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1. 发明申请

US20050267440A1 Devices and methods for measuring and enhancing drug or analyte transport to/from medical implant 审中-公开
标题翻译：用于测量和增强药物或分析物输送到医用植入物的装置和方法
公开(公告)号：US20050267440A1
公开(公告)日：2005-12-01
申请号：US11142629
申请日：2005-06-01
申请人： Stephen Herman , Timothy Kreiger , John Santini , James Prescott , Mark Staples , Sara Lipka
发明人： Stephen Herman , Timothy Kreiger , John Santini , James Prescott , Mark Staples , Sara Lipka
IPC分类号： A61B5/00 , A61B5/03 , A61B5/042 , A61B5/07 , A61M31/00 , A61M37/00 , A61N1/05 , A61N1/30
CPC分类号： A61K9/0009 , A61B5/03 , A61B5/04001 , A61B5/042 , A61B5/076 , A61B5/14528 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/686 , A61K9/0024 , A61K9/0097 , A61M37/00 , A61N1/05 , A61N1/30 , A61N1/306
摘要： Methods and devices are provided for enhancing mass transport through any fibrous tissue capsule that may form around an implanted medical device following implantation. Methods and devices are also provided to enhance vascularization around the implanted device, which also will aid in mass transport to/from the device. The device preferably comprises multiple reservoirs containing (i) a drug formulation for short- or long-term, controlled drug delivery, (ii) sensors for sensing an analyte in the patient, or (iii) a combination thereof.
摘要翻译：提供的方法和装置用于增强通过植入后可能在植入的医疗装置周围形成的任何纤维组织胶囊的质量传递。还提供了方法和装置以增强植入装置周围的血管化，这也有助于大量运输到装置。装置优选地包括多个储存器，其包含（i）用于短期或长期，受控药物递送的药物制剂，（ii）用于感测患者中的分析物的传感器，或（iii）其组合。

2. 发明申请

US20080015494A1 MULTI-RESERVOIR PUMP DEVICE FOR DIALYSIS, BIOSENSING, OR DELIVERY OF SUBSTANCES 审中-公开
标题翻译：用于透析，生物传感或输送物质的多储层泵装置
公开(公告)号：US20080015494A1
公开(公告)日：2008-01-17
申请号：US11776351
申请日：2007-07-11
申请人： John Santini , Michael Cima , Jonathan Coppeta , James Prescott , Zouhair Sbiaa , Mark Staples
发明人： John Santini , Michael Cima , Jonathan Coppeta , James Prescott , Zouhair Sbiaa , Mark Staples
IPC分类号： A61M31/00
CPC分类号： A61M37/0015 , A61M5/1409 , A61M5/14248 , A61M5/1452 , A61M5/14526 , A61M2005/14204 , A61M2005/14268 , A61M2037/0023
摘要： A pump patch device is provided for drug delivery. The device may include a substrate having a plurality of discrete reservoirs, each reservoir having a reservoir opening; a drug disposed in the reservoirs; a pump for delivering a carrier fluid through or adjacent to the reservoir openings; a flow channel for receiving and combining the carrier fluid from the pump with the drug from the reservoirs to form a fluidized drug; and a needle for delivering the fluidized drug into the skin or another biological tissue of a patient. A device is provided for use in dialysis that includes a non-disposable module including a pump or pressure generator; and a disposable cassette operably connected to the pump or pressure generator and including a plurality of discrete reservoirs containing drug and sensors. A fluidics connection device is provided that includes a compression cold weld seal for a microfluidic via.
摘要翻译：提供泵补丁装置用于药物递送。该装置可以包括具有多个分立储存器的基板，每个储存器具有储存器开口; 贮存在药物中的药物; 用于将载体流体输送通过或邻近储存器开口的泵; 流动通道，用于接收和组合来自泵的载体流体与来自储存器的药物以形成流化药物; 以及用于将流化药物输送到患者的皮肤或另一生物组织中的针。提供用于透析的装置，其包括非一次性模块，其包括泵或压力发生器; 以及可操作地连接到泵或压力发生器并且包括多个包含药物和传感器的离散储存器的一次性盒。提供一种流体连接装置，其包括用于微流体通孔的压缩冷焊缝。

3. 发明申请

US20070088442A1 PASSIVE WEAR-INDICATING SENSOR FOR IMPLANTABLE PROSTHETIC DEVICE 审中-公开
标题翻译：无源磨损传感器，用于可植入的前置设备
公开(公告)号：US20070088442A1
公开(公告)日：2007-04-19
申请号：US11549831
申请日：2006-10-16
申请人： Michael Cima , John Santini , Kurt Shelton , James Prescott , Mark Staples , Jonathan Coppeta
发明人： Michael Cima , John Santini , Kurt Shelton , James Prescott , Mark Staples , Jonathan Coppeta
IPC分类号： A61F2/30 , A61F2/28 , A61B6/12
CPC分类号： A61B5/055 , A61B5/4514 , A61B5/4528 , A61B6/037 , A61B6/481 , A61B8/481 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/38 , A61F2/3804 , A61F2/3859 , A61F2/389 , A61F2/40 , A61F2/4425 , A61F2/4657 , A61F2002/2817 , A61F2002/30004 , A61F2002/30062 , A61F2002/30075 , A61F2002/30113 , A61F2002/30154 , A61F2002/30156 , A61F2002/30326 , A61F2002/30673 , A61F2002/30677 , A61F2002/30682 , A61F2002/30733 , A61F2002/30787 , A61F2002/3081 , A61F2002/30838 , A61F2002/30878 , A61F2002/30884 , A61F2002/30904 , A61F2002/30971 , A61F2002/3401 , A61F2002/3456 , A61F2002/3469 , A61F2002/3495 , A61F2002/3611 , A61F2002/3625 , A61F2002/4662 , A61F2002/488 , A61F2210/0004 , A61F2210/0061 , A61F2230/0006 , A61F2230/0021 , A61F2230/0023 , A61F2250/0014 , A61F2250/0037 , A61F2310/00011 , A61F2310/00179 , A61L27/50
摘要： A method is provided for non-invasively detecting mechanical wear of a prosthetic device implanted in a patient, the method comprises using a non-invasive imaging technique to image the prosthetic device that includes a wear indicating composition; and detecting whether the wear indicating composition has been released from the prosthetic device, and, if so, the location, type, and/or amount thereof. The implant device includes a prosthetic device body having at least one outer surface area; at least one reservoir (e.g., a plurality of discretely spaced micro-reservoirs) in the device body; a wear indicator composition disposed in said at least one reservoir, wherein mechanical wear of the at least one outer surface area of the device body in vivo causes release of at least part of the wear indicator composition. The prosthetic device body may be one for replacement of a hip, a knee, a shoulder, an elbow, or a vertebra.
摘要翻译：提供了一种用于非侵入性地检测植入患者体内的假体装置的机械磨损的方法，所述方法包括使用非侵入性成像技术对包括磨损指示组合物的假体装置进行成像; 以及检测磨损指示组合物是否已经从假体装置释放，以及如果是，则其位置，类型和/或数量。植入装置包括具有至少一个外表面区域的假体装置主体; 设备主体中的至少一个储存器（例如，多个离散间隔的微储器）; 布置在所述至少一个储存器中的磨损指示剂组合物，其中所述装置主体的所述至少一个外表面区域的体内机械磨损导致所述磨损指示剂组合物的至少一部分的释放。假体装置主体可以是用于替换髋部，膝盖，肩部，肘部或椎骨的人造体。

4. 发明申请

US20060024358A1 Multi-reservoir device for transdermal drug delivery and sensing 有权
公开(公告)号：US20060024358A1
公开(公告)日：2006-02-02
申请号：US11194157
申请日：2005-08-01
申请人： John Santini , Mark Staples , Stephen Herman
发明人： John Santini , Mark Staples , Stephen Herman
IPC分类号： A61F13/02 , A61L15/16
CPC分类号： A61K9/703 , A61F2013/00642 , A61K9/0009 , A61K9/0021 , A61K9/0097 , A61K9/7084 , A61K9/7092 , A61M37/0015 , A61M2037/0023 , A61N1/30
摘要： Devices and methods are provided for transdermal administration of a pharmaceutical agent to a patient in need thereof. The device includes a substrate, a plurality of discrete reservoirs in the substrate, one or more pharmaceutical agents stored in the reservoirs, discrete reservoir caps that prevent the pharmaceutical agent from passing out from the reservoirs until desired, control means for actuating release of the one or more pharmaceutical agents from one or more of the reservoirs by disintegrating or permeabilizing the reservoir caps, means for securing the device to the skin of the patient, and means for transporting the pharmaceutical agent to the skin following release from the one or more of the reservoirs. In another embodiment, the device is adapted for diagnostic sensing instead of or in addition to drug delivery.

5. 发明申请

US20060093646A1 Orthopedic and dental implant devices providing controlled drug delivery 审中-公开
标题翻译：提供控制药物输送的矫形和牙种植体装置
公开(公告)号：US20060093646A1
公开(公告)日：2006-05-04
申请号：US11262413
申请日：2005-10-28
申请人： Michael Cima , John Santini , Mark Staples , Charles Hutchinson
发明人： Michael Cima , John Santini , Mark Staples , Charles Hutchinson
IPC分类号： A61F2/28 , A61F2/02
CPC分类号： A61F2/30771 , A61B17/0642 , A61B17/80 , A61B17/86 , A61B17/8625 , A61B2017/0648 , A61C8/0012 , A61C8/0016 , A61C19/063 , A61F2/30744 , A61F2/30767 , A61F2/36 , A61F2/3662 , A61F2/367 , A61F2/3676 , A61F2/38 , A61F2/3804 , A61F2/3859 , A61F2/389 , A61F2/40 , A61F2/4425 , A61F2/446 , A61F2002/2817 , A61F2002/30013 , A61F2002/30032 , A61F2002/30036 , A61F2002/30062 , A61F2002/30064 , A61F2002/30075 , A61F2002/30224 , A61F2002/30324 , A61F2002/30326 , A61F2002/30677 , A61F2002/3068 , A61F2002/30787 , A61F2002/30808 , A61F2002/3081 , A61F2002/30838 , A61F2002/30878 , A61F2002/30929 , A61F2002/30971 , A61F2002/3611 , A61F2002/3625 , A61F2002/3631 , A61F2002/4631 , A61F2210/0004 , A61F2210/0061 , A61F2230/0069 , A61F2250/0024 , A61F2250/003 , A61F2250/0035 , A61F2250/0036 , A61F2250/0037 , A61F2250/0068 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00131 , A61F2310/00179 , A61L27/54 , A61L2300/406 , A61L2300/414 , A61L2300/604 , A61N1/30
摘要： Implantable prosthetic devices are provided for controlled drug delivery, for orthopedic and dental applications. The device may include a prosthetic device body having at least one outer surface area; two or more discrete reservoirs located in spaced apart positions across at least a portion of the outer surface area, the reservoirs formed with an opening at the surface of the device body and extending into the device body; and a release system disposed in the reservoirs which comprises at least one therapeutic or prophylactic agent, wherein following implantation into a patient the therapeutic or prophylactic agent is released in a controlled manner from the reservoirs. The prosthetic device body preferably is a joint prosthesis or part thereof, such as a hip prosthesis, a knee prosthesis, a vertebral or spinal disc prosthesis, or part thereof. Optional reservoir caps may further control release kinetics.
摘要翻译：提供可植入的假体装置用于受控的药物递送，用于矫形和牙科应用。该装置可以包括具有至少一个外表面区域的假体装置主体; 两个或更多个离散的储存器位于跨过外表面区域的至少一部分的间隔位置，储存器在装置主体的表面处形成并延伸到装置主体中的开口; 以及设置在储存器中的释放系统，其包括至少一种治疗或预防剂，其中在植入患者体内后，以受控的方式从所述储存器释放所述治疗剂或预防剂。修复装置本体优选地是关节假体或其部分，例如髋关节假体，膝假体，椎骨或脊椎椎间盘假体或其一部分。可选的储存瓶盖可进一步控制释放动力学。

6. 发明申请

US20060178655A1 Implantable, tissue conforming drug delivery device 失效
标题翻译：可植入，组织贴合药物输送装置
公开(公告)号：US20060178655A1
公开(公告)日：2006-08-10
申请号：US11291973
申请日：2005-12-01
申请人： John Santini , Michael Cima , Norman Sheppard , Stephen Herman
发明人： John Santini , Michael Cima , Norman Sheppard , Stephen Herman
IPC分类号： A61K9/22 , A61M31/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61K9/0097 , H01L24/96 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01027 , H01L2924/01033 , H01L2924/01074 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19043 , H01L2924/00
摘要： A drug delivery device for implantation into a patient is provided that includes at least one device element which comprises a substrate having a plurality of discrete reservoirs disposed therein, said reservoirs containing drug molecules and a degradable matrix material which controls in vivo release of the drug molecules from the reservoirs, wherein the drug delivery device is adapted to conform to a curved bone tissue surface. In one embodiment, the substrate is flexible and conforms to a bone tissue surface. In another embodiment, the device has two or more device elements attached to or integral with a flexible supporting layer.
摘要翻译：提供了一种用于植入患者的药物递送装置，其包括至少一个装置元件，其包括具有设置在其中的多个离散储存器的基底，所述储存器包含药物分子和控制体内释放药物分子的可降解基质材料其中所述药物递送装置适于符合弯曲的骨组织表面。在一个实施例中，基底是柔性的并且符合骨组织表面。在另一个实施例中，该装置具有两个或更多个装置元件，其连接到柔性支撑层或与柔性支撑层成一体。

7. 发明申请

US20050077584A1 Hermetically sealed microchip reservoir devices 有权
标题翻译：密封微芯片油藏装置
公开(公告)号：US20050077584A1
公开(公告)日：2005-04-14
申请号：US11005391
申请日：2004-12-06
申请人： Scott Uhland , Benjamin Polito , Stephen Herman , John Santini , John Maloney
发明人： Scott Uhland , Benjamin Polito , Stephen Herman , John Santini , John Maloney
IPC分类号： B81C3/00 , A61K9/00 , A61K9/22 , B23K1/06 , B23K26/00 , B81B1/00 , H01L27/14
CPC分类号： A61K9/0097
摘要： Devices are provided for the controlled exposure or release of contents stored in hermetically sealed reservoirs. The devices comprise a primary substrate having a front side and a back side, and including one or more hermetic sealing materials; a plurality of reservoirs in the primary substrate positioned between the front side and the back side; reservoir contents, which comprise chemical molecules (such as drugs) or a secondary device (such as a glucose sensor), located inside the reservoirs; a hermetic sealing substrate having a surface composed of one or more hermetic sealing materials; and a hermetic seal formed between and joining the primary substrate and the hermetic sealing substrate, wherein the hermetic seal independently seals the reservoirs.
摘要翻译：提供了用于控制曝光或释放存储在密封储存器中的内容物的装置。这些装置包括具有前侧和后侧的主基板，并且包括一个或多个密封材料; 位于前侧和后侧之间的主要基底中的多个储存器; 包括化学分子（如药物）或位于储存器内部的次级装置（如葡萄糖传感器）的储存器内容物; 具有由一种或多种密封材料构成的表面的气密密封基材; 以及形成在主基板和气密密封基板之间并与其接合的气密密封件，其中气密密封独立地密封储存器。

8. 发明申请

US20050096587A1 Medical device for sensing glucose 有权
标题翻译：用于感测葡萄糖的医疗设备
公开(公告)号：US20050096587A1
公开(公告)日：2005-05-05
申请号：US10980551
申请日：2004-11-03
申请人： John Santini , Stephen Herman
发明人： John Santini , Stephen Herman
IPC分类号： A61B5/00 , A61M31/00 , A61N1/00
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/1486 , A61B5/4839 , B33Y80/00
摘要： Medical devices, utilizing multiple reservoirs to protect and selectively expose sensors or other reservoir contents, are provided having (i) a reservoir contents destruction mechanism to interrupt the release or exposure of reservoir contents, for example, to deactivate an unneeded sensor and prevent it from negatively impacting other sensors, (ii) a protective covering material layer over the sensor underneath the reservoir cap, which protects the sensor membrane and sensor during reservoir cap disintegration and then is removed, (iii) a device design for containing sensors in shallow, wide reservoir structures to enhance sensor exposure by minimizing molecular diffusion distances, (iv) an implantable sensor unit and a separate drug delivery unit, or (v) combinations thereof.
摘要翻译：提供了利用多个储存器来保护和选择性地暴露传感器或其他贮存器内容物的医疗装置，其具有（i）用于中断储存器内容物的释放或暴露的储存器内容物破坏机制，例如，去激活不需要的传感器并防止负面影响其他传感器，（ii）储存器盖下方的传感器上方的保护性覆盖材料层，其在储存器盖分解期间保护传感器膜和传感器然后被去除，（iii）用于在浅的，宽的储存器结构，以通过最小化分子扩散距离来增强传感器暴露，（iv）植入式传感器单元和单独的药物递送单元，或（v）其组合。

9. 发明申请

US20050143715A1 Device for controlled reservoir opening with reinforced reservoir caps 审中-公开
标题翻译：受控储层开启装置，加强储层盖
公开(公告)号：US20050143715A1
公开(公告)日：2005-06-30
申请号：US10937616
申请日：2004-09-09
申请人： Michael Cima , John Santini , Stephen Herman
发明人： Michael Cima , John Santini , Stephen Herman
IPC分类号： A61K9/00 , A61K9/22 , A61M31/00
CPC分类号： A61K9/0097 , A61K9/0009 , Y10T137/8242
摘要： Device are provided for the controlled release or exposure of molecules or secondary devices comprising a substrate; a plurality of reservoirs located in the substrate; reservoir contents comprising molecules, a secondary device, or both, isolated inside the reservoirs; reservoir caps positioned on the reservoirs over the reservoir contents, wherein the reservoir caps (which can comprise a metal film) are mechanically reinforced with a second material deposited and patterned on the surface of the metal film inside the reservoir or on the surface of the metal film outside the reservoir or on both of said surfaces; and control circuitry and a power source for disintegrating the reservoir caps to initiate exposure or release of the reservoir contents in selected reservoirs.
摘要翻译：提供了用于受控释放或暴露包括基底的分子或二次装置的装置; 位于所述基板中的多个储存器; 储存器内容物包含分离在储存器内部的分子，次要装置或二者; 储存器盖位于储存器上方的储存器内容物上，其中储存器盖（其可以包括金属膜）用沉积和图案化的第二材料机械地增强，该金属膜在储存器内部或金属表面上的金属膜的表面上在所述储存器外部或所述两个所述表面上的膜; 以及控制电路和用于分解储存器盖的电源，以开始在所选择的储存器中储存器内容物的曝光或释放。

10. 发明申请

US20080083041A1 Pre-Clinical Animal Testing Method 审中-公开
标题翻译：临床前动物试验方法
公开(公告)号：US20080083041A1
公开(公告)日：2008-04-03
申请号：US11927316
申请日：2007-10-29
申请人： John Santini , Dennis Ausiello
发明人： John Santini , Dennis Ausiello
IPC分类号： A61D7/00
CPC分类号： A61B1/041 , A61B5/0402 , A61B5/0476 , A61B5/14539 , A61K9/0009 , A61K9/0051 , A61K9/0097 , A61M5/14 , A61M5/14276 , A61M2205/0244 , A61M2205/3523 , A61M2210/0612 , A61M2210/1042
摘要： Devices and methods are provided for wirelessly powering and/or communicating with implanted medical devices used for the controlled exposure and release of reservoir contents, such as drugs or sensors. The device may include a substrate having a plurality of reservoirs containing reservoir contents for release or exposure; and a rechargeable or on-demand power source comprising a local component which can wirelessly receive power from a remote transmitter wherein the received power can be used, directly or following transduction, to activate the release or exposure of the reservoir contents.
摘要翻译：提供了用于与用于受控地暴露和释放储存器内容物（例如药物或传感器）的植入式医疗装置的无线供电和/或通信的装置和方法。该装置可以包括具有多个储存器的基板，该储存器包含用于释放或暴露的储存器内容物; 以及可充电或点播电源，其包括本地组件，其可以从远程发射机无线地接收电力，其中可以直接或继续使用所接收的功率来激活所述储存器内容物的释放或暴露。

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