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1. 发明授权

US08603606B2 Preventing adhesion between nanostructures 有权
标题翻译：防止纳米结构之间的粘附
公开(公告)号：US08603606B2
公开(公告)日：2013-12-10
申请号：US12916239
申请日：2010-10-29
申请人： Michael Josef Stuke , Zhiyong Li , Shih-Yuan Wang , Fung Suong Ou , Min Hu , Wei Wu , Lars Helge Thylen
发明人： Michael Josef Stuke , Zhiyong Li , Shih-Yuan Wang , Fung Suong Ou , Min Hu , Wei Wu , Lars Helge Thylen
IPC分类号： B32B3/00 , B05D7/00
CPC分类号： G01N21/658 , B81B3/0005 , Y10T428/24355 , Y10T428/24612
摘要： A device for Surface Enhanced Raman Scattering (SERS). The device includes a plurality of nanostructures protruding from a surface of a substrate, a SERS active metal disposed on a portion of said plurality of nanostructures, and a low friction film disposed over the plurality of nanostructures and the SERS active metal. The low friction film is to prevent adhesion between the plurality of nanostructures.
摘要翻译：用于表面增强拉曼散射（SERS）的器件。该装置包括从衬底表面突出的多个纳米结构，设置在所述多个纳米结构的一部分上的SERS活性金属，以及设置在多个纳米结构和SERS活性金属上的低摩擦膜。低摩擦膜是为了防止多个纳米结构之间的粘附。

2. 发明授权

US08279437B2 Multi-wavelength Raman light detection for detecting a species 有权
标题翻译：用于检测物种的多波长拉曼光检测
公开(公告)号：US08279437B2
公开(公告)日：2012-10-02
申请号：US12836097
申请日：2010-07-14
申请人： Min Hu , Alexandre M. Bratkovski , Huel Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
发明人： Min Hu , Alexandre M. Bratkovski , Huel Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01J3/18 , G01J3/44 , G01N21/65 , G01N2021/651
摘要： An apparatus for detecting at least one species using Raman light detection includes at least one laser source for illuminating a sample containing the at least one species. The apparatus also includes a modulating element for modulating a spatial relationship between the sample and the light beams to cause relative positions of the sample and the light beams to be oscillated, in which Raman light at differing intensity levels are configured to be emitted from the at least one species based upon the different wavelengths of the light beams illuminating the sample. The apparatus also includes a Raman light detector and a post-signal processing unit configured to detect the at least one species.
摘要翻译：用于使用拉曼光检测来检测至少一种物质的装置包括用于照亮含有至少一种物质的样品的至少一个激光源。该装置还包括用于调制样品与光束之间的空间关系的调制元件，以使得样品和光束的相对位置发生振荡，其中以不同强度水平的拉曼光被配置为从at 基于照射样品的光束的不同波长的至少一种物质。该装置还包括拉曼光检测器和被配置为检测至少一种物种的后信号处理单元。

3. 发明授权

US07947485B2 Method and apparatus for molecular analysis using nanoelectronic circuits 有权
标题翻译：使用纳米电子电路进行分子分析的方法和装置
公开(公告)号：US07947485B2
公开(公告)日：2011-05-24
申请号：US11144586
申请日：2005-06-03
申请人： Wei Wu , Zhiyong Li , Shih-Yuan Wang , Philip J. Kuekes
发明人： Wei Wu , Zhiyong Li , Shih-Yuan Wang , Philip J. Kuekes
IPC分类号： C12M1/00 , G01N15/06 , C07H21/04
CPC分类号： G01N33/48721 , B82Y5/00 , B82Y10/00 , G01N27/414
摘要： Devices and methods for detecting the constituent parts of biological polymers are disclosed. A molecular analysis device comprises a molecule sensor and a molecule guide. The molecule sensor comprises a single electron transistor including a first terminal, a second terminal, and a nanogap or at least one quantum dot positioned between the first terminal and the second terminal. A nitrogenous material disposed on the at least one quantum dot is configured for an interaction with an identifiable configuration of a molecule. The molecule sensor develops an electronic effect responsive to the interaction. The molecule guide is configured for guiding at least a portion of the molecule substantially near the molecule sensor to enable the interaction.
摘要翻译：公开了用于检测生物聚合物的组成部分的装置和方法。分子分析装置包括分子传感器和分子引导件。分子传感器包括单电子晶体管，其包括位于第一端子和第二端子之间的第一端子，第二端子和纳米隙隙或至少一个量子点。设置在至少一个量子点上的含氮材料被配置用于与分子的可识别构型的相互作用。分子传感器产生响应于相互作用的电子效应。分子引导件被配置用于基本上在分子传感器附近引导分子的至少一部分，以实现相互作用。

4. 发明授权

US07805028B2 Optical sensor and method employing half-core hollow optical waveguide 失效
标题翻译：采用半芯空心光波导的光学传感器和方法
公开(公告)号：US07805028B2
公开(公告)日：2010-09-28
申请号：US12253123
申请日：2008-10-16
申请人： Zhiyong Li , Michael Tan , Shih-Yuan Wang , Wei Wu , Jing Tang
发明人： Zhiyong Li , Michael Tan , Shih-Yuan Wang , Wei Wu , Jing Tang
IPC分类号： G02B6/00 , G02B6/32 , G02B6/10
CPC分类号： G02B6/02328 , B82Y20/00 , G01N21/05 , G01N21/31 , G01N21/645 , G01N21/658 , G01N2021/0346 , G01N2021/052 , G01N2021/6467 , G01N2021/7763 , G01N2021/7783 , G02B6/1226
摘要： An optical sensor, sensing system and method of sensing employ a half-core hollow optical waveguide adjacent to a surface of an optical waveguide layer of a substrate. The half-core hollow optical waveguide and the adjacent optical waveguide layer cooperatively provide both an optical path that confines and guides an optical signal and an internal hollow channel. The optical path and channel extend longitudinally along a hollow core of the half-core hollow optical waveguide. The system further includes an optical source at an input of the optical path and an optical detector at an output of the optical path. A spectroscopic interaction between an analyte material that is introduced into the channel and an optical signal propagating along the optical path determines a characteristic of the analyte material.
摘要翻译：光学传感器，感测系统和感测方法使用与衬底的光波导层的表面相邻的半芯空心光波导。半芯空心光波导和相邻的光波导层协同地提供限制和引导光信号和内部中空通道的光路。光路和通道沿半芯空心光波导的中空芯纵向延伸。该系统还包括在光路的输入处的光源和在光路的输出处的光学检测器。引入到通道中的分析物质与沿光路传播的光信号之间的光谱相互作用决定了分析物质的特性。

5. 发明申请

US20060164635A1 Monolithic system and method for enhanced Raman spectroscopy 有权
公开(公告)号：US20060164635A1
公开(公告)日：2006-07-27
申请号：US11044421
申请日：2005-01-27
申请人： M. Saif Islam , Shih-Yuan Wang , Wei Wu , Zhiyong Li , R. Stanley Williams
发明人： M. Saif Islam , Shih-Yuan Wang , Wei Wu , Zhiyong Li , R. Stanley Williams
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/658 , G01N2201/0873
摘要： Devices, systems, and methods for enhancing Raman spectroscopy and hyper-Raman are disclosed. A molecular analysis device for performing Raman spectroscopy comprises a substrate and a laser source disposed on the substrate. The laser source may be configured for emanating a laser radiation, which may irradiate an analyte disposed on a Raman enhancement structure. The Raman enhancement structure may be disposed in a waveguide. The molecular analysis device also includes a wavelength demultiplexer and radiation sensors disposed on the substrate and configured for receiving a Raman scattered radiation, which may be generated by the irradiation of the analyte and Raman enhancement structure.

6. 发明授权

US08472018B2 Grating for multiple discrete wavelengths of Raman scattering 有权
标题翻译：用于多个离散波长的拉曼散射的光栅
公开(公告)号：US08472018B2
公开(公告)日：2013-06-25
申请号：US12847982
申请日：2010-07-30
申请人： Michael J. Stuke , Michael R. T. Tan , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan Wang , Wei Wu
发明人： Michael J. Stuke , Michael R. T. Tan , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01N21/658
摘要： Systems and methods employ a layer having a pattern that provides multiple discrete guided mode resonances for respective couplings of separated wavelengths into the layer. Further, a structure including features shaped to enhance Raman scattering to produce light of the resonant wavelengths can be employed with the patterned layer.
摘要翻译：系统和方法采用具有图案的层，该图案为分离的波长的各个耦合提供到层中提供多个离散的引导模式谐振。此外，可以使用包括成形为增强拉曼散射以产生谐振波长的光的特征的结构与图案化层。

7. 发明申请

US20120236298A1 TUNABLE APPARATUS FOR PERFORMING SERS 审中-公开
标题翻译：用于执行人员的装置
公开(公告)号：US20120236298A1
公开(公告)日：2012-09-20
申请号：US13048594
申请日：2011-03-15
申请人： Michael Josef Stuke , Zhiyong Li , Wei Wu , Shih-Yuan Wang , Min Hu , Fung Suong Ou
发明人： Michael Josef Stuke , Zhiyong Li , Wei Wu , Shih-Yuan Wang , Min Hu , Fung Suong Ou
IPC分类号： G01J3/44
CPC分类号： G01N21/658
摘要： A tunable apparatus for performing Surface Enhanced Raman Spectroscopy (SERS) includes a deformable substrate and a plurality of SERS-active nanoparticles disposed at a plurality of locations on the deformable substrate. The plurality of SERS-active nanoparticles are to enhance Raman scattered light emission from an analyte molecule located in close proximity to the SERS-active nanoparticles. In addition, the deformable substrate is to be deformed to vary distances between the SERS-active nanoparticles, in which varying distances between the SERS-active nanoparticles varies enhancement of an intensity of Raman scattered light emission from the analyte molecule.
摘要翻译：用于执行表面增强拉曼光谱（SERS）的可调谐装置包括可变形基板和设置在可变形基板上的多个位置处的多个SERS活性纳米颗粒。多个SERS活性纳米颗粒是增强来自位于紧邻SERS活性纳米颗粒的分析物分子的拉曼散射光发射。此外，可变形基底将变形以改变SERS活性纳米粒子之间的距离，其中SERS-活性纳米粒子之间的变化距离改变了来自分析物分子的拉曼散射光发射强度的增强。

8. 发明申请

US20120074378A1 MEMORY ELEMENT HAVING ELASTICALLY DEFORMABLE ACTIVE REGION 审中-公开
标题翻译：具有弹性变形活动区域的记忆元件
公开(公告)号：US20120074378A1
公开(公告)日：2012-03-29
申请号：US12889389
申请日：2010-09-23
申请人： Wei Wu , Jianhua Yang , Zhiyong Li , Shih-Yuan Wang , Dmitri Strukov , Alexandre Bratkovski
发明人： Wei Wu , Jianhua Yang , Zhiyong Li , Shih-Yuan Wang , Dmitri Strukov , Alexandre Bratkovski
IPC分类号： H01L45/00 , H01L25/03
CPC分类号： H01L27/10 , B82Y10/00 , G11C13/0016 , G11C13/0069 , G11C2013/0095 , H01L27/0688 , H01L27/105 , H01L27/115 , H01L27/11551 , H01L27/2472 , H01L27/2481 , H01L29/86 , H01L45/04 , H01L45/1233 , H01L45/14 , H01L45/146
摘要： A memory element is provided that includes a first electrode, a second electrode, and an active region disposed between the first electrode and the second electrode, wherein at least a portion of the active region comprises an elastically deformable material, and wherein deformation of the elastically deformable material causes said memory element to change from a lower conductive state to a higher conductive state. A multilayer structure also is provided that includes a base and a multilayer circuit disposed above the base, where the multilayer circuit includes at least of the memory elements including the elastically deformable material.
摘要翻译：提供了一种存储元件，其包括第一电极，第二电极和设置在第一电极和第二电极之间的有源区，其中有源区的至少一部分包括可弹性变形的材料，并且其中弹性变形可变形材料使得所述存储元件从较低的导电状态变为较高的导电状态。还提供了一种多层结构，其包括设置在基底之上的基底和多层电路，其中多层电路至少包括包括可弹性变形的材料的存储元件。

9. 发明申请

US20120026493A1 GRATING FOR MULTIPLE DISCRETE WAVELENGTHS OF RAMAN SCATTERING 有权
标题翻译：用于拉曼散射的多个分辨波长的光刻
公开(公告)号：US20120026493A1
公开(公告)日：2012-02-02
申请号：US12847982
申请日：2010-07-30
申请人： Michael J. Stuke , Michael R.T. Tan , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan Wang , Wei Wu
发明人： Michael J. Stuke , Michael R.T. Tan , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01N21/658
摘要： Systems and methods employ a layer having a pattern that provides multiple discrete guided mode resonances for respective couplings of separated wavelengths into the layer. Further, a structure including features shaped to enhance Raman scattering to produce light of the resonant wavelengths can be employed with the patterned layer.
摘要翻译：系统和方法采用具有图案的层，该图案为分离的波长的各个耦合提供到层中提供多个离散的引导模式谐振。此外，可以使用包括成形为增强拉曼散射以产生谐振波长的光的特征的结构与图案化层。

10. 发明授权

US07405822B2 Systems and methods for detection of Raman scattered photons 有权
标题翻译：用于检测拉曼散射光子的系统和方法
公开(公告)号：US07405822B2
公开(公告)日：2008-07-29
申请号：US11584020
申请日：2006-10-20
申请人： Zhiyong Li , Wei Wu , Shih-Yuan Wang
发明人： Zhiyong Li , Wei Wu , Shih-Yuan Wang
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01N21/658
摘要： Raman spectroscopy systems include an analyte, a radiation source configured to emit incident radiation having a wavelength, and a detector that is capable of detecting only radiation having wavelengths within a detectable range that includes at least one wavelength corresponding to hyper Raman scattered radiation scattered by the analyte. The wavelength of the incident radiation is outside the detectable range. In particular systems, all wavelengths of radiation that are scattered in the direction of the detector impinge on the detector. Raman spectroscopy methods include providing an analyte and irradiating the analyte with incident radiation having a wavelength, providing a detector capable of detecting only wavelengths of radiation within a detectable range that does not include the wavelength of the incident radiation, and detecting Raman scattered radiation scattered by the analyte. A continuous path free of radiation filters may be provided between the analyte and the detector.
摘要翻译：拉曼光谱系统包括分析物，被配置为发射具有波长的入射辐射的辐射源，以及检测器，其能够仅检测波长在可检测范围内的辐射，所述波长包括对应于由所述波长散射的超拉曼散射辐射的至少一个波长分析物。入射辐射的波长在可检测范围之外。在特定系统中，在检测器的方向上散射的所有辐射波长都照射在检测器上。拉曼光谱方法包括提供分析物并用具有波长的入射辐射照射分析物，提供检测器，该检测器仅能够检测不包括入射辐射波长的可检测范围内的辐射波长，并且检测散射的拉曼散射辐射分析物。可以在分析物和检测器之间提供不含辐射过滤器的连续路径。

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