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11. 发明申请

US20060093528A1 Device including a dissolvable structure for flow control 审中-公开
标题翻译：装置包括用于流量控制的可溶解结构
公开(公告)号：US20060093528A1
公开(公告)日：2006-05-04
申请号：US11252821
申请日：2005-10-18
申请人： Debjyoti Banerjee , Konrad Faulstich , Aldrich Lau , Umberto Ulmanella , Jun Xie
发明人： Debjyoti Banerjee , Konrad Faulstich , Aldrich Lau , Umberto Ulmanella , Jun Xie
IPC分类号： B01L3/00
CPC分类号： F16K99/0001 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0415 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0661 , B01L2400/0677 , B01L2400/0683 , B01L2400/082 , B01L2400/084 , B01L2400/086 , F16K99/003 , F16K99/0036 , F16K99/0057 , F16K2099/0084 , Y10S422/901 , Y10T137/0318 , Y10T137/0324 , Y10T137/1624 , Y10T137/1812 , Y10T137/2191 , Y10T137/8376 , Y10T137/8593 , Y10T137/85978 , Y10T436/143333 , Y10T436/2575
摘要： A diagnostic device is provided that includes a plurality of retainment regions, with the retainment regions that are separated by at least one dissolvable barrier. The retainment regions can be interconnected through at least one fluid processing passageway. A retainment region can include a container such as a retainment region, well, chamber, or other receptacle, or a retainment region such as a surface on which the material is retained. The retainment regions can include a reaction retainment region, one or more reagent retainment regions, each containing unreacted reagents, and a sample retainment region. A pressure-actuated valve can be positioned in each fluid processing passageway interconnecting the one or more reagent retainment regions with the respective intermediate retainment regions interposed between each of the one or more reagent retainment regions and the reaction retainment region. The dissolvable barrier can be a fluid flow modulator in the at least one fluid processing passageway.
摘要翻译：提供了一种诊断装置，其包括多个保持区域，其中保留区域被至少一个可溶解屏障隔开。保持区域可以通过至少一个流体处理通道相互连接。保持区域可以包括诸如保持区域，孔，腔室或其它容器的容器，或诸如保持材料的表面的保持区域。保留区域可以包括反应保留区域，一个或多个试剂保留区域，每个含有未反应的试剂和样品保留区域。压力致动阀可以定位在每个流体处理通道中，其将一个或多个试剂保留区域与插入在一个或多个试剂保留区域中的每一个和反应保留区域之间的各个中间保留区域互连。可溶解屏障可以是至少一个流体处理通道中的流体流动调节器。

12. 发明申请

US20060093526A1 Fluid processing device including composite material flow modulator 有权
标题翻译：流体处理装置包括复合材料流量调节器
公开(公告)号：US20060093526A1
公开(公告)日：2006-05-04
申请号：US11252915
申请日：2005-10-18
申请人： Konrad Faulstich , Aldrich Lau , Debjyoti Banerjee , Umberto Ulmanella , Jun Xie
发明人： Konrad Faulstich , Aldrich Lau , Debjyoti Banerjee , Umberto Ulmanella , Jun Xie
IPC分类号： B01L3/00
CPC分类号： F16K99/0001 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0415 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0661 , B01L2400/0677 , B01L2400/0683 , B01L2400/082 , B01L2400/084 , B01L2400/086 , F16K99/003 , F16K99/0036 , F16K99/0057 , F16K2099/0084 , Y10S422/901 , Y10T137/0318 , Y10T137/0324 , Y10T137/1624 , Y10T137/1812 , Y10T137/2191 , Y10T137/8376 , Y10T137/8593 , Y10T137/85978 , Y10T436/143333 , Y10T436/2575
摘要： A fluid processing device is provided that includes a substrate, a plurality of fluid retainment regions formed in or on the substrate, and a barrier at least partially separating two or more of the fluid retainment regions. The barrier includes a mixture of a sequestering material and a reaction component. The reaction component can be at least one of a reactant, a reagent, a catalyst, an initiator, a promoter, a cofactor, an enzyme, a salt, or a combination thereof. The sequestering material can be a porous material, a dissolvable material, or both.
摘要翻译：提供了一种流体处理装置，其包括衬底，形成在衬底中或衬底上的多个流体保持区域，以及至少部分地分离两个或更多个流体保持区域的屏障。屏障包括螯合材料和反应组分的混合物。反应组分可以是反应物，试剂，催化剂，引发剂，助催化剂，辅因子，酶，盐或其组合中的至少一种。隔离材料可以是多孔材料，可溶解材料或两者。

13. 发明授权

US08704158B2 Fluorescence standard, and the use thereof 有权
标题翻译：荧光标准及其用途
公开(公告)号：US08704158B2
公开(公告)日：2014-04-22
申请号：US12937009
申请日：2009-04-17
申请人： Klaus Haberstroh , Konrad Faulstich
发明人： Klaus Haberstroh , Konrad Faulstich
IPC分类号： G01D18/00 , G01J1/58 , G01N21/00 , C12M1/34
CPC分类号： G01N21/278 , B01L3/50857 , B01L3/5088 , B01L2200/148 , B01L2300/0822 , B01L2300/0829 , G01K11/14 , G01N1/28 , G01N21/6452 , G01N2001/2893 , G01N2015/1018 , G01T1/362 , Y10T436/10
摘要： The invention concerns fluorescence standards, and in particular fluorescence standards for calibrating optical detectors. According to the invention, a fluorescent mineral or mixtures of minerals are employed for use as a fluorescence standard. The fluorescent mineral can be a naturally occurring mineral or a synthetically produced mineral. Preferred fluorescent minerals for use as fluorescence standards are corundum, fluorite, turquoise, amber, zircon, zoisite, iolite or cordierite, spinel, topaz, calcium fluorite, sphalerite or zincblende, calcite or calcspar, apatite, scheelite or calcium tungstate, willemite, feldspars, sodalite, a uranium mineral, a mineral containing Al3+, and in particular ruby and sapphire.
摘要翻译：本发明涉及荧光标准，特别是用于校准光学检测器的荧光标准。根据本发明，荧光矿物或矿物质的混合物用作荧光标准。荧光矿物可以是天然存在的矿物质或合成产生的矿物质。用作荧光标准的优选的荧光矿物是刚玉，萤石，绿松石，琥珀，锆石，堇青石，石英或堇青石，尖晶石，黄玉，萤石，闪锌矿或闪锌矿，方解石或钙质，磷灰石，白钨矿或钨酸钙，硅锌矿，长石，钠盐，铀矿物质，含有Al3 +的矿物，特别是红宝石和蓝宝石。

14. 发明授权

US08202479B1 Light collection system 有权
标题翻译：集光系统
公开(公告)号：US08202479B1
公开(公告)日：2012-06-19
申请号：US11270263
申请日：2005-11-09
申请人： Dar Bahatt , Konrad Faulstich
发明人： Dar Bahatt , Konrad Faulstich
IPC分类号： C12M1/34
CPC分类号： C12Q1/66 , G01N21/6428 , G01N21/645 , G01N21/66 , G01N21/763 , G01N33/581 , G01N2021/6439 , G01N2021/6469
摘要： The present teachings provide a detection cell for a biological material and methods for detecting biological material including a photosensitive material optically coupled to an interior volume containing the biological material so to avoid optical components or an external light source.
摘要翻译：本教导提供了用于生物材料的检测单元和用于检测生物材料的方法，所述生物材料包括与包含生物材料的内部空间光学耦合的感光材料，以避免光学部件或外部光源。

15. 发明申请

US20110126913A1 Device Including A Dissolvable Structure For Flow Control 有权
标题翻译：包括流量控制可溶解结构的装置
公开(公告)号：US20110126913A1
公开(公告)日：2011-06-02
申请号：US12954519
申请日：2010-11-24
申请人： Debjyoti Banerjee , Konrad Faulstich , Aldrich N. K. Lau , Umberto Ulmanella , Jun Xie
发明人： Debjyoti Banerjee , Konrad Faulstich , Aldrich N. K. Lau , Umberto Ulmanella , Jun Xie
IPC分类号： F16K31/64 , F16K51/00
CPC分类号： F16K99/0001 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0415 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0661 , B01L2400/0677 , B01L2400/0683 , B01L2400/082 , B01L2400/084 , B01L2400/086 , F16K99/003 , F16K99/0036 , F16K99/0057 , F16K2099/0084 , Y10S422/901 , Y10T137/0318 , Y10T137/0324 , Y10T137/1624 , Y10T137/1812 , Y10T137/2191 , Y10T137/8376 , Y10T137/8593 , Y10T137/85978 , Y10T436/143333 , Y10T436/2575
摘要： A diagnostic device is provided that includes a plurality of retainment regions, with the retainment regions that are separated by at least one dissolvable barrier. The retainment regions can be interconnected through at least one fluid processing passageway. A retainment region can include a container such as a retainment region, well, chamber, or other receptacle, or a retainment region such as a surface on which the material is retained. The retainment regions can include a reaction retainment region, one or more reagent retainment regions, each containing unreacted reagents, and a sample retainment region. A pressure-actuated valve can be positioned in each fluid processing passageway interconnecting the one or more reagent retainment regions with the respective intermediate retainment regions interposed between each of the one or more reagent retainment regions and the reaction retainment region. The dissolvable barrier can be a fluid flow modulator in the at least one fluid processing passageway.
摘要翻译：提供了一种诊断装置，其包括多个保持区域，其中保留区域被至少一个可溶解的屏障隔开。保持区域可以通过至少一个流体处理通道相互连接。保持区域可以包括诸如保持区域，孔，腔室或其它容器的容器，或诸如保持材料的表面的保持区域。保留区域可以包括反应保留区域，一个或多个试剂保留区域，每个含有未反应的试剂和样品保留区域。压力致动阀可以定位在每个流体处理通道中，其将一个或多个试剂保留区域与插入在一个或多个试剂保留区域中的每一个和反应保留区域之间的各个中间保留区域互连。可溶解屏障可以是至少一个流体处理通道中的流体流动调节器。

16. 发明授权

US06627416B1 5′-modified nucleotides and the application thereof in molecular biology and medicine 失效
标题翻译： 5'-修饰的核苷酸及其在分子生物学和医学中的应用
公开(公告)号：US06627416B1
公开(公告)日：2003-09-30
申请号：US09646890
申请日：2001-01-10
申请人： Konrad Faulstich , Wilhelm Ansorge
发明人： Konrad Faulstich , Wilhelm Ansorge
IPC分类号： C12Q168
CPC分类号： C12Q1/6869 , C12Q2527/119 , C12Q2527/101 , C12Q2525/113
摘要： The invention relates to 5′-modified nucleotides and to nucleic acids which contain these nucleotides. Processes for incorporating the 5′-modified nucleotides into nucleic acids, and the subsequent site-specific cleavage of the nucleic acids at the 5′-modified monomer building blocks, are also disclosed. These processes can be employed for nucleic acid sequencing, for generating nucleic acid libraries, for detecting mutations, for preparing support-bound nucleic acids and for pharmaceutical purposes.
摘要翻译：本发明涉及5'-修饰的核苷酸和含有这些核苷酸的核酸。还公开了将5'-修饰的核苷酸并入核酸的方法，以及随后的5'-修饰的单体结构单元上的核酸的位点特异性切割。这些方法可用于核酸测序，产生核酸文库，检测突变，制备载体结合核酸和用于制药目的。

17. 发明申请

US20100110439A1 OPTICAL MEASURING INSTRUMENT 审中-公开
标题翻译：光学测量仪器
公开(公告)号：US20100110439A1
公开(公告)日：2010-05-06
申请号：US12449649
申请日：2008-02-25
申请人： Roman Gruler , Konrad Faulstich
发明人： Roman Gruler , Konrad Faulstich
IPC分类号： G01N21/01 , G01N1/10 , G01N21/55 , G01T1/10
CPC分类号： G01N21/645 , G01N21/255 , G01N21/8483 , G01N2201/0228 , G01N2201/024
摘要： The invention provides for an optical measuring instrument and measuring device. The optical measuring instrument for investigating a specimen contained in a sample comprises at least one source for providing at least one electromagnetic beam intended to irradiate the sample and to interact with the specimen within the sample, at least one sensor for detecting an output of the interaction between the specimen and the electromagnetic beam, an integrally formed mechanical bench for the optical and electronic components, a sample holder for holding the sample, wherein the at least one source, the at least one sensor, and the mechanical bench are integrated in one monolithic optoelectronic module and the sample holder can be connected to this module.
摘要翻译：本发明提供一种光学测量仪器和测量装置。用于调查包含在样品中的样本的光学测量仪器包括至少一个源，用于提供用于照射样品的至少一个电磁束并与样品内的样品相互作用，用于检测相互作用的输出的至少一个传感器在样品和电磁束之间，用于光学和电子部件的整体形成的机械台，用于保持样品的样品保持器，其中所述至少一个源，所述至少一个传感器和所述机械台被集成在一个单片光电模块和样品架可以连接到该模块。

18. 发明授权

US08551697B1 Electrochemical polynucleotide detection comprising ligation 失效
标题翻译：包含连接的电化学多核苷酸检测
公开(公告)号：US08551697B1
公开(公告)日：2013-10-08
申请号：US11609111
申请日：2006-12-11
申请人： Vladimir I. Bashkirov , Konrad Faulstich
发明人： Vladimir I. Bashkirov , Konrad Faulstich
IPC分类号： C12Q1/68 , C12P19/36 , C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6834 , C12Q1/6825 , C12Q1/6823 , C12Q2521/501 , C12Q2563/113 , C12Q2565/607
摘要： Disclosed, for example, are methods comprising cleaving an uncleaved probe to form a cleaved oligonucleotide flap, forming a hybridization complex between the cleaved oligonucleotide flap, a bridging oligonucleotide, and a capture oligonucleotide that is immobilized on a surface, such that the oligonucleotide flap and the capture oligonucleotide are hybridized to immediately adjacent, complementary regions of the bridging oligonucleotide, ligating the oligonucleotide flap to the capture oligonucleotide to form an immobilized ligation product, and detecting the ligation product.
摘要翻译：公开了例如，切割未切割的探针以形成切割的寡核苷酸瓣，在切割的寡核苷酸瓣，桥连寡核苷酸和固定在表面上的捕获寡核苷酸之间形成杂交复合物的方法，使得寡核苷酸瓣和将捕获寡核苷酸与桥接寡核苷酸的紧邻的互补区域杂交，将寡核苷酸片段连接至捕获寡核苷酸以形成固定化的连接产物，并检测连接产物。

19. 发明申请

US20120214156A1 DEVICE INCLUDING A DISSOLVABLE STRUCTURE FOR FLOW CONTROL 审中-公开
标题翻译：包括用于流量控制的不溶性结构的装置
公开(公告)号：US20120214156A1
公开(公告)日：2012-08-23
申请号：US13403355
申请日：2012-02-23
申请人： Debjyoti BANERJEE , Konrad Faulstich , Aldrich N.K. Lau , Umberto Ulmanella , Jun Xie
发明人： Debjyoti BANERJEE , Konrad Faulstich , Aldrich N.K. Lau , Umberto Ulmanella , Jun Xie
IPC分类号： C12Q1/68 , B01L3/02 , G01N1/38
CPC分类号： F16K99/0001 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0415 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0661 , B01L2400/0677 , B01L2400/0683 , B01L2400/082 , B01L2400/084 , B01L2400/086 , F16K99/003 , F16K99/0036 , F16K99/0057 , F16K2099/0084 , Y10S422/901 , Y10T137/0318 , Y10T137/0324 , Y10T137/1624 , Y10T137/1812 , Y10T137/2191 , Y10T137/8376 , Y10T137/8593 , Y10T137/85978 , Y10T436/143333 , Y10T436/2575
摘要： A diagnostic device is provided that includes a plurality of retainment regions, with the retainment regions that are separated by at least one dissolvable barrier. The retainment regions can be interconnected through at least one fluid processing passageway. A retainment region can include a container such as a retainment region, well, chamber, or other receptacle, or a retainment region such as a surface on which the material is retained. The retainment regions can include a reaction retainment region, one or more reagent retainment regions, each containing unreacted reagents, and a sample retainment region. A pressure-actuated valve can be positioned in each fluid processing passageway interconnecting the one or more reagent retainment regions with the respective intermediate retainment regions interposed between each of the one or more reagent retainment regions and the reaction retainment region. The dissolvable barrier can be a fluid flow modulator in the at least one fluid processing passageway.
摘要翻译：提供了一种诊断装置，其包括多个保持区域，其中保留区域被至少一个可溶解屏障隔开。保持区域可以通过至少一个流体处理通道相互连接。保持区域可以包括诸如保持区域，孔，腔室或其它容器的容器，或诸如保持材料的表面的保持区域。保留区域可以包括反应保留区域，一个或多个试剂保留区域，每个含有未反应的试剂和样品保留区域。压力致动阀可以定位在每个流体处理通道中，其将一个或多个试剂保留区域与插入在一个或多个试剂保留区域中的每一个和反应保留区域之间的各个中间保留区域互连。可溶解屏障可以是至少一个流体处理通道中的流体流动调节器。

20. 发明授权

US08062611B2 Fluid processing device including composite material flow modulator 有权
标题翻译：流体处理装置包括复合材料流量调节器
公开(公告)号：US08062611B2
公开(公告)日：2011-11-22
申请号：US11252915
申请日：2005-10-18
申请人： Konrad Faulstich , Aldrich N. K. Lau , Debjyoti Banerjee , Umberto Ulmanella , Jun Xie
发明人： Konrad Faulstich , Aldrich N. K. Lau , Debjyoti Banerjee , Umberto Ulmanella , Jun Xie
IPC分类号： B01L3/00
CPC分类号： F16K99/0001 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0415 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0661 , B01L2400/0677 , B01L2400/0683 , B01L2400/082 , B01L2400/084 , B01L2400/086 , F16K99/003 , F16K99/0036 , F16K99/0057 , F16K2099/0084 , Y10S422/901 , Y10T137/0318 , Y10T137/0324 , Y10T137/1624 , Y10T137/1812 , Y10T137/2191 , Y10T137/8376 , Y10T137/8593 , Y10T137/85978 , Y10T436/143333 , Y10T436/2575
摘要： A fluid processing device is provided that includes a substrate, a plurality of fluid retainment regions formed in or on the substrate, and a barrier at least partially separating two or more of the fluid retainment regions. The barrier includes a mixture of a sequestering material and a reaction component. The reaction component can be at least one of a reactant, a reagent, a catalyst, an initiator, a promoter, a cofactor, an enzyme, a salt, or a combination thereof. The sequestering material can be a porous material, a dissolvable material, or both.
摘要翻译：提供了一种流体处理装置，其包括衬底，形成在衬底中或衬底上的多个流体保持区域，以及至少部分地分离两个或更多个流体保持区域的屏障。屏障包括螯合材料和反应组分的混合物。反应组分可以是反应物，试剂，催化剂，引发剂，助催化剂，辅因子，酶，盐或其组合中的至少一种。隔离材料可以是多孔材料，可溶解材料或两者。

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