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1. 发明申请

US20090155875A1 Methods to Enhance Carbon Monoxide Dehydrogenase Activity and Uses Thereof 审中-公开
标题翻译：增强一氧化碳脱氢酶活性的方法及其用途
公开(公告)号：US20090155875A1
公开(公告)日：2009-06-18
申请号：US11884522
申请日：2006-02-16
申请人： David A. Berry , Robert S. Langer , Richard J. Resnick
发明人： David A. Berry , Robert S. Langer , Richard J. Resnick
IPC分类号： C12P3/00 , C12N9/02 , C12N1/21
CPC分类号： C12P3/00 , C12N9/0008 , C12Y102/99002
摘要： This invention relates, in part, to methods and compositions for modulating the water-gas shift reaction (e.g., promoting the water-gas shift forward reaction) or in which the water-gas shift reaction has been modulated. The methods and compositions, therefore, also relate, in part, to increasing the oxidation rate of carbon monoxide (CO), for increasing the availability of CO (e.g., to the carbon monoxide dehydrogenase (CODH) enzyme complex), for removing and/or promoting the release of hydrogen and/or carbon dioxide (CO2), for regulating the redox potential of cells, for preventing free radical damage and/or promoting cell survivability, etc. The invention also relates, in part, to methods and compositions for modulating CODH activity, such as increasing CODH activity. Methods and compositions are also provided for modulating the PSII reaction (e.g., promoting the PSII forward reaction) or in which the PSII reaction has been modulated. The modulation of the PSII reaction can be in conjunction with the modulation of the water-gas shift reaction. The invention also relates, in part, to methods and compositions for modulating PSII activity, such as increasing PSII activity. The invention further relates to uses of the aforementioned methods and compositions. For example, methods and compositions are provided for the production of hydrogen and/or for the elimination of CO. The methods and compositions provided can be used for a variety of industrial and medical applications, and such applications are also provided as part of the invention.
摘要翻译：本发明部分地涉及用于调节水煤气变换反应（例如促进水煤气前进反应）的方法和组合物，或其中水煤气变换反应被调制的方法和组合物。因此，方法和组合物还部分地涉及提高一氧化碳（CO）的氧化速率，以增加CO（例如，一氧化碳脱氢酶（CODH）酶复合物）的可用性，用于除去和/ 或促进氢和/或二氧化碳（CO 2）的释放，用于调节细胞的氧化还原电位，用于防止自由基损伤和/或促进细胞存活力等。本发明还部分涉及用于调节CODH活性，如增加CODH活性。还提供了用于调节PSII反应（例如，促进PSII正向反应）或其中已经调节PSII反应的方法和组合物。 PSII反应的调节可以与水煤气变换反应的调节相结合。本发明还部分涉及用于调节PSII活性的方法和组合物，例如增加PSII活性。本发明还涉及上述方法和组合物的用途。例如，提供了用于生产氢和/或消除CO的方法和组合物。所提供的方法和组合物可用于各种工业和医疗应用，并且这些应用也作为本发明的一部分提供。

2. 发明申请

US20090156477A1 Compositions and Methods for Regulating Inflammatory Responses 审中-公开
标题翻译：调节炎症反应的组成和方法
公开(公告)号：US20090156477A1
公开(公告)日：2009-06-18
申请号：US11887561
申请日：2006-03-29
申请人： David A. Berry , Chi-Pong Kwan , Robert S. Langer , Ram Sasisekharan
发明人： David A. Berry , Chi-Pong Kwan , Robert S. Langer , Ram Sasisekharan
IPC分类号： A61K38/18 , A61P29/00
CPC分类号： C07K14/50 , A61K38/1825 , Y02A50/401 , A61K2300/00
摘要： This invention relates, in part, to compositions and methods for the regulation of inflammatory responses. Specifically, the invention relates, in part, to compositions of and methods for using fibroblast growth factor (FGF) proteins, proteoglycans (e.g., syndecans), agents that modulate proteoglycans and agents that affect Wnt signaling. The invention also provides compositions and methods for treating subjects with undesired inflammatory activity and/or diseases associated therewith. The invention further provides, in part, compositions and methods for disrupting intercellular junctions with FGFs, such as for the enhanced delivery of therapeutic agents.
摘要翻译：本发明部分涉及用于调节炎症反应的组合物和方法。具体而言，本发明部分涉及使用成纤维细胞生长因子（FGF）蛋白质，蛋白聚糖（例如，syndecans），调节蛋白聚糖的试剂和影响Wnt信号传导的试剂的组合物和方法。本发明还提供了用于治疗具有不希望的炎症活性和/或与其相关的疾病的受试者的组合物和方法。本发明还部分地提供用于破坏与FGF的细胞间连接的组合物和方法，例如用于增强治疗剂的递送。

3. 发明申请

US20100015068A1 Methods and Compositions For Altering Biological Surfaces 审中-公开
标题翻译：改变生物表面的方法和组成
公开(公告)号：US20100015068A1
公开(公告)日：2010-01-21
申请号：US12309049
申请日：2007-07-06
申请人： Jeffrey M. Karp , Alireza Khademhosseini , David A. Berry , Robert S. Langer , Frank X. Gu
发明人： Jeffrey M. Karp , Alireza Khademhosseini , David A. Berry , Robert S. Langer , Frank X. Gu
IPC分类号： A61K8/24 , C01B25/32 , B32B5/16 , A61K33/42 , A61Q11/00 , A61P19/10
CPC分类号： A61K8/11 , A61K6/0008 , A61K6/0017 , A61K6/0067 , A61K6/0085 , A61K6/0235 , A61K6/024 , A61K6/0612 , A61K6/0643 , A61K6/0668 , A61K8/19 , A61K8/88 , A61K2800/412 , A61K2800/94 , A61L24/02 , A61Q11/00 , Y10T428/2982 , C08L1/286 , C08L5/00 , C08L5/08 , C08L33/02 , C08L1/00
摘要： Compositions, methods and kits are provided for altering the properties of a biological surface using particles such as, for instance, calcium based particles in combination with an agent that binds to the biological surface. Properties such as color, sheen, texture, strength, and odor of biological surfaces such as teeth and bone are alterable.
摘要翻译：提供了组合物，方法和试剂盒，用于使用颗粒例如钙基颗粒与结合生物表面的试剂组合来改变生物表面的性质。诸如牙齿和骨骼等生物表面的颜色，光泽，质地，强度和气味等特性是可以改变的。

4. 发明授权

US08227237B2 Engineered CO2 fixing microorganisms producing carbon-based products of interest 有权
标题翻译：工程化的二氧化碳固定微生物生产碳基产品
公开(公告)号：US08227237B2
公开(公告)日：2012-07-24
申请号：US13174580
申请日：2011-06-30
申请人： Nikos B. Reppas , Martha Sholl , Sriram Kosuri , Brian D. Green , Christian P. Ridley , Frank A. Skraly , Dan E. Robertson , David A. Berry , Noubar B. Afeyan
发明人： Nikos B. Reppas , Martha Sholl , Sriram Kosuri , Brian D. Green , Christian P. Ridley , Frank A. Skraly , Dan E. Robertson , David A. Berry , Noubar B. Afeyan
IPC分类号： C12N1/04 , C12N1/13 , C12N7/02 , C12N15/31
CPC分类号： C12P7/065 , C12N1/20 , C12N9/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0083 , C12N9/1007 , C12N9/1029 , C12N9/88 , C12N15/74 , C12P1/04 , C12P5/00 , C12P5/02 , C12P5/026 , C12P7/00 , C12P7/6409 , C12P7/6427 , C12P7/6436 , C12P7/6463 , C12P7/6472 , C12P7/649 , C12P13/04 , C12R1/01 , C12Y103/03006 , Y02E50/13 , Y02E50/17 , Y02E50/18 , Y02E50/343
摘要： The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof.
摘要翻译：本发明公开了确定感兴趣的碳基产物如乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体在光自养生物体中生产的途径和机制，使得这些生物有效地转化二氧化碳和特别是利用这些有机物用于商业生产乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体。

5. 发明授权

US08142756B1 Methods of reforming hydrocarbon fuels using hexaaluminate catalysts 有权
标题翻译：使用六铝酸盐催化剂重整烃燃料的方法
公开(公告)号：US08142756B1
公开(公告)日：2012-03-27
申请号：US12717372
申请日：2010-03-04
申请人： Todd H. Gardner , David A. Berry , Dushyant Shekhawat
发明人： Todd H. Gardner , David A. Berry , Dushyant Shekhawat
IPC分类号： C01B3/26
CPC分类号： B01J23/83 , B01D53/864 , B01D53/944 , B01D2255/2042 , B01D2255/206 , B01D2255/2065 , B01D2255/20715 , B01D2255/20753 , B01D2255/2092 , B01D2257/702 , B01D2258/012 , B01J23/002 , B01J23/78 , B01J37/031 , B01J2523/00 , C01B3/326 , C01B3/386 , C01B3/40 , C01B2203/0233 , C01B2203/0244 , C01B2203/0261 , C01B2203/1041 , C01B2203/1058 , C01B2203/1217 , C01B2203/1235 , Y02P20/52 , B01J2523/25 , B01J2523/31 , B01J2523/3712 , B01J2523/48 , B01J2523/847 , B01J2523/375
摘要： A metal substituted hexaaluminate catalyst for reforming hydrocarbon fuels to synthesis gas of the general formula AByAl12-yO19-δ, A being selected from alkali metals, alkaline earth metals and lanthanide metals or mixtures thereof. A dopant or surface modifier selected from a transitions metal, a spinel of an oxygen-ion conductor is incorporated. The dopant may be Ca, Cs, K, La, Sr, Ba, Li, Mg, Ce, Co, Fe, Ir, Rh, Ni, Ru, Cu, Pe, Os, Pd, Cr, Mn, W, Re, Sn, Gd, V, Ti, Ag, Au, and mixtures thereof. The oxygen-ion conductor may be a perovskite selected from M′RhO3, M′PtO3, M′PdO3, M′IrO3, M′RuO3 wherein M′=Mg, Sr, Ba, La, Ca; a spinel selected from MRh2O4, MPt2O4, MPd2O4, MIr2O4, MRu2O4 wherein M=Mg, Sr, Ba, La, Ca and mixtures thereof; a florite is selected from M″O2.
摘要翻译：一种用于将烃燃料重整成通式为AByAl 12-y O 19-δ的合成气的金属取代六铝酸盐催化剂，A选自碱金属，碱土金属和镧系金属或其混合物。从过渡金属，氧离子导体的尖晶石中掺入掺杂剂或表面改性剂。掺杂剂可以是Ca，Cs，K，La，Sr，Ba，Li，Mg，Ce，Co，Fe，Ir，Rh，Ni，Ru，Cu，Pe，Os，Pd，Cr，Mn， Sn，Gd，V，Ti，Ag，Au及其混合物。氧离子导体可以是选自M'RhO3，M'PtO3，M'PdO3，M'IrO3，M'RuO3的钙钛矿，其中M'= Mg，Sr，Ba，La，Ca; 选自MRh 2 O 4，MPt 2 O 4，MP d 2 O 4，MIr 2 O 4，MRu 2 O 4的尖晶石，其中M = Mg，Sr，Ba，La，Ca及其混合物; 选自M“O2的花青石。

6. 发明授权

US08133463B1 Pyrochlore-type catalysts for the reforming of hydrocarbon fuels 有权
标题翻译：用于烃燃料重整的热解型催化剂
公开(公告)号：US08133463B1
公开(公告)日：2012-03-13
申请号：US12422346
申请日：2009-04-13
申请人： David A. Berry , Dushyant Shekhawat , Daniel Haynes , Mark Smith , James J. Spivey
发明人： David A. Berry , Dushyant Shekhawat , Daniel Haynes , Mark Smith , James J. Spivey
IPC分类号： C01B31/18 , C01B3/26
CPC分类号： C01B3/40 , B01J23/002 , B01J23/63 , B01J23/83 , B01J37/0236 , B01J37/031 , B01J2523/00 , C01B3/326 , C01B2203/0233 , C01B2203/0238 , C01B2203/0261 , C01B2203/1011 , C01B2203/1023 , C01B2203/1041 , C01B2203/1047 , C01B2203/1082 , C01B2203/1088 , C01B2203/1217 , C01B2203/1235 , Y02P20/52 , B01J2523/24 , B01J2523/3706 , B01J2523/48 , B01J2523/847 , B01J2523/828 , B01J2523/822 , B01J2523/821 , B01J2523/22 , B01J2523/23 , B01J2523/25 , B01J2523/3712 , B01J2523/375 , B01J2523/3737 , B01J2523/36 , B01J2523/47
摘要： A method of catalytically reforming a reactant gas mixture using a pyrochlore catalyst material comprised of one or more pyrochlores having the composition A2-w-xA′wA″xB2-y-zB′yB″zO7-Δ. Distribution of catalytically active metals throughout the structure at the B site creates an active and well dispersed metal locked into place in the crystal structure. This greatly reduces the metal sintering that typically occurs on supported catalysts used in reforming reactions, and reduces deactivation by sulfur and carbon. Further, oxygen mobility may also be enhanced by elemental exchange of promoters at sites in the pyrochlore. The pyrochlore catalyst material may be utilized in catalytic reforming reactions for the conversion of hydrocarbon fuels into synthesis gas (H2+CO) for fuel cells, among other uses.
摘要翻译：使用由具有组合物A2-w-xA'wA“xB2-y-zB'yB”zO7-＆Dgr的一种或多种烧绿石组成的烧绿石催化剂材料催化重整反应气体混合物的方法。催化活性金属在B位置的整个结构中的分布产生锁定在晶体结构中的活性和良好分散的金属。这大大降低了在重整反应中使用的负载催化剂上通常发生的金属烧结，并减少了硫和碳的失活。此外，通过在烧绿石中的位点处促进剂的元素交换也可以提高氧迁移率。烧绿石催化剂材料可用于催化重整反应，用于将燃料转化为用于燃料电池的合成气（H 2 + CO）等。

7. 发明授权

US07981647B2 Engineered CO2 fixing microorganisms producing carbon-based products of interest 有权
标题翻译：工程化的二氧化碳固定微生物生产碳基产品
公开(公告)号：US07981647B2
公开(公告)日：2011-07-19
申请号：US12867738
申请日：2009-03-03
申请人： David A. Berry , Dan E. Robertson , Frank A. Skraly , Brian D. Green , Christian P. Ridley , Sriram Kosuri , Nikos B. Reppas , Martha Sholl , Noubar B. Afeyan
发明人： David A. Berry , Dan E. Robertson , Frank A. Skraly , Brian D. Green , Christian P. Ridley , Sriram Kosuri , Nikos B. Reppas , Martha Sholl , Noubar B. Afeyan
IPC分类号： C12P7/06 , C12N1/13 , A01H13/00
CPC分类号： C12P7/065 , C12N1/20 , C12N9/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0083 , C12N9/1007 , C12N9/1029 , C12N9/88 , C12N15/74 , C12P1/04 , C12P5/00 , C12P5/02 , C12P5/026 , C12P7/00 , C12P7/6409 , C12P7/6427 , C12P7/6436 , C12P7/6463 , C12P7/6472 , C12P7/649 , C12P13/04 , C12R1/01 , C12Y103/03006 , Y02E50/13 , Y02E50/17 , Y02E50/18 , Y02E50/343
摘要： The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, alkanes, isoprenoids, pharmaceutical products or intermediates thereof.
摘要翻译：本发明公开了确定感兴趣的碳基产物如乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体在光自养生物体中生产的途径和机制，使得这些生物有效地转化二氧化碳和特别是利用这些生物来商业生产乙醇，乙烯，化学品，聚合物，烷烃，类异戊二烯，药物产品或其中间体。

8. 发明授权

US07913618B2 Punch press tool for stamping successive multicharacter impressions into a workpiece 有权
标题翻译：冲压工具用于将连续的多重变形印模冲压成工件
公开(公告)号：US07913618B2
公开(公告)日：2011-03-29
申请号：US11820827
申请日：2007-06-21
申请人： Gregory S. Ferry , David A. Berry
发明人： Gregory S. Ferry , David A. Berry
IPC分类号： B44B5/00 , B44B5/02 , B41K3/10
CPC分类号： B44B5/026 , B21D28/12 , B44B5/0057 , Y10T83/9423
摘要： A punch press tool for stamping successive multicharacter impressions into a workpiece such as a piece of steel, sheet metal, or other workpiece, includes a guide body in which a stamp driver is slidably mounted for being driven downwardly toward the workpiece by a punch press ram which is a standard part of a high speed commercial punch press. A multicharacter marking stamp is supported at the lower end of the stamp driver for reciprocal movement therewith. The marking stamp includes multicharacter wheels that are rotated automatically during operation for advancing characters in sequence responsive to the movement of a character advancing arm. At least one character stamp operating lever is operatively associated with the punch press tool for articulation responsive to motion imparted to the tool by the ram. The lever has an operating element that is operatively associated with the character advancing arm of the multicharacter stamp for indexing the arm to enable successive characters thereof to be placed in an operating position responsive to a stroke of the punch press ram.
摘要翻译：用于将连续的多焦点印模冲压成诸如一块钢，金属片或其它工件的工件的冲压工具包括导向体，其中印模驱动器可滑动地安装，以便通过冲压压头向下朝向工件这是高速商业冲压机的标准部件。在印章驱动器的下端支撑多字符标记印章，用于与之相互移动。标记印章包括多字符轮，其在操作期间自动旋转，以响应于字符前进臂的移动顺序前进字符。至少一个字符印记操作杆与冲压工具可操作地相关联，用于响应于由冲头施加到工具的运动而进行铰接。杠杆具有操作性地与多焦头印字机的字符前进臂相关联的操作元件，用于对臂进行分度，以使得其连续的字符能够响应于冲压压头的行程而被放置在操作位置。

9. 发明申请

US20100087634A1 Fluorous Oligonucleotide Reagents and Affinity Purification of Oligonucleotides 审中-公开
标题翻译：氟代寡核苷酸试剂和寡核苷酸的亲和纯化
公开(公告)号：US20100087634A1
公开(公告)日：2010-04-08
申请号：US12582432
申请日：2009-10-20
申请人： David A. Berry , William H. Pearson
发明人： David A. Berry , William H. Pearson
IPC分类号： C09B29/00 , C07H19/10 , C07H19/20 , C07F9/02 , C07F9/06 , C07D311/02 , C07D207/46
CPC分类号： C07H21/00 , C07B63/00 , C07B2200/11 , C07C245/08 , C07F9/2408 , C07F9/6561 , C07H19/067 , C07H19/073 , C07H19/167 , C07H19/173 , C07H21/04 , C07H23/00
摘要： Fluorous-tagged oligonucleotide reagents and an oligonucleotide purification methodology making use thereof, the method comprising: Synthesizing oligonucleotides using oligonucleotide reagents each bearing at least one fluorous group to yield a mixture of synthesis products and reagents, the mixture including at least one target synthesized oligonucleotide bearing at least one fluorous group; passing the mixture through a separation medium having an affinity for the at least one fluorous group so that the target synthesized oligonucleotide bearing at least one fluorous group is adsorbed by the separation medium; washing the separation medium with at least a first solvent to selectively dissociate therefrom substantially all synthesis products and reagents of the heterogenous mixture other than the at least one target synthesized oligonucleotide bearing at least one fluorous group; and subsequently dissociating the at least one synthesized oligonucleotide from the separation medium, with or without the fluorous group.
摘要翻译：含氟标记的寡核苷酸试剂和利用其的寡核苷酸纯化方法，所述方法包括：使用各自携带至少一个氟基的寡核苷酸试剂合成寡核苷酸试剂以产生合成产物和试剂的混合物，所述混合物包含至少一种靶合成寡核苷酸轴承至少一个氟团; 使混合物通过对至少一个氟族具有亲和力的分离介质，使得带有至少一个氟团的靶合成寡核苷酸被分离介质吸附; 用至少一种第一溶剂洗涤分离介质以选择性地从其中分离除了至少一种带有至少一个氟基的至少一种目标合成寡核苷酸之外的异质混合物的所有合成产物和试剂; 并随后使用或不与氟基离开分离介质中的至少一种合成的寡核苷酸。

10. 发明申请

US20090047295A1 Methods and Compositions for Reducing Stemness in Oncogenesis 审中-公开
标题翻译：减少肿瘤发生中的干细胞的方法和组合
公开(公告)号：US20090047295A1
公开(公告)日：2009-02-19
申请号：US12171923
申请日：2008-07-11
申请人： David A. Berry , Eric J. Devroe , Noubar Boghos Afeyan , Brett Chevalier , Sashank K. Reddy
发明人： David A. Berry , Eric J. Devroe , Noubar Boghos Afeyan , Brett Chevalier , Sashank K. Reddy
IPC分类号： A61K39/395 , C12N5/08 , A61K31/7105 , A61P31/00
CPC分类号： A61K39/39558 , A61K31/00 , A61K31/713 , A61K2300/00
摘要： The invention provides methods and compositions for reducing the number of cancer stem cells in a mixed population of differentiated cells (for example, cancer cells) and cancer stem cells. The cancer stem cells, if present, can be more resistant to traditional drug-based therapies and can provide a source for new, differentiated cancer cells associated with the development of drug-resistance and more aggressive phenotypes. When combined with traditional cancer therapies, for example, drug-based therapies, the methods and compositions of the invention provide a more effective way for treating cancer and can provide a model system for developing new cancer therapies and new treatment modalities.
摘要翻译：本发明提供了用于减少分化细胞（例如癌细胞）和癌干细胞的混合群体中的癌干细胞数目的方法和组合物。癌症干细胞（如果存在）可以更好地抵抗传统的基于药物的疗法，并且可以为与耐药性和更具侵袭性的表型的发展相关联的新的分化癌细胞提供来源。当与传统的癌症疗法结合时，例如基于药物的疗法，本发明的方法和组合提供了治疗癌症的更有效的方法，并且可以提供用于开发新的癌症疗法和新的治疗方式的模型系统。

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