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1. 发明申请

US20170007569A1 COMPOSITIONS AND METHODS FOR PREPARATION OF POORLY WATER SOLUBLE DRUGS WITH INCREASED STABILITY 审中-公开
标题翻译：用于制备具有增加的稳定性的不良水溶性药物的组合物和方法
公开(公告)号：US20170007569A1
公开(公告)日：2017-01-12
申请号：US15178469
申请日：2016-06-09
申请人： ABRAXIS BIOSCIENCE, LLC
发明人： Tapas DE , Neil P. DESAI , Andrew YANG , Zachary YIM , Patrick SOON-SHIONG
IPC分类号： A61K31/337 , A61K9/51 , A61K47/26 , A61K47/12 , A61K47/02 , A61K47/42 , A61K9/19
CPC分类号： A61K31/337 , A61K9/0019 , A61K9/19 , A61K9/5169 , A61K38/13 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/42 , Y02A50/473 , Y10S977/702 , Y10S977/705 , Y10S977/773 , Y10S977/788 , Y10T428/2982 , A61K2300/00
摘要： The present invention provides stable pharmaceutical compositions of poorly water soluble pharmaceutical agents and stabilizing agents which function to increase stability of the compositions. The use of stabilizing agents provide extended stability of nanoparticle suspensions and other formulations of poorly water soluble pharmaceutical agents such as docetaxel under certain conditions, for example upon dilution for administration.
摘要翻译：本发明提供用于提高组合物稳定性的稳定的水溶性较差的药剂和稳定剂的稳定药物组合物。稳定剂的使用提供了在某些条件下，例如稀释给药时，纳米颗粒悬浮液和水溶性差的药物如多西紫杉醇的其它制剂的稳定性。

2. 发明授权

US08628980B2 Optical microlabels: shapes and reflectors 失效
标题翻译：光学微标签：形状和反射镜
公开(公告)号：US08628980B2
公开(公告)日：2014-01-14
申请号：US13562260
申请日：2012-07-30
申请人： Richard C. Willson , Raul Ruchhoedft
发明人： Richard C. Willson , Raul Ruchhoedft
IPC分类号： G01N33/543
CPC分类号： G01N33/54373 , B82Y5/00 , C12Q1/6837 , Y10S436/805 , Y10S977/701 , Y10S977/702 , Y10S977/704 , Y10S977/705 , Y10S977/773 , Y10S977/774 , Y10S977/834 , Y10S977/92 , C12Q2563/155
摘要： Labels and methods of producing labels for use in clinical, analytical and pharmaceutical development assays are provided. Labels may comprise shape-encoded particles which may be coupled to ligands such as DNA, RNA and antibodies, where different shapes are used to identify which ligand(s) are present. Labels may also comprise reflectors, including retroreflectors and retroreflectors susceptible to analyte-dependent assembly for efficient homogeneous assays.
摘要翻译：提供了生产用于临床，分析和药物开发测定的标签的标签和方法。标签可以包括可以与诸如DNA，RNA和抗体的配体偶联的形状编码的颗粒，其中使用不同的形状来鉴定哪些配体存在。标签还可以包括反射器，包括对分析物依赖性装配易于进行有效均匀测定的后向反射器和后向反射器。

3. 发明授权

US08209127B2 Molecular communication system and molecular communication method 有权
标题翻译：分子通信系统和分子通信方法
公开(公告)号：US08209127B2
公开(公告)日：2012-06-26
申请号：US11740466
申请日：2007-04-26
申请人： Yuki Moritani , Satoshi Hiyama , Tatsuya Suda
发明人： Yuki Moritani , Satoshi Hiyama , Tatsuya Suda
IPC分类号： G01N33/50 , C12P19/34 , C12Q1/58
CPC分类号： H04B13/00 , Y10S977/702
摘要： A molecular communication system includes a molecular transmitter (20) configured to transmit an information molecules (15) onto which prescribed information is encoded; a molecular receiver (30) configured to receive the information molecule, a molecule propagation channel (40) extending from the molecular transmitter to the molecular receiver, and a molecular capsule (10) configured to encapsulate the information molecules to be transmitted from the molecular transmitter to the molecular receiver, wherein the surfaces of the molecular transmitter, the molecular receiver, and the molecular capsule have lipid bilayer membrane structure, and wherein the system further includes encapsulation means for applying a first chemical substance to the molecular transmitter, or to the molecular transmitter and the molecular capsule to encapsulate the information molecules into the molecular capsule, and decapsulation means for applying a second chemical substance to the molecular capsule and the molecular receiver to take the information molecules out of the molecular capsule and take them into the molecular receiver.
摘要翻译：分子通信系统包括分配发射机（20），其被配置为传送其上编码有规定信息的信息分子（15）被配置为接收所述信息分子的分子接收器（30），从所述分子发射器延伸到所述分子接收器的分子传播通道（40）以及分子胶囊（10），被配置为封装要从所述分子发射器传输的信息分子其中分子发射器，分子接收器和分子胶囊的表面具有脂质双层膜结构，并且其中所述系统还包括用于将第一化学物质施加到分子发射器或分子发射器和分子胶囊将信息分子包封到分子胶囊中，以及解封装置，用于将第二化学物质施加到分子胶囊和分子接收器以将信息分子从分子胶囊中取出并将其带入分子接收器。

4. 发明申请

US20110172390A1 Protein-Proteophore Complexes 有权
标题翻译：蛋白质 - 蛋白质复合物
公开(公告)号：US20110172390A1
公开(公告)日：2011-07-14
申请号：US12967285
申请日：2010-12-14
申请人： Dirk Vetter , Ulrich Hersel , Harald Rau , Robert Schnepf , Thomas Wegge
发明人： Dirk Vetter , Ulrich Hersel , Harald Rau , Robert Schnepf , Thomas Wegge
IPC分类号： A61K38/28 , C07K14/805
CPC分类号： B82Y5/00 , A61K47/56 , A61K47/6949 , Y10S977/70 , Y10S977/702 , Y10S977/705 , Y10S977/754
摘要： The application relates to a composition comprising a hyperbranched polymer attached to a core and a biologically active moiety. The biologically active moiety is attached to the core by means of a substantially non-enzymatically cleavable linker L. The composition can be used to deliver the biologically active moiety to its target.
摘要翻译：本申请涉及包含连接到核和生物活性部分的超支化聚合物的组合物。生物活性部分通过基本上非酶切割的接头L连接到芯上。该组合物可用于将生物活性部分递送至其靶。

5. 发明申请

US20110049412A1 Fluorescent Carbon Nanoparticles 审中-公开
标题翻译：荧光碳纳米粒子
公开(公告)号：US20110049412A1
公开(公告)日：2011-03-03
申请号：US12941561
申请日：2010-11-08
申请人： Ya-Ping Sun
发明人： Ya-Ping Sun
IPC分类号： C09K11/08 , B32B5/16 , H01F1/00 , B82Y30/00
CPC分类号： C09K11/025 , C01B32/05 , C09K11/65 , G01N33/587 , Y10S977/70 , Y10S977/702 , Y10S977/703 , Y10S977/704 , Y10S977/705 , Y10S977/773 , Y10T428/2982 , Y10T428/2991 , Y10T428/2998
摘要： Disclosed are photoluminescent particles. The particles include a core nano-sized particle of carbon and a passivation agent bound to the surface of the nanoparticle. The passivation agent can be, for instance, a polymeric material. The passivation agent can also be derivatized for particular applications. For example, the photoluminescent carbon nanoparticles can be derivatized to recognize and bind to a target material, for instance a biologically active material, a pollutant, or a surface receptor on a tissue or cell surface, such as in a tagging or staining protocol.
摘要翻译：披露的是光致发光颗粒。颗粒包括核心纳米尺寸的碳颗粒和与纳米颗粒表面结合的钝化剂。钝化剂可以是例如聚合物材料。钝化剂也可以为特定应用衍生化。例如，可以将光致发光碳纳米颗粒衍生化以识别和结合目标材料，例如组织或细胞表面上的生物活性材料，污染物或表面受体，例如标记或染色方案。

6. 发明授权

US07879588B2 Protein-proteophore complexes 有权
标题翻译：蛋白质 - 蛋白质复合物
公开(公告)号：US07879588B2
公开(公告)日：2011-02-01
申请号：US10574213
申请日：2004-10-01
申请人： Dirk Vetter , Ulrich Hersel , Harald Rau , Robert Schnepf , Thomas Wegge
发明人： Dirk Vetter , Ulrich Hersel , Harald Rau , Robert Schnepf , Thomas Wegge
IPC分类号： C12N9/48 , A61K48/00 , A61K38/48
CPC分类号： B82Y5/00 , A61K47/56 , A61K47/6949 , Y10S977/70 , Y10S977/702 , Y10S977/705 , Y10S977/754
摘要： The application relates to a composition comprising a hyperbranched polymer attached to a core and a biologically active moiety. The biologically active moiety is attached to the core by means of a substantially non-enzymatically cleavable linker L. The composition can be used to deliver the biologically active moiety to its target.
摘要翻译：本申请涉及包含连接到核和生物活性部分的超支化聚合物的组合物。生物活性部分通过基本上非酶切割的接头L连接到芯上。该组合物可用于将生物活性部分递送至其靶。

7. 发明授权

US07611579B2 Systems and methods for synthesis of extended length nanostructures 有权
标题翻译：用于合成延长长度纳米结构的系统和方法
公开(公告)号：US07611579B2
公开(公告)日：2009-11-03
申请号：US11035471
申请日：2005-01-14
申请人： David Lashmore , Joseph J. Brown , Robert C. Dean, Jr. , Peter L. Antoinette
发明人： David Lashmore , Joseph J. Brown , Robert C. Dean, Jr. , Peter L. Antoinette
IPC分类号： C30B23/00 , C30B28/12 , H01L21/322 , C03C17/00
CPC分类号： B82Y40/00 , B82Y10/00 , B82Y30/00 , C01B32/162 , C01B2202/34 , Y10S438/909 , Y10S977/70 , Y10S977/701 , Y10S977/702 , Y10S977/844 , Y10S977/89 , Y10S977/963 , Y10T428/249978 , Y10T428/2916 , Y10T428/2918 , Y10T428/298 , Y10T442/60 , Y10T442/605
摘要： A system for synthesizing nanostructures using chemical vapor deposition (CVD) is provided. The system includes a housing, a porous substrate within the housing, and on a downstream surface of the substrate, a plurality of catalyst particles from which nanostructures can be synthesized upon interaction with a reaction gas moving through the porous substrate. Electrodes may be provided to generate an electric field to support the nanostructures during growth. A method for synthesizing extended length nanostructures is also provided. The nanostructures are useful as heat conductors, heat sinks, windings for electric motors, solenoid, transformers, for making fabric, protective armor, as well as other applications.
摘要翻译：提供了一种使用化学气相沉积（CVD）合成纳米结构的系统。该系统包括壳体，壳体内的多孔基底，以及在基底的下游表面上，多个催化剂颗粒，当与通过多孔基底移动的反应气体相互作用时，可从该催化剂颗粒合成纳米结构。可以提供电极以在生长期间产生电场以支持纳米结构。还提供了一种合成延伸长度纳米结构的方法。纳米结构可用作热导体，散热器，用于电动机的绕组，螺线管，变压器，用于制造织物，保护性装甲以及其它应用。

8. 发明申请

US20090074875A1 Nanoparticulate compositions having lysozyme as a surface stabilizer 有权
标题翻译：具有溶菌酶作为表面稳定剂的纳米颗粒组合物
公开(公告)号：US20090074875A1
公开(公告)日：2009-03-19
申请号：US12292091
申请日：2008-11-12
申请人： Christian F. Wertz , Niels P. Ryde
发明人： Christian F. Wertz , Niels P. Ryde
IPC分类号： A61K47/42 , A61K9/16
CPC分类号： A61K47/42 , A61K8/02 , A61K8/66 , A61K9/145 , A61K9/146 , A61K31/045 , A61K31/047 , A61K31/192 , A61K31/327 , A61K31/337 , A61K31/496 , A61K31/569 , A61K31/573 , A61K31/58 , A61K33/04 , A61K45/06 , A61K47/6907 , A61K49/0438 , A61K2800/413 , A61Q19/00 , B82Y5/00 , Y10S977/702 , Y10S977/717 , Y10S977/739 , Y10S977/904 , Y10S977/914
摘要： The present invention is directed to nanoparticulate active agent compositions comprising lysozyme as a surface stabilizer. Also encompassed by the invention are pharmaceutical compositions comprising a nanoparticulate active agent composition of the invention and methods of making and using such nanoparticulate and pharmaceutical compositions.
摘要翻译：本发明涉及包含溶菌酶作为表面稳定剂的纳米颗粒活性剂组合物。本发明还包括包含本发明的纳米颗粒活性剂组合物的药物组合物以及制备和使用这些纳米颗粒和药物组合物的方法。

9. 发明申请

US20090010871A1 Method for Production of a Transformed Cell 有权
标题翻译：生产转化细胞的方法
公开(公告)号：US20090010871A1
公开(公告)日：2009-01-08
申请号：US12280499
申请日：2007-02-21
申请人： Christoph Erbacher , Ute Kruger
发明人： Christoph Erbacher , Ute Kruger
IPC分类号： A61K31/77 , C12N15/00 , A61K35/12 , C08G59/02
CPC分类号： A61K48/00 , A61K47/59 , C07H21/00 , C12N15/87 , Y10S977/702
摘要： The invention relates to a method for incorporation of a biomolecule into a cell including the method steps: i) production of a complex from a biomolecule, preferably a nucleic acid and a polymer which may be obtained by reaction of an amine monomer having at least two amine groups with an epoxide monomer having at least two epoxide groups and ii) incorporation of the biomolecule into a cell bx bringing the cell into contact with the complex. The invention further relates to the transformed cell obtained by said method, the use of a particular polymer for incorporation of a biomolecule into a cell, a kit for incorporation of a biomolecule into a cell, the use of said kit, a complex made from a biomolecule and a polymer, a therapeutic composition, the use of a complex of a biomolecule and a polymer for therapeutic treatment of the human or animal being and a method for treatment of a disease by means of gene therapy.
摘要翻译：本发明涉及用于将生物分子结合到细胞中的方法，包括以下步骤：i）从生物分子，优选核酸和聚合物制备复合物，所述核酸和聚合物可以通过具有至少两个胺基与具有至少两个环氧基团的环氧化物单体，和ii）将生物分子掺入到使细胞与复合物接触的细胞bx中。本发明还涉及通过所述方法获得的转化细胞，将特定聚合物用于将生物分子并入细胞中的用途，用于将生物分子并入细胞的试剂盒，所述试剂盒的使用，由生物分子和聚合物，治疗组合物，生物分子和聚合物的复合物在人或动物的治疗中的用途以及通过基因治疗治疗疾病的方法。

10. 发明授权

US07459283B2 Nanoparticulate compositions having lysozyme as a surface stabilizer 有权
标题翻译：具有溶菌酶作为表面稳定剂的纳米颗粒组合物
公开(公告)号：US07459283B2
公开(公告)日：2008-12-02
申请号：US10357514
申请日：2003-02-04
申请人： Christian F. Wertz , Niels P. Ryde
发明人： Christian F. Wertz , Niels P. Ryde
IPC分类号： C12Q1/34 , A61K38/47 , A61K39/40 , B82B3/00
CPC分类号： A61K47/42 , A61K8/02 , A61K8/66 , A61K9/145 , A61K9/146 , A61K31/045 , A61K31/047 , A61K31/192 , A61K31/327 , A61K31/337 , A61K31/496 , A61K31/569 , A61K31/573 , A61K31/58 , A61K33/04 , A61K45/06 , A61K47/6907 , A61K49/0438 , A61K2800/413 , A61Q19/00 , B82Y5/00 , Y10S977/702 , Y10S977/717 , Y10S977/739 , Y10S977/904 , Y10S977/914
摘要： The present invention is directed to nanoparticulate active agent compositions comprising lysozyme as a surface stabilizer. Also encompassed by the invention are pharmaceutical compositions comprising a nanoparticulate active agent composition of the invention and methods of making and using such nanoparticulate and pharmaceutical compositions.
摘要翻译：本发明涉及包含溶菌酶作为表面稳定剂的纳米颗粒活性剂组合物。本发明还包括包含本发明的纳米颗粒活性剂组合物的药物组合物以及制备和使用这些纳米颗粒和药物组合物的方法。

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