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1. 发明授权

US6031133A Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof 失效
标题翻译：多羟基，二烯基内酯及其模拟物的合成技术和中间体
公开(公告)号：US6031133A
公开(公告)日：2000-02-29
申请号：US21878
申请日：1998-02-11
申请人： Amos B. Smith, III , Yuping Qiu , Michael Kaufman , Hirokaza Arimoto , David R. Jones , Kaoru Kobayashi
发明人： Amos B. Smith, III , Yuping Qiu , Michael Kaufman , Hirokaza Arimoto , David R. Jones , Kaoru Kobayashi
IPC分类号： C07D303/16 , A61K31/047 , A61K31/12 , A61K31/27 , A61K31/336 , A61K31/351 , A61K31/366 , A61K31/422 , A61K31/427 , A61K31/5355 , A61K31/7028 , A61P35/00 , A61P37/06 , C07C239/06 , C07D263/22 , C07D309/10 , C07D309/30 , C07D309/32 , C07D319/06 , C07D413/06 , C07D413/12 , C07D417/06 , C07F7/18 , C07H23/00 , C07C233/04
CPC分类号： C07D413/12 , C07C239/06 , C07D263/22 , C07D309/30 , C07D319/06 , C07F7/1892
摘要： Synthetic methods for lactone-containing compounds such as the discodermolides are provided, as are compounds which mimic the chemical and/or biological activity thereof, and methods and intermediates useful in their preparation.
摘要翻译：提供了含内酯化合物如脱氧胆甾醇的合成方法，以及模拟其化学和/或生物活性的化合物，以及可用于其制备的方法和中间体。

2. 发明授权

US5789605A Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof 失效
公开(公告)号：US5789605A
公开(公告)日：1998-08-04
申请号：US759817
申请日：1996-12-03
申请人： Amos B. Smith, III , Yuping Qiu , Michael Kaufman , Hirokaza Arimoto , David R. Jones , Kaoru Kobayashi
发明人： Amos B. Smith, III , Yuping Qiu , Michael Kaufman , Hirokaza Arimoto , David R. Jones , Kaoru Kobayashi
IPC分类号： C07D303/16 , A61K31/047 , A61K31/12 , A61K31/27 , A61K31/336 , A61K31/351 , A61K31/366 , A61K31/422 , A61K31/427 , A61K31/5355 , A61K31/7028 , A61P35/00 , A61P37/06 , C07C239/06 , C07D263/22 , C07D309/10 , C07D309/30 , C07D309/32 , C07D319/06 , C07D413/06 , C07D413/12 , C07D417/06 , C07F7/18 , C07H23/00 , C07D407/06
CPC分类号： C07D413/12 , C07C239/06 , C07D263/22 , C07D309/30 , C07D319/06 , C07F7/1892
摘要： Synthetic methods for lactone-containing compounds such as the discodermolides are provided, as are compounds which mimic the chemical and/or biological activity thereof, and methods and intermediates useful in their preparation.

3. 发明授权

US6096904A Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives 失效
标题翻译：多羟基，二烯基内酯衍生物的合成技术和中间体
公开(公告)号：US6096904A
公开(公告)日：2000-08-01
申请号：US121551
申请日：1998-07-23
申请人： Amos B. Smith, III , Yuping Qiu , Michael Kaufman , Hirokazu Arimoto , David R. Jones , Kaoru Kobayashi , Thomas J. Beauchamp
发明人： Amos B. Smith, III , Yuping Qiu , Michael Kaufman , Hirokazu Arimoto , David R. Jones , Kaoru Kobayashi , Thomas J. Beauchamp
IPC分类号： C07D263/22 , A61K31/047 , A61K31/12 , A61K31/27 , A61K31/336 , A61K31/351 , A61K31/366 , A61K31/422 , A61K31/427 , A61K31/5355 , A61K31/7028 , A61P35/00 , A61P37/06 , C07C29/38 , C07C33/02 , C07C33/42 , C07C239/06 , C07C271/12 , C07D303/16 , C07D309/10 , C07D309/30 , C07D309/32 , C07D319/06 , C07D413/06 , C07D413/12 , C07D417/06 , C07F7/18 , C07F9/54 , C07H23/00 , C07F9/02
CPC分类号： C07C239/06 , C07D263/22 , C07D309/30 , C07D319/06 , C07D407/06 , C07D413/06 , C07D413/12 , C07F7/1856 , C07F7/1892 , Y02P20/55
摘要： Synthetic methods for lactone-containing compounds such as the discodermolides are provided, as are compounds which mimic the chemical and/or biological activity thereof, and methods and intermediates useful in their preparation.
摘要翻译：提供了含内酯化合物如脱氧胆甾醇的合成方法，以及模拟其化学和/或生物活性的化合物，以及可用于其制备的方法和中间体。

4. 发明申请

US20090187031A1 Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof 有权
标题翻译：多羟基二烯基内酯的合成技术和中间体及其模拟物
公开(公告)号：US20090187031A1
公开(公告)日：2009-07-23
申请号：US12072730
申请日：2008-02-28
申请人： Amos B. Smith, III , Thomas J. Beauchamp , Matthew J. LaMarche , Yuping Qiu , Michael D. Kaufman , Hirokazu Arimoto , David R. Jones , Kaoru Kobayashi
发明人： Amos B. Smith, III , Thomas J. Beauchamp , Matthew J. LaMarche , Yuping Qiu , Michael D. Kaufman , Hirokazu Arimoto , David R. Jones , Kaoru Kobayashi
IPC分类号： C07D309/30 , C07F7/08 , C07D319/06
CPC分类号： C07C271/12 , C07B2200/07 , C07D213/30 , C07D263/22 , C07D303/16 , C07D309/10 , C07D309/30 , C07D309/32 , C07D319/06 , C07D339/08 , C07D407/06 , C07D413/06 , C07D413/12 , C07D417/06 , C07F7/1804 , C07F7/1892 , C07F9/5428 , C07F9/5442
摘要： Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.
摘要翻译：提供了可用于制备含内酯化合物如discodermolide的合成方法和中间体以及模拟discodermolide的化学或生物活性的化合物。

5. 发明授权

US07723536B2 Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof 有权
标题翻译：多羟基二烯基内酯的合成技术和中间体及其模拟物
公开(公告)号：US07723536B2
公开(公告)日：2010-05-25
申请号：US12072730
申请日：2008-02-28
申请人： Amos B. Smith, III , Thomas J. Beauchamp , Matthew J. LaMarche , Yuping Qiu , Michael D. Kaufman , Hirokazu Arimoto , David R. Jones , Kaoru Kobayashi
发明人： Amos B. Smith, III , Thomas J. Beauchamp , Matthew J. LaMarche , Yuping Qiu , Michael D. Kaufman , Hirokazu Arimoto , David R. Jones , Kaoru Kobayashi
IPC分类号： C07F9/02 , C07F9/28
CPC分类号： C07C271/12 , C07B2200/07 , C07D213/30 , C07D263/22 , C07D303/16 , C07D309/10 , C07D309/30 , C07D309/32 , C07D319/06 , C07D339/08 , C07D407/06 , C07D413/06 , C07D413/12 , C07D417/06 , C07F7/1804 , C07F7/1892 , C07F9/5428 , C07F9/5442
摘要： Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.
摘要翻译：提供了可用于制备含内酯化合物如discodermolide的合成方法和中间体以及模拟discodermolide的化学或生物活性的化合物。

6. 发明申请

US20050065353A1 Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof 审中-公开
标题翻译：多羟基二烯基内酯的合成技术和中间体及其模拟物
公开(公告)号：US20050065353A1
公开(公告)日：2005-03-24
申请号：US10779049
申请日：2004-02-13
申请人： Amos Smith , Yuping Qin , Michael Kaufman , Hirokazu Arimoto , David Jones , Kaoru Kobayashi , Thomas Beauchamp
发明人： Amos Smith , Yuping Qin , Michael Kaufman , Hirokazu Arimoto , David Jones , Kaoru Kobayashi , Thomas Beauchamp
IPC分类号： C07C271/12 , C07D213/30 , C07D263/22 , C07D303/16 , C07D309/10 , C07D309/30 , C07D309/32 , C07D319/06 , C07D339/08 , C07D407/06 , C07D413/06 , C07D413/12 , C07D417/06 , C07F7/18 , C07F9/54
CPC分类号： C07C271/12 , C07B2200/07 , C07D213/30 , C07D263/22 , C07D303/16 , C07D309/10 , C07D309/30 , C07D309/32 , C07D319/06 , C07D339/08 , C07D407/06 , C07D413/06 , C07D413/12 , C07D417/06 , C07F7/1804 , C07F7/1892 , C07F9/5428 , C07F9/5442
摘要： Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.
摘要翻译：提供了可用于制备含内酯化合物如discodermolide的合成方法和中间体以及模拟discodermolide的化学或生物活性的化合物。

7. 发明申请

US20120218048A1 OSCILLATION DEVICE 失效
标题翻译：振荡器件
公开(公告)号：US20120218048A1
公开(公告)日：2012-08-30
申请号：US13406694
申请日：2012-02-28
申请人： Kazuo Akaike , Kaoru Kobayashi
发明人： Kazuo Akaike , Kaoru Kobayashi
IPC分类号： H03L7/00
CPC分类号： H03L1/00
摘要： Provided is an oscillation device capable of obtaining a stable oscillation frequency by compensating for a change in oscillation frequency caused with an elapse of operating time of a quartz-crystal oscillator. A difference value ΔF between a frequency difference between first and second quartz-crystal oscillators after a predetermined period of time has elapsed from a reference time and a frequency difference between the first and second quartz-crystal oscillators at the reference time is determined.
摘要翻译：提供一种能够通过补偿由石英晶体振荡器的经过时间引起的振荡频率变化而获得稳定的振荡频率的振荡装置。确定从参考时间起经过了预定时间段之后的第一和第二石英晶体振荡器之间的频率差与基准时刻的第一和第二石英晶体振荡器之间的频率差的差值Dgr; F。

8. 发明授权

US08228970B2 Signal processing device and wireless apparatus 有权
标题翻译：信号处理装置和无线装置
公开(公告)号：US08228970B2
公开(公告)日：2012-07-24
申请号：US12213881
申请日：2008-06-25
申请人： Kaoru Kobayashi , Shigeru Takegishi , Nobuo Tsukamoto
发明人： Kaoru Kobayashi , Shigeru Takegishi , Nobuo Tsukamoto
IPC分类号： H04B1/00
CPC分类号： H04B1/707
摘要： There is provided a signal processing device and a wireless apparatus capable of not erroneously determining polarity, appropriately performing a spread modulation process, a carrier modulation process, and reception data demodulation process, improving reception accuracy, and miniaturizing a circuit, even when IF carrier frequency shift occurs. The signal processing device and the wireless apparatus includes a spread modulation unit which includes a first differential encoding process section for performing a differential encoding process on a reception data, a differential encoding process section for performing a second differential encoding process on the output, and a spread modulation process section for performing a spread modulation process on the output using a spread code; a carrier modulation unit which quadrature-modulates a transmission data spread modulation signal and a continuous wave; and a reception data decoding unit which performs a correlation process twice and a delay detection process twice.
摘要翻译：提供了一种能够不错误地确定极性的信号处理装置和无线装置，适当地执行扩频调制处理，载波调制处理和接收数据解调处理，提高接收精度和使电路小型化，即使在IF载波频率班次发生。信号处理装置和无线装置包括扩展调制部，其包括对接收数据进行差分编码处理的第一差分编码处理部，对输出进行第二差分编码处理的差分编码处理部，扩展调制处理部分，用于使用扩展码对输出进行扩展调制处理; 载波调制单元，对发送数据扩展调制信号和连续波进行正交调制; 以及接收数据解码单元，其执行两次相关处理和延迟检测处理两次。

9. 发明授权

US08138335B2 Carboxylic acid compounds and medicinal compositions containing the same as the active ingredient 有权
标题翻译：羧酸化合物和含有与活性成分相同的药物组合物
公开(公告)号：US08138335B2
公开(公告)日：2012-03-20
申请号：US12551860
申请日：2009-09-01
申请人： Atsushi Naganawa , Maki Iwahashi , Atsushi Kinoshita , Atsushi Shimabukuro , Seiji Ogawa , Koji Yano , Kaoru Kobayashi , Yutaka Okada , Yoko Kishida , Shouji Kawauchi , Kohki Tsukamoto , Yoko Matsunaga , Fumio Nambu
发明人： Atsushi Naganawa , Maki Iwahashi , Atsushi Kinoshita , Atsushi Shimabukuro , Seiji Ogawa , Koji Yano , Kaoru Kobayashi , Yutaka Okada , Yoko Kishida , Shouji Kawauchi , Kohki Tsukamoto , Yoko Matsunaga , Fumio Nambu
IPC分类号： C07D265/36 , A61K31/535
CPC分类号： C07D307/80 , A61K31/343 , A61K31/538 , C07D265/36 , C07D317/48
摘要： A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g., scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis, etc. Since it specifically binds to DP receptor and binds weakly to other prostaglandins receptors, they can be pharmaceuticals having little side effect.
摘要翻译：由式（I）表示的化合物，其中式中的符号与说明书中的符号相同，其盐，溶剂合物或其前药与DP受体结合并显示DP受体的拮抗活性。因此，它可用于预防和/或治疗过敏性疾病（例如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症，伴有全身性肥大细胞活化的病症，过敏性休克，支气管收缩，荨麻疹，湿疹，伴有瘙痒的疾病（例如特应性皮炎和荨麻疹），伴随瘙痒的行为的结果产生的疾病（例如白内障，视网膜脱离，炎症，感染和睡眠障碍）（例如，搔抓和殴打），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，慢性类风湿关节炎，胸膜炎，溃疡性结肠炎等。由于其特异性结合DP受体并且弱结合到其他前列腺素受体，它们可以是具有小副作用。

10. 发明授权

US08026273B2 8-azaprostaglandin derivative compound and agent comprising the compound as active ingredient 失效
标题翻译： 8-氮杂的前列腺素衍生物化合物和包含该化合物作为活性成分的试剂
公开(公告)号：US08026273B2
公开(公告)日：2011-09-27
申请号：US12683609
申请日：2010-01-07
申请人： Kousuke Tani , Kaoru Kobayashi , Toru Maruyama , Tohru Kambe , Mikio Ogawa , Tsutomu Shiroya
发明人： Kousuke Tani , Kaoru Kobayashi , Toru Maruyama , Tohru Kambe , Mikio Ogawa , Tsutomu Shiroya
IPC分类号： A61K31/40 , A61K31/405 , C07D207/00 , C07D209/00
CPC分类号： C07D413/06 , C07D207/26 , C07D263/24 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/12 , C07D417/06 , C07D417/12
摘要： An 8-azaprostaglandin represented by formula (I) (wherein all symbols have the same meanings as described in the specification), a pharmaceutically acceptable salt thereof or a cyclodextrin clathrate thereof. Since the compound represented by formula (I) binds to EP2 subtype among PGE receptor strongly, it is useful for preventive and/or treatment for immune diseases, allergic diseases, neuronal cell death, dysmenorrhea, premature birth, abortion, baldness, retinal neuropathy such as glaucoma, erectile dysfunction, arthritis, pulmonary injury, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, hepatic injury, acute hepatitis, liver cirrhosis, shock, nephritis, renal failure, circulatory diseases, systemic inflammatory response syndrome, sepsis, hemophagocytosis syndrome, macrophage activation syndrome, still disease, Kawasaki Disease, burn, systemic granuloma, ulcerative colitis, Crohn disease, hypercytokinemia at dialysis, multiple organ failure, or bone diseases etc.
摘要翻译：由式（I）（其中所有符号具有与说明书中所述相同的含义）表示的8-氮杂前列腺素，其药学上可接受的盐或其环糊精包合物。由于式（I）表示的化合物强烈地与PGE受体中的EP2亚型结合，因此可用于免疫疾病，过敏性疾病，神经元细胞死亡，痛经，早产，流产，秃发，视网膜神经病变等的预防和/或治疗青光眼，勃起功能障碍，关节炎，肺损伤，肺纤维化，肺气肿，支气管炎，慢性阻塞性肺病，肝损伤，急性肝炎，肝硬化，休克，肾炎，肾衰竭，循环系统疾病，全身性炎症反应综合征，败血症，血细胞增多综合征，巨噬细胞活化综合征，静止病，川崎病，烧伤，全身肉芽肿，溃疡性结肠炎，克罗恩病，透析中的高细胞因子血症，多器官功能衰竭或骨骼疾病等。

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