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21. 发明申请

US20120258544A1 Plasmonic Force Manipulation in Nanostructures 有权
标题翻译：纳米结构中的等离子体力学操作
公开(公告)号：US20120258544A1
公开(公告)日：2012-10-11
申请号：US13518570
申请日：2010-12-24
申请人： Chang Chen , Pol Van Dorpe , Kai Cheng , Tim Stakenborg , Liesbet Lagae
发明人： Chang Chen , Pol Van Dorpe , Kai Cheng , Tim Stakenborg , Liesbet Lagae
IPC分类号： G01N21/65
CPC分类号： B82Y15/00 , C12Q1/6869 , G01N33/48721 , G01N33/538 , Y10T436/143333 , C12Q2565/631 , C12Q2565/607
摘要： A system (100) is described for characterizing and/or manipulating molecules. The system may especially be suitable for biological molecules, although the invention is not limited thereto. The system (100) comprises a substrate (110) comprising a nanostructure (120) being suitable for translocation of molecules through the nanostructure (120). It furthermore comprises a means (210) for translocating molecules through the nanostructure (120) and a plasmonic force field generating means (130) adapted for influencing the translocation speed of the particle by applying a plasmonic force field at the nanostructure (120). A corresponding method also is described.
摘要翻译：描述了用于表征和/或操纵分子的系统（100）。该系统可以特别适用于生物分子，尽管本发明不限于此。该系统（100）包括一个衬底（110），该衬底（110）包括适合于通过纳米结构（120）的分子易位的纳米结构（120）。它还包括用于使分子转移通过纳米结构（120）的装置（210）和适于通过在纳米结构（120）处施加等离子体力场来影响颗粒的易位速度的等离子体激元场产生装置（130）。还描述了相应的方法。

22. 发明授权

US08164755B2 Method for determining an analyte in a sample 有权
标题翻译：测定样品中分析物的方法
公开(公告)号：US08164755B2
公开(公告)日：2012-04-24
申请号：US13232794
申请日：2011-09-14
申请人： Iwijn De Vlaminck , Pol Van Dorpe , Liesbet Lagae
发明人： Iwijn De Vlaminck , Pol Van Dorpe , Liesbet Lagae
IPC分类号： G01N21/55
CPC分类号： G01N21/554 , B82Y15/00 , G01N2021/258
摘要： In one aspect of the invention, a method or apparatus is described for determining concentration(s) of one or more analytes in a sample using plasmonic excitations. In another aspect, a method relates to designing systems for such concentration determination, wherein metallic nanostructures are used in combination with local electrical detection of such plasmon resonances via a semiconducting photodetector. In certain aspects, the method exploits the coupling of said metallic nanostructure(s) to a semiconducting photodetector, said detector being placed in the “metallic structure's” near field. Surface plasmon excitation can be transduced efficiently into an electrical signal through absorption of light that is evanescently coupled or scattered in a semiconductor volume. This local detection technique allows the construction of sensitive nanoscale bioprobes and arrays thereof.
摘要翻译：在本发明的一个方面，描述了一种用于使用等离子体激发来测定样品中一种或多种分析物的浓度的方法或装置。在另一方面，一种方法涉及设计用于这种浓度测定的系统，其中金属纳米结构经由半导体光电检测器与这种等离子体共振的局部电检测结合使用。在某些方面，该方法利用所述金属纳米结构与半导体光电检测器的耦合，所述检测器被放置在“金属结构”的近场中。表面等离子体激发可以通过吸收在半导体体积中瞬时耦合或散射的光而有效地转换成电信号。这种局部检测技术允许构建敏感的纳米级生物探针及其阵列。

23. 发明申请

US20070285184A1 Fully Integrated Tuneable Spin Torque Device For Generating An Oscillating Signal And Method For Tuning Such Apparatus 有权
标题翻译：用于产生振荡信号的完全集成的可调谐自旋扭矩装置和用于调谐这种装置的方法
公开(公告)号：US20070285184A1
公开(公告)日：2007-12-13
申请号：US10584700
申请日：2004-12-24
申请人： Wouter Eyckmans , Liesbet Lagae
发明人： Wouter Eyckmans , Liesbet Lagae
IPC分类号： H03B9/14
CPC分类号： G01R33/02 , B82Y25/00 , G11C11/161 , G11C11/1673 , G11C11/1675 , H01F10/193 , H01F10/26 , H01F10/3213 , H01F10/3254 , H01F10/3268 , H01L43/08 , H03B15/006 , H03H2/001 , H03H9/02574 , H03H9/02645 , H03H9/02976 , H03H9/135 , H03H9/6486 , H03K19/19
摘要： The present invention is related to a a device and corresponding methods for generating an oscillating signal. The device comprises a means for providing a current of spin polarised charge carriers, a magnetic, e.g. ferromagnetic, excitable layer adapted for receiving the generated current of spin polarised charge carriers thus generating an oscillating signal with a frequency and an integrated means for interacting with said magnetic, e.g. ferromagnetic, excitable layer such that a selection of said oscillation frequency is achieved. No external field needs to be applied to select or tune the frequency. Different types of integrated means can be used, such as e.g. means inducing mechanical stress in the magnetic, e.g. ferromagnetic, excitable layer, means inducing exchange bias interactions and means inducing magnetostatic interactions.
摘要翻译：本发明涉及一种用于产生振荡信号的装置和相应的方法。该装置包括用于提供自旋极化电荷载流子的电流的装置，例如磁性的。铁磁性，可激发层，适于接收所产生的自旋极化电荷载流的电流，从而产生具有频率的振荡信号和用于与所述磁性相互作用的集成装置。铁磁性，可激发层，从而实现所述振荡频率的选择。不需要外部场来选择或调整频率。可以使用不同类型的集成装置，例如，意味着在磁性中诱导机械应力，例如，铁磁性，可激发层，意味着诱导交换偏压相互作用和诱导静磁相互作用的手段。

24. 发明申请

US20150197742A1 Plasma Membrane Isolation 审中-公开
标题翻译：等离子体膜分离
公开(公告)号：US20150197742A1
公开(公告)日：2015-07-16
申请号：US14563268
申请日：2014-12-08
申请人： Deepak Balaji Thimiri Govinda Raj , Liesbet Lagae , Wim Annaert , Gustaaf Borghs
发明人： Deepak Balaji Thimiri Govinda Raj , Liesbet Lagae , Wim Annaert , Gustaaf Borghs
IPC分类号： C12N13/00 , C12N11/08 , H01F1/01
CPC分类号： C12N13/00 , B82Y5/00 , C12N11/08 , G01N33/5076 , G01N33/6842 , H01F1/01 , Y10S977/702 , Y10S977/703 , Y10S977/713 , Y10S977/773 , Y10S977/779 , Y10S977/783 , Y10S977/962
摘要： The present invention relates to a population of monodisperse magnetic nanoparticles with a diameter between 1 and 100 nm which are coated with a layer with hydrophilic end groups. Herein the layer with hydrophilic end groups comprises an inner layer of monosaturated and/or monounsaturated fatty acids bound to said nanoparticles and bound to said fatty acids, an outer layer of a phospholipid conjugated to a monomethoxy polyethyleneglycol (PEG) comprising a hydrophilic end group,or comprises a covalently bound hydrophilic layer bound to said nanoparticles.
摘要翻译：本发明涉及直径为1至100nm的单分散磁性纳米颗粒群，其涂覆有具有亲水端基的层。本文中，具有亲水端基的层包含与所述纳米颗粒结合并结合到所述脂肪酸的单一和/或单不饱和脂肪酸的内层，与包含亲水端基的单甲氧基聚乙二醇（PEG）缀合的磷脂外层，或包含与所述纳米颗粒结合的共价结合的亲水层。

25. 发明授权

US08936935B2 Plasma membrane isolation 有权
标题翻译：血浆膜隔离
公开(公告)号：US08936935B2
公开(公告)日：2015-01-20
申请号：US13111428
申请日：2011-05-19
申请人： Deepak Balaji Thimiri Govinda Raj , Liesbet Lagae , Wim Annaert , Gustaaf Borghs
发明人： Deepak Balaji Thimiri Govinda Raj , Liesbet Lagae , Wim Annaert , Gustaaf Borghs
IPC分类号： B82Y40/00 , G01N33/50 , B82Y5/00 , G01N33/68
CPC分类号： C12N13/00 , B82Y5/00 , C12N11/08 , G01N33/5076 , G01N33/6842 , H01F1/01 , Y10S977/702 , Y10S977/703 , Y10S977/713 , Y10S977/773 , Y10S977/779 , Y10S977/783 , Y10S977/962
摘要： The present invention relates to a population of monodisperse magnetic nanoparticles with a diameter between 1 and 100 nm which are coated with a layer with hydrophilic end groups. Herein the layer with hydrophilic end groups comprises an inner layer of monosaturated and/or monounsaturated fatty acids bound to said nanoparticles and bound to said fatty acids, an outer layer of a phospholipid conjugated to a monomethoxy polyethyleneglycol (PEG) comprising a hydrophilic end group,or comprises a covalently bound hydrophilic layer bound to said nanoparticles.
摘要翻译：本发明涉及直径为1至100nm的单分散磁性纳米颗粒群，其涂覆有具有亲水端基的层。本文中，具有亲水端基的层包含与所述纳米颗粒结合并结合到所述脂肪酸的单一和/或单不饱和脂肪酸的内层，与包含亲水端基的单甲氧基聚乙二醇（PEG）缀合的磷脂外层，或包含与所述纳米颗粒结合的共价结合的亲水层。

26. 发明申请

US20120064567A1 ACTIVE MICRO SIEVE AND METHODS FOR BIOLOGICAL APPLICATIONS 审中-公开
标题翻译：活性微生物和生物应用方法
公开(公告)号：US20120064567A1
公开(公告)日：2012-03-15
申请号：US13227904
申请日：2011-09-08
申请人： Tim Stakenborg , Chengxun Liu , Liesbet Lagae , Ronald Kox
发明人： Tim Stakenborg , Chengxun Liu , Liesbet Lagae , Ronald Kox
IPC分类号： C12Q1/06 , C12Q1/02 , H05K3/10 , C12M1/42
CPC分类号： G01N15/1209 , B01L2200/0668 , B01L2300/0636 , B01L2300/0645 , B03C5/005 , B03C5/026 , C12M41/36 , C12M47/04 , G01N15/1245 , G01N2015/1254 , Y10T29/49155
摘要： An active sieve device for the isolation and characterization of bio-analytes is provided, comprising a substrate for supporting the bio-analytes. The substrate comprises a plurality of interconnections and a plurality of regions, each region comprising a hole and at least one electrode embedded in or located on the substrate and electrically associated with the hole. Each region further comprises at least one transistor integrated in the substrate and operably connected to the at least one electrode and to at least one of the plurality of interconnections.
摘要翻译：提供了用于分离和表征生物分析物的活性筛分装置，其包括用于支持生物分析物的底物。衬底包括多个互连和多个区域，每个区域包括孔和至少一个电极，其嵌入或位于衬底上并与孔电连接。每个区域还包括集成在衬底中并且可操作地连接到至少一个电极和至少一个互连的至少一个晶体管。

27. 发明申请

US20120057163A1 METHOD FOR FORMING A NANOSTRUCTURE PENETRATING A LAYER 有权
标题翻译：形成一层纳米结构的方法
公开(公告)号：US20120057163A1
公开(公告)日：2012-03-08
申请号：US13157154
申请日：2011-06-09
申请人： Kai Cheng , Pol Van Dorpe , Liesbet Lagae , Gustaaf Borghs , Chang Chen
发明人： Kai Cheng , Pol Van Dorpe , Liesbet Lagae , Gustaaf Borghs , Chang Chen
IPC分类号： H01L31/00 , H01L31/18 , G01N21/55 , B82Y40/00 , B82Y99/00
CPC分类号： B82Y15/00 , B82Y20/00 , B82Y40/00 , G01N21/554 , G01N21/648 , G01N21/658 , G01N33/48721 , G01N2021/653 , Y10S977/724 , Y10S977/924
摘要： A method for forming a nanostructure penetrating a layer and the device made thereof is disclosed. In one aspect, the device has a substrate, a layer present thereon, and a nanostructure penetrating the layer. The nanostructure defines a nanoscale passageway through which a molecule to be analyzed can pass through. The nanostructure has, in cross-sectional view, a substantially triangular shape. This shape is particularly achieved by growth of an epitaxial layer having crystal facets defining tilted sidewalls of the nanostructure. It is highly suitably for use for optical characterization of molecular structure, particularly with surface plasmon enhanced transmission spectroscopy.
摘要翻译：公开了一种形成穿透层的纳米结构的方法及其制造的器件。在一个方面，该装置具有基底，存在于其上的层和穿透该层的纳米结构。纳米结构定义了一个纳米尺度的通道，待分析的分子通过该通道通过。纳米结构在横截面图中具有基本上三角形的形状。通过具有限定纳米结构的倾斜侧壁的晶面的外延层的生长，特别地实现了该形状。它非常适合用于分子结构的光学表征，特别是用于表面等离子体增强透射光谱。

28. 发明申请

US20110312056A1 Plasma Membrane Isolation 有权
标题翻译：等离子体膜分离
公开(公告)号：US20110312056A1
公开(公告)日：2011-12-22
申请号：US13111428
申请日：2011-05-19
申请人： Deepak Balaji Thimiri Govinda Raj , Liesbet Lagae , Wim Annaert , Gustaaf Borghs
发明人： Deepak Balaji Thimiri Govinda Raj , Liesbet Lagae , Wim Annaert , Gustaaf Borghs
IPC分类号： C12N1/00 , H01F1/42 , C12N13/00 , B05D5/12
CPC分类号： C12N13/00 , B82Y5/00 , C12N11/08 , G01N33/5076 , G01N33/6842 , H01F1/01 , Y10S977/702 , Y10S977/703 , Y10S977/713 , Y10S977/773 , Y10S977/779 , Y10S977/783 , Y10S977/962
摘要： The present invention relates to a population of monodisperse magnetic nanoparticles with a diameter between 1 and 100 nm which are coated with a layer with hydrophilic end groups. Herein the layer with hydrophilic end groups comprises an inner layer of monosaturated and/or monounsaturated fatty acids bound to said nanoparticles and bound to said fatty acids, an outer layer of a phospholipid conjugated to a monomethoxy polyethyleneglycol (PEG) comprising a hydrophilic end group,or comprises a covalently bound hydrophilic layer bound to said nanoparticles.
摘要翻译：本发明涉及直径为1至100nm的单分散磁性纳米颗粒群，其涂覆有具有亲水端基的层。本文中，具有亲水端基的层包含与所述纳米颗粒结合并结合到所述脂肪酸的单一和/或单不饱和脂肪酸的内层，与包含亲水端基的单甲氧基聚乙二醇（PEG）缀合的磷脂外层，或包含与所述纳米颗粒结合的共价结合的亲水层。

29. 发明授权

US07859349B2 Fully integrated tuneable spin torque device for generating an oscillating signal and method for tuning such apparatus 有权
标题翻译：用于产生振荡信号的完全集成的可调自旋转矩装置和用于调谐这种装置的方法
公开(公告)号：US07859349B2
公开(公告)日：2010-12-28
申请号：US10584700
申请日：2004-12-24
申请人： Wouter Eyckmans , Liesbet Lagae
发明人： Wouter Eyckmans , Liesbet Lagae
IPC分类号： H01S1/00 , H03B28/00
CPC分类号： G01R33/02 , B82Y25/00 , G11C11/161 , G11C11/1673 , G11C11/1675 , H01F10/193 , H01F10/26 , H01F10/3213 , H01F10/3254 , H01F10/3268 , H01L43/08 , H03B15/006 , H03H2/001 , H03H9/02574 , H03H9/02645 , H03H9/02976 , H03H9/135 , H03H9/6486 , H03K19/19
摘要： The present invention is related to a device and corresponding methods for generating an oscillating signal. The device comprises a means for providing a current of spin polarised charge carriers, a magnetic, e.g. ferromagnetic, excitable layer adapted for receiving the generated current of spin polarised charge carriers thus generating an oscillating signal with a frequency Vosc and an integrated means for interacting with said magnetic, e.g. ferromagnetic, excitable layer such that a selection of said oscillation frequency is achieved. No external field needs to be applied to select or tune the frequency. Different types of integrated means can be used, such as e.g. means inducing mechanical stress in the magnetic, e.g. ferromagnetic, excitable layer, means inducing exchange bias interactions and means inducing magnetostatic interactions.
摘要翻译：本发明涉及一种用于产生振荡信号的装置和相应的方法。该装置包括用于提供自旋极化电荷载流子的电流的装置，例如磁性的。铁磁的可激发层，适于接收所产生的自旋极化电荷载流的电流，从而产生具有频率Vosc的振荡信号和用于与所述磁性相互作用的集成装置，例如，铁磁性，可激发层，从而实现所述振荡频率的选择。不需要外部场来选择或调整频率。可以使用不同类型的集成装置，例如，意味着在磁性中诱导机械应力，例如，铁磁性，可激发层，意味着诱导交换偏压相互作用和诱导静磁相互作用的手段。

30. 发明授权

US07682840B2 Magnetic device and method of making the same 有权
标题翻译：磁性装置及其制造方法
公开(公告)号：US07682840B2
公开(公告)日：2010-03-23
申请号：US11398089
申请日：2006-04-04
申请人： Wayne Hiebert , Jo De Boeck , Liesbet Lagae , Roel Wirix-Speetjens
发明人： Wayne Hiebert , Jo De Boeck , Liesbet Lagae , Roel Wirix-Speetjens
IPC分类号： H01L21/00
CPC分类号： G11C11/16
摘要： A method and magnetic device for improving the desirable properties of a magnetic device, e.g., magnetization uniformity and reproducibility. Moreover the invention provides magnetic cells that are more magnetically homogeneous, with smaller amount of end domain magnetization canting from the average cell magnetization direction. The invention may provide a magnetic memory cell with less variation in switching fields, more spatially coherent dynamical magnetic properties for high speed and processional or coherent magnetic switching, and higher signal due to the increased uniformity. It may provide a magnetic sensor with more spatially coherent magnetic properties for high speed and processional or coherent magnetic switching, and increased signal. It may provide a read head element with more spatially coherent magnetic properties for high speed and processional or coherent magnetic sensing, and increased signal.
摘要翻译：一种用于改善磁性装置所需性能的方法和磁性装置，例如磁化均匀性和再现性。此外，本发明提供了磁性更均匀的磁性细胞，具有从平均细胞磁化方向的较小量的端畴磁化倾斜。本发明可以提供一种磁存储单元，其具有较小的开关场变化，更高的空间相干的动态磁特性用于高速和加工或相干的磁性开关，以及由于增加的均匀性而产生的较高的信号。它可以提供具有更高空间相干磁性的磁传感器，用于高速和加工或相干磁切换，以及增加的信号。它可以提供具有更高的空间相干磁性的读头元件，用于高速和加工或相干磁感测，以及增加的信号。

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