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1. 发明申请

US20120002207A1 Method for Determining an Analyte in a Sample 有权
标题翻译：测定样品中分析物的方法
公开(公告)号：US20120002207A1
公开(公告)日：2012-01-05
申请号：US13232794
申请日：2011-09-14
申请人： Iwijn De Vlaminck , Pol Van Dorpe , Liesbet Lagae
发明人： Iwijn De Vlaminck , Pol Van Dorpe , Liesbet Lagae
IPC分类号： G01N21/55
CPC分类号： G01N21/554 , B82Y15/00 , G01N2021/258
摘要： In one aspect of the invention, a method or apparatus is described for determining concentration(s) of one or more analytes in a sample using plasmonic excitations. In another aspect, a method relates to designing systems for such concentration determination, wherein metallic nanostructures are used in combination with local electrical detection of such plasmon resonances via a semiconducting photodetector. In certain aspects, the method exploits the coupling of said metallic nanostructure(s) to a semiconducting photodetector, said detector being placed in the “metallic structure's” near field. Surface plasmon excitation can be transduced efficiently into an electrical signal through absorption of light that is evanescently coupled or scattered in a semiconductor volume. This local detection technique allows the construction of sensitive nanoscale bioprobes and arrays thereof.
摘要翻译：在本发明的一个方面，描述了一种用于使用等离子体激发来测定样品中一种或多种分析物的浓度的方法或装置。在另一方面，一种方法涉及设计用于这种浓度测定的系统，其中金属纳米结构经由半导体光电检测器与这种等离子体共振的局部电检测结合使用。在某些方面，该方法利用所述金属纳米结构与半导体光电检测器的耦合，所述检测器被放置在“金属结构”的近场中。表面等离子体激发可以通过吸收在半导体体积中瞬时耦合或散射的光而有效地转换成电信号。这种局部检测技术允许构建敏感的纳米级生物探针及其阵列。

2. 发明授权

US08027040B2 Method for determining an analyte in a sample 有权
标题翻译：测定样品中分析物的方法
公开(公告)号：US08027040B2
公开(公告)日：2011-09-27
申请号：US12220346
申请日：2008-07-24
申请人： Iwijn De Vlaminck , Pol Van Dorpe , Liesbet Lagae
发明人： Iwijn De Vlaminck , Pol Van Dorpe , Liesbet Lagae
IPC分类号： G01N21/55
CPC分类号： G01N21/554 , B82Y15/00 , G01N2021/258
摘要： In one aspect of the invention, a method or apparatus is described for determining concentration(s) of one or more analytes in a sample using plasmonic excitations. In another aspect, a method relates to designing systems for such concentration determination, wherein metallic nanostructures are used in combination with local electrical detection of such plasmon resonances via a semiconducting photodetector. In certain aspects, the method exploits the coupling of said metallic nanostructure(s) to a semiconducting photodetector, said detector being placed in the “metallic structure's” near field. Surface plasmon excitation can be transduced efficiently into an electrical signal through absorption of light that is evanescently coupled or scattered in a semiconductor volume. This local detection technique allows the construction of sensitive nanoscale bioprobes and arrays thereof.
摘要翻译：在本发明的一个方面，描述了一种用于使用等离子体激发来测定样品中一种或多种分析物的浓度的方法或装置。在另一方面，一种方法涉及设计用于这种浓度测定的系统，其中金属纳米结构经由半导体光电检测器与这种等离子体共振的局部电检测结合使用。在某些方面，该方法利用所述金属纳米结构与半导体光电检测器的耦合，所述检测器被放置在“金属结构”的近场中。表面等离子体激发可以通过吸收在半导体体积中瞬时耦合或散射的光而有效地转换成电信号。这种局部检测技术允许构建敏感的纳米级生物探针及其阵列。

3. 发明授权

US08810787B2 Single molecule optical spectroscopy in solid-state nanopores in a transmission-based approach 有权
标题翻译：在基于透射的方法中的固态纳米孔中的单分子光谱
公开(公告)号：US08810787B2
公开(公告)日：2014-08-19
申请号：US13133525
申请日：2009-12-09
申请人： Pol Van Dorpe , Iwijn De Vlaminck , Liesbet Lagae , Gustaaf Borghs
发明人： Pol Van Dorpe , Iwijn De Vlaminck , Liesbet Lagae , Gustaaf Borghs
IPC分类号： G01J3/44
CPC分类号： B82Y15/00 , B82Y20/00 , B82Y40/00 , G01N21/554 , G01N21/648 , G01N21/658 , G01N33/48721 , G01N2021/653 , Y10S977/724 , Y10S977/924
摘要： Methods and apparatus in the field of single molecule sensing are described, e.g. for molecular analysis of analytes such as molecular analytes, e.g. nucleic acids, proteins, polypeptides, peptides, lipids and polysaccharides. Molecular spectroscopy on a molecule translocating through a solid-state nanopore is described. Optical spectroscopic signals are enhanced by plasmonic field-confinement and antenna effects and probed in transmission by plasmon-enabled transmission of light through an optical channel that overlaps with the physical channel.
摘要翻译：描述了单分子感测领域的方法和装置，例如用于分析物如分子分析物的分子分析。核酸，蛋白质，多肽，肽，脂质和多糖。描述了通过固态纳米孔易位的分子的分子光谱。光谱信号通过等离激元场约束和天线效应增强，并通过等离子体激发的光透过与物理信道重叠的光信道进行传输。

4. 发明授权

US08164755B2 Method for determining an analyte in a sample 有权
标题翻译：测定样品中分析物的方法
公开(公告)号：US08164755B2
公开(公告)日：2012-04-24
申请号：US13232794
申请日：2011-09-14
申请人： Iwijn De Vlaminck , Pol Van Dorpe , Liesbet Lagae
发明人： Iwijn De Vlaminck , Pol Van Dorpe , Liesbet Lagae
IPC分类号： G01N21/55
CPC分类号： G01N21/554 , B82Y15/00 , G01N2021/258
摘要： In one aspect of the invention, a method or apparatus is described for determining concentration(s) of one or more analytes in a sample using plasmonic excitations. In another aspect, a method relates to designing systems for such concentration determination, wherein metallic nanostructures are used in combination with local electrical detection of such plasmon resonances via a semiconducting photodetector. In certain aspects, the method exploits the coupling of said metallic nanostructure(s) to a semiconducting photodetector, said detector being placed in the “metallic structure's” near field. Surface plasmon excitation can be transduced efficiently into an electrical signal through absorption of light that is evanescently coupled or scattered in a semiconductor volume. This local detection technique allows the construction of sensitive nanoscale bioprobes and arrays thereof.
摘要翻译：在本发明的一个方面，描述了一种用于使用等离子体激发来测定样品中一种或多种分析物的浓度的方法或装置。在另一方面，一种方法涉及设计用于这种浓度测定的系统，其中金属纳米结构经由半导体光电检测器与这种等离子体共振的局部电检测结合使用。在某些方面，该方法利用所述金属纳米结构与半导体光电检测器的耦合，所述检测器被放置在“金属结构”的近场中。表面等离子体激发可以通过吸收在半导体体积中瞬时耦合或散射的光而有效地转换成电信号。这种局部检测技术允许构建敏感的纳米级生物探针及其阵列。

5. 发明申请

US20110249259A1 Single Molecule Optical Spectroscopy in Solid-State Nanopores in a Transmission-Based Approach 有权
标题翻译：基于透射的方法中固态纳米孔中的单分子光学光谱
公开(公告)号：US20110249259A1
公开(公告)日：2011-10-13
申请号：US13133525
申请日：2009-12-09
申请人： Pol Van Dorpe , Iwijn De Vlaminck , Liesbet Lagae , Gustaaf Borghs
发明人： Pol Van Dorpe , Iwijn De Vlaminck , Liesbet Lagae , Gustaaf Borghs
IPC分类号： G01J3/44 , G01N21/55 , G01N21/64 , B82Y20/00
CPC分类号： B82Y15/00 , B82Y20/00 , B82Y40/00 , G01N21/554 , G01N21/648 , G01N21/658 , G01N33/48721 , G01N2021/653 , Y10S977/724 , Y10S977/924
摘要： Methods and apparatus in the field of single molecule sensing are described, e.g. for molecular analysis of analytes such as molecular analytes, e.g. nucleic acids, proteins, polypeptides, peptides, lipids and polysaccharides. Molecular spectroscopy on a molecule translocating through a solid-state nanopore is described. Optical spectroscopic signals are enhanced by plasmonic field-confinement and antenna effects and probed in transmission by plasmon-enabled transmission of light through an optical channel that overlaps with the physical channel.
摘要翻译：描述了单分子感测领域的方法和装置，例如用于分析物如分子分析物的分子分析。核酸，蛋白质，多肽，肽，脂质和多糖。描述了通过固态纳米孔易位的分子的分子光谱。光谱信号通过等离激元场约束和天线效应增强，并通过等离子体激发的光透过与物理信道重叠的光信道进行传输。

6. 发明申请

US20090027681A1 Method for determining an analyte in a sample 有权
标题翻译：测定样品中分析物的方法
公开(公告)号：US20090027681A1
公开(公告)日：2009-01-29
申请号：US12220346
申请日：2008-07-24
申请人： Iwijn De Vlaminck , Pol Van Dorpe , Liesbet Lagae
发明人： Iwijn De Vlaminck , Pol Van Dorpe , Liesbet Lagae
IPC分类号： G01N21/55
CPC分类号： G01N21/554 , B82Y15/00 , G01N2021/258
摘要： In one aspect of the invention, a method or apparatus is described for determining concentration(s) of one or more analytes in a sample using plasmonic excitations. In another aspect, a method relates to designing systems for such concentration determination, wherein metallic nanostructures are used in combination with local electrical detection of such plasmon resonances via a semiconducting photodetector. In certain aspects, the method exploits the coupling of said metallic nanostructure(s) to a semiconducting photodetector, said detector being placed in the “metallic structure's” near field. Surface plasmon excitation can be transduced efficiently into an electrical signal through absorption of light that is evanescently coupled or scattered in a semiconductor volume. This local detection technique allows the construction of sensitive nanoscale bioprobes and arrays thereof.
摘要翻译：在本发明的一个方面，描述了一种用于使用等离子体激发来测定样品中一种或多种分析物的浓度的方法或装置。在另一方面，一种方法涉及设计用于这种浓度测定的系统，其中金属纳米结构经由半导体光电检测器与这种等离子体共振的局部电检测结合使用。在某些方面，该方法利用所述金属纳米结构与半导体光电检测器的耦合，所述检测器被放置在“金属结构”的近场中。表面等离子体激发可以通过吸收在半导体体积中瞬时耦合或散射的光而有效地转换成电信号。这种局部检测技术允许构建敏感的纳米级生物探针及其阵列。

7. 发明申请

US20120258544A1 Plasmonic Force Manipulation in Nanostructures 有权
标题翻译：纳米结构中的等离子体力学操作
公开(公告)号：US20120258544A1
公开(公告)日：2012-10-11
申请号：US13518570
申请日：2010-12-24
申请人： Chang Chen , Pol Van Dorpe , Kai Cheng , Tim Stakenborg , Liesbet Lagae
发明人： Chang Chen , Pol Van Dorpe , Kai Cheng , Tim Stakenborg , Liesbet Lagae
IPC分类号： G01N21/65
CPC分类号： B82Y15/00 , C12Q1/6869 , G01N33/48721 , G01N33/538 , Y10T436/143333 , C12Q2565/631 , C12Q2565/607
摘要： A system (100) is described for characterizing and/or manipulating molecules. The system may especially be suitable for biological molecules, although the invention is not limited thereto. The system (100) comprises a substrate (110) comprising a nanostructure (120) being suitable for translocation of molecules through the nanostructure (120). It furthermore comprises a means (210) for translocating molecules through the nanostructure (120) and a plasmonic force field generating means (130) adapted for influencing the translocation speed of the particle by applying a plasmonic force field at the nanostructure (120). A corresponding method also is described.
摘要翻译：描述了用于表征和/或操纵分子的系统（100）。该系统可以特别适用于生物分子，尽管本发明不限于此。该系统（100）包括一个衬底（110），该衬底（110）包括适合于通过纳米结构（120）的分子易位的纳米结构（120）。它还包括用于使分子转移通过纳米结构（120）的装置（210）和适于通过在纳米结构（120）处施加等离子体力场来影响颗粒的易位速度的等离子体激元场产生装置（130）。还描述了相应的方法。

8. 发明申请

US20120057163A1 METHOD FOR FORMING A NANOSTRUCTURE PENETRATING A LAYER 有权
标题翻译：形成一层纳米结构的方法
公开(公告)号：US20120057163A1
公开(公告)日：2012-03-08
申请号：US13157154
申请日：2011-06-09
申请人： Kai Cheng , Pol Van Dorpe , Liesbet Lagae , Gustaaf Borghs , Chang Chen
发明人： Kai Cheng , Pol Van Dorpe , Liesbet Lagae , Gustaaf Borghs , Chang Chen
IPC分类号： H01L31/00 , H01L31/18 , G01N21/55 , B82Y40/00 , B82Y99/00
CPC分类号： B82Y15/00 , B82Y20/00 , B82Y40/00 , G01N21/554 , G01N21/648 , G01N21/658 , G01N33/48721 , G01N2021/653 , Y10S977/724 , Y10S977/924
摘要： A method for forming a nanostructure penetrating a layer and the device made thereof is disclosed. In one aspect, the device has a substrate, a layer present thereon, and a nanostructure penetrating the layer. The nanostructure defines a nanoscale passageway through which a molecule to be analyzed can pass through. The nanostructure has, in cross-sectional view, a substantially triangular shape. This shape is particularly achieved by growth of an epitaxial layer having crystal facets defining tilted sidewalls of the nanostructure. It is highly suitably for use for optical characterization of molecular structure, particularly with surface plasmon enhanced transmission spectroscopy.
摘要翻译：公开了一种形成穿透层的纳米结构的方法及其制造的器件。在一个方面，该装置具有基底，存在于其上的层和穿透该层的纳米结构。纳米结构定义了一个纳米尺度的通道，待分析的分子通过该通道通过。纳米结构在横截面图中具有基本上三角形的形状。通过具有限定纳米结构的倾斜侧壁的晶面的外延层的生长，特别地实现了该形状。它非常适合用于分子结构的光学表征，特别是用于表面等离子体增强透射光谱。

9. 发明授权

US09862601B2 Plasmonic force manipulation in nanostructures 有权
公开(公告)号：US09862601B2
公开(公告)日：2018-01-09
申请号：US13518570
申请日：2010-12-24
申请人： Chang Chen , Pol Van Dorpe , Kai Cheng , Tim Stakenborg , Liesbet Lagae
发明人： Chang Chen , Pol Van Dorpe , Kai Cheng , Tim Stakenborg , Liesbet Lagae
IPC分类号： B82Y15/00 , G01N21/65 , C12Q1/68 , G01N33/487 , G01N33/538
CPC分类号： B82Y15/00 , C12Q1/6869 , G01N33/48721 , G01N33/538 , Y10T436/143333 , C12Q2565/631 , C12Q2565/607
摘要： A system (100) is described for characterizing and/or manipulating molecules. The system may especially be suitable for biological molecules, although the invention is not limited thereto. The system (100) comprises a substrate (110) comprising a nanostructure (120) being suitable for translocation of molecules through the nanostructure (120). It furthermore comprises a means (210) for translocating molecules through the nanostructure (120) and a plasmonic force field generating means (130) adapted for influencing the translocation speed of the particle by applying a plasmonic force field at the nanostructure (120). A corresponding method also is described.

10. 发明授权

US08437001B2 Method for forming a nanostructure penetrating a layer 有权
标题翻译：形成穿透层的纳米结构的方法
公开(公告)号：US08437001B2
公开(公告)日：2013-05-07
申请号：US13157154
申请日：2011-06-09
申请人： Kai Cheng , Pol Van Dorpe , Liesbet Lagae , Gustaaf Borghs , Chang Chen
发明人： Kai Cheng , Pol Van Dorpe , Liesbet Lagae , Gustaaf Borghs , Chang Chen
IPC分类号： G01N21/00
CPC分类号： B82Y15/00 , B82Y20/00 , B82Y40/00 , G01N21/554 , G01N21/648 , G01N21/658 , G01N33/48721 , G01N2021/653 , Y10S977/724 , Y10S977/924
摘要： A method for forming a nanostructure penetrating a layer and the device made thereof is disclosed. In one aspect, the device has a substrate, a layer present thereon, and a nanostructure penetrating the layer. The nanostructure defines a nanoscale passageway through which a molecule to be analyzed can pass through. The nanostructure has, in cross-sectional view, a substantially triangular shape. This shape is particularly achieved by growth of an epitaxial layer having crystal facets defining tilted sidewalls of the nanostructure. It is highly suitably for use for optical characterization of molecular structure, particularly with surface plasmon enhanced transmission spectroscopy.
摘要翻译：公开了一种形成穿透层的纳米结构的方法及其制造的器件。在一个方面，该装置具有基底，存在于其上的层和穿透该层的纳米结构。纳米结构定义了一个纳米尺度的通道，待分析的分子通过该通道通过。纳米结构在横截面图中具有基本上三角形的形状。通过具有限定纳米结构的倾斜侧壁的晶面的外延层的生长，特别地实现了这种形状。它非常适合用于分子结构的光学表征，特别是用于表面等离子体增强透射光谱。

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