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1. 发明授权

US08395112B1 Mass spectrometer and method for using same 有权
标题翻译：质谱仪及其使用方法
公开(公告)号：US08395112B1
公开(公告)日：2013-03-12
申请号：US12898264
申请日：2010-10-05
申请人： Mark E. Bier
发明人： Mark E. Bier
IPC分类号： H01J49/34 , B01D59/44
CPC分类号： H01J49/422 , C12Q1/6872 , G01N21/53 , G01N21/6428 , G01N2021/6439 , G01N2021/6465 , G01N2021/6467 , G01N2021/6482 , G01N2021/6493 , H01J49/4255
摘要： Apparatus including an ion trap, a controller connected to the ion trap, wherein the controller includes a memory containing computer readable instructions which, when executed, cause the controller to send control signals to the ion trap so that the ion trap produce and maintain a trapping field in the ion trap, a waveform generator to change the trapping field so that ions of a predetermined mass in the trapping chamber are selectively moved; a secondary waveform generator to change the orbits of the ions; an energy source to excite ions to emit photons, an optical detector to detect the emitted photons, and a processor which can apply fast-Fourier transform analysis of the time-domain signal of the detected emitted photons to generate a frequency or mass spectrum related to mass-to-charge ratio of the ions.
摘要翻译：包括离子阱的装置，连接到离子阱的控制器，其中所述控制器包括含有计算机可读指令的存储器，所述计算机可读指令在执行时使所述控制器向所述离子阱发送控制信号，使得所述离子阱产生并保持捕集波形发生器，用于改变俘获场，使得俘获室中的预定质量的离子被选择性地移动; 次级波形发生器，用于改变离子的轨道; 用于激发离子发射光子的能量源，用于检测发射的光子的光学检测器，以及可以对所检测到的发射光子的时域信号进行快速傅里叶变换分析的处理器，以产生与离子的质荷比。

2. 发明申请

US20120112069A1 FIBER OPTICAL ASSSEMBLY FOR FLUORESCENCE SPECTROMETRY 有权
标题翻译：用于荧光光谱的光纤光学元件
公开(公告)号：US20120112069A1
公开(公告)日：2012-05-10
申请号：US13258727
申请日：2010-03-25
申请人： Martin S. Piltch , Perry Clayton Gray , Richard Rubenstein
发明人： Martin S. Piltch , Perry Clayton Gray , Richard Rubenstein
IPC分类号： G01N21/64 , G01T1/20
CPC分类号： G01N21/645 , G01N21/65 , G01N33/4833 , G01N2021/6467 , G01N2021/6484
摘要： System is provided for detecting the presence of an analyte of interest in a sample, said system comprising an elongated, transparent container for a sample; an excitation source in optical communication with the sample, wherein radiation from the excitation source is directed along the length of the sample, and wherein the radiation induces a signal which is emitted from the sample; and, at least two linear arrays disposed about the sample holder, each linear array comprising a plurality of optical fibers having a first end and a second end, wherein the first ends of the fibers are disposed along the length of the container and in proximity thereto; the second ends of the fibers of each array are bundled together to form a single end port.
摘要翻译：提供用于检测样品中感兴趣分析物的存在的系统，所述系统包括用于样品的细长透明容器; 与所述样品光学通信的激发源，其中来自所述激发源的辐射沿着所述样品的长度被引导，并且其中所述辐射诱导从所述样品发射的信号; 以及围绕所述样品保持器布置的至少两个线性阵列，每个线性阵列包括具有第一端和第二端的多根光纤，其中所述纤维的所述第一端沿着所述容器的长度并且在其附近设置 ; 每个阵列的纤维的第二端被捆绑在一起以形成单个端口。

3. 发明申请

US20110189787A1 SPECTROMETER AND METHOD OF OPERATING A SPECTROMETER 审中-公开
标题翻译：光谱仪和操作光谱仪的方法
公开(公告)号：US20110189787A1
公开(公告)日：2011-08-04
申请号：US13054064
申请日：2009-07-15
申请人： Pierre R. Graves
发明人： Pierre R. Graves
IPC分类号： G01N21/64 , H01J40/14
CPC分类号： G01N21/645 , G01J3/02 , G01J3/0213 , G01J3/4406 , G01J2003/1243 , G01N2021/6421 , G01N2021/6467 , G01N2021/6491
摘要： A photoluminescence spectrometer (100) is provided comprising; (i) a source of electromagnetic radiation (2) for exciting photoluminescence in a sample (16); (ii) a site (1) for location of the sample (iii) a detector (8) for detecting photoluminescence emitted from the sample and (iv) located in the optical path between the site for location of a sample and the detector, a means (10) of varying the intensity received by the detector of electromagnetic radiation having the same wavelength as the excitation radiation. The mean of varying the intensity may be formed by a tiltable interference filter or by a plurality of movable attenuating filters. A method of using such a spectrometer is also provided.
摘要翻译：提供了一种光致发光光谱仪（100），包括：（i）用于在样品（16）中激发光致发光的电磁辐射源（2）; （ii）用于样本位置的位置（1）（iii）用于检测从样品发射的光致发光的检测器（8）和（iv）位于样品位置与检测器的位置之间的光路中的检测器，用于改变由检测器接收的具有与激发辐射相同波长的电磁辐射的强度的装置（10）。改变强度的平均值可以由可倾斜干涉滤光器或多个可移动的衰减滤光器形成。还提供了使用这种光谱仪的方法。

4. 发明申请

US20110159579A1 THERMAL CYCLING REACTION BLOCK AND CONTINUOUS REAL-TIME MONITORING APPARATUS USING THE SAME 有权
标题翻译：热循环反应块和连续实时监测装置
公开(公告)号：US20110159579A1
公开(公告)日：2011-06-30
申请号：US12999696
申请日：2009-06-23
申请人： Han Oh Park , Hanee Park , Il Kyu Choi
发明人： Han Oh Park , Hanee Park , Il Kyu Choi
IPC分类号： C12M1/00
CPC分类号： B01L7/525 , B01L2300/0838 , B01L2300/0861 , B01L2300/1805 , G01N21/64 , G01N2021/6467
摘要： Disclosed is real-time monitoring apparatus comprising a thermal cycling reaction block having heating block which is formed of a hollow part and divided by an insulating layer, and a capillary tube through which a sample is flowed in and/or out and which is wound on the heating block so that the different temperatures are transferred and thus reaction cycle is repeatedly performed; a light source; a band pass filter; a condensing lens; a beam splitter; a reflecting mirror which is rotatably connected with a motor so as to transfer the excitation light reflected from the beam splitter to the capillary tube and reflect the fluorescence generated from the sample in the capillary tube; and a fluorescence detecting part.
摘要翻译：公开了一种实时监测装置，其包括具有加热块的热循环反应块，该加热块由中空部分形成并被绝缘层分开，毛细管通过该毛细管将样品流入和/或流出并且被卷绕在其上加热块，以便转移不同的温度，从而反复进行反应循环; 光源; 带通滤波器; 聚光透镜; 分束器; 反射镜，其与电动机可旋转地连接，以将从分束器反射的激发光转移到毛细管，并将从样品产生的荧光反射到毛细管中; 和荧光检测部。

5. 发明授权

US07830517B2 Flow schemes for enhanced light-target interaction in fluidic channels 有权
标题翻译：流体通道中增强的光 - 目标相互作用的流程
公开(公告)号：US07830517B2
公开(公告)日：2010-11-09
申请号：US12205730
申请日：2008-09-05
申请人： Markus Beck , Peter Kiesel , Michael Bassler , Tobias Burgel
发明人： Markus Beck , Peter Kiesel , Michael Bassler , Tobias Burgel
IPC分类号： G01N21/00
CPC分类号： G01N21/645 , B01L3/502715 , B01L3/502776 , B01L2200/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/087 , B01L2300/0877 , B01L2400/086 , G01N15/1434 , G01N21/05 , G01N2015/1411 , G01N2021/0346 , G01N2021/0378 , G01N2021/6467 , G01N2021/6482
摘要： An embodiment is a fluidic channel to enhance light-target interaction. A first channel portion receives a first excitation light, an analyte flow, and a sheath flow. The analyte flow and the first excitation light are separated while in the first channel portion. The sheath flow flows on two sides or surrounds the analyte flow. A second channel portion has a first redirection structure to redirect the analyte flow by the sheath flow into the first excitation light at a first detection area.
摘要翻译：一个实施例是用于增强光 - 目标相互作用的流体通道。第一通道部分接收第一激发光，分析物流和鞘流。分析物流和第一激发光在第一通道部分分离。鞘流在两侧流动或围绕分析物流。第二通道部分具有第一重定向结构，以将分析物流通过鞘流重定向到第一检测区域的第一激发光。

6. 发明申请

US20020064800A1 Microchip 审中-公开
公开(公告)号：US20020064800A1
公开(公告)日：2002-05-30
申请号：US09988488
申请日：2001-11-20
发明人： Yasuhiro Sando , Yasuhisa Fujii
IPC分类号： G01N033/53 , C12M003/00 , C12M001/34 , G01J003/00
CPC分类号： G01N21/645 , G01N21/0303 , G01N21/031 , G01N21/05 , G01N2021/0346 , G01N2021/058 , G01N2021/6467 , G01N2021/6482
摘要： A microchip is disclosed. One embodiment of the microchip has a flow pass for containing a reaction. A detection target region wherein light from the reaction is to be generated is located within at least a portion of the flow pass. The microchip has an optical path for detecting the light from the reaction. A length of the optical path is greater than a depth of the flow pass.
摘要翻译：公开了一种微芯片。微芯片的一个实施例具有用于包含反应的流程。将产生来自反应的光的检测对象区域位于流路的至少一部分内。微芯片具有用于检测来自反应的光的光路。光路的长度大于流路的深度。

7. 发明授权

US5650846A Microcolumnar analytical system with optical fiber sensor 失效
标题翻译：具有光纤传感器的微柱分析系统
公开(公告)号：US5650846A
公开(公告)日：1997-07-22
申请号：US562082
申请日：1995-11-21
申请人： Hongfeng Yin , Catherine Keely Templin
发明人： Hongfeng Yin , Catherine Keely Templin
IPC分类号： G01N21/64 , G01N21/01 , G01N21/05 , G01N21/65 , G01N27/447 , G01N30/74
CPC分类号： G01N21/645 , G01N27/44721 , G01N30/74 , G01N2021/6467 , G01N2021/6482 , G01N2021/6484
摘要： An analytical system for analyzing a fluid sample is disclosed. The analytical system includes a microcolumn for conducting the fluid sample, a light source for delivering light through the microcolumnar wall into the microcolumn near the outlet end of that microcolumn, and an optical fiber aligned with the microcolumn to detect light that radiates from the fluid sample without passing through the microcolumnar wall. The microcolumn has an inlet end and an outlet end. A light-inlet end of the optical fiber is nonfixedly coupled to the outlet end of the microcolumn. As the fluid sample is driven from the inlet end to the outlet end of the microcolumn, a light of a suitable wavelength is directed at the microcolumn near its outlet end to cause light interaction with the fluid sample. As a result, light radiates from the fluid sample. This light is collected by the optical fiber to provide information on the presence or quantity of an analyte in the fluid sample.
摘要翻译：公开了一种用于分析流体样品的分析系统。分析系统包括用于导入流体样品的微柱，用于将光通过微柱壁输送到微柱出口端附近的微柱中的光源和与微柱对准的光纤以检测从流体样品辐射的光而不通过微柱壁。微柱有入口端和出口端。光纤的光入口端非固定地耦合到微柱的出口端。当流体样品从微柱的入口端到出口端被驱动时，适当波长的光指向靠近其出口端的微柱，以引起与流体样品的光相互作用。结果，光从流体样品辐射。该光被光纤收集以提供关于流体样品中分析物的存在或数量的信息。

8. 发明授权

US08948563B2 Miniaturized on-line trace analysis 有权
标题翻译：小型化在线追踪分析
公开(公告)号：US08948563B2
公开(公告)日：2015-02-03
申请号：US13500792
申请日：2010-10-05
申请人： Helmut Hummel , Alfred Lechner
发明人： Helmut Hummel , Alfred Lechner
IPC分类号： G02B6/10 , G01N21/05 , B01F13/00 , B01L3/00 , G01N21/31 , G01N21/64 , G01N21/78 , G01N21/03
CPC分类号： G01N21/05 , B01F13/0066 , B01L3/502707 , B01L2300/0867 , G01N21/31 , G01N21/645 , G01N21/78 , G01N2021/0346 , G01N2021/0378 , G01N2021/056 , G01N2021/058 , G01N2021/6467 , G01N2021/6482 , G01N2201/08 , Y10T137/8376
摘要： The invention relates to a measuring apparatus comprising an apparatus for forming a liquid optical waveguide having a substrate (1) having an at least partially curved closed microchannel (2) having a low-refractive coating (13), whereby there is formed in the substrate (1) at least one feed line (6) for supplying liquid, and whereby there is provided at least at one end of the closed microchannel (2) an apparatus for coupling light axially into the closed microchannel and/or for coupling light axially out of the closed microchannel (2), further comprising a light source (4), a light detector (5), and a first liquid pump (9) which supplies a sample liquid (7) to the closed microchannel (2) via the at least one feed line (6, 6a).
摘要翻译：本发明涉及一种包括用于形成液体光波导的装置的测量装置，该装置具有一个具有至少部分弯曲的具有低折射涂层（13）的闭合微通道（2）的基底（1），由此形成在该基底（1）用于供应液体的至少一个供给管线（6），并且由此至少在所述封闭的微通道（2）的一端设置用于将光轴向耦合到所述封闭的微通道中和/或用于将光轴向向外耦合的装置所述闭合微通道（2）还包括光源（4），光检测器（5）和第一液体泵（9），所述第一液体泵（9）经由所述第一液体泵至少一个馈送线（6,6a）。

9. 发明申请

US20090194707A1 MICROFLUIDIC IMMUNOASSAY DEVICE 有权
标题翻译：微流感免疫设备
公开(公告)号：US20090194707A1
公开(公告)日：2009-08-06
申请号：US12282166
申请日：2006-03-07
申请人： Swee Chuan Tjin , Rudi Irawan
发明人： Swee Chuan Tjin , Rudi Irawan
IPC分类号： G01N21/64 , G01N21/05
CPC分类号： G01N21/645 , B01L3/502715 , B01L3/505 , B01L2200/10 , B01L2200/12 , B01L2300/0654 , B01L2300/087 , B01L2400/0406 , G01N21/05 , G01N33/54366 , G01N2021/0346 , G01N2021/6467 , G01N2021/6484
摘要： An optical fiber for use in an immunoassay device having at least one microfluidic channel, the optical fiber being for transmitting excitation light to the microfluidic channel and for transmitting emitted fluorescence to a light detector.
摘要翻译：一种用于具有至少一个微流体通道的免疫测定装置的光纤，所述光纤用于将激发光传输到所述微流体通道并将发射的荧光发射到光检测器。

10. 发明申请

US20090189088A1 Fluorescence-activated cell detector 有权
标题翻译：荧光激活细胞检测器
公开(公告)号：US20090189088A1
公开(公告)日：2009-07-30
申请号：US12378757
申请日：2009-02-19
申请人： Harold E. Ayliffe , Curtis S. King
发明人： Harold E. Ayliffe , Curtis S. King
IPC分类号： G01N21/64 , G01N21/85 , G01T1/20
CPC分类号： G01N21/05 , G01N21/645 , G01N2021/0346 , G01N2021/056 , G01N2021/058 , G01N2021/6421 , G01N2021/6441 , G01N2021/6467
摘要： An apparatus for detecting particles of interest that are dispersed in a fluid mix, which typically includes other particles. The apparatus typically is associated with an interrogation platform arranged to operate in harmony with an opaque member having an orifice sized to promote single-file travel of the particles there-through. A currently preferred embodiment includes a light pipe configured to impinge stimulation-radiation substantially transverse to a direction of fluid flow through the opaque member. Particles of interest may be tagged using antibody-binding, fluorescing molecules. Stimulation radiation from the source causes the tagged particles to undergo a Stokes-shift emission of fluorescence. The resulting fluorescence is detected by the radiation detector and indicates passage of the particles of interest. One workable opaque member is advantageously included in a thin film assembly carried on a removable and disposable card that is adapted for reception in the interrogation platform.
摘要翻译：用于检测分散在通常包括其它颗粒的流体混合物中的感兴趣的颗粒的装置。该装置通常与询问平台相关联，该询问平台被布置成与具有孔径的不透明构件协调地操作，该孔口的尺寸适于促进颗粒在其上的单文件行进。目前优选的实施例包括配置成将刺激辐射基本上横向于穿过不透明构件的流体流动的方向的光管。可以使用抗体结合荧光分子来标记感兴趣的颗粒。来自源的刺激辐射导致标记的颗粒经历斯托克斯发射的荧光。所产生的荧光由辐射检测器检测并指示感兴趣的颗粒通过。一个可加工的不透明构件有利地包括在携带在可移动和一次性卡上的薄膜组件中，该组件适于在询问平台中接收。

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