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1. 发明申请

US20190233854A1 OBLIGATELY ANAEROBIC ACETIC ACID-PRODUCING MICROORGANISM, AND RECOMBINANT MICROORGANISM 审中-公开
公开(公告)号：US20190233854A1
公开(公告)日：2019-08-01
申请号：US16335377
申请日：2017-09-05
申请人： SEKISUI CHEMICAL CO., LTD.
发明人： Kana MATSUSHIMA , Masahiro FURUTANI , Kazufumi KAWABATA
IPC分类号： C12P7/54 , C12N1/20 , C12R1/145
CPC分类号： C12P7/54 , C12N1/20 , C12N15/09 , C12R1/145 , C12Y102/99002
摘要： Provided is a modified obligately anaerobic acetogen in which activity of at least one enzyme selected from the group consisting of a restriction enzyme, a modification enzyme, and a recognition enzyme constituting a type I restriction modification system enzyme is deleted or suppressed. Preferably, the activity of at least the restriction enzyme is deleted or suppressed. The obligately anaerobic acetogen is preferably a Clostridium bacterium or a Moorella bacterium, and particularly preferably Clostridium ljungdahlii.

2. 发明授权

US09783828B2 Recombinant cell, and method for producing isoprene 有权
公开(公告)号：US09783828B2
公开(公告)日：2017-10-10
申请号：US14437034
申请日：2013-10-22
申请人： SEKISUI CHEMICAL CO., LTD. , FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
发明人： Masahiro Furutani , Akihiro Uenishi , Koichiro Iwasa , Stefan Jennewein , Rainer Fischer
IPC分类号： C12P5/02 , C12N1/20 , C12N15/00 , C07H21/04 , C12P5/00 , C12N9/88 , C12N9/02
CPC分类号： C12P5/007 , C12N9/0008 , C12N9/88 , C12Y102/07004 , C12Y102/99002 , C12Y302/01 , C12Y402/03027 , Y02E50/343
摘要： To provide a series of techniques capable of producing isoprene from syngas or the like.Provided is a recombinant cell prepared by introducing a nucleic acid encoding isoprene synthase into a host cell having an isopentenyl diphosphate synthesis ability by a non-mevalonate pathway, wherein the nucleic acid is expressed in the host cell, and the recombinant cell is capable of producing isoprene from at least one C1 compound selected from the group consisting of carbon monoxide, carbon dioxide, formic acid, and methanol. As the host cell, a Clostridium bacterium or a Moorella bacterium is exemplified. Also provided is a method for producing isoprene using the recombinant cell.

3. 发明申请

US20130102763A1 Method of thermostabilization of a protein and/or stabilization towards organic solvents 有权
公开(公告)号：US20130102763A1
公开(公告)日：2013-04-25
申请号：US13604094
申请日：2012-09-05
申请人： Jiri DAMBORSKY , Zbynek PROKOP , Tana KOUDELAKOVA , Veronika STEPANKOVA , Radka CHALOUPKOVA , Eva CHOVANCOVA , Artur Wiktor GORA , Jan BREZOVSKY
发明人： Jiri DAMBORSKY , Zbynek PROKOP , Tana KOUDELAKOVA , Veronika STEPANKOVA , Radka CHALOUPKOVA , Eva CHOVANCOVA , Artur Wiktor GORA , Jan BREZOVSKY
IPC分类号： C07K1/00
CPC分类号： C07K1/00 , C12N9/0006 , C12N9/0008 , C12N9/0073 , C12N9/1029 , C12N9/14 , C12N9/18 , C12Y101/03006 , C12Y102/99002 , C12Y114/13025 , C12Y301/01007 , C12Y303/0201 , C12Y308/01005
摘要： Thermostabilization of a protein where the protein contains access routes and wherein at least one amino acid in the bottleneck of the access route is mutated, includes identifying the amino acids of the bottleneck and the amino acids control exchange of the solvent between a buried protein core and surrounding environment and/or in the packing of the amino acids inside the access route. Modification of the amino acids are determined so that the packing of the amino acids inside the tunnel is improved and the access route prevents access of undesired solvent molecules to the protein core, while allowing passage of the compounds necessary at the protein core to enable the protein to perform its biological function.

4. 发明授权

US08580932B2 Method of thermostabilization of a protein and/or stabilization towards organic solvents 有权
标题翻译：蛋白质热稳定化和/或有机溶剂稳定化的方法
公开(公告)号：US08580932B2
公开(公告)日：2013-11-12
申请号：US13604094
申请日：2012-09-05
申请人： Jiri Damborsky , Zbynek Prokop , Tana Koudelakova , Veronika Stepankova , Radka Chaloupkova , Eva Chovancova , Artur Wiktor Gora , Jan Brezovsky
发明人： Jiri Damborsky , Zbynek Prokop , Tana Koudelakova , Veronika Stepankova , Radka Chaloupkova , Eva Chovancova , Artur Wiktor Gora , Jan Brezovsky
IPC分类号： C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00 , C08H1/00 , A23J1/00 , C07G1/00 , C08H7/00 , C08L97/00
CPC分类号： C07K1/00 , C12N9/0006 , C12N9/0008 , C12N9/0073 , C12N9/1029 , C12N9/14 , C12N9/18 , C12Y101/03006 , C12Y102/99002 , C12Y114/13025 , C12Y301/01007 , C12Y303/0201 , C12Y308/01005
摘要： Thermostabilization of a protein where the protein contains access routes and wherein at least one amino acid in the bottleneck of the access route is mutated, includes identifying the amino acids of the bottleneck and the amino acids control exchange of the solvent between a buried protein core and surrounding environment and/or in the packing of the amino acids inside the access route. Modification of the amino acids are determined so that the packing of the amino acids inside the tunnel is improved and the access route prevents access of undesired solvent molecules to the protein core, while allowing passage of the compounds necessary at the protein core to enable the protein to perform its biological function.
摘要翻译：蛋白质的热稳定化，其中所述蛋白质含有进入途径，并且其中所述进入途径的瓶颈中的至少一个氨基酸被突变，包括识别所述瓶颈的氨基酸，并且所述氨基酸控制所述溶剂在掩埋的蛋白质核心和周围环境和/或包装进入路线内的氨基酸。氨基酸的修饰被确定为使得隧道内的氨基酸的填充被改善，并且进入路线阻止不期望的溶剂分子进入蛋白质核心，同时允许通过蛋白质核心所需的化合物以使蛋白质执行其生物功能。

5. 发明申请

US20030108927A1 Compositions and methods for the prevention, treatment and detection of tuberculosis and other diseases 审中-公开
标题翻译：预防，治疗和检测结核病等疾病的组成和方法
公开(公告)号：US20030108927A1
公开(公告)日：2003-06-12
申请号：US10265190
申请日：2002-10-07
发明人： Kathryn Leishman
IPC分类号： A61K048/00 , A61K031/325 , A61K031/198 , A61K039/395 , A61K039/00 , C12Q001/68 , A61K031/70 , A01N043/04 , A61K039/38 , A61K031/27 , A01N047/10 , A61K031/195 , A01N037/12 , A01N037/44
CPC分类号： A61K31/198 , A61K31/325 , A61K38/44 , A61K39/04 , A61K2039/505 , C12Y102/99002
摘要： Methods and compositions are provided for the prevention and treatment of infectious diseases such as syphilis, tuberculosis, pneumonia, other bacterial infections, AIDS, and other viral infections. Many of the compositions are active against carbon monoxide dehydrogenase (nullCODHnull), and include substances such as antigens, antibodies specific for CODH, and other inhibitors of CODH such as nickel and molybdenum metal chelators. The methods and compositions are particularly suited for treatment of diseases from previously under recognized anaerobic or facultative anaerobic pathogens such as Mycobacterium tuberculosis and Mycobacterium pneumonia.
摘要翻译：提供方法和组合物用于预防和治疗感染性疾病如梅毒，肺结核，肺炎，其他细菌感染，艾滋病和其他病毒感染。许多组合物对一氧化碳脱氢酶（“CODH”）具有活性，并且包括诸如抗原的物质，对CODH特异的抗体，以及其它CODH抑制剂如镍和钼金属螯合剂。所述方法和组合物特别适用于治疗先前在识别的厌氧或兼性厌氧病原体如结核分枝杆菌和肺炎支原体之间的疾病。

6. 发明申请

US20180073042A1 CO HYDRATASE AND METHOD FOR PRODUCING FORMATE USING THE SAME 审中-公开
公开(公告)号：US20180073042A1
公开(公告)日：2018-03-15
申请号：US15526303
申请日：2017-01-05
申请人： C1CHEM CO., LTD.
发明人： Yong Hwan Kim , Kyoungseon Min , Young Joo Yeon , Dae Haeng Cho , Min Gee Jang , Eun-Gyu Choi , Ho Won Hwang
IPC分类号： C12P7/40 , C01B3/02 , C12P1/04 , C12N9/02
CPC分类号： C12P7/40 , C01B3/02 , C12N9/0008 , C12P1/04 , C12P3/00 , C12Y102/99002
摘要： Provided are CO hydratase and a method for producing formate using the same, and more specifically, to CO hydratase which is a novel enzyme which is produced by linking CO dehydrogenase (CODH) and CO2 reductase and can directly convert CO into formate, and use thereof.

7. 发明申请

US20150284742A1 RECOMBINANT CELL, AND METHOD FOR PRODUCING ISOPRENE 有权
标题翻译：重组细胞和生产异丙肾上腺素的方法
公开(公告)号：US20150284742A1
公开(公告)日：2015-10-08
申请号：US14437034
申请日：2013-10-22
申请人： SEKISUI CHEMICAL CO., LTD. , FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
发明人： Masahiro Furutani , Akihiro Uenishi , Koichiro Iwasa , Stefan Jennewein , Rainer Fischer
IPC分类号： C12P5/00 , C12N9/02 , C12N9/88
CPC分类号： C12P5/007 , C12N9/0008 , C12N9/88 , C12Y102/07004 , C12Y102/99002 , C12Y302/01 , C12Y402/03027 , Y02E50/343
摘要： To provide a series of techniques capable of producing isoprene from syngas or the like.Provided is a recombinant cell prepared by introducing a nucleic acid encoding isoprene synthase into a host cell having an isopentenyl diphosphate synthesis ability by a non-mevalonate pathway, wherein the nucleic acid is expressed in the host cell, and the recombinant cell is capable of producing isoprene from at least one C1 compound selected from the group consisting of carbon monoxide, carbon dioxide, formic acid, and methanol. As the host cell, a Clostridium bacterium or a Moorella bacterium is exemplified. Also provided is a method for producing isoprene using the recombinant cell.
摘要翻译：提供能够从合成气等产生异戊二烯的一系列技术。本发明提供了通过将异戊二烯合酶的核酸通过非甲羟戊酸途径引入具有异戊烯基二磷酸合成能力的宿主细胞中而制备的重组细胞，其中核酸在宿主细胞中表达，重组细胞能够产生来自至少一种选自一氧化碳，二氧化碳，甲酸和甲醇的C1化合物的异戊二烯。作为宿主细胞，例示了梭菌属细菌或毛雷氏杆菌属细菌。还提供了使用重组细胞产生异戊二烯的方法。

8. 发明申请

US20090155875A1 Methods to Enhance Carbon Monoxide Dehydrogenase Activity and Uses Thereof 审中-公开
标题翻译：增强一氧化碳脱氢酶活性的方法及其用途
公开(公告)号：US20090155875A1
公开(公告)日：2009-06-18
申请号：US11884522
申请日：2006-02-16
申请人： David A. Berry , Robert S. Langer , Richard J. Resnick
发明人： David A. Berry , Robert S. Langer , Richard J. Resnick
IPC分类号： C12P3/00 , C12N9/02 , C12N1/21
CPC分类号： C12P3/00 , C12N9/0008 , C12Y102/99002
摘要： This invention relates, in part, to methods and compositions for modulating the water-gas shift reaction (e.g., promoting the water-gas shift forward reaction) or in which the water-gas shift reaction has been modulated. The methods and compositions, therefore, also relate, in part, to increasing the oxidation rate of carbon monoxide (CO), for increasing the availability of CO (e.g., to the carbon monoxide dehydrogenase (CODH) enzyme complex), for removing and/or promoting the release of hydrogen and/or carbon dioxide (CO2), for regulating the redox potential of cells, for preventing free radical damage and/or promoting cell survivability, etc. The invention also relates, in part, to methods and compositions for modulating CODH activity, such as increasing CODH activity. Methods and compositions are also provided for modulating the PSII reaction (e.g., promoting the PSII forward reaction) or in which the PSII reaction has been modulated. The modulation of the PSII reaction can be in conjunction with the modulation of the water-gas shift reaction. The invention also relates, in part, to methods and compositions for modulating PSII activity, such as increasing PSII activity. The invention further relates to uses of the aforementioned methods and compositions. For example, methods and compositions are provided for the production of hydrogen and/or for the elimination of CO. The methods and compositions provided can be used for a variety of industrial and medical applications, and such applications are also provided as part of the invention.
摘要翻译：本发明部分地涉及用于调节水煤气变换反应（例如促进水煤气前进反应）的方法和组合物，或其中水煤气变换反应被调制的方法和组合物。因此，方法和组合物还部分地涉及提高一氧化碳（CO）的氧化速率，以增加CO（例如，一氧化碳脱氢酶（CODH）酶复合物）的可用性，用于除去和/ 或促进氢和/或二氧化碳（CO 2）的释放，用于调节细胞的氧化还原电位，用于防止自由基损伤和/或促进细胞存活力等。本发明还部分涉及用于调节CODH活性，如增加CODH活性。还提供了用于调节PSII反应（例如，促进PSII正向反应）或其中已经调节PSII反应的方法和组合物。 PSII反应的调节可以与水煤气变换反应的调节相结合。本发明还部分涉及用于调节PSII活性的方法和组合物，例如增加PSII活性。本发明还涉及上述方法和组合物的用途。例如，提供了用于生产氢和/或消除CO的方法和组合物。所提供的方法和组合物可用于各种工业和医疗应用，并且这些应用也作为本发明的一部分提供。

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