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1. 发明授权

US09952135B2 Microfluidic interrogation device 有权
公开(公告)号：US09952135B2
公开(公告)日：2018-04-24
申请号：US15006332
申请日：2016-01-26
申请人： E. I. SPECTRA, LLC
发明人： Harold E. Ayliffe
IPC分类号： G01N15/14 , H01J49/00 , G01N35/00 , G01N27/00 , B01L3/00 , G01N15/12 , G06F17/40 , G06F19/00 , B01L99/00 , G01N15/10 , G01N33/49
CPC分类号： G01N15/1404 , B01L3/502715 , B01L3/502761 , B01L99/00 , B01L2300/0645 , B01L2300/0874 , B01L2300/0887 , B01L2400/0487 , G01N15/1056 , G01N15/12 , G01N15/1209 , G01N15/1456 , G01N15/1463 , G01N27/00 , G01N33/49 , G01N35/00 , G01N2015/1037 , G01N2015/1062 , G01N2015/1087 , G01N2035/00306 , G06F17/40 , G06F19/00 , H01J49/0013 , H01J49/0022
摘要： A portable, stand-alone microfluidic interrogation device including a microprocessor and a touch-screen display. The touch-screen display can receive one or more user input to select a particular particle interrogation procedure, and subsequently show interrogation results. A microfluidic path extending through the interrogation device includes alignment structure that defines an interrogation zone in which particles carried in a fluid are urged toward single-file travel. Operable alignment structure may define sheath-, or non-sheath fluid flow. Desirably, a portion of the alignment structure is removable from the device in a tool-free procedure. The device may operate under the Coulter principle, and/or detect Stokes' shift phenomena, and/or other optically-based signal(s).

2. 发明申请

US20160025610A1 MEASUREMENT APPARATUS AND MEASUREMENT METHOD 审中-公开
标题翻译：测量装置和测量方法
公开(公告)号：US20160025610A1
公开(公告)日：2016-01-28
申请号：US14775099
申请日：2014-02-07
申请人： SONY CORPORATION
发明人： Yoichi Katsumoto , Kazumasa Sato , Marcaurele Brun
IPC分类号： G01N15/12 , G01N15/02
CPC分类号： G01N15/1209 , G01N15/0266 , G01N15/1031 , G01N15/1056 , G01N15/1227 , G01N2015/0065 , G01N2015/1081
摘要： A measurement apparatus includes a generation section and a measurement section and performs a predetermined measurement using a flow channel device including a narrow channel through which particles pass by a flow of a fluid and a measurement electrode section provided in the vicinity of the narrow channel. The generation section generates, in the measurement electrode section, an AC voltage that is higher than a characteristic frequency defined by a conductance of the fluid including the particles in the narrow channel and an electrical double layer capacitance formed by the measurement electrode section and has a frequency range indicating a conductance corresponding to a size of the particles. The measurement section measures, while the AC voltage is applied to the measurement electrode section, an electrical amount including at least the conductance obtained when the particles pass through the narrow channel.
摘要翻译：测量装置包括生成部分和测量部分，并且使用包括通过流体的微粒通过的窄通道的流道装置和设置在窄通道附近的测量电极部分的流路装置进行预定的测量。该生成部在测量电极部中产生高于由窄通道中包含粒子的流体的导电性所决定的特性频率的AC电压和由测量电极部形成的双电层电容，频率范围表示对应于颗粒尺寸的电导。测量部分测量交流电压被施加到测量电极部分时，至少包括当粒子通过窄通道时获得的电导的电量。

3. 发明授权

US08790929B2 Reagent for diluting blood sample and method for measuring mean corpuscular volume by using the same 有权
标题翻译：用于稀释血液样本的试剂和通过使用相同的方法测量平均红细胞体积
公开(公告)号：US08790929B2
公开(公告)日：2014-07-29
申请号：US12497952
申请日：2009-07-06
申请人： Yusuke Mori , Kinya Uchihashi , Yasuhiro Sakai
发明人： Yusuke Mori , Kinya Uchihashi , Yasuhiro Sakai
IPC分类号： G01N33/48
CPC分类号： G01N1/38 , G01N15/1209 , G01N2015/1236
摘要： The invention provides a reagent for diluting a blood sample, comprising water, polyoxyethylene alkyl ether having a hydroxyl value of 52 to 60, and an osmo-regulator for regulating the osmotic pressure of the reagent in the range of 150 to 400 mOsm/kg, as well as a method for measuring the mean corpuscular volume of a blood sample.
摘要翻译：本发明提供了一种用于稀释血液样品的试剂，包括水，羟值为52至60的聚氧乙烯烷基醚和用于调节试剂渗透压的渗透压调节剂，范围为150-400mOsm / kg，以及用于测量血液样品的平均红细胞体积的方法。

4. 发明授权

US08720288B2 Counter assembly, sheath flow impedance count device, and flow cytometer analyzer 有权
标题翻译：计数器组件，鞘流阻抗计数器和流式细胞仪分析仪
公开(公告)号：US08720288B2
公开(公告)日：2014-05-13
申请号：US13335763
申请日：2011-12-22
申请人： Tao Shen , Wenheng Guo , Jin Teng
发明人： Tao Shen , Wenheng Guo , Jin Teng
IPC分类号： G01N27/00
CPC分类号： G01N15/1209
摘要： A counter assembly, sheath flow impedance count device, and flow cytometer analyzer are disclosed.
摘要翻译：公开了一种计数器组件，鞘流阻抗计数装置和流式细胞仪分析仪。

5. 发明申请

US20110027826A1 LEUKOCYTE ANALYSIS METHOD AND ANALYSIS REAGENT FOR USE IN THE METHOD 审中-公开
标题翻译：方法中使用的低分子量分析方法和分析试剂
公开(公告)号：US20110027826A1
公开(公告)日：2011-02-03
申请号：US12936630
申请日：2009-04-30
申请人： Hiroshi Fukuya , Hidenon Iakagi
发明人： Hiroshi Fukuya , Hidenon Iakagi
IPC分类号： C12Q1/06
CPC分类号： G01N33/5094 , G01N15/1056 , G01N15/12 , G01N15/1209 , G01N2015/008 , G01N2015/1062 , G01N2015/1087
摘要： The present invention provides a method for analyzing leukocytes, by which the leukocytes can be classified and measured stably with high accuracy even when a dilution ratio of a sample containing the leukocytes is low or a flow velocity during the analysis is slow, and an analysis reagent used for the analysis method. The analysis method of the present invention includes the steps of mixing a sample containing leukocytes and erythrocytes and an analysis reagent containing a surfactant that reacts with leukocytes; and measuring the leukocytes by passing a mixed solution of the sample and the analysis reagent through a fine through-hole, measuring a signal detected when the mixed solution passes through the fine through-hole, and classifying and counting the leukocytes in the sample. The analysis reagent further contains a nonionic surfactant, and the nonionic surfactant has a sugar residue as a hydrophilic region and an aliphatic chain as a hydrophobic region.
摘要翻译：本发明提供一种分析白细胞的方法，即使在含有白细胞的样品的稀释倍数低或分析时的流速缓慢的情况下，白细胞可以以高精度稳定地分类和测定，分析试剂用于分析方法。本发明的分析方法包括将含有白细胞和红细胞的样品和含有与白细胞反应的表面活性剂的分析试剂混合的步骤; 通过细孔通过样品和分析试剂的混合溶液来测量白细胞，测量当混合溶液通过细通孔时检测到的信号，并对样品中的白细胞进行分类和计数。分析试剂还含有非离子表面活性剂，非离子表面活性剂具有作为亲水性区域的糖残基和疏水性区域的脂肪族链。

6. 发明申请

US20100228491A1 Cross-Instrument Method and System for Cell Population Discrimination 有权
标题翻译：用于细胞群体歧视的跨仪器方法和系统
公开(公告)号：US20100228491A1
公开(公告)日：2010-09-09
申请号：US12397650
申请日：2009-03-04
申请人： William H. GUTIERREZ , Cheng Qian , John S. Riley
发明人： William H. GUTIERREZ , Cheng Qian , John S. Riley
IPC分类号： G06F19/00
CPC分类号： G01N15/1429 , G01N15/12 , G01N15/1209 , G01N15/147 , G01N2015/0073 , G01N2015/008 , G01N2015/1037 , G01N2015/1497
摘要： The present invention provides methods and systems to combine the capabilities of a hematology analyzer with those of a flow cytometer to yield a far more powerful analytical system than either device alone. In one embodiment, a method of analyzing a cell sample includes receiving a first data generated by an analysis of a first aliquot of the sample on a first particle analyzer having a fluorescence measurement device such as a flow cytometer, detecting at least one unresolved cell population in the first data, and accessing a second data stored on a storage device wherein the second data was previously generated by interrogating a second aliquot of the sample using at least one of a cell volume measurement device and a cell conductivity measurement device in a second particle analyzer such as a hematology analyzer. The unresolved cell population in the first data is then resolved using the second data. Corresponding system embodiments are also disclosed.
摘要翻译：本发明提供了将血液分析仪的能力与流式细胞仪的能力相结合的方法和系统，以产生比任何一种装置更强大的分析系统。在一个实施方案中，分析细胞样品的方法包括通过在具有荧光测量装置例如流式细胞仪的第一粒子分析仪上接收样品的第一等分试样产生的第一数据，检测至少一个未解析的细胞群并且访问存储在存储设备上的第二数据，其中先前通过使用第二粒子中的细胞体积测量装置和细胞电导率测量装置中的至少一个询问样品的第二等分试样来生成第二数据分析仪如血液分析仪。然后使用第二数据来解析第一数据中的未解析细胞群。还公开了相应的系统实施例。

7. 发明授权

US5094818A Self-filling anti-siphon flow system for particle analysis 失效
标题翻译：自动填充反SIPHON流程系统进行粒子分析
公开(公告)号：US5094818A
公开(公告)日：1992-03-10
申请号：US347522
申请日：1989-05-04
申请人： Millard Longman , Oscar Proni , Richard A. Burdman
发明人： Millard Longman , Oscar Proni , Richard A. Burdman
IPC分类号： G01N33/49 , G01N1/00 , G01N15/00 , G01N15/10 , G01N15/12 , G01N15/14
CPC分类号： G01N15/1209 , G01N35/1095
摘要： A fluid flow system for use with an analytical instrument is provided having a sample reservoir for holding a liquid suspension of particles to be analyzed, a reagent reservoir for holding a reagent, pump means for pumping fluid to and from the reservoirs to a pumping reservoir, valve means for restricting fluid flow from the reagent reservoir to the pumping reservoir, first conduit means interconnecting the reagent and sample reservoirs, second conduit means connecting the sample and pumping reservoir at a point just behind a metered aperture provided in an end of the second conduit means, and in a preferred embodiment, third conduit means connecting the first and second reservoirs and valve means for restricting fluid flow from the reagent reservoir to the pumping reservoir through the third conduit means, the end of each of the conduit means being maintained at the same physical level.

8. 发明授权

US4607526A Particle analysis system 失效
标题翻译：粒子分析系统
公开(公告)号：US4607526A
公开(公告)日：1986-08-26
申请号：US684833
申请日：1984-12-21
申请人： Bernard O. Bachenheimer , Frank J. Antoci , Edward L. Carver, Jr. , Ernest N. Pellegrino , Richard C. Seltenreich
发明人： Bernard O. Bachenheimer , Frank J. Antoci , Edward L. Carver, Jr. , Ernest N. Pellegrino , Richard C. Seltenreich
IPC分类号： G01N1/00 , G01N15/12 , G01N15/10
CPC分类号： G01N35/1097 , G01N15/1209 , Y10T137/86445 , Y10T137/87249 , Y10T137/87788
摘要： A system that is particularly useful in biological fluid analysis includes a face plate member and a mating flexible member, one of which has a plurality of passages. Selected motion of the flexible member provides a valving action to control fluid flow into, through, and out of the passages. An analysis chamber in a surface of the face plate member is in fluid communication with a passage and has an analyzer which, for a hematology analyzer, is preferably an impedance-type particle counter.
摘要翻译：在生物流体分析中特别有用的系统包括面板构件和配合柔性构件，其中一个具有多个通道。柔性构件的选定的运动提供了一种阀门动作，以控制流入，通过和流出通道的流体流动。面板部件的表面中的分析室与通道流体连通，并且具有用于血液分析仪优选为阻抗型粒子计数器的分析器。

9. 发明授权

US4338564A Hematology control composition and methods for its use 失效
标题翻译：血液学控制组成及其使用方法
公开(公告)号：US4338564A
公开(公告)日：1982-07-06
申请号：US204238
申请日：1980-11-05
申请人： David D. Mundschenk
发明人： David D. Mundschenk
IPC分类号： G01N15/12 , G01N33/96 , G01N27/00
CPC分类号： G01N33/96 , G01N15/1209 , G01N2496/05
摘要： A control blood platelet preparation containing a population of platelets of known count range, electronic volume and electronic volume size distribution is used to check the threshold setting calibrations of an electronic particle counter. The control preparation preferably contains blood platelets from whole blood taken from animal species which are non-infectious with respect to human hepatitis, ideally animals of the bovine and parcine species.
摘要翻译：使用包含已知计数范围，电子体积和电子体积大小分布的血小板群的对照血小板制剂来检查电子粒子计数器的阈值设置校准。对照制剂优选含有从取自动物物种的全血的血小板，对于人类肝炎而言是非感染性的，理想地是牛和鹦鹉属的动物。

10. 发明授权

US4307339A Particle counter 失效
标题翻译：粒子计数器
公开(公告)号：US4307339A
公开(公告)日：1981-12-22
申请号：US101839
申请日：1979-12-10
申请人： Michael W. Ferrell
发明人： Michael W. Ferrell
IPC分类号： G01N15/12 , G01N27/00
CPC分类号： G01N15/1209 , G01N15/1218
摘要： A particle counter for determining the size and count of particulate substances suspended in an electrolytic solution includes a tube having an inlet hole for the passage of the solution therethrough, a pump connected to the tube for drawing the solution into the tube through the inlet hole, a pair of electrodes arranged on either side of the inlet hole in the flow path of the solution, and voltage monitoring apparatus for sensing fluctuations of voltage across the electrodes as particles pass through the inlet. A screen having precision size openings is disposed about the tube in the flow path of the solution prior to passage through the inlet hole for screening particles above a pre-determined size prior to reaching the inlet hole.
摘要翻译：用于确定悬浮在电解液中的颗粒物质的尺寸和数量的颗粒计数器包括具有用于溶液通过的入口孔的管，连接到管的泵，用于通过入口孔将溶液吸入管中，布置在溶液的流动路径中的入口孔的两侧的一对电极以及用于当粒子通过入口时感测电极两端的电压的波动的电压监视装置。具有精密尺寸开口的筛网在通过入口孔之前围绕管道的流动路径布置，用于在到达入口孔之前筛选高于预定尺寸的颗粒。

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