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21. 发明申请

US20060217798A1 Stent having active release reservoirs 审中-公开
标题翻译：支架具有主动释放储层
公开(公告)号：US20060217798A1
公开(公告)日：2006-09-28
申请号：US11373805
申请日：2006-03-10
申请人： John Santini , Charles Hutchinson
发明人： John Santini , Charles Hutchinson
IPC分类号： A61F2/82
CPC分类号： A61K9/0097 , A23L2/52 , A61F2/91 , A61F2250/0035 , A61F2250/0068 , A61K9/0009 , A61L31/14 , A61L31/16 , A61L2300/416 , A61M5/1407 , A61M15/0031 , A61M15/0045 , A61M15/005 , A61M15/008 , A61M15/0083 , A61M15/009 , A61M2205/8225
摘要： Devices for the controlled release of one or more drugs are provided. The devices include an implantable stent, at least two reservoirs in the stent, and a release system contained in each of the at least two reservoirs, wherein the release system comprises one or more drugs for release.
摘要翻译：提供用于控制释放一种或多种药物的装置。所述装置包括可植入支架，所述支架中的至少两个储存器和包含在所述至少两个储存器中的每一个中的释放系统，其中所述释放系统包括一种或多种用于释放的药物。

22. 发明申请

US20050267440A1 Devices and methods for measuring and enhancing drug or analyte transport to/from medical implant 审中-公开
标题翻译：用于测量和增强药物或分析物输送到医用植入物的装置和方法
公开(公告)号：US20050267440A1
公开(公告)日：2005-12-01
申请号：US11142629
申请日：2005-06-01
申请人： Stephen Herman , Timothy Kreiger , John Santini , James Prescott , Mark Staples , Sara Lipka
发明人： Stephen Herman , Timothy Kreiger , John Santini , James Prescott , Mark Staples , Sara Lipka
IPC分类号： A61B5/00 , A61B5/03 , A61B5/042 , A61B5/07 , A61M31/00 , A61M37/00 , A61N1/05 , A61N1/30
CPC分类号： A61K9/0009 , A61B5/03 , A61B5/04001 , A61B5/042 , A61B5/076 , A61B5/14528 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/686 , A61K9/0024 , A61K9/0097 , A61M37/00 , A61N1/05 , A61N1/30 , A61N1/306
摘要： Methods and devices are provided for enhancing mass transport through any fibrous tissue capsule that may form around an implanted medical device following implantation. Methods and devices are also provided to enhance vascularization around the implanted device, which also will aid in mass transport to/from the device. The device preferably comprises multiple reservoirs containing (i) a drug formulation for short- or long-term, controlled drug delivery, (ii) sensors for sensing an analyte in the patient, or (iii) a combination thereof.
摘要翻译：提供的方法和装置用于增强通过植入后可能在植入的医疗装置周围形成的任何纤维组织胶囊的质量传递。还提供了方法和装置以增强植入装置周围的血管化，这也有助于大量运输到装置。装置优选地包括多个储存器，其包含（i）用于短期或长期，受控药物递送的药物制剂，（ii）用于感测患者中的分析物的传感器，或（iii）其组合。

23. 发明申请

US20050096587A1 Medical device for sensing glucose 有权
标题翻译：用于感测葡萄糖的医疗设备
公开(公告)号：US20050096587A1
公开(公告)日：2005-05-05
申请号：US10980551
申请日：2004-11-03
申请人： John Santini , Stephen Herman
发明人： John Santini , Stephen Herman
IPC分类号： A61B5/00 , A61M31/00 , A61N1/00
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/1486 , A61B5/4839 , B33Y80/00
摘要： Medical devices, utilizing multiple reservoirs to protect and selectively expose sensors or other reservoir contents, are provided having (i) a reservoir contents destruction mechanism to interrupt the release or exposure of reservoir contents, for example, to deactivate an unneeded sensor and prevent it from negatively impacting other sensors, (ii) a protective covering material layer over the sensor underneath the reservoir cap, which protects the sensor membrane and sensor during reservoir cap disintegration and then is removed, (iii) a device design for containing sensors in shallow, wide reservoir structures to enhance sensor exposure by minimizing molecular diffusion distances, (iv) an implantable sensor unit and a separate drug delivery unit, or (v) combinations thereof.
摘要翻译：提供了利用多个储存器来保护和选择性地暴露传感器或其他贮存器内容物的医疗装置，其具有（i）用于中断储存器内容物的释放或暴露的储存器内容物破坏机制，例如，去激活不需要的传感器并防止负面影响其他传感器，（ii）储存器盖下方的传感器上方的保护性覆盖材料层，其在储存器盖分解期间保护传感器膜和传感器然后被去除，（iii）用于在浅的，宽的储存器结构，以通过最小化分子扩散距离来增强传感器暴露，（iv）植入式传感器单元和单独的药物递送单元，或（v）其组合。

24. 发明申请

US20050050859A1 Low temperature methods for hermetically sealing reservoir devices 有权
标题翻译：用于气密封装置的低温方法
公开(公告)号：US20050050859A1
公开(公告)日：2005-03-10
申请号：US10894265
申请日：2004-07-19
申请人： Jonathan Coppeta , Scott Uhland , Benjamin Polito , Norman Sheppard , Christina Feakes , Douglas Snell , John Santini
发明人： Jonathan Coppeta , Scott Uhland , Benjamin Polito , Norman Sheppard , Christina Feakes , Douglas Snell , John Santini
IPC分类号： A61K9/00 , B01L3/00 , B65B7/28 , H01L21/50
CPC分类号： B01L3/5085 , A61K9/0009 , A61K9/0097 , B01L3/5027 , B01L2400/0677 , B81B2201/058 , B81C1/00269 , B81C2203/0145 , H01L21/50
摘要： Methods are provided for hermetically sealing an opening in a reservoir of a containment device. The method comprises applying a polymeric material to an opening in a reservoir of a containment device, the reservoir comprising reservoir contents (such as a drug or a sensor) to be hermetically isolated within the reservoir, the applied polymeric material closing off the opening and forming a temporary seal; and adhering a hermetic sealing material onto the polymeric material to hermetically seal the opening. The reservoir can be a micro-reservoir. The containment device can comprises an array of two or more of reservoirs, and the method comprises hermetically sealing each of the two or more reservoirs.
摘要翻译：提供了用于气密地密封容纳装置的储存器中的开口的方法。该方法包括将聚合物材料施加到容纳装置的储存器中的开口中，所述储存器包括要在储存器内气密隔离的储存器内容物（例如药物或传感器），所施加的聚合物材料封闭开口并形成临时印章并将气密密封材料粘附到聚合物材料上以气密地密封开口。储层可以是微储层。容纳装置可以包括两个或更多个储存器的阵列，并且该方法包括气密地密封两个或更多储存器中的每一个。

25. 发明申请

US20120138281A1 Heat Exchanger for Electronic Assemblies 审中-公开
标题翻译：电子组装换热器
公开(公告)号：US20120138281A1
公开(公告)日：2012-06-07
申请号：US13240504
申请日：2011-09-22
申请人： John Santini , Ronald Tallman , Gary Mulcahy
发明人： John Santini , Ronald Tallman , Gary Mulcahy
IPC分类号： F28F3/12 , B21D53/02
CPC分类号： H05K7/20218 , B21D53/02 , F28F3/12 , F28F9/0246 , H01L23/473 , H01L2924/0002 , H05K7/20254 , H05K7/20927 , Y10T29/4935 , H01L2924/00
摘要： A liquid-cooled heat exchanger for electronic assemblies and a method of making the heat exchanger. The exchanger has a solid metal body in the form of an elongated flat plate to which the electronic assembly can be mounted, or a number of such plates formed in an L- or U-shaped configuration to enclose two or more sides of the assembly. The elongated body is formed by extrusion, with parallel enclosed longitudinal passages formed along a length of the body during the extrusion process. Transverse passages are drilled to intersect the extruded longitudinal passages. The longitudinal passages and transverse passages are plugged on at least one of their outside ends, and optionally at points along their lengths, to create desired patterns of liquid flow through the heat exchanger.
摘要翻译：一种用于电子组件的液冷式热交换器和一种制造该热交换器的方法。交换器具有呈细长平板形式的固体金属体，电子组件可安装到该固体金属体上，或者以L形或U形构型形成多个这样的板以封闭组件的两个或多个侧面。细长体通过挤出形成，在挤出过程中沿着主体的长度形成平行的封闭的纵向通道。钻出横向通道以与挤出的纵向通道相交。纵向通道和横向通道堵塞在其至少一个外端上，并且任选地沿着其长度的点处，以产生流过热交换器的所需液体流的图案。

26. 发明申请

US20070088442A1 PASSIVE WEAR-INDICATING SENSOR FOR IMPLANTABLE PROSTHETIC DEVICE 审中-公开
标题翻译：无源磨损传感器，用于可植入的前置设备
公开(公告)号：US20070088442A1
公开(公告)日：2007-04-19
申请号：US11549831
申请日：2006-10-16
申请人： Michael Cima , John Santini , Kurt Shelton , James Prescott , Mark Staples , Jonathan Coppeta
发明人： Michael Cima , John Santini , Kurt Shelton , James Prescott , Mark Staples , Jonathan Coppeta
IPC分类号： A61F2/30 , A61F2/28 , A61B6/12
CPC分类号： A61B5/055 , A61B5/4514 , A61B5/4528 , A61B6/037 , A61B6/481 , A61B8/481 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/38 , A61F2/3804 , A61F2/3859 , A61F2/389 , A61F2/40 , A61F2/4425 , A61F2/4657 , A61F2002/2817 , A61F2002/30004 , A61F2002/30062 , A61F2002/30075 , A61F2002/30113 , A61F2002/30154 , A61F2002/30156 , A61F2002/30326 , A61F2002/30673 , A61F2002/30677 , A61F2002/30682 , A61F2002/30733 , A61F2002/30787 , A61F2002/3081 , A61F2002/30838 , A61F2002/30878 , A61F2002/30884 , A61F2002/30904 , A61F2002/30971 , A61F2002/3401 , A61F2002/3456 , A61F2002/3469 , A61F2002/3495 , A61F2002/3611 , A61F2002/3625 , A61F2002/4662 , A61F2002/488 , A61F2210/0004 , A61F2210/0061 , A61F2230/0006 , A61F2230/0021 , A61F2230/0023 , A61F2250/0014 , A61F2250/0037 , A61F2310/00011 , A61F2310/00179 , A61L27/50
摘要： A method is provided for non-invasively detecting mechanical wear of a prosthetic device implanted in a patient, the method comprises using a non-invasive imaging technique to image the prosthetic device that includes a wear indicating composition; and detecting whether the wear indicating composition has been released from the prosthetic device, and, if so, the location, type, and/or amount thereof. The implant device includes a prosthetic device body having at least one outer surface area; at least one reservoir (e.g., a plurality of discretely spaced micro-reservoirs) in the device body; a wear indicator composition disposed in said at least one reservoir, wherein mechanical wear of the at least one outer surface area of the device body in vivo causes release of at least part of the wear indicator composition. The prosthetic device body may be one for replacement of a hip, a knee, a shoulder, an elbow, or a vertebra.
摘要翻译：提供了一种用于非侵入性地检测植入患者体内的假体装置的机械磨损的方法，所述方法包括使用非侵入性成像技术对包括磨损指示组合物的假体装置进行成像; 以及检测磨损指示组合物是否已经从假体装置释放，以及如果是，则其位置，类型和/或数量。植入装置包括具有至少一个外表面区域的假体装置主体; 设备主体中的至少一个储存器（例如，多个离散间隔的微储器）; 布置在所述至少一个储存器中的磨损指示剂组合物，其中所述装置主体的所述至少一个外表面区域的体内机械磨损导致所述磨损指示剂组合物的至少一部分的释放。假体装置主体可以是用于替换髋部，膝盖，肩部，肘部或椎骨的人造体。

27. 发明申请

US20070016163A1 MEDICAL AND DENTAL IMPLANT DEVICES FOR CONTROLLED DRUG DELIVERY 审中-公开
标题翻译：用于控制药物输送的医疗和牙科植入装置
公开(公告)号：US20070016163A1
公开(公告)日：2007-01-18
申请号：US11381646
申请日：2006-05-04
申请人： John Santini , Charles Hutchinson , Elizabeth Proos
发明人： John Santini , Charles Hutchinson , Elizabeth Proos
IPC分类号： A61M31/00
CPC分类号： A61C8/0012 , A61C8/0016 , A61C19/063 , A61C2008/0046 , A61F2/30744 , A61F2/30756 , A61F2/30767 , A61F2/30771 , A61F2/36 , A61F2/3662 , A61F2/3676 , A61F2/38 , A61F2/446 , A61F2002/2817 , A61F2002/2828 , A61F2002/2832 , A61F2002/2835 , A61F2002/30004 , A61F2002/30013 , A61F2002/30062 , A61F2002/30224 , A61F2002/30261 , A61F2002/30266 , A61F2002/30462 , A61F2002/30677 , A61F2002/30808 , A61F2002/3081 , A61F2002/30874 , A61F2002/30878 , A61F2002/30937 , A61F2002/3617 , A61F2002/4631 , A61F2002/4636 , A61F2002/482 , A61F2210/0004 , A61F2220/0075 , A61F2230/0069 , A61F2230/0082 , A61F2250/0014 , A61F2250/0024 , A61F2310/00011 , A61F2310/00023 , A61F2310/00029 , A61F2310/00179 , A61K9/0024 , A61L15/585 , A61L24/043 , A61L27/54 , A61L27/56 , A61L28/0026 , A61L2300/252 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/602 , A61L2430/02 , C08L31/04
摘要： Implantable devices and methods for use in the treatment of osteonecrosisare provided. The device includes at least one implant device body adapted for insertion into one or more channels or voids in bone tissue; a plurality of discrete reservoirs, which may preferably be microreservoirs, located in the surface of the at least one implant device body; and at least one release system disposed in one or more of the plurality of reservoirs, wherein the release system includes at least one drug selected from the group consisting of bone growth promoters, angiogenesis promoters, analgesics, anesthetics, antibiotics, and combinations thereof. The device body may be formed of a bone graft material, a polymer, a metal, a ceramic, or a combination thereof. The device body may be a monolithic structure, such as one having a cylindrical shape, or it may be in the form of multiple units, such as a plurality of beads.
摘要翻译：提供了用于治疗骨坏死的植入式装置和方法。所述装置包括适于插入到骨组织中的一个或多个通道或空隙中的至少一个植入物装置主体; 位于至少一个植入装置主体的表面中的多个分立储存器，其优选地可以是微贮器; 以及设置在所述多个贮存器中的一个或多个储存器中的至少一个释放系统，其中所述释放系统包括选自骨生长促进剂，血管生成促进剂，止痛剂，麻醉剂，抗生素及其组合中的至少一种药物。装置主体可以由骨移植材料，聚合物，金属，陶瓷或其组合形成。装置主体可以是诸如具有圆柱形形状的整体结构，或者其可以是多个单元的形式，例如多个珠。

28. 发明申请

US20060105275A1 Fabrication methods and structures for micro-reservoir devices 有权
标题翻译：微储层装置的制造方法和结构
公开(公告)号：US20060105275A1
公开(公告)日：2006-05-18
申请号：US10988667
申请日：2004-11-15
申请人： John Maloney , Zouhair Sbiaa , John Santini , Norman Sheppard , Scott Uhland
发明人： John Maloney , Zouhair Sbiaa , John Santini , Norman Sheppard , Scott Uhland
IPC分类号： G03F7/00
CPC分类号： B01L3/50853 , A61K9/0024 , A61K9/0097 , B01L2200/12 , B01L2300/0819 , B01L2400/0677
摘要： Methods are provided for making a multi-reservoir device comprising (i) patterning one or more photoresist layers on a substrate; (ii) depositing onto the substrate at least one metal layer by a sputtering process to form a plurality of reservoir caps and conductive traces; (iii) removing the photoresist layers using a liftoff process; (iv) forming a plurality of reservoirs in the substrate; (v) loading each reservoir with reservoir contents (such as a drug or sensor); and (vi) sealing each reservoir. Optionally, the reservoir cap comprises a first conductive metal layer coated with one or more protective noble metal films. To enhance the resistance of the substrate (e.g., a silicon substrate) to etching in vivo, the interior sidewalls of the reservoirs optionally can include a protective coating (e.g., gold, platinum, carbon, silicon carbide, silicon dioxide, and platinum silicide), or sidewalls comprising silicon can be doped with boron or another impurity.
摘要翻译：提供了用于制造多贮存器器件的方法，包括（i）在衬底上图案化一个或多个光致抗蚀剂层; （ii）通过溅射工艺在衬底上沉积至少一个金属层以形成多个储存器盖和导电迹线; （iii）使用剥离工艺除去光致抗蚀剂层; （iv）在所述基板中形成多个储存器; （v）向每个储存器装载储存器内容物（例如药物或传感器）; 和（vi）密封每个储存器。可选地，储存器盖包括涂覆有一个或多个保护性贵金属膜的第一导电金属层。为了增强衬底（例如，硅衬底）在体内蚀刻的电阻，存储器的内侧壁任选地可以包括保护涂层（例如金，铂，碳，碳化硅，二氧化硅和硅化铂），或者包含硅的侧壁可以掺杂硼或另一种杂质。

29. 发明申请

US20060024358A1 Multi-reservoir device for transdermal drug delivery and sensing 有权
公开(公告)号：US20060024358A1
公开(公告)日：2006-02-02
申请号：US11194157
申请日：2005-08-01
申请人： John Santini , Mark Staples , Stephen Herman
发明人： John Santini , Mark Staples , Stephen Herman
IPC分类号： A61F13/02 , A61L15/16
CPC分类号： A61K9/703 , A61F2013/00642 , A61K9/0009 , A61K9/0021 , A61K9/0097 , A61K9/7084 , A61K9/7092 , A61M37/0015 , A61M2037/0023 , A61N1/30
摘要： Devices and methods are provided for transdermal administration of a pharmaceutical agent to a patient in need thereof. The device includes a substrate, a plurality of discrete reservoirs in the substrate, one or more pharmaceutical agents stored in the reservoirs, discrete reservoir caps that prevent the pharmaceutical agent from passing out from the reservoirs until desired, control means for actuating release of the one or more pharmaceutical agents from one or more of the reservoirs by disintegrating or permeabilizing the reservoir caps, means for securing the device to the skin of the patient, and means for transporting the pharmaceutical agent to the skin following release from the one or more of the reservoirs. In another embodiment, the device is adapted for diagnostic sensing instead of or in addition to drug delivery.

30. 发明申请

US20050149000A1 Medical device with controlled reservoir opening 有权
标题翻译：具有受控储存器开口的医疗装置
公开(公告)号：US20050149000A1
公开(公告)日：2005-07-07
申请号：US11041161
申请日：2005-01-21
申请人： John Santini , Michael Cima , Robert Langer , Achim Gopferich
发明人： John Santini , Michael Cima , Robert Langer , Achim Gopferich
IPC分类号： A61K9/00 , A61M37/00 , A61K9/22
CPC分类号： A61K9/0009 , A61K9/0024 , A61K9/0097 , A61M5/14276 , A61M37/00 , A61M2205/0244 , C25F5/00 , C25F7/00 , Y10T137/8242
摘要： Reservoir-based medical devices are provided. In one embodiment, the medical device comprises a substrate; at least two discrete, microfabricated reservoirs provided in spaced positions across at least one surface of the substrate; discrete reservoir caps covering the at least two reservoirs; and control circuitry for selectively disintegrating the reservoir caps to open the reservoirs. The reservoirs of the device can include a diagnostic reagent or other molecules useful in medical diagnostics. In one embodiment, the reservoir cap comprises an anode and the control circuitry comprises a cathode and a power source for creating an electric potential between the cathode and the anode. Application of the electric potential causes the reservoir cap to disintegrate, thereby opening the reservoir.
摘要翻译：提供了基于水库的医疗设备。在一个实施例中，医疗装置包括基底; 至少两个离散的，微制造的储存器，跨过衬底的至少一个表面设置在间隔位置; 覆盖至少两个储存器的分立贮存器盖; 以及用于选择性地分解储存器盖以打开储存器的控制电路。装置的储存器可以包括诊断试剂或用于医学诊断的其它分子。在一个实施例中，储存器盖包括阳极，并且控制电路包括用于在阴极和阳极之间产生电位的阴极和电源。施加电势会导致储存器盖分解，从而打开储存器。

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