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111. 发明授权

US07901573B2 Separation column and liquid chromatography apparatus using the same 失效
标题翻译：分离柱和使用其的液相色谱仪
公开(公告)号：US07901573B2
公开(公告)日：2011-03-08
申请号：US12081572
申请日：2008-04-17
申请人： Kimihiko Ishii , Hironori Kaji , Masahito Ito , Yoshihiro Nagaoka , Kunihiko Takao
发明人： Kimihiko Ishii , Hironori Kaji , Masahito Ito , Yoshihiro Nagaoka , Kunihiko Takao
IPC分类号： B01D15/08
CPC分类号： B01D15/22 , B01D15/206 , B01J20/3236 , B01J2220/82 , B01J2220/86 , G01N30/52 , G01N30/6017 , G01N30/603 , G01N30/6047 , G01N30/6052 , G01N2030/528
摘要： Disclosed herein is a separation column comprising a porous block covered with a coating wherein space-free adhesion is attainable therebetween by low temperature process without releasing octadecylsilyl bases and others from the porous block. A monolith rod 1 is covered with a metal or resin coating 2. Then, the monolith rod 1 covered by the coating 2 is further covered with a rod retainer 3 made of a low melting point metal (melting point 100-200 degrees C.) to form a column body 19. Since the rod retainer 3 is formed by pressure molding at low temperature (100-200 degrees C.). It is therefore possible to absorb the surface irregularities of the monolith rod 1 by the coating 2 while octadecylsilyl bases and others from are released when the retainer 3 is formed. This allows the potential separation ability of the porous block to be brought out maximally.
摘要翻译：本文公开了一种分离柱，其包括用涂层覆盖的多孔块，其中通过低温工艺在其间实现无空隙粘合，而不从多孔块中释放十八烷基甲硅烷基等。整料棒1被金属或树脂涂层2覆盖。然后，用由低熔点金属（熔点100-200℃）制成的棒保持器3进一步覆盖由涂层2覆盖的整料棒1。以形成柱体19.由于杆保持器3通过在低温（100-200℃）下的模压而形成。因此，当保持器3形成时，可以通过涂层2吸收整料棒1的表面凹凸，同时十八烷基甲硅烷基等被释放。这允许最大限度地排出多孔块的潜在分离能力。

112. 发明申请

US20110023711A1 MONOLITH ADSORBENT AND METHOD AND APPARATUS FOR ADSORBING SAMPLES WITH THE SAME 有权
标题翻译：单体吸附剂和用于吸附样品的方法和装置
公开(公告)号：US20110023711A1
公开(公告)日：2011-02-03
申请号：US12665612
申请日：2008-06-18
申请人： Atsushi Sato , Hiroyuki Terashima , Yoshiyki Takei
发明人： Atsushi Sato , Hiroyuki Terashima , Yoshiyki Takei
IPC分类号： G01N1/10 , B01J20/00 , C01B31/08 , B01J20/18 , B01J20/14 , B01J20/26 , B01J20/08 , B01J20/04 , B01J20/22 , G01N1/22 , B01J20/28
CPC分类号： B01J20/28042 , B01J20/08 , B01J20/14 , B01J20/18 , B01J20/20 , B01J20/205 , B01J20/261 , B01J20/281 , B01J20/286 , B01J20/3204 , B01J20/321 , B01J20/3246 , B01J20/3248 , B01J20/327 , B01J20/3272 , B01J2220/54 , B01J2220/82 , B01J2220/825 , B82Y30/00 , G01N30/52 , G01N2030/528
摘要： The problem to be solved by the present invention is to provide a monolith adsorbent which can adsorb a target sample easily in a short time or regardless of whether the amount of the sample is small or large and extract the sample with a small amount of solvent, and easily secure the sample necessary for analysis, and a method and an apparatus for adsorption and retention using the same. The present invention, as the means for solving the problem, is a monolith adsorbent formed by allowing a monolith structure body to contain an adsorbing material such as activated carbon or graphite, exposing the adsorbing material on the surface of the structure body and further surface-treating the surface of the monolith structure body with a hydrophobic or hydrophilic compound or a resin.
摘要翻译：本发明要解决的问题是提供一种能够在短时间内容易地吸附目标样品的单块吸附剂，或者不管样品的量是否小或大，并且用少量的溶剂萃取样品，并且容易地确保用于分析所需的样品，以及使用其的吸附和保持的方法和装置。作为解决该问题的手段，本发明是通过使整料结构体含有活性炭或石墨等吸附材料形成的整料吸附剂，将吸附材料暴露在结构体的表面上，用疏水或亲水性化合物或树脂处理整料结构体的表面。

113. 发明申请

US20110000279A1 METHOD OF CLADDING MONOLITHIC SILICA BODY AND SEPARATION MEDIUM 有权
标题翻译：单晶二氧化硅体和分离介质的方法
公开(公告)号：US20110000279A1
公开(公告)日：2011-01-06
申请号：US12865815
申请日：2008-02-01
申请人： Shota Miyazaki , Hiroyuki Terashima , Masahiko Nyudo , Masayoshi Ohira , Kei Morisato , Masahiro Furuno
发明人： Shota Miyazaki , Hiroyuki Terashima , Masahiko Nyudo , Masayoshi Ohira , Kei Morisato , Masahiro Furuno
IPC分类号： G01N30/02 , C03C27/00 , C03C23/00
CPC分类号： B01D15/22 , B01D15/20 , B01J20/103 , B01J20/28042 , B01J20/283 , B01J20/3257 , B01J2220/54 , B01J2220/82 , B01J2220/825 , G01N30/50 , G01N30/6052 , G01N2030/528
摘要： To use a monolithic silica body in chromatography with a HPLC column or a GC column and to simplify the use thereof as a separation medium, it is intended to provide a method of cladding a main body of a monolithic adsorbent or separating agent with glass so as to protect the outer surface, and to provide a separation medium prepared by the method. To this end, a monolithic silica body alone is formed by molding, and the molding is coated with a glass body; and then the glass body and the monolithic silica body are fused and integrated at the melting temperature of the glass body at an appropriate pressure. The surface of the resulting monolithic silica body clad with glass is strongly protected by the glass, and the homogeneity of the interior of the monolithic silica body is maintained, and thus uniform flow of a sample solution ensures analytical accuracy.
摘要翻译：为了在使用HPLC柱或GC色谱柱的色谱法中使用整体二氧化硅体，并且为了简化其作为分离介质的用途，旨在提供一种用玻璃包覆整体式吸附剂或分离剂的主体的方法，以便以保护外表面，并提供通过该方法制备的分离介质。为此，通过模制单独形成整体式二氧化硅体，并且模塑被玻璃体涂覆; 然后玻璃体和整体式二氧化硅体在玻璃体的熔融温度下以适当的压力熔融并整合。用玻璃覆盖的所得整体二氧化硅体的表面被玻璃强烈保护，并且保持了整体二氧化硅体内部的均匀性，因此样品溶液的均匀流动确保了分析精度。

114. 发明申请

US20100262259A1 PROCESS FOR PRODUCING BONE GRAFTING MATERIAL, BONE GRAFTING MATERIAL, THREE-DIMENSIONAL SUPPORT FOR CELL CULTURE, AND SEPARATION SUPPORT FOR CHROMATOGRAPHY 审中-公开
标题翻译：生产骨材料，骨质素材料，细胞培养的三维支持和色谱分离支持的方法
公开(公告)号：US20100262259A1
公开(公告)日：2010-10-14
申请号：US12279531
申请日：2007-02-13
申请人： Yuichi Tei , Kay Teraoka , Shigeki Suzuki , Koutaro Shimizu , Katsuhisa Takane
发明人： Yuichi Tei , Kay Teraoka , Shigeki Suzuki , Koutaro Shimizu , Katsuhisa Takane
IPC分类号： A61F2/28
CPC分类号： A61L27/46 , A61F2/4644 , A61F2002/2835 , A61F2002/30138 , A61F2002/30172 , A61F2002/30179 , A61F2002/30247 , A61F2002/3025 , A61F2002/30303 , A61F2002/30677 , A61F2002/30957 , A61F2002/30968 , A61F2002/4648 , A61F2230/0017 , A61F2230/0052 , A61F2230/0058 , A61F2230/0063 , A61F2230/0071 , A61F2310/00293 , A61L2430/02 , B01J20/048 , B01J20/28014 , B01J20/28042 , B01J20/282 , B01J20/3007 , B01J20/3014 , B01J20/3078 , B01J2220/52 , G01N2030/528 , C08L31/04 , C08L33/10
摘要： A novel method for producing a bone filling material is provided. The method comprises the steps of: (a) kneading ingredient comprising calcium-based material and material comprising binder; (b) molding a predetermined shape of the mixture obtained in step (a) with an injection molding machine having a mold; (c) removing the binder contained in the mold formed in step (b) (i.e., degreasing) to obtain a degreased body; (d) and heating and sintering the degreased body obtained in step (c) to obtain a sintered body.
摘要翻译：提供了一种生产骨填充材料的新方法。该方法包括以下步骤：（a）捏合包含钙基材料的成分和包含粘合剂的材料; （b）用具有模具的注塑机模制步骤（a）中获得的混合物的预定形状; （c）除去步骤（b）中形成的模具中所含的粘合剂（即脱脂），得到脱脂体; （d），对步骤（c）中得到的脱脂体进行加热烧结，得到烧结体。

115. 发明申请

US20100012566A1 SEPARATION COLUMN AND LIQUID CHROMOTOGRAPH USING THE SAME 审中-公开
标题翻译：分离色谱柱和使用该色谱柱的液相色谱
公开(公告)号：US20100012566A1
公开(公告)日：2010-01-21
申请号：US12566601
申请日：2009-09-24
申请人： Yoshihiro NAGAOKA , Masahito ITO , Daizo TOKINAGA , Tomohiro SHOJI , Tomonari MORIOKA
发明人： Yoshihiro NAGAOKA , Masahito ITO , Daizo TOKINAGA , Tomohiro SHOJI , Tomonari MORIOKA
IPC分类号： B01D15/08
CPC分类号： B01D15/22 , B01J2220/82 , G01N30/6026 , G01N30/6047 , G01N30/6052 , G01N2030/528
摘要： The flow rate of a solvent is reduced as a separation column and the separation performance is improved even under high-pressure conditions. There is provided a separation column including a monolith rod into which a sample and a mobile phase flow, the separation column comprising: a coating material coated on the outer circumference of a monolith rod; a support member into which the monolith rod coated with the coating material is inserted, and a rod fixing material fitted into or filled a gap between the coating material and the support member; wherein the upper end face of the rod fixing material is sealed, the upper end face being the inflow-side end when the separation column is assembled.
摘要翻译：溶剂的流量作为分离塔减少，即使在高压条件下也提高了分离性能。提供了一种分离柱，其包括样品和流动相流入其中的整料棒，所述分离柱包括：涂覆在整料棒外圆周上的涂料; 插入涂覆有涂料的整料棒的支撑构件，以及装配到涂料和支撑构件之间或填充涂层材料和支撑构件之间的间隙的杆固定材料; 其中杆固定材料的上端面被密封，当组装分离柱时，上端面是流入侧端。

116. 发明申请

US20090308736A1 APPARATUS AND METHOD FOR SPECIFIC RELEASE OF CAPTURED EXTENSION PRODUCTS 审中-公开
标题翻译：特定扩展产品的特殊释放装置和方法
公开(公告)号：US20090308736A1
公开(公告)日：2009-12-17
申请号：US12400749
申请日：2009-03-09
申请人： Janice G. Shigeura , Jer-Kang Chen , John Shigeura
发明人： Janice G. Shigeura , Jer-Kang Chen , John Shigeura
IPC分类号： B01D35/30 , C25B15/02
CPC分类号： C12Q1/6874 , C07B2200/11 , C12N15/101 , C12Q1/6834 , C12Q1/6837 , C40B40/00 , G01N1/405 , G01N30/02 , G01N30/466 , G01N30/50 , G01N30/6043 , G01N30/6047 , G01N30/6052 , G01N30/6065 , G01N30/6069 , G01N30/6091 , G01N2030/3061 , G01N2030/521 , G01N2030/528 , G01N2030/562 , Y10T436/143333 , G01N2030/0035 , G01N30/463
摘要： Apparatus and methods for separating different polynucleotide populations in a mixture are provided, wherein different polynucleotides or polynucleotide populations are captured on different solid support. After hybridization, polynucleotides are selectively released from a selected support by altering a physical property of that support. The released polynucleotides can be eluted from a common flow path and isolated.
摘要翻译：提供了用于分离混合物中不同多核苷酸群体的装置和方法，其中不同的多核苷酸或多核苷酸群体被捕获在不同的固体支持物上。杂交后，通过改变该载体的物理性质，选择性地从选定的载体上释放多核苷酸。释放的多核苷酸可以从共同的流动路径洗脱并分离。

117. 发明申请

US20090203146A1 NARROW BORE LAYER OPEN TUBE CAPILLARY COLUMN AND USES THEREOF 审中-公开
标题翻译： NARROW BORE LAYER OPEN TUBE CAPILLARY COLUMN及其用途
公开(公告)号：US20090203146A1
公开(公告)日：2009-08-13
申请号：US12306232
申请日：2007-06-20
申请人： Barry L. Karger , Jian Zhang
发明人： Barry L. Karger , Jian Zhang
IPC分类号： G01N27/26 , B05D5/00 , G01N35/00 , G01N27/06
CPC分类号： G01N30/60 , B01J20/28085 , B01J20/285 , B01J20/289 , B01J20/327 , B01J20/3282 , B01J2220/54 , B01J2220/84 , B01J2220/86 , G01N30/6073 , G01N30/7266 , G01N2030/528 , Y10T436/11 , Y10T436/117497
摘要： A polymer-based PLOT column prepared by in situ copolymerization of a functional monomer, which usually contains the retentive chemistries, and a crosslinking monomer, which enhances the strength of the polymer matrix, is disclosed. Styrenic based monomers such as styrene and divinylbenzene or meth/acrylic based monomers such as butyl or stearyl methacrylate and ethylene glycol dimethacrylate, are preferred. Columns of the invention can be prepared in a robust fashion with a very narrow i.d., e.g., 5-15 μm. Thus, they are suitable for commercial use in ultratrace LC/MS proteomic analysis. Columns according to the invention are characterized by high resolving power, high column-to-column reproducibility and relatively high loading capacity. When these columns are coupled on-line with, e.g., ESI-MS detection, the resulting systems provide high sensitivity for analysis of complex proteomic samples, even down to the low attomole to sub-attomole level.
摘要翻译：公开了通过包含保持性化学物质的官能单体的原位共聚制备的聚合物基PLOT柱和提高聚合物基质的强度的交联单体。苯乙烯类单体如苯乙烯和二乙烯基苯或甲基丙烯酸类单体如甲基丙烯酸丁酯或硬脂基酯和乙二醇二甲基丙烯酸酯是优选的。可以以非常窄的i.d.例如5-15mum的稳健方式制备本发明的色谱柱。因此，它们适用于超临界LC / MS蛋白质组学分析中的商业用途。根据本发明的色谱柱的特征在于高分辨能力，高柱色谱重现性和相对较高的负载能力。当这些色谱柱与ESI-MS检测在线偶联时，所得到的系统为复杂蛋白质组样品的分析提供了高灵敏度，甚至低至低阿托莫尔至亚阿托莫尔水平。

118. 发明申请

US20090001007A1 SEPARATION COLUMN FOR LIQUID CHROMATOGRAPH APPARATUS AND LIQUID CHROMATOGRAPH APPARATUS USING THEREOF 失效
标题翻译：液相色谱仪和液相色谱仪的分离色谱柱
公开(公告)号：US20090001007A1
公开(公告)日：2009-01-01
申请号：US12146912
申请日：2008-06-26
申请人： Katsutoshi Shimizu , Masahito Ito , Kimihiko Ishii , Yoshihiro Nagaoka , Kisaburo Deguchi , Takefumi Yokokura
发明人： Katsutoshi Shimizu , Masahito Ito , Kimihiko Ishii , Yoshihiro Nagaoka , Kisaburo Deguchi , Takefumi Yokokura
IPC分类号： B01D15/08
CPC分类号： B01D15/22 , B01J20/282 , B01J2220/82 , B01J2220/825 , G01N30/22 , G01N30/6047 , G01N30/6052 , G01N30/6069 , G01N2030/522 , G01N2030/528
摘要： Both a column having high-pressure resistance and capable of performing high-speed separation and analysis even with a small flow rate and a liquid chromatograph apparatus using thereof are to be provided.A separation column according to the present invention has a monolithic rod being arranged in the center, being made of a porous material, and having a circular cross section, a filler layer arranged such that it encircles a circumferential surface of the monolithic rod, and a cylindrical support medium arranged outside the filler layer. The filler layer is formed by filling a tube-like gap between the monolithic rod and the support medium with particles or beads.
摘要翻译：提供具有高耐压性并且即使使用小流量也能够进行高速分离和分析的柱和使用其的液相色谱装置。根据本发明的分离柱具有中心的整体式杆，由多孔材料制成，并且具有圆形横截面，填充层布置成围绕整体式杆的圆周表面，并且圆柱形支撑介质布置在填充层外部。通过在颗粒或珠粒之间填充整体棒和支撑介质之间的管状间隙来形成填充层。

119. 发明授权

US07469557B2 Method for forming a capillary column for filtering, separation and concentration 失效
标题翻译：形成用于过滤，分离和浓缩的毛细管柱的方法
公开(公告)号：US07469557B2
公开(公告)日：2008-12-30
申请号：US10866626
申请日：2004-06-12
申请人： Teresanne Griffin , Stephen E. Griffin
发明人： Teresanne Griffin , Stephen E. Griffin
IPC分类号： C03B23/207
CPC分类号： G01N30/52 , G01N30/6052 , G01N30/6082 , G01N2030/528
摘要： The column according to the present invention provides greatly increased effective length and tortuosity, per unit length of column material, by providing a smooth or textured, tight radius helical channel or channels within a silica monolith. The capillary according to the present invention is useful in enabling fully automated massively parallel analyses, syntheses, separations and concentrations at reduced costs and higher speed as well as in immobilization, filtration, and miniaturization/acceleration/automation of classical instrumentation for practicality of general deployment in environmental threat monitoring and other applications.
摘要翻译：根据本发明的柱通过在二氧化硅整体中提供光滑或纹理紧密的半径螺旋形通道或通道来提供每单位长度的柱材料的有效长度和弯曲度。根据本发明的毛细管可用于实现全面自动化的大规模并行分析，合成，分离和浓缩，降低成本和更高的速度以及固定，过滤以及经典仪器的小型化/加速/自动化，以实现普遍部署在环境威胁监测等应用中。

120. 发明申请

US20080283458A1 Separation column and liquid chromatography apparatus using the same 失效
标题翻译：分离柱和使用其的液相色谱仪
公开(公告)号：US20080283458A1
公开(公告)日：2008-11-20
申请号：US12081572
申请日：2008-04-17
申请人： Kimihiko Ishii , Hironori Kaji , Masahito Ito , Yoshihiro Nagaoka , Kunihiko Takao
发明人： Kimihiko Ishii , Hironori Kaji , Masahito Ito , Yoshihiro Nagaoka , Kunihiko Takao
IPC分类号： B01D15/08 , B01D15/22
CPC分类号： B01D15/22 , B01D15/206 , B01J20/3236 , B01J2220/82 , B01J2220/86 , G01N30/52 , G01N30/6017 , G01N30/603 , G01N30/6047 , G01N30/6052 , G01N2030/528
摘要： Disclosed herein is a separation column comprising a porous block covered with a coating wherein space-free adhesion is attainable therebetween by low temperature process without releasing octadecylsilyl bases and others from the porous block.A monolith rod 1 is covered with a metal or resin coating 2. Then, the monolith rod 1 covered by the coating 2 is further covered with a rod retainer 3 made of a low melting point metal (melting point 100-200 degrees C.) to form a column body 19. Since the rod retainer 3 is formed by pressure molding at low temperature (100-200 degrees C.). It is therefore possible to absorb the surface irregularities of the monolith rod 1 by the coating 2 while octadecylsilyl bases and others from are released when the retainer 3 is formed. This allows the potential separation ability of the porous block to be brought out maximally.
摘要翻译：本文公开了一种分离柱，其包括用涂层覆盖的多孔块，其中通过低温工艺在其间实现无空隙粘合，而不从多孔块中释放十八烷基甲硅烷基等。整料棒1被金属或树脂涂层2覆盖。然后，用由低熔点金属（熔点为100-200℃）制成的棒保持器3进一步覆盖由涂层2覆盖的整料棒1，以形成柱体19。由于杆保持器3通过在低温（100-200℃）下进行压力成型而形成。因此，当保持器3形成时，可以通过涂层2吸收整料棒1的表面凹凸，同时十八烷基甲硅烷基等被释放。这允许最大限度地排出多孔块的潜在分离能力。

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