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21. 发明授权

US07609377B2 Surface enhanced raman spectroscopy with periodically deformed SERS-active structure 有权
标题翻译：具有周期性变形的SERS活性结构的表面增强拉曼光谱
公开(公告)号：US07609377B2
公开(公告)日：2009-10-27
申请号：US11796455
申请日：2007-04-26
申请人： Wei Wu , Zhiyong Li , Shih-Yuan Wang , Zhaoning Yu , R. Stanley Williams
发明人： Wei Wu , Zhiyong Li , Shih-Yuan Wang , Zhaoning Yu , R. Stanley Williams
IPC分类号： G01J3/44
CPC分类号： G01N21/658
摘要： An apparatus and related methods for facilitating surface-enhanced Raman spectroscopy (SERS) is described. A SERS-active structure near which a plurality of analyte molecules is disposed is periodically deformed at an actuation frequency. A synchronous measuring device synchronized with the actuation frequency receives Raman radiation scattered from the analyte molecules and generates therefrom at least one Raman signal measurement.
摘要翻译：描述了用于促进表面增强拉曼光谱（SERS）的装置和相关方法。多个分析物分子附近的SERS-活性结构以致动频率周期性地变形。与致动频率同步的同步测量装置接收从分析物分子散射的拉曼辐射，并由此产生至少一个拉曼信号测量。

22. 发明申请

US20090245718A1 Optical Sensor And Method Employing Half-Core Hollow Optical Waveguide 失效
标题翻译：使用半空心光波导的光学传感器和方法
公开(公告)号：US20090245718A1
公开(公告)日：2009-10-01
申请号：US12253123
申请日：2008-10-16
申请人： Zhiyong Li , Michael Tan , Shih-Yuan Wang , Wei Wu , Jing Tang
发明人： Zhiyong Li , Michael Tan , Shih-Yuan Wang , Wei Wu , Jing Tang
IPC分类号： G02B6/00
CPC分类号： G02B6/02328 , B82Y20/00 , G01N21/05 , G01N21/31 , G01N21/645 , G01N21/658 , G01N2021/0346 , G01N2021/052 , G01N2021/6467 , G01N2021/7763 , G01N2021/7783 , G02B6/1226
摘要： An optical sensor, sensing system and method of sensing employ a half-core hollow optical waveguide adjacent to a surface of an optical waveguide layer of a substrate. The half-core hollow optical waveguide and the adjacent optical waveguide layer cooperatively provide both an optical path that confines and guides an optical signal and an internal hollow channel. The optical path and channel extend longitudinally along a hollow core of the half-core hollow optical waveguide. The system further includes an optical source at an input of the optical path and an optical detector at an output of the optical path. A spectroscopic interaction between an analyte material that is introduced into the channel and an optical signal propagating along the optical path determines a characteristic of the analyte material.
摘要翻译：光学传感器，感测系统和感测方法使用与衬底的光波导层的表面相邻的半芯空心光波导。半芯空心光波导和相邻的光波导层协同地提供限制和引导光信号和内部中空通道的光路。光路和通道沿半芯空心光波导的中空芯纵向延伸。该系统还包括在光路的输入处的光源和在光路的输出处的光学检测器。引入到通道中的分析物质与沿光路传播的光信号之间的光谱相互作用决定了分析物质的特性。

23. 发明授权

US07474396B2 Raman spectroscopy system and method using a subwavelength resonant grating filter 有权
标题翻译：拉曼光谱系统和使用亚波长谐振光栅滤波器的方法
公开(公告)号：US07474396B2
公开(公告)日：2009-01-06
申请号：US11257073
申请日：2006-01-17
申请人： Wei Wu , Zhiyong Li , Shih-Yuan Wang
发明人： Wei Wu , Zhiyong Li , Shih-Yuan Wang
IPC分类号： G01J3/44 , G01J3/00
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0227 , G01J3/0256 , G01J3/18 , G01N21/65 , G01N21/658 , G02B5/1809
摘要： A Raman spectroscopy system is disclosed which includes a sub-wavelength resonant grating filter and a photodiode with integrated sub-wavelength resonant grating filter are disclosed. The resonant grating filter comprises an array of diffraction elements having a periodic spacing that is less than the wavelength of radiation to be filtered and which are formed over a waveguide layer. The filter, which can reject a specific wavelength of radiation, can be placed between a Raman sample and a Raman detector in order to filter radiation that is elastically scattered from the sample while transmitting other wavelengths. The wavelength rejected by the filter can be selected by tilting the filter with respect to the radiation incident upon the filter.
摘要翻译：公开了一种拉曼光谱系统，其包括亚波长谐振光栅滤光器和具有集成子波长谐振光栅滤光器的光电二极管。谐振光栅滤波器包括衍射元件的阵列，其具有小于待滤波的辐射的波长并且在波导层上形成的周期性间隔。可以将能够抑制特定波长的辐射的滤光器放置在拉曼样品和拉曼检测器之间，以便过滤从样品弹性散射的辐射，同时传输其他波长。可以通过使过滤器相对于入射到过滤器上的辐射倾斜来选择由过滤器拒绝的波长。

24. 发明申请

US20080193359A1 Methods of forming single-crystal metal-silicide nanowires and resulting nanowire structures 失效
标题翻译：形成单晶金属硅化物纳米线和所得纳米线结构的方法
公开(公告)号：US20080193359A1
公开(公告)日：2008-08-14
申请号：US11707601
申请日：2007-02-13
申请人： Zhaoning Yu , Zhiyong Li , Wei Wu , Shih-Yuan Wang , R. Stanley Williams
发明人： Zhaoning Yu , Zhiyong Li , Wei Wu , Shih-Yuan Wang , R. Stanley Williams
IPC分类号： C01B21/068
CPC分类号： C30B29/10 , C30B29/60
摘要： Various embodiments of the present invention are directed to methods of forming single-crystal metal-silicide nanowires and resulting nanowire structures. In one embodiment of the present invention, a method of fabricating nanowires is disclosed. In the method, a number of nanowire-precursor members are formed. Each of the nanowire-precursor members includes a substantially single-crystal silicon region and a polycrystalline- metallic region. The substantially single-crystal silicon region and the polycrystalline-metallic region of each of the nanowire-precursor members is reacted to form corresponding substantially single-crystal metal-silicide nanowires. In another embodiment of the present invention, a nanowire structure is disclosed. The nanowire structure includes a substrate having an electrically insulating layer. A number of substantially single-crystal metal-silicide nanowires are positioned on the electrically insulating layer.
摘要翻译：本发明的各种实施方案涉及形成单晶金属硅化物纳米线和所得纳米线结构的方法。在本发明的一个实施例中，公开了一种制造纳米线的方法。在该方法中，形成许多纳米线前体部件。每个纳米线前体构件包括大致单晶硅区域和多晶金属区域。每个纳米线前体部件的大致单晶硅区域和多晶金属区域反应形成对应的基本单晶金属硅化物纳米线。在本发明的另一个实施方案中，公开了一种纳米线结构。纳米线结构包括具有电绝缘层的衬底。大量单晶金属硅化物纳米线位于电绝缘层上。

25. 发明申请

US20080093217A1 Method for arranging nanoparticles by way of an electric field, structures and systems therefor 审中-公开
标题翻译：通过电场，结构和系统布置纳米颗粒的方法
公开(公告)号：US20080093217A1
公开(公告)日：2008-04-24
申请号：US11584678
申请日：2006-10-20
申请人： Wei Wu , R. Stanley Williams , Shih-Yuan Wang , Philip J. Kuekes , Zhiyong Li
发明人： Wei Wu , R. Stanley Williams , Shih-Yuan Wang , Philip J. Kuekes , Zhiyong Li
IPC分类号： G01N27/26
CPC分类号： G01N21/658
摘要： A method of forming a plurality of NERS-active structures is disclosed. Particularly, a substrate having a surface and a liquid including nanoparticles is deposited on at least a portion of the surface of the substrate. At least one electric field may be generated proximate to the surface and at least a portion of the nanoparticles may be arranged via the electric field. A system includes at least two electrodes configured for producing at least one electric field for substantially arranging nanoparticles substantially according to a selected pattern. A NERS-active structure includes a substrate and a plurality of features located at predetermined positions on a surface of the substrate and at least one NERS-active nanoparticle at least partially embedded therein.
摘要翻译：公开了一种形成多个NERS-活性结构的方法。特别地，具有表面和包含纳米颗粒的液体的基底沉积在基底表面的至少一部分上。可以在表面附近产生至少一个电场，并且可以经由电场布置至少一部分纳米颗粒。一种系统包括至少两个电极，所述至少两个电极被配置用于产生至少一个电场，用于基本上根据所选择的图案基本上布置纳米颗粒。 NERS活性结构包括基底和位于基底表面上的预定位置的多个特征以及至少部分地嵌入其中的至少一个NERS-活性纳米颗粒。

26. 发明申请

US20070165214A1 Raman spectroscopy system and method using a subwavelength resonant grating filter 有权
标题翻译：拉曼光谱系统和使用亚波长谐振光栅滤波器的方法
公开(公告)号：US20070165214A1
公开(公告)日：2007-07-19
申请号：US11257073
申请日：2006-01-17
申请人： Wei Wu , Zhiyong Li , Shih-Yuan Wang
发明人： Wei Wu , Zhiyong Li , Shih-Yuan Wang
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0227 , G01J3/0256 , G01J3/18 , G01N21/65 , G01N21/658 , G02B5/1809
摘要： A Raman spectroscopy system is disclosed which includes a sub-wavelength resonant grating filter and a photodiode with integrated sub-wavelength resonant grating filter are disclosed. The resonant grating filter comprises an array of diffraction elements having a periodic spacing that is less than the wavelength of radiation to be filtered and which are formed over a waveguide layer. The filter, which can reject a specific wavelength of radiation, can be placed between a Raman sample and a Raman detector in order to filter radiation that is elastically scattered from the sample while transmitting other wavelengths. The wavelength rejected by the filter can be selected by tilting the filter with respect to the radiation incident upon the filter.
摘要翻译：公开了一种拉曼光谱系统，其包括亚波长谐振光栅滤波器和具有集成子波长谐振光栅滤波器的光电二极管。谐振光栅滤波器包括衍射元件的阵列，其具有小于待滤波的辐射的波长并且在波导层上形成的周期间隔。可以将能够抑制特定波长的辐射的滤光器放置在拉曼样品和拉曼检测器之间，以便过滤从样品弹性散射的辐射，同时传输其他波长。可以通过使过滤器相对于入射到过滤器上的辐射倾斜来选择由过滤器拒绝的波长。

27. 发明授权

US07151599B2 Monolithic system and method for enhanced Raman spectroscopy 有权
标题翻译：用于增强拉曼光谱的单片系统和方法
公开(公告)号：US07151599B2
公开(公告)日：2006-12-19
申请号：US11044421
申请日：2005-01-27
申请人： M. Saif Islam , Shih-Yuan Wang , Wei Wu , Zhiyong Li , R. Stanley Williams
发明人： M. Saif Islam , Shih-Yuan Wang , Wei Wu , Zhiyong Li , R. Stanley Williams
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/658 , G01N2201/0873
摘要： Devices, systems, and methods for enhancing Raman spectroscopy and hyper-Raman are disclosed. A molecular analysis device for performing Raman spectroscopy comprises a substrate and a laser source disposed on the substrate. The laser source may be configured for emanating a laser radiation, which may irradiate an analyte disposed on a Raman enhancement structure. The Raman enhancement structure may be disposed in a waveguide. The molecular analysis device also includes a wavelength demultiplexer and radiation sensors disposed on the substrate and configured for receiving a Raman scattered radiation, which may be generated by the irradiation of the analyte and Raman enhancement structure.
摘要翻译：公开了用于增强拉曼光谱和超拉曼的装置，系统和方法。用于执行拉曼光谱的分子分析装置包括设置在基板上的基板和激光源。激光源可以被配置为发射激光辐射，其可照射设置在拉曼增强结构上的分析物。拉曼增强结构可以设置在波导中。该分子分析装置还包括布置在基板上的波长解复用器和辐射传感器，并且被配置为用于接收可以通过分析物的照射和拉曼增强结构产生的拉曼散射辐射。

28. 发明申请

US20060275911A1 Method and apparatus for moleclular analysis using nanostructure-enhanced Raman spectroscopy 审中-公开
标题翻译：使用纳米结构增强拉曼光谱进行分析的方法和装置
公开(公告)号：US20060275911A1
公开(公告)日：2006-12-07
申请号：US11145038
申请日：2005-06-03
申请人： Shih-Yuan Wang , Wei Wu , Zhiyong Li
发明人： Shih-Yuan Wang , Wei Wu , Zhiyong Li
IPC分类号： G01N33/00
CPC分类号： G01N21/658 , B01L3/5027 , B01L2200/0663 , B82Y15/00 , C12Q1/6825 , C12Q1/6869 , G01N33/48707 , Y10T436/17 , C12Q2565/632 , C12Q2565/631
摘要： Devices and methods for detecting the constituent parts of biological polymers are disclosed. A molecular analysis device includes a molecule sensor and a molecule guide. The molecule sensor comprises a nanostructure, which is configured for producing a nanostructure-enhanced Raman scattered radiation when an excitation radiation irradiates at least a portion of a molecule disposed near the NERS structure.
摘要翻译：公开了用于检测生物聚合物的组成部分的装置和方法。分子分析装置包括分子传感器和分子指导。分子传感器包括纳米结构，其被配置为当激发辐射照射设置在NERS结构附近的分子的至少一部分时产生纳米结构增强的拉曼散射辐射。

29. 发明授权

US08665432B2 Apparatus for performing SERS 有权
标题翻译：用于执行SERS的装置
公开(公告)号：US08665432B2
公开(公告)日：2014-03-04
申请号：US12915148
申请日：2010-10-29
申请人： Min Hu , Michael Josef Stuke , Zhiyong Li , Wei Wu , Fung Suong Ou , Shih-Yuan Wang , Lars Helge Thylen
发明人： Min Hu , Michael Josef Stuke , Zhiyong Li , Wei Wu , Fung Suong Ou , Shih-Yuan Wang , Lars Helge Thylen
IPC分类号： G01N21/65
CPC分类号： G01J3/44 , G01N21/658
摘要： An apparatus for performing surface enhanced Raman spectroscopy (SERS) includes a substrate and a plurality of nano-pillars, each of the plurality of nano-pillars having a first end attached to the substrate, a second end located distally from the substrate, and a body portion extending between the first end and the second end, in which the plurality of nano-pillars are arranged in an array on the substrate, and in which each of the plurality of nano-pillars is formed of a polymer material that is functionalized to expand in the presence of a fluid to cause gaps between the plurality of nano-pillars to shrink when the fluid is supplied onto the nano-pillars.
摘要翻译：用于进行表面增强拉曼光谱（SERS）的设备包括基底和多个纳米柱，多个纳米柱中的每一个具有连接到基底的第一端，位于远离基底的第二端，以及主体部分在所述第一端和所述第二端之间延伸，其中所述多个纳米柱以阵列布置在所述基底上，并且所述多个纳米柱中的每一个由聚合物材料形成，所述聚合物材料被官能化为在存在流体的情况下膨胀，以便当将流体供应到纳米支柱上时，使多个纳米柱之间的间隙收缩。

30. 发明授权

US08208137B2 Molecule detection using Raman light detection 失效
标题翻译：使用拉曼光检测的分子检测
公开(公告)号：US08208137B2
公开(公告)日：2012-06-26
申请号：US12696853
申请日：2010-01-29
申请人： Min Hu , Alexandre M. Bratkovski , Jingjing Li , Huei Pei Kuo , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
发明人： Min Hu , Alexandre M. Bratkovski , Jingjing Li , Huei Pei Kuo , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01J3/44
摘要： An apparatus for detecting at least one molecule using Raman light detection includes a substrate for supporting a sample containing the at least one molecule, a laser source for emitting a laser beam to cause Raman light emission from the at least one molecule, a modulating element for modulating a spatial relationship between the laser beam and the substrate at an identified frequency to cause the Raman light to be emitted from the at least one molecule at the identified frequency, at least one detector for detecting the Raman light emitted from the at least one molecule, and a post-signal processing unit configured to process the detected Raman light emission at the identified frequency to detect the at least one molecule.
摘要翻译：用于使用拉曼光检测检测至少一个分子的装置包括用于支撑含有至少一个分子的样品的基底，用于发射激光束以产生来自至少一个分子的拉曼光发射的激光源，以识别的频率调制激光束和衬底之间的空间关系，以使所述拉曼光以所识别的频率从所述至少一个分子发射;至少一个检测器，用于检测从所述至少一个分子发射的拉曼光以及后信号处理单元，被配置为处理所识别的频率处的所检测的拉曼光发射以检测所述至少一个分子。

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