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1. 发明申请

US20120064567A1 ACTIVE MICRO SIEVE AND METHODS FOR BIOLOGICAL APPLICATIONS 审中-公开
标题翻译：活性微生物和生物应用方法
公开(公告)号：US20120064567A1
公开(公告)日：2012-03-15
申请号：US13227904
申请日：2011-09-08
申请人： Tim Stakenborg , Chengxun Liu , Liesbet Lagae , Ronald Kox
发明人： Tim Stakenborg , Chengxun Liu , Liesbet Lagae , Ronald Kox
IPC分类号： C12Q1/06 , C12Q1/02 , H05K3/10 , C12M1/42
CPC分类号： G01N15/1209 , B01L2200/0668 , B01L2300/0636 , B01L2300/0645 , B03C5/005 , B03C5/026 , C12M41/36 , C12M47/04 , G01N15/1245 , G01N2015/1254 , Y10T29/49155
摘要： An active sieve device for the isolation and characterization of bio-analytes is provided, comprising a substrate for supporting the bio-analytes. The substrate comprises a plurality of interconnections and a plurality of regions, each region comprising a hole and at least one electrode embedded in or located on the substrate and electrically associated with the hole. Each region further comprises at least one transistor integrated in the substrate and operably connected to the at least one electrode and to at least one of the plurality of interconnections.
摘要翻译：提供了用于分离和表征生物分析物的活性筛分装置，其包括用于支持生物分析物的底物。衬底包括多个互连和多个区域，每个区域包括孔和至少一个电极，其嵌入或位于衬底上并与孔电连接。每个区域还包括集成在衬底中并且可操作地连接到至少一个电极和至少一个互连的至少一个晶体管。

2. 发明申请

US20120258544A1 Plasmonic Force Manipulation in Nanostructures 有权
标题翻译：纳米结构中的等离子体力学操作
公开(公告)号：US20120258544A1
公开(公告)日：2012-10-11
申请号：US13518570
申请日：2010-12-24
申请人： Chang Chen , Pol Van Dorpe , Kai Cheng , Tim Stakenborg , Liesbet Lagae
发明人： Chang Chen , Pol Van Dorpe , Kai Cheng , Tim Stakenborg , Liesbet Lagae
IPC分类号： G01N21/65
CPC分类号： B82Y15/00 , C12Q1/6869 , G01N33/48721 , G01N33/538 , Y10T436/143333 , C12Q2565/631 , C12Q2565/607
摘要： A system (100) is described for characterizing and/or manipulating molecules. The system may especially be suitable for biological molecules, although the invention is not limited thereto. The system (100) comprises a substrate (110) comprising a nanostructure (120) being suitable for translocation of molecules through the nanostructure (120). It furthermore comprises a means (210) for translocating molecules through the nanostructure (120) and a plasmonic force field generating means (130) adapted for influencing the translocation speed of the particle by applying a plasmonic force field at the nanostructure (120). A corresponding method also is described.
摘要翻译：描述了用于表征和/或操纵分子的系统（100）。该系统可以特别适用于生物分子，尽管本发明不限于此。该系统（100）包括一个衬底（110），该衬底（110）包括适合于通过纳米结构（120）的分子易位的纳米结构（120）。它还包括用于使分子转移通过纳米结构（120）的装置（210）和适于通过在纳米结构（120）处施加等离子体力场来影响颗粒的易位速度的等离子体激元场产生装置（130）。还描述了相应的方法。

3. 发明授权

US09862601B2 Plasmonic force manipulation in nanostructures 有权
公开(公告)号：US09862601B2
公开(公告)日：2018-01-09
申请号：US13518570
申请日：2010-12-24
申请人： Chang Chen , Pol Van Dorpe , Kai Cheng , Tim Stakenborg , Liesbet Lagae
发明人： Chang Chen , Pol Van Dorpe , Kai Cheng , Tim Stakenborg , Liesbet Lagae
IPC分类号： B82Y15/00 , G01N21/65 , C12Q1/68 , G01N33/487 , G01N33/538
CPC分类号： B82Y15/00 , C12Q1/6869 , G01N33/48721 , G01N33/538 , Y10T436/143333 , C12Q2565/631 , C12Q2565/607
摘要： A system (100) is described for characterizing and/or manipulating molecules. The system may especially be suitable for biological molecules, although the invention is not limited thereto. The system (100) comprises a substrate (110) comprising a nanostructure (120) being suitable for translocation of molecules through the nanostructure (120). It furthermore comprises a means (210) for translocating molecules through the nanostructure (120) and a plasmonic force field generating means (130) adapted for influencing the translocation speed of the particle by applying a plasmonic force field at the nanostructure (120). A corresponding method also is described.

4. 发明授权

US08409415B2 Manipulation of magnetic or magnetizable objects using magnetophoresis and dielectrophoresis 有权
标题翻译：使用组合的磁电泳和介电电泳操纵磁性或可磁化物体
公开(公告)号：US08409415B2
公开(公告)日：2013-04-02
申请号：US11844171
申请日：2007-08-23
申请人： Chengxun Liu , Liesbet Lagae
发明人： Chengxun Liu , Liesbet Lagae
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： B03C1/32 , B03C5/026 , B03C2201/18 , B03C2201/22 , B03C2201/26
摘要： A device for manipulating magnetic or magnetizable objects in a medium is provided. The device has a surface lying in a plane and comprises a set of at least two conductors electrically isolated from each other, wherein the at least two conductors are adapted for both generating a magnetophoresis force for moving the magnetic or magnetizable objects over the surface of the device in a direction substantially parallel to the plane of the surface, and generating a dielectrophoresis force for moving the magnetic or magnetizable objects in a direction substantially perpendicular to the plane of the surface. Also provided is a method for manipulating magnetic or magnetizable objects in a medium. The method uses a combined magnetophoresis and dielectrophoresis actuation principle for controlling in-plane as well as out-of-plane movement of the magnetic or magnetizable objects.
摘要翻译：提供了一种用于在介质中操纵磁性或可磁化物体的装置。该装置具有位于平面中的表面，并且包括彼此电隔离的一组至少两个导体，其中所述至少两个导体适于产生用于使磁性或可磁化物体在所述表面上移动的磁电泳力装置，其基本上平行于所述表面的平面，并且产生用于在基本上垂直于所述表面的平面的方向上移动所述磁性或可磁化物体的介电电泳力。还提供了一种用于操纵介质中的磁性或可磁化物体的方法。该方法使用组合的磁电泳和介电电泳致动原理来控制磁性或可磁化物体的面内以及平面外的运动。

5. 发明授权

US09597692B2 Micro-fluidic device for sorting particles, and methods for sorting particles 有权
公开(公告)号：US09597692B2
公开(公告)日：2017-03-21
申请号：US14241375
申请日：2012-08-27
申请人： Jorge A. Bernate , Chengxun Liu , Liesbet Lagae , German Drazer
发明人： Jorge A. Bernate , Chengxun Liu , Liesbet Lagae , German Drazer
IPC分类号： B03B5/28 , B01L3/00 , G01N33/49
CPC分类号： B03B5/28 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2300/0816 , B01L2300/0851 , B01L2300/0864 , B01L2400/086 , G01N33/491
摘要： A method and device for the sorting and focusing of suspended particles is disclosed. The device has a micro-fluidic channel, at least one inlet and a number of outlets for providing, sorting and receiving particles. A patterned array of grooves is present inside the micro-fluidic channel. The inlets and outlets are connected to the micro-fluidic channel. The particles are sorted by the array of grooves. The method consists of providing particles in a flow-focused manner to one end of the micro-fluidic channel using at least one inlet. The particles are sorted by the array of grooves present in the micro-fluidic channel. Particles are collected by a number of outlets which are connected to the other end of the micro-fluidic channel.

6. 发明申请

US20140174994A1 Micro-Fluidic Device for Sorting Particles, and Methods for Sorting Particles 有权
标题翻译：用于分选颗粒的微流体装置和用于分选颗粒的方法
公开(公告)号：US20140174994A1
公开(公告)日：2014-06-26
申请号：US14241375
申请日：2012-08-27
申请人： Jorge A. Bemate , Chengxun Liu , Liesbet Lagae , German Drazer
发明人： Jorge A. Bemate , Chengxun Liu , Liesbet Lagae , German Drazer
IPC分类号： B01L3/00 , B03B5/28
CPC分类号： B03B5/28 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2300/0816 , B01L2300/0851 , B01L2300/0864 , B01L2400/086 , G01N33/491
摘要： A method and device for the sorting and focusing of suspended particles is disclosed. The device has a micro-fluidic channel, at least one inlet and a number of outlets for providing, sorting and receiving particles. A patterned array of grooves is present inside the micro-fluidic channel. The inlets and outlets are connected to the micro-fluidic channel. The particles are sorted by the array of grooves. The method consists of providing particles in a flow-focused manner to one end of the micro-fluidic channel using at least one inlet. The particles are sorted by the array of grooves present in the micro-fluidic channel. Particles are collected by a number of outlets which are connected to the other end of the micro-fluidic channel.
摘要翻译：公开了一种用于分选和聚焦悬浮颗粒的方法和装置。该装置具有微流体通道，至少一个入口和多个出口，用于提供，分选和接收颗粒。在微流体通道内部存在图案化的凹槽阵列。入口和出口连接到微流体通道。颗粒由凹槽阵列排列。该方法包括使用至少一个入口以流动聚焦的方式将微粒提供到微流体通道的一端。颗粒通过微流体通道中存在的凹槽阵列进行分选。颗粒由连接到微流体通道另一端的多个出口收集。

7. 发明申请

US20130043132A1 MANIPULATION OF MAGNETIC OR MAGNETIZABLE OBJECTS USING COMBINED MAGNETOPHORESIS AND DIELECTROPHORESIS 有权
标题翻译：使用组合磁电和电介质来控制磁性或可磁化物体
公开(公告)号：US20130043132A1
公开(公告)日：2013-02-21
申请号：US11844171
申请日：2007-08-23
申请人： Chengxun Liu , Liesbet Lagae
发明人： Chengxun Liu , Liesbet Lagae
IPC分类号： G01N27/447 , C25B9/00
CPC分类号： B03C1/32 , B03C5/026 , B03C2201/18 , B03C2201/22 , B03C2201/26
摘要： A device for manipulating magnetic or magnetizable objects in a medium is provided. The device has a surface lying in a plane and comprises a set of at least two conductors electrically isolated from each other, wherein the at least two conductors are adapted for both generating a magnetophoresis force for moving the magnetic or magnetizable objects over the surface of the device in a direction substantially parallel to the plane of the surface, and generating a dielectrophoresis force for moving the magnetic or magnetizable objects in a direction substantially perpendicular to the plane of the surface. Also provided is a method for manipulating magnetic or magnetizable objects in a medium. The method uses a combined magnetophoresis and dielectrophoresis actuation principle for controlling in-plane as well as out-of-plane movement of the magnetic or magnetizable objects.
摘要翻译：提供了一种用于在介质中操纵磁性或可磁化物体的装置。该装置具有位于平面中的表面，并且包括彼此电隔离的一组至少两个导体，其中所述至少两个导体适于产生用于使磁性或可磁化物体在所述表面上移动的磁电泳力装置，其基本上平行于所述表面的平面，并且产生用于在基本上垂直于所述表面的平面的方向上移动所述磁性或可磁化物体的介电电泳力。还提供了一种用于操纵介质中的磁性或可磁化物体的方法。该方法使用组合的磁电泳和介电电泳致动原理来控制磁性或可磁化物体的面内以及平面外的运动。

8. 发明申请

US20100164487A1 Method for Ultra-Fast Controlling of a Magnetic Cell and Related Devices 有权
标题翻译：用于超快速控制磁性细胞和相关器件的方法
公开(公告)号：US20100164487A1
公开(公告)日：2010-07-01
申请号：US12648958
申请日：2009-12-29
申请人： Wouter Eyckmans , Liesbet Lagae
发明人： Wouter Eyckmans , Liesbet Lagae
IPC分类号： G01N27/72 , H01H55/00
CPC分类号： G01R33/02 , B82Y25/00 , G11C11/161 , G11C11/1673 , G11C11/1675 , H01F10/193 , H01F10/26 , H01F10/3213 , H01F10/3254 , H01F10/3268 , H01L43/08 , H03B15/006 , H03H2/001 , H03H9/02574 , H03H9/02645 , H03H9/02976 , H03H9/135 , H03H9/6486 , H03K19/19
摘要： The present invention relates to a device and corresponding method for ultrafast controlling of the magnetization of a magnetic element. A device (100) includes a surface acoustic wave generating means (102), a transport layer (104), which is typically functionally and partially structurally comprised in said SAW generating means (102), and at least one ferromagnetic element (106). A surface acoustic wave is generated and propagates in a transport layer (104) which typically consists of a piezo-electric material. Thus, strain is induced in the transport layer (104) and in the ferromagnetic element (106) in contact with this transport layer (104). Due to magneto elastic coupling this generates an effective magnetic field in the ferromagnetic element (106). If the surface acoustic wave has a frequency substantially close to the ferromagnetic resonance (FMR) frequency νFMR the ferromagnetic element (106) is absorbed well and the magnetization state of the element can be controlled with this FMR frequency. The device can be used in an RF-magnetic resonator, a sensor and a camera. The corresponding method can be used for ultrafast reading-out and switching of magnetic components and in magnetic logic.
摘要翻译：本发明涉及一种用于超快速控制磁性元件的磁化的装置和相应的方法。一种装置（100）包括表面声波产生装置（102），通常在功能上和部分结构上包括在所述SAW发生装置（102）中的传输层（104）和至少一个铁磁元件（106）。生成表面声波并在通常由压电材料组成的传输层（104）中传播。因此，在与该传输层（104）接触的传输层（104）和铁磁元件（106）中诱发应变。由于磁弹性耦合，这在铁磁元件（106）中产生有效的磁场。如果表面声波具有基本上接近铁磁共振（FMR）频率和频率FMR的频率，铁磁元件（106）被很好地吸收，并且可以用该FMR频率来控制元件的磁化状态。该器件可用于射频磁共振器，传感器和相机。相应的方法可用于磁性部件的超快速读出和切换以及磁逻辑。

9. 发明授权

US07719280B2 Detection of resonant tags by ultra-wideband (UWB) radar 有权
标题翻译：通过超宽带（UWB）雷达检测谐振标签
公开(公告)号：US07719280B2
公开(公告)日：2010-05-18
申请号：US11750155
申请日：2007-05-17
申请人： Liesbet Lagae , Gustaaf Borghs
发明人： Liesbet Lagae , Gustaaf Borghs
IPC分类号： G01V3/00
CPC分类号： G01S13/0209 , A61N1/403 , G01S7/411 , G01S13/75 , G01S13/753 , H04B1/7163
摘要： A detection system having a receiver for detecting a material having a magnetic resonance response to illumination by pulses of ultra-wideband (UWB) electromagnetic radiation is disclosed. The receiver comprises a detector for detecting the pulses after they have interacted with the material, and a discriminator arranged to identify in the detected pulses the magnetic resonance response of the material. By scanning an item tagged with a tag having a material having a magnetic resonant response, by illuminating the item with UWB pulses and identifying in detected pulses the magnetic resonance response of the material, items can be located, imaged, or activated. The magnetic resonance response of the tag can cause activation of the tag. The tag can have a magnetic resonance response arranged to provide an identifiable magnetic resonance signature such that different tags can be identified and distinguished by their signatures.
摘要翻译：公开了一种检测系统，其具有用于通过超宽带（UWB）电磁辐射的脉冲检测具有对照明的磁共振响应的材料的接收器。接收机包括用于在与材料相互作用之后检测脉冲的检测器，以及用于在检测到的脉冲中识别材料的磁共振响应的鉴别器。通过扫描具有具有磁共振响应的材料的标签的项目，通过用UWB脉冲照亮该项目并且在检测到的脉冲中识别材料的磁共振响应，物品可以被定位，成像或激活。标签的磁共振响应可能导致标签的激活。标签可以具有布置成提供可识别的磁共振签名的磁共振响应，使得可以通过其签名识别和区分不同的标签。

10. 发明授权

US07068537B2 Magnetic device and method of making the same 有权
公开(公告)号：US07068537B2
公开(公告)日：2006-06-27
申请号：US10703151
申请日：2003-11-06
申请人： Wayne Hiebert , Jo De Boeck , Liesbet Lagae , Roel Wirix-Speetjens
发明人： Wayne Hiebert , Jo De Boeck , Liesbet Lagae , Roel Wirix-Speetjens
IPC分类号： G11C11/14
CPC分类号： G11C11/16
摘要： A method and magnetic device for improving the desirable properties of a magnetic device, e.g., magnetization uniformity and reproducibility. Moreover the invention provides magnetic cells that are more magnetically homogeneous, with smaller amount of end domain magnetization canting from the average cell magnetization direction. The invention may provide a magnetic memory cell with less variation in switching fields, more spatially coherent dynamical magnetic properties for high speed and processional or coherent magnetic switching, and higher signal due to the increased uniformity. It may provide a magnetic sensor with more spatially coherent magnetic properties for high speed and processional or coherent magnetic switching, and increased signal. It may provide a read head element with more spatially coherent magnetic properties for high speed and processional or coherent magnetic sensing, and increased signal.

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