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1. 发明授权

US09229210B2 Tissue specimen stage for an optical sectioning microscope 有权
标题翻译：用于光学切片显微镜的组织样品台
公开(公告)号：US09229210B2
公开(公告)日：2016-01-05
申请号：US13778083
申请日：2013-02-26
申请人： William J. Fox , Christopher C. DiStasio
发明人： William J. Fox , Christopher C. DiStasio
IPC分类号： G02B21/26 , G02B21/34
CPC分类号： G02B21/26 , G02B21/34
摘要： A tissue specimen stage is provided having a window with surface curvature upon which an excised tissue specimen is locatable, a carriage having a tissue specimen receptacle to which the window is mounted, and a platform supporting the carriage and presenting the window to the objective lens of an optical sectioning microscope. The carriage is mounted to the platform for movement along two rotational axes so that the carriage's movement follows the curvature of all or part of the window while maintaining the same optical geometry of the window with respect to the objective lens. The window has surface curvature adapted to at least approximate the shape or curvature of the non-histologically prepared tissue specimen to be placed thereupon.
摘要翻译：提供组织样本台，其具有具有表面曲率的窗口，切割的组织样本可定位在其上，具有安装窗口的组织样本容器的滑架和支撑滑架并将窗口呈现到物镜的平台光学切片显微镜。滑架安装到平台上以沿着两个旋转轴线移动，使得滑架的运动遵循窗口的全部或部分的曲率，同时保持窗口相对于物镜的相同光学几何形状。窗口具有适于至少近似待放置在其上的非组织学准备的组织样本的形状或曲率的表面曲率。

2. 发明授权

US09055867B2 Confocal scanning microscope having optical and scanning systems which provide a handheld imaging head 有权
标题翻译：共焦扫描显微镜具有提供手持成像头的光学和扫描系统
公开(公告)号：US09055867B2
公开(公告)日：2015-06-16
申请号：US11920195
申请日：2006-05-12
申请人： William J. Fox , Scott R. Grodevant , Christopher C. Distasio
发明人： William J. Fox , Scott R. Grodevant , Christopher C. Distasio
IPC分类号： G01B9/02 , A61B5/00 , G02B21/00
CPC分类号： A61B5/0068 , A61B5/0062 , A61B5/0064 , A61B5/445 , A61B90/20 , G02B5/3083 , G02B21/0008 , G02B21/0028 , G02B21/0048 , G02B21/0068 , G02B21/0072 , G02B21/008
摘要： A confocal microscope having a scanning head in the form of a hand piece which may be placed at selected locations on the body of a patient. A laser beam is scanned in orthogonal (horizontal and vertical) directions by scanners which drive scan mirrors, which are closely adjacent to each other. The optics include an objective lens and a telescope lenses that image the objective lens entrance pupil between the scan mirrors. Scanner is a pulse driven resonant scanner which is feed back controlled to maintain scanning rate and can change the scan angle and obtain dynamic, electronic image zooming without changing the positional relationship of the telescope.
摘要翻译：一种共焦显微镜，其具有手部形式的扫描头，其可以放置在患者身体的选定位置。通过扫描器在正交（水平和垂直）方向上扫描激光束，扫描仪驱动彼此紧密相邻的扫描镜。光学元件包括物镜和在扫描镜之间对物镜入射光瞳进行成像的望远镜。扫描仪是一个脉冲驱动的谐振扫描器，其被反馈控制以保持扫描速率并且可以改变扫描角度并且获得动态的电子图像变焦而不改变望远镜的位置关系。

3. 发明申请

US20130222899A1 TISSUE SPECIMEN STAGE FOR AN OPTICAL SECTIONING MICROSCOPE 有权
标题翻译：用于光学分段显微镜的组织样本阶段
公开(公告)号：US20130222899A1
公开(公告)日：2013-08-29
申请号：US13778083
申请日：2013-02-26
申请人： William J. Fox , Christopher C. DiStasio
发明人： William J. Fox , Christopher C. DiStasio
IPC分类号： G02B21/26
CPC分类号： G02B21/26 , G02B21/34
摘要： A tissue specimen stage is provided having a window with surface curvature upon which an excised tissue specimen is locatable, a carriage having a tissue specimen receptacle to which the window is mounted, and a platform supporting the carriage and presenting the window to the objective lens of an optical sectioning microscope. The carriage is mounted to the platform for movement along two rotational axes so that the carriage's movement follows the curvature of all or part of the window while maintaining the same optical geometry of the window with respect to the objective lens. The window has surface curvature adapted to at least approximate the shape or curvature of the non-histologically prepared tissue specimen to be placed thereupon.
摘要翻译：提供组织样本台，其具有具有表面曲率的窗口，切割的组织样本可定位在其上，具有安装窗口的组织样本容器的滑架和支撑滑架并将窗口呈现到物镜的平台光学切片显微镜。滑架安装到平台上以沿着两个旋转轴线移动，使得滑架的运动遵循窗口的全部或部分的曲率，同时保持窗口相对于物镜的相同光学几何形状。窗口具有适于至少近似待放置在其上的非组织学准备的组织样本的形状或曲率的表面曲率。

4. 发明申请

US20130182318A1 Cassette for facilitating optical sectioning of a retained tissue specimen 有权
标题翻译：用于促进保留的组织标本的光学切片的盒
公开(公告)号：US20130182318A1
公开(公告)日：2013-07-18
申请号：US13385980
申请日：2012-03-19
申请人： Jay M. Eastman , William J. Fox , Roger J. Greenwald , Kevin P. Roesser , James M. Zavislan
发明人： Jay M. Eastman , William J. Fox , Roger J. Greenwald , Kevin P. Roesser , James M. Zavislan
IPC分类号： G02B21/34
CPC分类号： G02B21/368 , B01L3/508 , B01L2200/0642 , B01L2300/021 , B01L2300/043 , B01L2300/044 , B01L2300/0609 , B01L2300/0822 , B01L2300/123 , G01N2001/315 , G02B21/0012 , G02B21/26 , G02B21/33 , G02B21/34
摘要： A cassette for retaining a specimen of surgically exposed tissue from a patient in an orientation that facilitates optical sectioning of the tissue by a confocal microscopic or other optical imaging microscope. The cassette includes a base member having a rigid optically transparent window upon which a tissue specimen is situated, a pliable membrane locatable over a substantial portion of the base member including the window, and an upper member, having an aperture therethrough, which can cover the base member to provide an enclosed cavity between the membrane and the window sealing the tissue specimen therein. The edges of the tissue specimen may be positioned planar against the window and retained in that position by bonds formed between the membrane and window at multiple points or locations around the tissue specimen. The specimen retained in the cavity is imagible a microscope through the window of the base member.
摘要翻译：用于通过共聚焦显微镜或其他光学成像显微镜以方便光学切片的方向从患者保持外科手术曝光的组织的样本的盒。盒包括具有刚性光学透明窗口的基部构件，组织样本位于该基部构件上，柔性膜可定位在包括窗口的基部构件的主要部分上方，以及具有穿过其的孔的上部构件，其可覆盖在膜和窗户之间提供封闭的腔，密封组织样本。组织样本的边缘可以相对于窗户定位，并且通过在组织样本周围的多个点或位置处形成在膜和窗之间的结合保持在该位置。保留在腔中的样品通过基底构件的窗口成像显微镜。

5. 发明申请

US20110073036A1 Selectively Coating Luminal Surfaces of Stents 有权
标题翻译：选择性地涂覆支架的腔内表面
公开(公告)号：US20110073036A1
公开(公告)日：2011-03-31
申请号：US12960389
申请日：2010-12-03
申请人： Andrew J. Tochterman , William J. Fox , Nathan Harold
发明人： Andrew J. Tochterman , William J. Fox , Nathan Harold
IPC分类号： B05B15/04 , B05C13/00
CPC分类号： A61F2/82 , B05B13/02 , B05B13/0627 , B05B13/0636 , B05B13/0654 , B05D1/32 , B05D7/22 , B05D2258/02 , Y10T29/53678 , Y10T29/53683 , Y10T29/53909
摘要： With abluminal side of a stent masked, the luminal side of the stent is selectively coated with a substance, such as an anti-coagulant, a platelet inhibitor and/or a pro-healing substance. The stent can be masked by inserting it into a rigid mandrel chamber or by compressing a masking sleeve onto the outer side of the stent. A spray nozzle inserted into the masked stent spray coats the substance onto the luminal side. The sprayed coating can be cured onto the stent such as by inserting an electrical-resistance heater bar into the stent.
摘要翻译：随着支架的外侧面被遮盖，支架的腔侧选择性地涂覆有诸如抗凝血剂，血小板抑制剂和/或前维持物质的物质。可以通过将支架插入刚性心轴腔室中或通过将掩蔽套管压缩到支架的外侧来掩蔽支架。插入掩模的支架喷雾器中的喷嘴将物质涂覆在腔侧。喷涂的涂层可以固化到支架上，例如通过将电阻加热棒插入支架中。

6. 发明授权

US07867547B2 Selectively coating luminal surfaces of stents 有权
标题翻译：选择性地涂覆支架的腔表面
公开(公告)号：US07867547B2
公开(公告)日：2011-01-11
申请号：US11312139
申请日：2005-12-19
申请人： Andrew J. Tochterman , William J. Fox , Nathan Harold
发明人： Andrew J. Tochterman , William J. Fox , Nathan Harold
IPC分类号： B05D3/02 , B05D1/02 , B05D1/32 , B05C13/00
CPC分类号： A61F2/82 , B05B13/02 , B05B13/0627 , B05B13/0636 , B05B13/0654 , B05D1/32 , B05D7/22 , B05D2258/02 , Y10T29/53678 , Y10T29/53683 , Y10T29/53909
摘要： With abluminal side of a stent masked, the luminal side of the stent is selectively coated with a substance, such as an anti-coagulant, a platelet inhibitor and/or a pro-healing substance. The stent can be masked by inserting it into a rigid mandrel chamber or by compressing a masking sleeve onto the outer side of the stent. A spray nozzle inserted into the masked stent spray coats the substance onto the luminal side. The sprayed coating can be cured onto the stent such as by inserting an electrical-resistance heater bar into the stent.
摘要翻译：随着支架的外侧面被遮盖，支架的腔侧选择性地涂覆有诸如抗凝血剂，血小板抑制剂和/或前维持物质的物质。可以通过将支架插入刚性心轴腔室中或通过将掩蔽套管压缩到支架的外侧来掩蔽支架。插入掩模的支架喷雾器中的喷嘴将物质涂覆在腔侧。喷涂的涂层可以固化到支架上，例如通过将电阻加热棒插入支架中。

7. 发明授权

US07841232B2 Method of dynamically measuring stiffness of a wheel and tire assembly 有权
标题翻译：动态测量车轮和轮胎组件刚度的方法
公开(公告)号：US07841232B2
公开(公告)日：2010-11-30
申请号：US12243999
申请日：2008-10-02
申请人： Kurt K. Schleif , Jochen E. Scheuing , David M. Russell , William J. Fox , Elton R. Eaton, III
发明人： Kurt K. Schleif , Jochen E. Scheuing , David M. Russell , William J. Fox , Elton R. Eaton, III
IPC分类号： G01M17/02
CPC分类号： G01M17/013 , G01M17/027
摘要： A test machine and method for dynamically testing a tire/wheel assembly. A first laser measurement gage is directed to an inboard rim flange of the wheel to measure radial deflection of the tire/wheel assembly. A second laser measurement gage is directed to the inboard rim flange to measure axial deflection of the tire/wheel assembly. Displacement data and loading data are correlated to provide values for lateral stiffness, radial stiffness and ride stiffness.
摘要翻译：一种用于动态测试轮胎/轮组件的试验机和方法。第一激光测量计被引导到车轮的内侧轮缘凸缘以测量轮胎/车轮组件的径向偏转。第二激光测量计被引导到内侧凸缘以测量轮胎/轮组件的轴向偏转。位移数据和载荷数据相关，以提供横向刚度，径向刚度和行驶刚度的值。

8. 发明授权

US07821413B2 Enhanced AC immunity in ground fault detection 有权
标题翻译：增强接地故障检测中的交流电抗
公开(公告)号：US07821413B2
公开(公告)日：2010-10-26
申请号：US12239944
申请日：2008-09-29
申请人： William J. Fox , Michael Carter
发明人： William J. Fox , Michael Carter
IPC分类号： G08B21/00 , G01R31/08 , H02H3/00 , H02H3/20 , H02H9/04
CPC分类号： H04M3/18
摘要： A method for reducing the occurrence of false ground fault detections in a central office terminal is provided. The method includes generating a no-fault signal when no ground current is detected, delaying generation of a fault signal when ground current is detected at least for the duration of an expected pulse in AC induced signal, and when the ground current persists for a sufficient period, generating a signal indicating a fault condition.
摘要翻译：提供了一种用于减少中心局终端中的假接地故障检测的发生的方法。该方法包括当没有检测到接地电流时产生无故障信号，当至少在AC感应信号中的期望脉冲的持续时间内检测到接地电流时，延迟产生故障信号，并且当地电流持续足够的时候周期，产生指示故障状况的信号。

9. 发明申请

US20080239474A1 Confocal microscope for imaging of selected locations of the body of a patient 有权
标题翻译：共焦显微镜，用于对患者身体的选定位置进行成像
公开(公告)号：US20080239474A1
公开(公告)日：2008-10-02
申请号：US12154981
申请日：2008-05-29
申请人： William J. Fox , Christopher C. DiStasio , Scott R. Grodevant
发明人： William J. Fox , Christopher C. DiStasio , Scott R. Grodevant
IPC分类号： G02B21/00
CPC分类号： G02B21/0048 , A61B5/0064 , A61B5/0068 , A61B5/6835 , G02B21/0012 , G02B21/0028 , G02B21/008 , G02B21/362
摘要： A confocal imaging microscope, especially for the cellular imaging of the skin at selected locations, is ergonomic in use, compact, and positionable at the locations thereby providing for patient comfort during imaging. An imaging head (28) is gimble mounted on a multi-axis compound arm (34) to allow for precise placement of a confocal objective (116) extending from the head at selected locations against the skin of the patient while providing for patient comfort. The arm (34) attaches the head to an upright station (10) which may be movable along the floor on which the station is disposed. The station (10) has a platform (16) on which a keyboard (24) and a display (22) for monitoring the images is supported. The station (10) also supports a personal computer (PC) (26) for processing signals providing the images on the display and controlling the microscope. The head (28) contains an integrated assembly of the optical and mechanical components of the microscope. The assembly includes a main chassis plate (82). The optical components are mounted principally on one side of the plate while a PC board (130) is mounted on the opposite side of the plate. The board (130) mounts the electronic components, including interfaces, a microprocessor (222), and drivers (206, 208, 210) for motors (105, 106, 108) which control scanning and may also control fine positioning of the locations being imaged. Controls (50) for the fine positioning and focusing are on the head (28) for ease of use. The head (28) is detachable from the arm for manual disposition which is useful when imaging, not only the skin but other tissues, especially for research in investigating living processes at the cellular level.
摘要翻译：共焦成像显微镜，特别是用于在选定位置处的皮肤的细胞成像，其在使用中是人体工程学的，紧凑的和可定位的，从而在成像期间提供患者的舒适度。成像头（28）被安装在多轴复合臂（34）上，以允许在选定位置处从选定位置延伸的聚焦物镜（116）精确地放置在患者皮肤上，同时提供患者舒适度。臂（34）将头部附接到直立站（10），其可以沿着设置站的地板移动。站（10）具有平台（16），支撑用于监视图像的键盘（24）和显示器（22）。站（10）还支持个人计算机（PC）（26），用于处理在显示器上提供图像并控制显微镜的信号。头部（28）包含显微镜的光学和机械部件的集成组件。组件包括主底板（82）。光学部件主要安装在板的一侧，而PC板（130）安装在板的相对侧上。板（130）安装包括接口的电子部件，微处理器（222）和用于控制扫描的电动机（105,106,108）的驱动器（206,208,210），并且还可以控制位置的精细定位成像。用于精细定位和聚焦的控制器（50）位于头部（28）上以便于使用。头部（28）可从手臂上拆卸，用于手动配置，这对于成像不仅皮肤而且其它组织尤其是用于调查细胞水平的生物过程的研究是有用的。

10. 发明授权

US06816262B1 Colorimeter having field programmable gate array 失效
标题翻译：色度计具有现场可编程门阵列
公开(公告)号：US06816262B1
公开(公告)日：2004-11-09
申请号：US09650182
申请日：2000-08-29
申请人： David Slocum , Justin R. Louise , Cormic K. Merle , John A. Boles , Jay M. Eastman , William J. Fox , Roger J. Greenwald , Robert J. Hutchinson
发明人： David Slocum , Justin R. Louise , Cormic K. Merle , John A. Boles , Jay M. Eastman , William J. Fox , Roger J. Greenwald , Robert J. Hutchinson
IPC分类号： G01N2125
CPC分类号： G01J1/06 , G01J3/02 , G01J3/0256 , G01J3/0264 , G01J3/0291 , G01J3/465 , G01J3/51 , G01J3/513 , G01J5/602
摘要： A colorimeter capable of calibrating color monitors, whether having cathode ray tube or liquid crystal (LCD) displays, is provided by a photometric array of photodetector and optical filter pairs. The filters include long-pass, edge filters which cover overlapping regions at the upper end of the visible spectrum and a filter which covers the entire visible spectrum. The outputs of the photodetectors are digitally synthesized to provide a response which mimics the response established by the Commission Internationale de 1′Eclairage (CIE) xyz (bar) functions almost perfectly. The response which is mimicked may be represented by the CIE color matching functions. The pairs and the associated components are mounted on a printed circuit board captured in a clamshell housing and having an array of apertures which define angularly constrained fields of view of a surface from which the light, to be colormetrically analyzed, emanates. The printed circuit board includes a field programmable gate array programmed to read data from the plurality of filter/detector pairs in parallel. The colorimeter is capable generally of measuring the color characteristics, especially the color temperatures of radiation radiating and reflecting bodies (sources), including so-called black bodies.
摘要翻译：通过光电检测器和光学滤波器对的光度阵列提供能够校准彩色监视器的色度计（无论是阴极射线管还是液晶显示器）。滤波器包括覆盖可见光谱上端的重叠区域的覆盖整个可见光谱的滤光片，可以覆盖整个可见光谱的滤光片。光电探测器的输出是数字合成的，以提供模拟国际委员会（CIE）xyz（bar）委员会建立的响应几乎完美的响应。模拟的响应可以由CIE颜色匹配功能表示。成对和相关联的部件安装在捕获在蛤壳式壳体中的印刷电路板上，并且具有定义角度约束的表面角度约束的视场阵列的孔阵列，要从其中发光的光进行多角度分析。印刷电路板包括编程为并行地从多个滤波器/检测器对读取数据的现场可编程门阵列。色度计通常能够测量颜色特性，特别是辐射辐射和反射体（光源）的色温，包括所谓的黑体。

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