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11. 发明授权

US5732172A Laser pulse sampler 失效
标题翻译：激光脉冲采样器
公开(公告)号：US5732172A
公开(公告)日：1998-03-24
申请号：US705448
申请日：1996-08-29
申请人： Charles Vann
发明人： Charles Vann
IPC分类号： G01J11/00 , G02B6/34 , G02B6/26
CPC分类号： G01J11/00 , G02B6/34
摘要： The Laser Pulse Sampler (LPS) measures temporal pulse shape without the problems of a streak camera. Unlike the streak camera, the laser pulse directly illuminates a camera in the LPS, i.e., no additional equipment or energy conversions are required. The LPS has several advantages over streak cameras. The dynamic range of the LPS is limited only by the range of its camera, which for a cooled camera can be as high as 16 bits, i.e., 65,536. The LPS costs less because there are fewer components, and those components can be mass produced. The LPS is easier to calibrate and maintain because there is only one energy conversion, i.e., photons to electrons, in the camera.
摘要翻译：激光脉冲采样器（LPS）测量时间脉冲形状而没有条纹相机的问题。与条纹相机不同，激光脉冲直接照射LPS中的相机，即不需要额外的设备或能量转换。 LPS相对于条纹相机具有几个优点。 LPS的动态范围仅受照相机的范围的限制，相机的范围可以高达16位，即65,536。 LPS成本较低，因为组件数量较少，而且这些组件可以批量生产。由于在照相机中只有一个能量转换，即光子到电子，LPS更容易校准和维护。

12. 发明申请

US20070148050A1 APPARATUS AND METHOD FOR SPOTTING A SUBSTRATE 审中-公开
标题翻译：装置和方法用于分选基板
公开(公告)号：US20070148050A1
公开(公告)日：2007-06-28
申请号：US11683794
申请日：2007-03-08
申请人： Charles Vann , Zbigniew Bryning
发明人： Charles Vann , Zbigniew Bryning
IPC分类号： B01L3/02
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00369 , B01J2219/00376 , B01J2219/00387 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01L3/0251 , B01L3/0262 , B01L2300/0819 , B01L2300/0838 , B01L2400/028 , B01L2400/0406 , C40B60/14 , G01N35/1016 , G01N35/1067 , G01N35/1074 , G01N2035/00237 , G01N2035/1034 , G01N2035/1037 , G01N2035/1039 , G01N2035/1069 , Y10T436/25 , Y10T436/2575
摘要： The present invention provides a method and apparatus for dispensing a small volume of a selected liquid, such as a biological sample or reagent, onto a substrate. The device includes a tube adapted to contain the liquid. An elongated fiber is disposed within the tube for axial movement therein between raised and lowered positions. Upon shifting or oscillating the fiber between its raised and lowered positions, a liquid spot can be formed at a selected position on the substrate. The device is readily adaptable for the production of micro-arrays having a great number of individual spots.
摘要翻译：本发明提供了一种将少量体积的选定液体（例如生物样品或试剂）分配到基底上的方法和装置。该装置包括适于容纳液体的管。细长纤维设置在管内用于在升高和降低位置之间的轴向移动。当纤维在其升高和降低位置之间移动或摆动时，可以在衬底上的选定位置处形成液体斑点。该装置易于适用于具有大量单个斑点的微阵列的生产。

13. 发明申请

US20050208543A1 Phosphor particle coded beads 有权
标题翻译：荧光粉颗粒编码珠
公开(公告)号：US20050208543A1
公开(公告)日：2005-09-22
申请号：US11031983
申请日：2005-01-06
申请人： Charles Vann , Charles Connell , Aldrich Lau , Meng Taing , Steven Menchen
发明人： Charles Vann , Charles Connell , Aldrich Lau , Meng Taing , Steven Menchen
IPC分类号： C12Q1/68 , C40B20/04 , C40B70/00 , G01N33/53 , G01N33/533 , G01N33/543 , G01N33/58
CPC分类号： B82Y5/00 , C12Q2563/155 , G01N33/54346 , G01N33/587
摘要： Beads coded with phosphor particles and methods of making and using them are provided.
摘要翻译：提供用磷光体颗粒编码的珠子，并制作和使用它们的方法。

14. 发明申请

US20050118589A1 Digital array 审中-公开
标题翻译：数字阵列
公开(公告)号：US20050118589A1
公开(公告)日：2005-06-02
申请号：US10496300
申请日：2002-11-21
申请人： Charles Vann , Kai Lao , Mark Reed
发明人： Charles Vann , Kai Lao , Mark Reed
IPC分类号： G01N33/53 , A61K20060101 , C07H21/02 , C12N9/22 , C12P19/34 , C12Q1/68 , G01N33/543 , G01N33/566
CPC分类号： C12Q1/6816 , B82Y5/00 , B82Y10/00 , C12Q1/6827 , C12Q2563/155 , C12Q2561/125 , C12Q2545/114 , C12Q2565/102 , C12Q2563/143
摘要： The invention relates to methods and compositions for the detection of targets in a sample.
摘要翻译：本发明涉及用于检测样品中靶标的方法和组合物。

15. 发明申请

US20050026209A1 Optical fiber bundle for detecting binding of chemical species 审中-公开
标题翻译：用于检测化学物质结合的光纤束
公开(公告)号：US20050026209A1
公开(公告)日：2005-02-03
申请号：US10932608
申请日：2004-09-01
申请人： Charles Vann
发明人： Charles Vann
IPC分类号： B01J19/00 , B01L3/00 , C40B40/06 , C40B50/14 , C40B60/14 , G01N21/64 , G01N21/77 , C12Q1/68
CPC分类号： G01N21/7703 , B01J19/0046 , B01J2219/00326 , B01J2219/0043 , B01J2219/00495 , B01J2219/00515 , B01J2219/00524 , B01J2219/00572 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00657 , B01J2219/00675 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B01L3/5023 , B01L3/5085 , B82Y30/00 , C40B40/06 , C40B50/14 , C40B60/14 , G01N21/6452 , G01N21/648 , G01N2201/0833
摘要： The system includes a bundle of elongate optical fibers, multiple probes, a well, a light source and a detector. The optical fibers each have a first end remote from a second end. Each of the multiple probes is attached to one of the optical fibers within a predetermined section between each of the optical fiber's first and second ends. The well is configured to hold a solution comprising a target and to receive at least the predetermined section of each of the optical fibers. The light source is configured to direct light into the first end of each of the optical fibers. Finally, the detector is configured to detect light emitted by the binding of the target to at least one of the multiple probes. In some embodiments, there are multiple bundles and multiple wells.
摘要翻译：该系统包括一束细长的光纤，多个探针，阱，光源和检测器。光纤各自具有远离第二端的第一端。多个探针中的每一个在每个光纤的第一和第二端之间的预定部分内附接到光纤中的一个。井被配置为保持包括目标的解决方案并且接收每个光纤的至少预定部分。光源被配置为将光引导到每个光纤的第一端。最后，检测器被配置为检测由目标物与至少一个多个探针的结合发射的光。在一些实施例中，存在多个束和多个孔。

16. 发明申请

US20060102477A1 Electrowetting dispensing devices and related methods 审中-公开
公开(公告)号：US20060102477A1
公开(公告)日：2006-05-18
申请号：US11213355
申请日：2005-08-26
申请人： Charles Vann , Debjyoti Banerjee , Timothy Geiser , James Nurse , Nigel Beard
发明人： Charles Vann , Debjyoti Banerjee , Timothy Geiser , James Nurse , Nigel Beard
IPC分类号： C07K1/26
摘要： A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. The method may further comprise dispensing the aligned liquid from the plurality of predetermined locations through a plurality of openings respectively aligned with the predetermined locations. The dispensing may be via electrowetting.

17. 发明申请

US20050130318A1 Bead dispensing system 有权
公开(公告)号：US20050130318A1
公开(公告)日：2005-06-16
申请号：US10990714
申请日：2004-11-16
申请人： Charles Vann , Dennis Lehto
发明人： Charles Vann , Dennis Lehto
IPC分类号： G01N33/53 , B01J19/00 , B01L3/02 , B01L99/00 , C40B40/06 , C40B60/14 , C40B70/00 , G01N35/00 , G01N35/10 , G01N37/00 , B01L3/00
CPC分类号： G01N35/1065 , B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/00315 , B01J2219/00317 , B01J2219/00369 , B01J2219/00468 , B01J2219/005 , B01J2219/00545 , B01J2219/00549 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/0065 , B01J2219/00659 , B01J2219/00677 , B01J2219/00689 , B01J2219/00691 , B01J2219/00693 , B01J2219/00702 , B01J2219/00722 , B01L3/021 , B01L3/0289 , B01L3/563 , B01L2200/021 , B01L2200/0647 , B01L2200/0657 , B01L2200/143 , B01L2300/0654 , B01L2300/0864 , B01L2400/0415 , B01L2400/043 , B01L2400/0487 , B01L2400/049 , B82Y30/00 , C40B40/06 , C40B60/14 , C40B70/00 , G01N35/10 , G01N2035/00574 , Y10T436/11 , Y10T436/255 , Y10T436/2575
摘要： A bead dispensing system is provided for delivering small amounts of substances onto substrates. The system can include, for example, a movable support structure having an array of spaced-apart projections depending from its lower side. An attraction source, such as a vacuum, magnetic, and/or electrostatic force, is operable at each projection end region to attract and retain one bead. The projection array can be aligned with an array of bead-receiving regions of a substrate, e.g., an array of spaced-apart wells of a micro-plate or card. In one embodiment, a plurality of reagent-carrying beads are picked up, retained at respective projection end regions, and moved to a location over a multi-well plate. The beads are then released in a fashion permitting each bead to land in a respective well. The system of the invention is particularly useful for fabricating arrays of reagents.

18. 发明申请

US20050120949A1 Apparatus and method for spotting a substrate 失效
标题翻译：用于点样衬底的装置和方法
公开(公告)号：US20050120949A1
公开(公告)日：2005-06-09
申请号：US11038334
申请日：2005-01-18
申请人： Charles Vann , Zbigniew Bryning
发明人： Charles Vann , Zbigniew Bryning
IPC分类号： G01N37/00 , B01J19/00 , B01L3/02 , C40B60/14 , G01N35/00 , G01N35/10 , B05C3/00
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00369 , B01J2219/00376 , B01J2219/00387 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01L3/0251 , B01L3/0262 , B01L2300/0819 , B01L2300/0838 , B01L2400/028 , B01L2400/0406 , C40B60/14 , G01N35/1016 , G01N35/1067 , G01N35/1074 , G01N2035/00237 , G01N2035/1034 , G01N2035/1037 , G01N2035/1039 , G01N2035/1069 , Y10T436/25 , Y10T436/2575
摘要： The present invention provides a method and apparatus for dispensing a small volume of a selected liquid, such as a biological sample or reagent, onto a substrate. The device includes a tube adapted to contain the liquid. An elongated fiber is disposed within the tube for axial movement therein between raised and lowered positions. Upon shifting or oscillating the fiber between its raised and lowered positions, a liquid spot can be formed at a selected position on the substrate. The device is readily adaptable for the production of micro-arrays having a great number of individual spots.
摘要翻译：本发明提供了一种将少量体积的选定液体（例如生物样品或试剂）分配到基底上的方法和装置。该装置包括适于容纳液体的管。细长纤维设置在管内用于在升高和降低位置之间的轴向移动。当纤维在其升高和降低位置之间移动或摆动时，可以在衬底上的选定位置处形成液体斑点。该装置易于适用于具有大量单个斑点的微阵列的生产。

19. 发明授权

US08536099B2 Methods of bead manipulation and forming bead arrays 有权
标题翻译：珠粒操作和形成珠粒阵列的方法
公开(公告)号：US08536099B2
公开(公告)日：2013-09-17
申请号：US12872333
申请日：2010-08-31
申请人： Mark Oldham , George Fry , Christina Inman , John Bridgham , Timothy Hunkapillar , Charles Vann
发明人： Mark Oldham , George Fry , Christina Inman , John Bridgham , Timothy Hunkapillar , Charles Vann
IPC分类号： C40B30/00 , C40B30/04 , C40B30/08 , C40B30/10
CPC分类号： C12Q1/6869 , B01F13/0059 , B01F13/0222 , B01J19/0046 , B01J2219/00317 , B01J2219/00466 , B01J2219/00527 , B01J2219/00576 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00722 , B01L3/502707 , B01L3/50273 , B01L2200/027 , B01L2200/0647 , B01L2200/0684 , B01L2200/16 , B01L2300/0819 , B01L2300/0822 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/1822 , B01L2400/0427 , C12Q1/6874 , G01N35/00069 , G01N35/1002 , G01N35/1097 , G01N2035/00148 , G01N2035/00237 , G01N2035/1034 , G02B21/34 , Y10T436/11 , Y10T436/143333
摘要： According to various embodiments, a method is provided that comprises washing an array of DNA-coated beads on a substrate, with a wash solution to remove stacked beads from the substrate. The wash solution can include inert solid beads in a carrier. The DNA-coated beads can have an average diameter and the solid beads in the wash solution can have an average diameter that is at least twice the diameter of the DNA-coated beads. The washing can form dislodged DNA-coated beads and a monolayer of DNA-coated beads. In some embodiments, first beads for forming an array are contacted with a poly(ethylene glycol) (PEG) solution comprising a PEG having a molecular weight of about 350 Da or less. In some embodiments, slides for forming bead arrays are provided as are systems for imaging the same.
摘要翻译：根据各种实施方案，提供了一种方法，其包括用洗涤溶液洗涤基底上的DNA包被的珠粒阵列以从基底去除堆叠的珠粒。洗涤溶液可以在载体中包括惰性固体珠。 DNA包被的珠可以具有平均直径，并且洗涤溶液中的固体珠的平均直径可以是DNA包被的珠的直径的至少两倍。洗涤可以形成脱落的DNA包被的珠粒和单层DNA包被的珠粒。在一些实施方案中，用于形成阵列的第一珠粒与包含分子量约350Da或更低的PEG的聚（乙二醇）（PEG）溶液接触。在一些实施例中，用于形成珠阵列的滑块被提供为用于对其进行成像的系统。

20. 发明申请

US20070258862A1 Variable volume dispenser and method 审中-公开
标题翻译：可变体积分配器和方法
公开(公告)号：US20070258862A1
公开(公告)日：2007-11-08
申请号：US11799546
申请日：2007-05-02
申请人： Charles Vann
发明人： Charles Vann
IPC分类号： B01L3/00
CPC分类号： B01L3/0217 , B01J2219/00459 , B01L2200/0605 , B01L2200/0657 , B01L2300/0681 , B01L2400/0487 , G01F11/18 , G01F15/001 , G01F15/125
摘要： A variable volume dispenser contains a set of one or more fill tubes, each having a rod or other volume-limiting member slidably mounted therein. Suction pressure can aspirate supported oligonucleotide beads or other powder, granulate, or particulate material into the fill tubes for dispensing selected volumes into wells or other containers. The rods or other members can be constructed to comprise a filter having a pore size smaller than the particulate material to be manipulated so that the material cannot be lodged inside the fill tube. In various embodiments, the volume of powder or other material to be aspirated can be selectively set by moving the rods to different locations within the fill tubes using electromagnets. In various embodiments, individual rods can be independently activated.
摘要翻译：可变体积分配器包含一组一个或多个填充管，每个填充管具有可滑动地安装在其中的杆或其他容积限制构件。吸入压力可以将负载的寡核苷酸珠或其它粉末，颗粒或颗粒材料吸入填充管中，以将选定体积分配到孔或其它容器中。杆或其它构件可以被构造成包括孔径小于待操作的颗粒材料的过滤器，使得材料不能被填充在填充管内。在各种实施例中，可以通过使用电磁体将棒移动到填充管内的不同位置来选择性地设置待吸入的粉末或其它材料的体积。在各种实施例中，单独的杆可以被独立地激活。

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