938 , Y10S514/946 , Y10S514/947
摘要： The present invention provides for a composition containing a pharmacologically active agent and a selected imidazole or an imidazole derivative, such composition exhibiting enhanced penetration of the pharmacologically active agent component when a composition containing the aforementioned components is applied to skin.A method of enhancing dermal penetration of compositions containing a pharmacologically active agent is also provided.

9. 发明授权

US08309577B2 Quinuclidine compounds as α-7 nicotinic acetylcholine receptor ligands 有权
标题翻译：奎宁环化合物作为α-7烟碱乙酰胆碱受体配体
公开(公告)号：US08309577B2
公开(公告)日：2012-11-13
申请号：US12607354
申请日：2009-10-28
申请人： James H. Cook, II , Ivar M. McDonald , Dalton King , Richard E. Olson , Nenghui Wang , Christiana I. Iwuagwu , F. Christopher Zusi , John E. Macor
发明人： James H. Cook, II , Ivar M. McDonald , Dalton King , Richard E. Olson , Nenghui Wang , Christiana I. Iwuagwu , F. Christopher Zusi , John E. Macor
IPC分类号： A01N43/40 , A61K31/445 , C07D413/00
CPC分类号： A61K31/506 , A61K31/439 , C07D498/20 , C07D519/00
摘要： The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
摘要翻译：本公开提供式I化合物，包括其盐，以及使用该化合物的组合物和方法。这些化合物是烟碱型α7受体的配体，可用于治疗中枢神经系统的各种疾病，特别是情感和神经退行性疾病。

10. 发明申请

US20110263605A1 Azabicyclo[2.2.1]Heptane Compounds as Alpha-7 Nicotinic Acetylcholine Receptor Ligands 有权
标题翻译：氮杂双环[2.2.1]庚烷化合物作为α-7烟碱乙酰胆碱受体配体
公开(公告)号：US20110263605A1
公开(公告)日：2011-10-27
申请号：US12907122
申请日：2010-10-19
申请人： Ivar M. McDonald , Robert A. Mate , James H. Cook, II , Dalton King , Richard E. Olson , Nenghui Wang , Christiana I. Iwuagwu , F. Christopher Zusi , Matthew D. Hill , Haiquan Fang , John E. Macor
发明人： Ivar M. McDonald , Robert A. Mate , James H. Cook, II , Dalton King , Richard E. Olson , Nenghui Wang , Christiana I. Iwuagwu , F. Christopher Zusi , Matthew D. Hill , Haiquan Fang , John E. Macor
IPC分类号： A61K31/439 , C07D487/00 , A61K31/506 , A61K31/497 , A61K31/53 , A61P1/00 , A61P25/28 , A61P25/18 , A61P19/02 , A61P1/04 , A61P3/10 , C07D498/20 , A61K31/519
CPC分类号： C07D498/20 , C07D519/00
摘要： The disclosure provides compounds of formula I, including Ia, Ib, Ic, or Id, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
摘要翻译：本公开提供式I化合物，包括Ia，Ib，Ic或Id，包括其盐，以及使用该化合物的组合物和方法。这些化合物是烟碱型α7受体的配体，可用于治疗中枢神经系统的各种疾病，特别是情感和神经退行性疾病。

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