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11. 发明授权

US07394592B2 Confocal microscope for imaging of selected locations of the body of a patient 有权
标题翻译：共焦显微镜，用于对患者身体的选定位置进行成像
公开(公告)号：US07394592B2
公开(公告)日：2008-07-01
申请号：US10557461
申请日：2004-05-20
申请人： William J. Fox , Christopher C. DiStasio , Scott R. Grodevant
发明人： William J. Fox , Christopher C. DiStasio , Scott R. Grodevant
IPC分类号： G02B21/00
CPC分类号： G02B21/0048 , A61B5/0064 , A61B5/0068 , A61B5/6835 , G02B21/0012 , G02B21/0028 , G02B21/008 , G02B21/362
摘要： A confocal imaging microscope, especially for the cellular imaging of the skin at selected locations. An imaging head (28) is gimble mounted on a multi-axis compound arm (34) to allow for precise placement of a confocal objective (116) extending from the head at selected locations against the skin of the patient. The arm (34) attaches the head to an upright station (10) which may be movable along the floor on which the station is disposed. The station (10) has a platform (16) on which a keyboard (24) and a display (22) for monitoring the images is supported. The head (28) contains an integrated assembly of the optical and mechanical components of the microscope, which control scanning and may also control fine positioning of the locations being imaged. The head (28) is detachable from the arm for manual disposition.
摘要翻译：共焦成像显微镜，特别适用于选定位置的皮肤细胞成像。成像头（28）被安装在多轴复合臂（34）上，以允许在选定位置处从头部延伸的共焦物镜（116）精确地放置在患者皮肤上。臂（34）将头部附接到直立站（10），其可以沿着设置站的地板移动。站（10）具有平台（16），支撑用于监视图像的键盘（24）和显示器（22）。头部（28）包含显微镜的光学和机械部件的集成组件，其控制扫描并且还可以控制被成像位置的精细定位。头部（28）可从手臂上拆下来进行手动配置。

12. 发明授权

US08149506B2 Cassette for facilitating optical sectioning of a retained tissue specimen 有权
标题翻译：用于促进保留的组织标本的光学切片的盒
公开(公告)号：US08149506B2
公开(公告)日：2012-04-03
申请号：US10162317
申请日：2002-06-04
申请人： Jay M. Eastman , William J. Fox , Roger J. Greenwald , Kevin P. Roesser , James M. Zavislan
发明人： Jay M. Eastman , William J. Fox , Roger J. Greenwald , Kevin P. Roesser , James M. Zavislan
IPC分类号： G02B21/26
CPC分类号： G02B21/368 , B01L3/508 , B01L2200/0642 , B01L2300/021 , B01L2300/043 , B01L2300/044 , B01L2300/0609 , B01L2300/0822 , B01L2300/123 , G01N2001/315 , G02B21/0012 , G02B21/26 , G02B21/33 , G02B21/34
摘要： A cassette for retaining a specimen of surgically exposed tissue from a patient in an orientation that facilitates optical sectioning of the tissue by a confocal microscopic or other optical imaging microscope. The cassette includes a base member having an optically transparent window upon which a tissue specimen is situated, a membrane locatable over a substantial portion of the base member including the window, and an upper member which can cover the base member to provide an enclosed cavity between the membrane and the window sealing the tissue specimen therein. The edges of the tissue specimen may then be positioned planar against the window and retained in that position by bonds formed between the membrane and window around the tissue specimen. The cassette may be part of a confocal imaging system to produce microscopic images of sections of the tissue specimen useful for Mohs surgery.
摘要翻译：用于通过共聚焦显微镜或其他光学成像显微镜以方便光学切片的方向从患者保持外科手术曝光的组织的样本的盒。所述盒包括基部构件，所述基座构件具有光学透明窗口，组织样本位于所述窗口上，可以位于包括所述窗口的所述基座构件的主要部分上的膜;以及上部构件，其可以覆盖所述基座构件以在膜和窗口密封组织标本。然后可以将组织样本的边缘定位成相对于窗户平面并且通过在组织样本周围的膜和窗口之间形成的粘结保持在该位置。盒可以是共焦成像系统的一部分，以产生用于莫氏手术的组织标本的切片的显微镜图像。

13. 发明申请

US20090097108A1 Confocal scanning microscope having optical and scanning systems which provide a handheld imaging head 有权
标题翻译：共焦扫描显微镜具有提供手持成像头的光学和扫描系统
公开(公告)号：US20090097108A1
公开(公告)日：2009-04-16
申请号：US11920195
申请日：2006-05-12
申请人： William J. Fox , Scott R. Grodevant , Christopher C. Distasio
发明人： William J. Fox , Scott R. Grodevant , Christopher C. Distasio
IPC分类号： G02B21/06
CPC分类号： A61B5/0068 , A61B5/0062 , A61B5/0064 , A61B5/445 , A61B90/20 , G02B5/3083 , G02B21/0008 , G02B21/0028 , G02B21/0048 , G02B21/0068 , G02B21/0072 , G02B21/008
摘要： A confocal microscope having a scanning head in the form of a hand piece (102) which may be placed at selected locations on the body of a patient. A laser beam is scanned in orthogonal (horizontal and vertical) directions by scanners (128, 130) which drive scan mirrors (128a, 130a), which are closely adjacent to each other The optics include an objective lens (138) and a single telescope lens (132, 134). The telescope provides sufficient magnification to overfill the entrance pupil of the objective lens (138) over the entire scan angle produced by the scan mirrors (128a, 130a). The telescope images (has a focus) in the beam path between the mirrors of the scanners, thereby limiting the distance over the entrance pupil of the objective as the beam executes the scan angle. Scanner (128) represents pulse driven resonant scanner (7) which is pulse driven. The pulse duration is controlled to vary the scan angle and obtain dynamic, electronic image zooming without changing the positional relationship of the telescope lenses.
摘要翻译：一种共焦显微镜，其具有手部形式的扫描头（102），该扫描头可放置在患者身体的选定位置。通过扫描器（128,130）沿正交（水平和垂直）方向扫描激光束，扫描器驱动彼此紧密相邻的扫描镜（128a，130a）。光学器件包括物镜（138）和单个望远镜透镜（132,134）。望远镜提供足够的放大倍率以在由扫描镜（128a，130a）产生的整个扫描角度上覆盖物镜（138）的入射光瞳。在扫描仪的反射镜之间的光束路径中的望远镜图像（具有焦点），从而当光束执行扫描角度时限制物镜入射光瞳上的距离。扫描器（128）表示脉冲驱动的脉冲驱动谐振扫描器（7）。控制脉冲持续时间以改变扫描角度并获得动态的电子图像变焦而不改变望远镜透镜的位置关系。

14. 发明授权

US5907579A Repeater bipolar violation in-service detection system 失效
标题翻译：中继器双极违规在线检测系统
公开(公告)号：US5907579A
公开(公告)日：1999-05-25
申请号：US770360
申请日：1996-12-20
申请人： Bruce E. Urban , Brian D. Vanvoorhis , William J. Fox
发明人： Bruce E. Urban , Brian D. Vanvoorhis , William J. Fox
IPC分类号： H04M3/22 , H04B3/36
CPC分类号： H04M3/2254
摘要： A repeater bipolar violation in-service detection system is provided for in-service detection of a bipolar violation in a smart repeater, and includes a repeater bipolar violation in-service detection controller and a repeater bipolar violation in-service detection reporting unit. The repeater bipolar violation in-service detection controller provides a repeater bipolar violation in-service detection control signal containing a control request for information about an in-service detection of a bipolar violation in a smart repeater, and responds to a repeater bipolar violation in-service detection reporting unit signal containing information about the in-service detection of the bipolar violation in the smart repeater. The repeater bipolar violation in-service detection reporting unit responds to the repeater bipolar violation in-service detection control signal from the repeater bipolar violation in-service detection controller, for providing the repeater bipolar violation in-service detection reporting unit signal to the repeater bipolar violation in-service detection controller.
摘要翻译：提供了一种中继器双极违规在线检测系统，用于在智能中继器中进行双极违例的在线检测，并且包括中继器双极性违规在役检测控制器和中继器双极违例在职检测报告单元。中继器双极违规在役检测控制器提供一个中继器双极违规在线检测控制信号，其中包含有关智能中继器中双极违例的在线检测信息的控制请求，服务检测报告单元信号，其包含关于智能中继器中双极违规的在役检测的信息。中继器双极违例在役检测报告单元响应来自中继器双工违规在线检测控制器的中继器双向违规在线检测控制信号，用于向中继器双极设备提供中继器双极性违规在役检测报告单元信号违规在线检测控制器。

15. 发明授权

US5126477A Carbamates, their production and use as fuels additives 失效
标题翻译：氨基甲酸酯，其生产和用作燃料添加剂
公开(公告)号：US5126477A
公开(公告)日：1992-06-30
申请号：US737457
申请日：1991-07-29
申请人： Richard A'Court , William J. Fox , John E. Hamlin , Sean P. O'Connor
发明人： Richard A'Court , William J. Fox , John E. Hamlin , Sean P. O'Connor
IPC分类号： C10L1/224 , C10L1/232 , C10L1/233
CPC分类号： C10L1/224 , C10L1/232 , C10L1/2335
摘要： A process for the production of a carbamate suitable for use as a detergent additive to internal combustion engine fuels which process comprises reacting either ammonia, a primary amime or a secondary amine with a dihydrocarbyl carbonate in the presence as catalyst of a strong organic base and in the proportions necessary to produce either a mono-carbamate or a bis-carbamate. A process for the production of a carbamate having formula (I), wherein X and Y are independently either hydrogen, a hydrocarbyl group or a hetero-substituted hydrocarbyl group or the group of formula (II), wherein Z is either a divalent hydrocarbyl, a substituted hydrocarbyl group or the group of formula (III) [alkytene)m(NH)n(alkylene)m] in which n=0 to 4 and m=1 to 4, and R is a hydrocarbly or substituted hydrocarbyl group, provided that if either one of X or Y is the group of formula (II), the other of X or Y is hydrogen, which process comprises reacting a compound of formula (IV), wherein X and Y are independently either hydrogen, a hydrocarbyl group or a hetero-substituted hydrocarbyl group with a dihydrocarbyl carbonate having formula (V), wherein independently R is as defined above in the presence as catalyst of a strong organic base and in the proportions necessary to produce either a mono-carbamate or a bis-carbamate.
摘要翻译：用于生产适合用作内燃机燃料的洗涤剂添加剂的氨基甲酸酯的方法，该方法包括在作为强有机碱的催化剂存在下，将氨，伯胺或仲胺与碳酸二烃基反应，生产单氨基甲酸酯或双氨基甲酸酯所需的比例。制备具有式（I）的氨基甲酸酯的方法，其中X和Y独立地为氢，烃基或杂取代的烃基或式（II）的基团，其中Z为二价烃基，取代的烃基或式（III）[烷基] m（NH）n（亚烷基）m]的基团，其中n = 0至4且m = 1至4，并且R为烃基或取代的烃基，如果X或Y中的任一个是式（II）的基团，X或Y中的另一个是氢，该方法包括使式（IV）化合物与其中X和Y独立地是氢，烃基或具有式（Ⅴ）的二碳代碳酸酯的杂取代烃基，其中独立地R如上所定义，在作为强有机碱的催化剂存在下，以生成单氨基甲酸酯或双 - 氨基甲酸酯。

16. 发明授权

US09052523B2 Cassette for facilitating optical sectioning of a retained tissue specimen 有权
标题翻译：用于促进保留的组织标本的光学切片的盒
公开(公告)号：US09052523B2
公开(公告)日：2015-06-09
申请号：US13385980
申请日：2012-03-19
申请人： Jay M. Eastman , William J. Fox , Roger J. Greenwald , Kevin P. Roesser , James M. Zavislan
发明人： Jay M. Eastman , William J. Fox , Roger J. Greenwald , Kevin P. Roesser , James M. Zavislan
IPC分类号： G02B21/34 , B01L3/00 , G01N1/31
CPC分类号： G02B21/368 , B01L3/508 , B01L2200/0642 , B01L2300/021 , B01L2300/043 , B01L2300/044 , B01L2300/0609 , B01L2300/0822 , B01L2300/123 , G01N2001/315 , G02B21/0012 , G02B21/26 , G02B21/33 , G02B21/34
摘要： A cassette for retaining a specimen of surgically exposed tissue from a patient in an orientation that facilitates optical sectioning of the tissue by a confocal microscopic or other optical imaging microscope. The cassette includes a base member having a rigid optically transparent window upon which a tissue specimen is situated, a pliable membrane locatable over a substantial portion of the base member including the window, and an upper member, having an aperture therethrough, which can cover the base member to provide an enclosed cavity between the membrane and the window sealing the tissue specimen therein. The edges of the tissue specimen may be positioned planar against the window and retained in that position by bonds formed between the membrane and window at multiple points or locations around the tissue specimen. The specimen retained in the cavity is imagible by a microscope through the window of the base member.
摘要翻译：用于通过共聚焦显微镜或其他光学成像显微镜以方便光学切片的方向从患者保持外科手术曝光的组织的样本的盒。盒包括具有刚性光学透明窗口的基部构件，组织样本位于该基部构件上，柔性膜可定位在包括窗口的基部构件的主要部分上方，以及具有穿过其的孔的上部构件，其可覆盖在膜和窗户之间提供封闭的腔，密封组织样本。组织样本的边缘可以相对于窗户定位，并且通过在组织样本周围的多个点或位置处形成在膜和窗之间的结合保持在该位置。通过显微镜通过基底构件的窗口可以保持保留在空腔中的样品。

17. 发明授权

US07859749B2 Confocal microscope for imaging of selected locations of the body of a patient 有权
标题翻译：共焦显微镜，用于对患者身体的选定位置进行成像
公开(公告)号：US07859749B2
公开(公告)日：2010-12-28
申请号：US12154981
申请日：2008-05-29
申请人： William J. Fox , Christopher C. DiStasio , Scott R. Grodevant
发明人： William J. Fox , Christopher C. DiStasio , Scott R. Grodevant
IPC分类号： G02B21/00
CPC分类号： G02B21/0048 , A61B5/0064 , A61B5/0068 , A61B5/6835 , G02B21/0012 , G02B21/0028 , G02B21/008 , G02B21/362
摘要： A confocal imaging microscope, especially for the cellular imaging of the skin at selected locations, is ergonomic in use, compact, and positionable at the locations thereby providing for patient comfort during imaging. The head (28) contains an integrated assembly of the optical and mechanical components of the microscope. The assembly includes a main chassis plate (82). The optical components are mounted principally on one side of the plate while a PC board (130) is mounted on the opposite side of the plate. The board (130) mounts the electronic components, including interfaces, a microprocessor (222), and drivers (206, 208, 210) for motors (105, 106, 108) which control scanning and may also control fine positioning of the locations being imaged. The head (28) is detachable from the arm for manual disposition which is useful when imaging, not only the skin but other tissues, especially for research in investigating living processes at the cellular level.
摘要翻译：共焦成像显微镜，特别是用于在选定位置处的皮肤的细胞成像，其在使用中是人体工程学的，紧凑的和可定位的，从而在成像期间提供患者的舒适度。头部（28）包含显微镜的光学和机械部件的集成组件。组件包括主底盘（82）。光学部件主要安装在板的一侧，而PC板（130）安装在板的相对侧上。板（130）安装包括接口的电子部件，微处理器（222）和用于控制扫描的电动机（105,106,108）的驱动器（206,208,210），并且还可以控制位置的精细定位成像。头部（28）可从手臂上拆卸，用于手动配置，这对于成像不仅皮肤而且其它组织尤其是用于调查细胞水平的生物过程的研究是有用的。

18. 发明授权

US06575287B2 Product conveying and accumulation system and method 有权
标题翻译：产品输送和积累系统及方法
公开(公告)号：US06575287B2
公开(公告)日：2003-06-10
申请号：US09984682
申请日：2001-10-25
申请人： Mark C. Garvey , William J. Fox
发明人： Mark C. Garvey , William J. Fox
IPC分类号： B65G4730
CPC分类号： B65G47/684 , B65G2201/0244
摘要： A product conveying and accumulation system is provided for use with products of various sizes, shapes, and stability characteristics. The system comprises multiple moving conveyors, including a first conveyor which transports product from an upstream location. This same conveyor or another conveyor delivers product to a downstream location. An accumulator conveyor, traveling at a substantially similar speed or a designated variable speed as the first conveyor or conveyors, is aligned in the same plane as, is adjacent to, and may mate with the first conveyor at a predetermined location for contiguous movement in the same direction as the first conveyor at this predetermined location. A product guide is provided which allows for the movement of product from the upstream to downstream locations during normal operation and directs product to the accumulator section of the second conveyor when there is a disruption or malfunction downstream. Any product which cannot be accepted downstream is thus accumulated in a designated area and such products are re-circulated to that area and ultimately to the downstream location when the downstream disruption or malfunction is remedied.
摘要翻译：提供产品输送和积聚系统，用于各种尺寸，形状和稳定性特征的产品。该系统包括多个移动输送机，包括从上游位置输送产品的第一输送机。相同的输送机或另一个输送机将产品输送到下游位置。以与第一输送机或输送机基本类似的速度或指定的可变速度行进的蓄能器输送机在与第一输送机相邻的平面内对准，并且可与第一输送机配合在预定位置，以在与该预定位置处的第一输送机相同的方向。提供产品指南，其允许在正常操作期间产品从上游位置移动到下游位置，并且当下游处于中断或故障时将产品引导到第二输送机的蓄能器部分。任何不能被接受下游的产品因此被累积在指定区域，并且当补救下游故障或故障时，这些产品被再循环到该区域并且最终到达下游位置。

19. 发明授权

US5286265A Carbamates, their production and use as fuels additives 失效
标题翻译：氨基甲酸酯，其生产和用作燃料添加剂
公开(公告)号：US5286265A
公开(公告)日：1994-02-15
申请号：US868485
申请日：1992-04-14
申请人： Richard A'Court , William J. Fox , John E. Hamlin , Sean P. O'Connor
发明人： Richard A'Court , William J. Fox , John E. Hamlin , Sean P. O'Connor
IPC分类号： C07D295/12 , B01J31/02 , C07B61/00 , C07C67/00 , C07C239/00 , C07C269/04 , C07C271/12 , C07C271/16 , C07D211/14 , C10L1/22 , C10L1/224 , C10L1/232 , C10L1/233 , C11D1/10
CPC分类号： C10L1/224 , C10L1/232 , C10L1/2335
摘要： The invention relates to an internal combustion fuel concentrate comprising: (a) from 1 to 95% of a chlorine-free carbamate prepared by reacting a carbamate of formula ##STR1## with a compound of the formula R OH (VI) in the presence of either a strone organic base or a tetra hydrocarbyl titanate so as to exchange the group R in formula (I) with a group R.sup.1 in formula (II), and (b) a fuel compatible solvent therefor. In the formula (I) R is a hydrocarbyl or substituted hydrocarbyl group and R.sup.1 is a hydrocarbyl or a hetero-substituted hydrocarbyl group different from R. In formula (I), X and Y are independently any of hydrogen, a hydrocarbyl group, or the group of the formula ##STR2## where Z is either a divalent hydrocarbyl, a substituted hydrocarbyl group or the group of formula(alkylene).sub.m (NH.sub.n (alkylene).sub.m (III)in which n=0 to 4 and m=1 to 4, and R is hydrocarbyl a substituted hydrocarbyl, provided that if either one of X or Y is the group of formula (II), the other of X or Y is hydrogen.
摘要翻译：本发明涉及一种内燃燃料浓缩物，其包含：（a）通过使式（* CHEMICAL STRUCTURE *）（I）的氨基甲酸酯与式R OH的化合物（I）反应制备的1-95％的无氯氨基甲酸酯 VI）在有条件的有机碱或四烃基钛酸酯的存在下，以使式（I）中的基团R与式（II）中的基团R 1交换，和（b）与其相容的燃料相容性溶剂。在式（I）中，R是烃基或取代的烃基，R 1是与R不同的烃基或杂取代的烃基。在式（I）中，X和Y独立地是氢，烃基或其中Z是二价烃基，取代的烃基或式（亚烷基）m（NH，（亚烷基）m（III）的基团，其中n = 0〜 4和m = 1至4，并且R是烃基取代的烃基，条件是如果X或Y中的任一个是式（II）的基团，则X或Y中的另一个是氢。

20. 发明授权

US5185736A Synchronous optical transmission system 失效
标题翻译：同步光传输系统
公开(公告)号：US5185736A
公开(公告)日：1993-02-09
申请号：US351861
申请日：1989-05-12
申请人： Raymond E. Tyrrell , O. Lamar Bishop , William E. Powell , Dale L. Krisher , William H. Stephenson , M. Rodney Briscoe , Hal A. Thorne , Claude M. Hurlocker , V. Paul Runyon , Timothy J. Williams , Joseph E. Sutherland , William B. Weeber , Michael J. Gingell , Kenneth J. Stoia , William J. Fox , Jeffrey P. Jones , Richard M. Czerwiec , Ertugrul Baydar , Heinrich T. Sonnenberg , Richard Peters , Gus C. Sanders , Richard J. Sanders, Jr. , Francis G. Noser , Joseph L. Smith , Jak Yaemsiri , Camille A. Abu-Saba , Patrick M. Farrell , Wenkwei Rou , Victor W. Wilkerson , Mohammad S. Arani , Stephen C. Dunning , Keith Bernhardt , Dana Merrill , Michael Sutton
发明人： Raymond E. Tyrrell , O. Lamar Bishop , William E. Powell , Dale L. Krisher , William H. Stephenson , M. Rodney Briscoe , Hal A. Thorne , Claude M. Hurlocker , V. Paul Runyon , Timothy J. Williams , Joseph E. Sutherland , William B. Weeber , Michael J. Gingell , Kenneth J. Stoia , William J. Fox , Jeffrey P. Jones , Richard M. Czerwiec , Ertugrul Baydar , Heinrich T. Sonnenberg , Richard Peters , Gus C. Sanders , Richard J. Sanders, Jr. , Francis G. Noser , Joseph L. Smith , Jak Yaemsiri , Camille A. Abu-Saba , Patrick M. Farrell , Wenkwei Rou , Victor W. Wilkerson , Mohammad S. Arani , Stephen C. Dunning , Keith Bernhardt , Dana Merrill , Michael Sutton
IPC分类号： H04J3/08 , H04J3/16 , H04Q11/04
CPC分类号： H04J3/1611 , H04J3/08 , H04J2203/0048 , H04J2203/006
摘要： A synchronous optical transmission system for interfacing SONET formatted channels to lower speed channels in either a SONET format or otherwise. The transmission system incorporates a fiber transmission system, terminal multiplexers and add/drop multiplexers that in turn incorporate a plurality of features, such as parallel scrambling circuitry, frame synchronization circuitry and the like.

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