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1. 发明申请

US20090155875A1 Methods to Enhance Carbon Monoxide Dehydrogenase Activity and Uses Thereof 审中-公开
标题翻译：增强一氧化碳脱氢酶活性的方法及其用途
公开(公告)号：US20090155875A1
公开(公告)日：2009-06-18
申请号：US11884522
申请日：2006-02-16
申请人： David A. Berry , Robert S. Langer , Richard J. Resnick
发明人： David A. Berry , Robert S. Langer , Richard J. Resnick
IPC分类号： C12P3/00 , C12N9/02 , C12N1/21
CPC分类号： C12P3/00 , C12N9/0008 , C12Y102/99002
摘要： This invention relates, in part, to methods and compositions for modulating the water-gas shift reaction (e.g., promoting the water-gas shift forward reaction) or in which the water-gas shift reaction has been modulated. The methods and compositions, therefore, also relate, in part, to increasing the oxidation rate of carbon monoxide (CO), for increasing the availability of CO (e.g., to the carbon monoxide dehydrogenase (CODH) enzyme complex), for removing and/or promoting the release of hydrogen and/or carbon dioxide (CO2), for regulating the redox potential of cells, for preventing free radical damage and/or promoting cell survivability, etc. The invention also relates, in part, to methods and compositions for modulating CODH activity, such as increasing CODH activity. Methods and compositions are also provided for modulating the PSII reaction (e.g., promoting the PSII forward reaction) or in which the PSII reaction has been modulated. The modulation of the PSII reaction can be in conjunction with the modulation of the water-gas shift reaction. The invention also relates, in part, to methods and compositions for modulating PSII activity, such as increasing PSII activity. The invention further relates to uses of the aforementioned methods and compositions. For example, methods and compositions are provided for the production of hydrogen and/or for the elimination of CO. The methods and compositions provided can be used for a variety of industrial and medical applications, and such applications are also provided as part of the invention.
摘要翻译：本发明部分地涉及用于调节水煤气变换反应（例如促进水煤气前进反应）的方法和组合物，或其中水煤气变换反应被调制的方法和组合物。因此，方法和组合物还部分地涉及提高一氧化碳（CO）的氧化速率，以增加CO（例如，一氧化碳脱氢酶（CODH）酶复合物）的可用性，用于除去和/ 或促进氢和/或二氧化碳（CO 2）的释放，用于调节细胞的氧化还原电位，用于防止自由基损伤和/或促进细胞存活力等。本发明还部分涉及用于调节CODH活性，如增加CODH活性。还提供了用于调节PSII反应（例如，促进PSII正向反应）或其中已经调节PSII反应的方法和组合物。 PSII反应的调节可以与水煤气变换反应的调节相结合。本发明还部分涉及用于调节PSII活性的方法和组合物，例如增加PSII活性。本发明还涉及上述方法和组合物的用途。例如，提供了用于生产氢和/或消除CO的方法和组合物。所提供的方法和组合物可用于各种工业和医疗应用，并且这些应用也作为本发明的一部分提供。

2. 发明申请

US20100015068A1 Methods and Compositions For Altering Biological Surfaces 审中-公开
标题翻译：改变生物表面的方法和组成
公开(公告)号：US20100015068A1
公开(公告)日：2010-01-21
申请号：US12309049
申请日：2007-07-06
申请人： Jeffrey M. Karp , Alireza Khademhosseini , David A. Berry , Robert S. Langer , Frank X. Gu
发明人： Jeffrey M. Karp , Alireza Khademhosseini , David A. Berry , Robert S. Langer , Frank X. Gu
IPC分类号： A61K8/24 , C01B25/32 , B32B5/16 , A61K33/42 , A61Q11/00 , A61P19/10
CPC分类号： A61K8/11 , A61K6/0008 , A61K6/0017 , A61K6/0067 , A61K6/0085 , A61K6/0235 , A61K6/024 , A61K6/0612 , A61K6/0643 , A61K6/0668 , A61K8/19 , A61K8/88 , A61K2800/412 , A61K2800/94 , A61L24/02 , A61Q11/00 , Y10T428/2982 , C08L1/286 , C08L5/00 , C08L5/08 , C08L33/02 , C08L1/00
摘要： Compositions, methods and kits are provided for altering the properties of a biological surface using particles such as, for instance, calcium based particles in combination with an agent that binds to the biological surface. Properties such as color, sheen, texture, strength, and odor of biological surfaces such as teeth and bone are alterable.
摘要翻译：提供了组合物，方法和试剂盒，用于使用颗粒例如钙基颗粒与结合生物表面的试剂组合来改变生物表面的性质。诸如牙齿和骨骼等生物表面的颜色，光泽，质地，强度和气味等特性是可以改变的。

3. 发明申请

US20090156477A1 Compositions and Methods for Regulating Inflammatory Responses 审中-公开
标题翻译：调节炎症反应的组成和方法
公开(公告)号：US20090156477A1
公开(公告)日：2009-06-18
申请号：US11887561
申请日：2006-03-29
申请人： David A. Berry , Chi-Pong Kwan , Robert S. Langer , Ram Sasisekharan
发明人： David A. Berry , Chi-Pong Kwan , Robert S. Langer , Ram Sasisekharan
IPC分类号： A61K38/18 , A61P29/00
CPC分类号： C07K14/50 , A61K38/1825 , Y02A50/401 , A61K2300/00
摘要： This invention relates, in part, to compositions and methods for the regulation of inflammatory responses. Specifically, the invention relates, in part, to compositions of and methods for using fibroblast growth factor (FGF) proteins, proteoglycans (e.g., syndecans), agents that modulate proteoglycans and agents that affect Wnt signaling. The invention also provides compositions and methods for treating subjects with undesired inflammatory activity and/or diseases associated therewith. The invention further provides, in part, compositions and methods for disrupting intercellular junctions with FGFs, such as for the enhanced delivery of therapeutic agents.
摘要翻译：本发明部分涉及用于调节炎症反应的组合物和方法。具体而言，本发明部分涉及使用成纤维细胞生长因子（FGF）蛋白质，蛋白聚糖（例如，syndecans），调节蛋白聚糖的试剂和影响Wnt信号传导的试剂的组合物和方法。本发明还提供了用于治疗具有不希望的炎症活性和/或与其相关的疾病的受试者的组合物和方法。本发明还部分地提供用于破坏与FGF的细胞间连接的组合物和方法，例如用于增强治疗剂的递送。

4. 发明授权

US10696944B2 Intracellular delivery 有权
公开(公告)号：US10696944B2
公开(公告)日：2020-06-30
申请号：US14352354
申请日：2012-10-17
申请人： Massachusetts Institute of Technology , Armon R. Sharei , Andrea Adamo , Robert S. Langer , Klavs F. Jensen
发明人： Armon R. Sharei , Andrea Adamo , Robert S. Langer , Klavs F. Jensen
IPC分类号： C12N5/071 , C12M1/42 , C12M3/06 , C12N15/87 , B82Y5/00
摘要： A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.

5. 发明授权

US09333179B2 Amphiphilic compound assisted nanoparticles for targeted delivery 有权
标题翻译：两亲化合物辅助纳米颗粒用于靶向递送
公开(公告)号：US09333179B2
公开(公告)日：2016-05-10
申请号：US12573591
申请日：2009-10-05
申请人： Liangfang Zhang , Aleksandar F. Radovic-Moreno , Frank X. Gu , Frank Alexis , Robert S. Langer , Omid C. Farokhzad
发明人： Liangfang Zhang , Aleksandar F. Radovic-Moreno , Frank X. Gu , Frank Alexis , Robert S. Langer , Omid C. Farokhzad
IPC分类号： A61K9/51 , A61K47/48 , B82Y5/00
CPC分类号： A61K9/5123 , A61K9/5153 , A61K9/5192 , A61K47/62 , A61K47/6935 , A61K47/6937 , B82Y5/00
摘要： The present invention generally relates to nanoparticles with an amphiphilic component. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.
摘要翻译：本发明通常涉及具有两亲性组分的纳米颗粒。本发明的一个方面涉及一种开发具有所需性质的纳米颗粒的方法。在一组实施方案中，该方法包括制备具有高度控制性质的纳米颗粒的文库，其可通过将两种或多种不同比例的大分子混合在一起形成。一个或多个大分子可以是部分与生物相容性聚合物的聚合物缀合物。在一些情况下，纳米颗粒可以含有药物。本发明的其它方面涉及使用纳米颗粒文库的方法。

6. 发明授权

US09216188B2 Hydrogels for vocal cord and soft tissue augmentation and repair 有权
标题翻译：用于声带和软组织增强和修复的水凝胶
公开(公告)号：US09216188B2
公开(公告)日：2015-12-22
申请号：US12553800
申请日：2009-09-03
申请人： Steven M. Zeitels , Robert Edward Hillman , Sandeep Sidram Karajanagi , Robert S. Langer
发明人： Steven M. Zeitels , Robert Edward Hillman , Sandeep Sidram Karajanagi , Robert S. Langer
IPC分类号： A61K9/00 , A61K31/00 , A61K31/7052 , A61L27/26 , A61L27/38 , A61L27/52 , C08J3/075 , C08J3/24
CPC分类号： A61L27/26 , A61K31/00 , A61K31/7052 , A61L27/38 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2400/06 , A61L2430/34 , C08J3/075 , C08J3/246 , C08J2305/08 , C08J2371/02 , C08L71/02
摘要： The present invention provides hydrogels and compositions thereof for vocal cord repair or augmentation, as well as other soft tissue repair or augmentation (e.g., bladder neck augmentation, dermal fillers, breast implants, intervertebral disks, muscle-mass). The hydrogels or compositions thereof are injected into the superficial lamina propria or phonatory epithelium to restore the phonatory mucosa of the vocal cords, thereby restoring a patient's voice. In particular, it has been discovered that hydrogels with an elastic shear modulus of approximately 25 Pa are useful in restoring the pliability of the phonatory mucosa. The invention also provides methods of preparing and using the inventive hydrogels.
摘要翻译：本发明提供水凝胶及其组合物，用于声带修复或增强，以及其它软组织修复或增强（例如，膀胱颈增大，皮肤填充剂，乳房植入物，椎间盘，肌肉质量）。将水凝胶或其组合物注射到表层固有层或声音上皮中以恢复声带的声音粘膜，从而恢复患者的声音。特别地，已经发现弹性剪切模量为约25Pa的水凝胶可用于恢复发音粘膜的柔韧性。本发明还提供了制备和使用本发明水凝胶的方法。

7. 发明授权

US08808681B2 Crosslinked, degradable polymers and uses thereof 有权
标题翻译：交联的可降解聚合物及其用途
公开(公告)号：US08808681B2
公开(公告)日：2014-08-19
申请号：US11758078
申请日：2007-06-05
申请人： Daniel Griffith Anderson , Jason Alan Burdick , Robert S. Langer
发明人： Daniel Griffith Anderson , Jason Alan Burdick , Robert S. Langer
IPC分类号： A61K47/32 , A61K35/00 , C08F2/48 , C08G73/00 , C08F299/04 , C08F290/06 , C08F283/00 , C08G73/02 , C08F299/02 , C08L79/02 , C08G63/685
CPC分类号： C08L79/02 , C08F283/00 , C08F290/06 , C08F290/061 , C08F290/065 , C08F299/024 , C08F299/0485 , C08G63/6858 , C08G73/02
摘要： Acrylate-terminated poly(beta-amino esters) are cross-linked to form materials useful in the medical as well as non-medical field. The polymeric starting material is combined with a free radical initiator, either a thermal initiator or a photoinitiator, and the mixture for cross-linking is heated or exposed to light depending on the initiator used. The resulting materials due to the hydrolysable ester bond in the polymer backbone are biodegradable under physiological conditions. These cross-linked materials are particular useful as drug delivery vehicles, tissue engineering scaffolds, and in fabricating microdevices. The materials may also be used as plastics, coating, adhesives, inks, etc. The cross-linked materials prepared exhibit a wide range of degradation times, mass loss profiles, and mechanical properties. Therefore, the properties of the material may be tuned for the desired use. The high-throughput approach to preparing a library of cross-linked poly(beta-amino esters) allows for the rapid screening and design of degradable polymers for a variety of applications.
摘要翻译：丙烯酸酯封端的聚（β-氨基酯）被交联以形成用于医疗和非医学领域的材料。将聚合起始材料与自由基引发剂，热引发剂或光引发剂组合，并且根据所使用的引发剂将用于交联的混合物加热或暴露于光。由于聚合物骨架中的可水解的酯键导致的所得材料在生理条件下是可生物降解的。这些交联材料特别用作药物递送载体，组织工程支架和制造微型装置。这些材料也可以用作塑料，涂料，粘合剂，油墨等。制备的交联材料表现出广泛的降解时间，质量损失曲线和机械性能。因此，可以调整材料的性质以达到期望的用途。制备交联聚（β-氨基酯）文库的高通量方法允许快速筛选和设计可降解聚合物用于各种应用。

8. 发明授权

US08637028B2 Adjuvant incorporation in immunonanotherapeutics 有权
标题翻译：佐剂掺入免疫疗法
公开(公告)号：US08637028B2
公开(公告)日：2014-01-28
申请号：US13123888
申请日：2009-10-09
申请人： Frank Alexis , Matteo Iannacone , Jinjun Shi , Pamela Basto , Elliott Ashley Moseman , Ulrich von Andrian , Robert S. Langer , Omid C. Farokhzad , Elena Tonti
发明人： Frank Alexis , Matteo Iannacone , Jinjun Shi , Pamela Basto , Elliott Ashley Moseman , Ulrich von Andrian , Robert S. Langer , Omid C. Farokhzad , Elena Tonti
IPC分类号： A61K39/40 , A61K39/395 , A61K49/04
CPC分类号： A61K9/14 , A61K38/20 , A61K38/21 , A61K39/00 , A61K39/0002 , A61K39/002 , A61K39/05 , A61K39/08 , A61K39/12 , A61K39/39 , A61K45/06
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
摘要翻译：本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。本发明提供能够刺激T细胞和/或B细胞中的免疫应答的纳米载体。本发明提供包含免疫表面和免疫刺激部分的纳米载体。在一些实施方案中，免疫刺激部分是佐剂。本发明提供包含本发明纳米载体的药物组合物。本发明提供了设计，制造和使用本发明的纳米载体及其药物组合物的方法。

9. 发明申请

US20130302401A1 POLY(BETA-AMINO ALCOHOLS), THEIR PREPARATION, AND USES THEREOF 有权
标题翻译：聚（氨基 - 氨基醇），其制备及其用途
公开(公告)号：US20130302401A1
公开(公告)日：2013-11-14
申请号：US13819280
申请日：2011-08-26
申请人： Minglin Ma , Wendy F. Liu , Robert S. Langer , Daniel Griffith Anderson
发明人： Minglin Ma , Wendy F. Liu , Robert S. Langer , Daniel Griffith Anderson
IPC分类号： C08G73/02 , C09D179/02
CPC分类号： C08G73/0206 , A61K9/1273 , A61K31/7088 , A61K47/34 , A61K47/59 , A61L31/10 , C08G59/22 , C08G59/306 , C08G59/50 , C08G73/02 , C09D5/1637 , C09D179/02 , Y10T428/31725
摘要： A new class of poly(beta-amino alcohols) (PBAAs) has been prepared using combinatorial polymerization. The inventive PBAAs may be used in biotechnology and biomedical applications as coatings (such as coatings of films or multilayer films for medical devices or implants), additives, materials, excipients, non-biofouling agents, micropatterning agents, and cellular encapsulation agents. When used as surface coatings, these PBAAs elicited different levels of inflammation, both in vitro and in vivo, depending on their chemical structures. The large chemical diversity of this class of materials allowed us to identify polymer coatings that inhibit macrophage activation in vitro. Furthermore, these coatings reduce the recruitment of inflammatory cells, and reduce fibrosis, following the subcutaneous implantation of carboxylated polystyrene microparticles. These polymers may be used to form polyelectrolyte complex capsules for cell encapsulation. The invention may also have many other biological applications such as antimicrobial coatings, DNA or siRNA delivery, and stem cell tissue engineering.
摘要翻译：使用组合聚合制备了一类新的聚（β-氨基醇）（PBAAs）。本发明的PBAAs可用于生物技术和生物医学应用中，作为涂层（例如用于医疗装置或植入物的膜或多层膜的涂层），添加剂，材料，赋形剂，非生物污垢剂，微图案化剂和细胞包封剂。当用作表面涂层时，这些PBAAs根据其化学结构在体外和体内引起不同程度的炎症。这类材料的大化学多样性使我们能够鉴定体外抑制巨噬细胞活化的聚合物涂层。此外，在皮下植入羧化聚苯乙烯微粒之后，这些涂层减少了炎性细胞的募集，并减少了纤维化。这些聚合物可用于形成用于细胞包封的聚电解质复合物胶囊。本发明还可以具有许多其他生物学应用，例如抗微生物涂层，DNA或siRNA递送以及干细胞组织工程。

10. 发明授权

US08557231B2 Biodegradable poly(beta-amino esters) and uses thereof 有权
公开(公告)号：US08557231B2
公开(公告)日：2013-10-15
申请号：US11099886
申请日：2005-04-06
申请人： Robert S. Langer , David M. Lynn , David Putnam , Mansoor M. Amiji , Daniel G. Anderson
发明人： Robert S. Langer , David M. Lynn , David Putnam , Mansoor M. Amiji , Daniel G. Anderson
IPC分类号： A61K31/785 , A61K31/765 , C08G69/08
CPC分类号： A61K47/34 , A61K9/5146 , A61K31/711 , A61K31/713 , A61K47/59 , A61K47/593 , A61K47/6929 , B82Y5/00 , C08G63/685 , C08G73/02 , C08G73/0273 , C08G73/06 , C08G73/0611 , C08G73/0616 , C12N15/88
摘要： Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

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