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161. 发明申请

US20100256465A1 DEVICES AND TECHNIQUES ASSOCIATED WITH DIAGNOSTICS, THERAPIES, AND OTHER APPLICATIONS, INCLUDING SKIN-ASSOCIATED APPLICATIONS 有权
标题翻译：与诊断，治疗和其他应用相关的设备和技术，包括皮肤相关应用
公开(公告)号：US20100256465A1
公开(公告)日：2010-10-07
申请号：US12716229
申请日：2010-03-02
申请人： Howard Bernstein , Donald E. Chickering, III , Douglas A. Levinson , David R. Walt , Shawn Davis , Ramin Haghgooie , Robert S. Langer , Timothy M. Blicharz
发明人： Howard Bernstein , Donald E. Chickering, III , Douglas A. Levinson , David R. Walt , Shawn Davis , Ramin Haghgooie , Robert S. Langer , Timothy M. Blicharz
IPC分类号： A61B5/00 , A61B5/145 , G01N21/00
CPC分类号： A61B5/150099 , A61B5/0013 , A61B5/0022 , A61B5/0077 , A61B5/1438 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1459 , A61B5/14865 , A61B5/150022 , A61B5/150221 , A61B5/150358 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150503 , A61B5/150969 , A61B5/150984 , A61B5/151 , A61B5/15125 , A61B5/157 , A61B5/411 , A61B5/4839 , A61B5/4845 , A61B5/486 , A61B5/685 , A61B5/6898 , A61B5/743
摘要： The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor.
摘要翻译：本发明一般涉及与诊断，治疗和其它应用相关联的装置和技术，包括皮肤相关应用，例如用于递送和/或从主体（例如通过皮肤）排出流体的装置。在一些实施例中，所述装置包括用于在进入位置从所述受试者的皮肤和/或穿过所述受试者的皮肤接入可提取介质的系统，以及由支撑结构支撑的压力调节器，所述压力调节器能够至少在所述皮肤上形成压差访问站点的一部分。在一些情况下，该装置还可以包括由支撑结构支持的传感器，用于确定来自主体的可提取介质的至少一个状况，以及可选地由支撑结构支撑的信号发生器，用于产生与介质由传感器确定。

162. 发明申请

US20100233251A1 Vaccine Nanotechnology 审中-公开
标题翻译：疫苗纳米技术
公开(公告)号：US20100233251A1
公开(公告)日：2010-09-16
申请号：US12681814
申请日：2008-10-12
申请人： Ulrich H. Von Andrian , Omid C. Farokhzad , Robert S. Langer , Tobias Junt , Ashley Moseman , Liangfang Zhang , Pamela Basto , Matteo Iannacone , Frank Alexis
发明人： Ulrich H. Von Andrian , Omid C. Farokhzad , Robert S. Langer , Tobias Junt , Ashley Moseman , Liangfang Zhang , Pamela Basto , Matteo Iannacone , Frank Alexis
IPC分类号： A61K9/127 , A61K9/14 , A61K39/00
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.
摘要翻译：本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。本发明提供能够刺激T细胞和/或B细胞中的免疫应答的疫苗纳米载体，在一些实施方案中，包含至少一种免疫调节剂，并且任选地包含至少一种靶向部分和任选的至少一种免疫刺激剂。本发明提供包含本发明疫苗纳米载体的药物组合物。本发明提供了设计，制造和使用本发明疫苗纳米载体及其药物组合物的方法。本发明提供了预防和/或治疗疾病，病症和病症的方法，包括向有需要的受试者施用至少一种本发明的疫苗纳米载体。

163. 发明申请

US20100137696A1 MEDICAL DEVICE WITH RESERVOIR-BASED SENSORS 有权
标题翻译：具有基于储存器的传感器的医疗装置
公开(公告)号：US20100137696A1
公开(公告)日：2010-06-03
申请号：US12688508
申请日：2010-01-15
申请人： John T. Santini, JR. , Norman F. Sheppard, JR. , Chung Chang Young , Robert S. Langer
发明人： John T. Santini, JR. , Norman F. Sheppard, JR. , Chung Chang Young , Robert S. Langer
IPC分类号： A61B5/1473 , A61N1/08
CPC分类号： B01L3/50853 , A61B5/00 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61K9/0004 , A61K9/0009 , A61K9/0097 , A61K47/6957 , A61K49/0002 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00783 , B01J2219/00819 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00844 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00925 , B01J2219/00952 , B01J2219/00957 , B01J2219/00966 , B01J2219/0097 , B01J2219/00984 , B01J2219/00986 , B01L2200/12 , B01L2300/023 , B01L2300/049 , B01L2300/0627 , B01L2300/0654 , B01L2300/0819 , B01L2400/0677 , C40B60/14 , G01N2035/00158 , G01N2035/00247 , Y10T29/49007 , Y10T29/49117 , Y10T436/25
摘要： A medical device is provided which may include a reservoir which has an opening and contains a sensor; a reservoir cap closing off the opening to isolate the sensor from an environmental component outside the reservoirs, the reservoir cap being impermeable to the environmental component and adapted to selectively undergo a phase change to disintegrate the reservoir cap and thereby expose the sensor to the environmental component. A method of use may include (i) selectively disintegrating a reservoir cap to expose a sensor which is disposed inside a reservoir of a device implanted in a patient, the disintegrating comprising inducing a phase change in the reservoir cap; and (ii) using the sensor to generate an output signal, wherein the output signal is recorded and stored in a writeable computer memory chips, directed to a microprocessor for immediate analysis and processing, or sent to a remote location away from the device.
摘要翻译：提供一种医疗装置，其可以包括具有开口并包含传感器的储存器; 储存器盖封闭开口以将传感器与储存器外部的环境部件隔离，储存器盖不可渗透到环境部件并且适于选择性地进行相变以使储存器盖分解，从而将传感器暴露于环境部件。使用的方法可以包括（i）选择性地分解储存器盖以暴露设置在植入患者体内的装置的储存器内部的传感器，所述分解包括引起储存器盖中的相变; 以及（ii）使用所述传感器来产生输出信号，其中所述输出信号被记录并存储在可写入计算机存储器芯片中，指向微处理器以进行即时分析和处理，或者发送到远离所述设备的远程位置。

164. 发明申请

US20100015068A1 Methods and Compositions For Altering Biological Surfaces 审中-公开
标题翻译：改变生物表面的方法和组成
公开(公告)号：US20100015068A1
公开(公告)日：2010-01-21
申请号：US12309049
申请日：2007-07-06
申请人： Jeffrey M. Karp , Alireza Khademhosseini , David A. Berry , Robert S. Langer , Frank X. Gu
发明人： Jeffrey M. Karp , Alireza Khademhosseini , David A. Berry , Robert S. Langer , Frank X. Gu
IPC分类号： A61K8/24 , C01B25/32 , B32B5/16 , A61K33/42 , A61Q11/00 , A61P19/10
CPC分类号： A61K8/11 , A61K6/0008 , A61K6/0017 , A61K6/0067 , A61K6/0085 , A61K6/0235 , A61K6/024 , A61K6/0612 , A61K6/0643 , A61K6/0668 , A61K8/19 , A61K8/88 , A61K2800/412 , A61K2800/94 , A61L24/02 , A61Q11/00 , Y10T428/2982 , C08L1/286 , C08L5/00 , C08L5/08 , C08L33/02 , C08L1/00
摘要： Compositions, methods and kits are provided for altering the properties of a biological surface using particles such as, for instance, calcium based particles in combination with an agent that binds to the biological surface. Properties such as color, sheen, texture, strength, and odor of biological surfaces such as teeth and bone are alterable.
摘要翻译：提供了组合物，方法和试剂盒，用于使用颗粒例如钙基颗粒与结合生物表面的试剂组合来改变生物表面的性质。诸如牙齿和骨骼等生物表面的颜色，光泽，质地，强度和气味等特性是可以改变的。

165. 发明授权

US07628977B2 Particles for inhalation having sustained release properties 失效
公开(公告)号：US07628977B2
公开(公告)日：2009-12-08
申请号：US10420071
申请日：2003-04-18
申请人： David A. Edwards , Robert S. Langer , Rita Vanbever , Jeffrey Mintzes , Jue Wang , Donghao Chen
发明人： David A. Edwards , Robert S. Langer , Rita Vanbever , Jeffrey Mintzes , Jue Wang , Donghao Chen
IPC分类号： A61K9/14 , A61K31/66 , A61K31/661 , A61K31/6615
CPC分类号： A61K9/0073 , A61K9/0075 , A61K9/16 , A61K9/1617 , A61K9/1623 , A61K9/1641 , A61K9/1647 , A61K9/1658 , A61K9/1694 , A61K31/135 , A61K31/137 , A61K31/566 , A61K38/28 , A61K38/38 , A61K47/12 , A61K47/183 , A61K47/24 , A61K47/6927
摘要： The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.

166. 发明申请

US20090274654A1 METHODS AND DEVICES FOR THE SUSTAINED RELEASE OF MULTIPLE DRUGS 有权
标题翻译：用于持续释放多种药物的方法和装置
公开(公告)号：US20090274654A1
公开(公告)日：2009-11-05
申请号：US12125581
申请日：2008-05-22
申请人： Eyal S. Ron , Robert S. Langer , William F. Crowley, JR.
发明人： Eyal S. Ron , Robert S. Langer , William F. Crowley, JR.
IPC分类号： A61K38/21 , A61K38/09 , A61K31/566
CPC分类号： A61F6/08 , A61F6/142 , A61K9/0036 , A61K9/0056 , A61K31/565 , A61K31/57 , A61K38/09 , A61K45/06 , Y10S514/843 , A61K2300/00
摘要： The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.
摘要翻译：本发明涉及药物递送装置和用于在长时间内递送多种药物的方法。药物递送装置具有两个或多个包含药物可渗透的聚合物质的整体段，其中至少一个区段还包含药物活性剂。本发明还涉及治疗女性哺乳动物良性卵巢分泌障碍的方法，避孕方法以及缓解与女性绝经期，绝经期和绝经后期相关的症状的方法。

167. 发明申请

US20090155875A1 Methods to Enhance Carbon Monoxide Dehydrogenase Activity and Uses Thereof 审中-公开
标题翻译：增强一氧化碳脱氢酶活性的方法及其用途
公开(公告)号：US20090155875A1
公开(公告)日：2009-06-18
申请号：US11884522
申请日：2006-02-16
申请人： David A. Berry , Robert S. Langer , Richard J. Resnick
发明人： David A. Berry , Robert S. Langer , Richard J. Resnick
IPC分类号： C12P3/00 , C12N9/02 , C12N1/21
CPC分类号： C12P3/00 , C12N9/0008 , C12Y102/99002
摘要： This invention relates, in part, to methods and compositions for modulating the water-gas shift reaction (e.g., promoting the water-gas shift forward reaction) or in which the water-gas shift reaction has been modulated. The methods and compositions, therefore, also relate, in part, to increasing the oxidation rate of carbon monoxide (CO), for increasing the availability of CO (e.g., to the carbon monoxide dehydrogenase (CODH) enzyme complex), for removing and/or promoting the release of hydrogen and/or carbon dioxide (CO2), for regulating the redox potential of cells, for preventing free radical damage and/or promoting cell survivability, etc. The invention also relates, in part, to methods and compositions for modulating CODH activity, such as increasing CODH activity. Methods and compositions are also provided for modulating the PSII reaction (e.g., promoting the PSII forward reaction) or in which the PSII reaction has been modulated. The modulation of the PSII reaction can be in conjunction with the modulation of the water-gas shift reaction. The invention also relates, in part, to methods and compositions for modulating PSII activity, such as increasing PSII activity. The invention further relates to uses of the aforementioned methods and compositions. For example, methods and compositions are provided for the production of hydrogen and/or for the elimination of CO. The methods and compositions provided can be used for a variety of industrial and medical applications, and such applications are also provided as part of the invention.
摘要翻译：本发明部分地涉及用于调节水煤气变换反应（例如促进水煤气前进反应）的方法和组合物，或其中水煤气变换反应被调制的方法和组合物。因此，方法和组合物还部分地涉及提高一氧化碳（CO）的氧化速率，以增加CO（例如，一氧化碳脱氢酶（CODH）酶复合物）的可用性，用于除去和/ 或促进氢和/或二氧化碳（CO 2）的释放，用于调节细胞的氧化还原电位，用于防止自由基损伤和/或促进细胞存活力等。本发明还部分涉及用于调节CODH活性，如增加CODH活性。还提供了用于调节PSII反应（例如，促进PSII正向反应）或其中已经调节PSII反应的方法和组合物。 PSII反应的调节可以与水煤气变换反应的调节相结合。本发明还部分涉及用于调节PSII活性的方法和组合物，例如增加PSII活性。本发明还涉及上述方法和组合物的用途。例如，提供了用于生产氢和/或消除CO的方法和组合物。所提供的方法和组合物可用于各种工业和医疗应用，并且这些应用也作为本发明的一部分提供。

168. 发明申请

US20080286339A1 METHODS AND DEVICES FOR THE SUSTAINED RELEASE OF MULTIPLE DRUGS 审中-公开
标题翻译：用于持续释放多种药物的方法和装置
公开(公告)号：US20080286339A1
公开(公告)日：2008-11-20
申请号：US12125606
申请日：2008-05-22
申请人： Eyal S. Ron , Robert S. Langer , William F. Crowley, JR.
发明人： Eyal S. Ron , Robert S. Langer , William F. Crowley, JR.
IPC分类号： A61F6/14 , A61K31/565
CPC分类号： A61F6/08 , A61F6/142 , A61K9/0036 , A61K9/0056 , A61K31/565 , A61K31/57 , A61K38/09 , A61K45/06 , Y10S514/843 , A61K2300/00
摘要： The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.
摘要翻译：本发明涉及药物递送装置和用于在长时间内递送多种药物的方法。药物递送装置具有两个或多个包含药物可渗透的聚合物质的整体段，其中至少一个区段还包含药物活性剂。本发明还涉及治疗女性哺乳动物良性卵巢分泌障碍的方法，避孕方法以及缓解与女性绝经期，绝经期和绝经后期相关的症状的方法。

169. 发明授权

US07435408B2 Porous particles comprising excipients for deep lung delivery 有权
标题翻译：包含用于深肺输送的赋形剂的多孔颗粒
公开(公告)号：US07435408B2
公开(公告)日：2008-10-14
申请号：US10818902
申请日：2004-04-06
申请人： David A. Edwards , Giovanni Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Robert S. Langer , Abdellaziz Ben-Jebria
发明人： David A. Edwards , Giovanni Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Robert S. Langer , Abdellaziz Ben-Jebria
IPC分类号： A61K9/00 , A61K9/12 , A61K9/14 , A61K38/00 , A61K33/00 , A61K31/00 , A61K31/70 , A61K31/7052
CPC分类号： A61K9/0075 , A61K9/1647 , A61K31/137 , Y10S514/826 , Y10S514/851
摘要： Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.4 g/cm3/. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear a-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, porous particles having a relatively large mean diameter, for example greater than 5 μm, can be used for enhanced delivery of a therapeutic agent to the alveolar region of the lung. The porous particles incorporating a therapeutic agent may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of wide variety of therapeutic agents.
摘要翻译：提供用于向肺系统递送药物的改进的多孔颗粒，以及用于其合成和给药的方法。在优选的实施方案中，多孔颗粒由可生物降解的材料制成，并具有小于0.4g / cm 3的质量密度。颗粒可以由可生物降解的材料如可生物降解的聚合物形成。例如，颗粒可以由官能化的聚酯接枝共聚物形成，该聚酯接枝共聚物由具有至少一个氨基酸基团的直链α-羟基酸聚酯主链和至少一个从氨基酸延伸的至少一个（氨基酸）侧链集团在聚酯骨干。在一个实施方案中，具有相对大的平均直径，例如大于5um的多孔颗粒可用于增强治疗剂递送至肺的肺泡区域。掺入治疗剂的多孔颗粒可以有效地雾化，用于给予呼吸道以允许全身或局部递送多种治疗剂。

170. 发明授权

US07427394B2 Biodegradable poly(β-amino esters) and uses thereof 有权
标题翻译：可生物降解的聚（β-氨基酯）及其用途
公开(公告)号：US07427394B2
公开(公告)日：2008-09-23
申请号：US10446444
申请日：2003-05-28
申请人： Daniel G. Anderson , David M. Lynn , Akin Akinc , Robert S. Langer
发明人： Daniel G. Anderson , David M. Lynn , Akin Akinc , Robert S. Langer
IPC分类号： A61K31/765 , C08G69/44 , C08G63/44 , C07C327/00
CPC分类号： C08G69/44 , A61K9/5138 , A61K47/59 , A61K47/593 , A61K47/645 , A61K47/6925 , B82Y5/00 , C08G63/40 , C08G63/6856 , C08G73/02 , C08G73/0273 , C08G73/028 , C08G73/06 , C08G73/0611 , C08G73/0616 , C08L67/02 , C08L67/04 , C08L77/04 , C08L79/02 , C08L89/00 , C08L99/00 , C12N15/88 , C08L2666/02
摘要： Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings. A system for preparing and screening polymers in parallel using semi-automated robotic fluid delivery systems is also provided.
摘要翻译：描述了从双（仲胺）或伯胺向双（丙烯酸酯）共轭加成制备的聚（β-氨基酯）。还提供了从市售的原料制备这些聚合物的方法。这些含叔胺的聚合物优选是可生物降解的和生物相容的并且可以用于各种药物递送系统中。鉴于这些聚合物的聚（胺）性质，它们特别适用于递送多核苷酸。已经制备了含有聚合物/多核苷酸复合物的纳米颗粒。本发明的聚合物也可以用于包封待递送的其它试剂。考虑到缓冲其周围环境的pH值，它们特别适用于提供不稳定剂。还提供了使用半自动机器人流体输送系统并行制备和筛选聚合物的系统。

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