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1. 发明授权

US07909817B2 Lateral laser fiber for high average power and peak pulse energy 有权
标题翻译：横向激光光纤，具有较高的平均功率和峰值脉冲能量
公开(公告)号：US07909817B2
公开(公告)日：2011-03-22
申请号：US11148817
申请日：2005-06-08
申请人： Stephen E. Griffin , Teresanne Griffin
发明人： Stephen E. Griffin , Teresanne Griffin
IPC分类号： A61B18/18
CPC分类号： A61B18/20 , A61B18/22 , A61B2018/00023 , A61B2018/00029 , A61B2018/2272
摘要： An improved optical fiber comprising a waveguide with an input for coupling focused laser energy into the waveguide and communicating electromagnetic radiation in a propagation direction to an internally reflective tip of the waveguide, a tissue contacting surface wherein the light path from the reflecting surface to the transmitting surface in substantially homogenous in refractive index and cooled by fluid flow. In minimizing the variations in refractive index within the lateral light path, while providing active cooling directly below the tissue contact surface, the invention prevents internal reflections and beam distortion and greatly improves the efficiency and durability of the laterally directing probe. Free rotation of the tissue contact surface, about the lateral tip, may be provided and tissue vaporization efficiency may be improved by providing a morcellating tool on the tissue contact surface.
摘要翻译：一种改进的光纤，包括具有输入的波导，所述输入用于将聚焦的激光能量耦合到所述波导中并将传播方向上的电磁辐射传送到所述波导的内反射尖端，组织接触表面，其中从所述反射表面到所述透射表面基本上具有均匀的折射率并且通过流体流冷却。在使侧光路径内的折射率的变化最小化的同时，在组织接触表面的正下方提供主动冷却的同时，本发明可防止内部反射和光束变形，并大大提高了侧向引导探针的效率和耐久性。可以提供组织接触表面围绕侧向末端的自由旋转，并且可以通过在组织接触表面上设置一个脱毛工具来改善组织蒸发效率。

2. 发明授权

US07469557B2 Method for forming a capillary column for filtering, separation and concentration 失效
标题翻译：形成用于过滤，分离和浓缩的毛细管柱的方法
公开(公告)号：US07469557B2
公开(公告)日：2008-12-30
申请号：US10866626
申请日：2004-06-12
申请人： Teresanne Griffin , Stephen E. Griffin
发明人： Teresanne Griffin , Stephen E. Griffin
IPC分类号： C03B23/207
CPC分类号： G01N30/52 , G01N30/6052 , G01N30/6082 , G01N2030/528
摘要： The column according to the present invention provides greatly increased effective length and tortuosity, per unit length of column material, by providing a smooth or textured, tight radius helical channel or channels within a silica monolith. The capillary according to the present invention is useful in enabling fully automated massively parallel analyses, syntheses, separations and concentrations at reduced costs and higher speed as well as in immobilization, filtration, and miniaturization/acceleration/automation of classical instrumentation for practicality of general deployment in environmental threat monitoring and other applications.
摘要翻译：根据本发明的柱通过在二氧化硅整体中提供光滑或纹理紧密的半径螺旋形通道或通道来提供每单位长度的柱材料的有效长度和弯曲度。根据本发明的毛细管可用于实现全面自动化的大规模并行分析，合成，分离和浓缩，降低成本和更高的速度以及固定，过滤以及经典仪器的小型化/加速/自动化，以实现普遍部署在环境威胁监测等应用中。

3. 发明授权

US08529561B2 Lateral laser fiber for high average power and peak pulse energy 有权
标题翻译：横向激光光纤，具有较高的平均功率和峰值脉冲能量
公开(公告)号：US08529561B2
公开(公告)日：2013-09-10
申请号：US13028867
申请日：2011-02-16
申请人： Stephen E. Griffin , Teresanne Griffin
发明人： Stephen E. Griffin , Teresanne Griffin
IPC分类号： A61B18/18
CPC分类号： A61B18/20 , A61B18/22 , A61B2018/00023 , A61B2018/00029 , A61B2018/2272
摘要： An improved optical fiber comprising a waveguide with an input for coupling focused laser energy into the waveguide and communicating electromagnetic radiation in a propagation direction to an internally reflective tip of the waveguide, a tissue contacting surface wherein the light path from the reflecting surface to the transmitting surface in substantially homogenous in refractive index and cooled by fluid flow. In minimizing the variations in refractive index within the lateral light path, while providing active cooling directly below the tissue contact surface, the invention prevents internal reflections and beam distortion and greatly improves the efficiency and durability of the laterally directing probe. Free rotation of the tissue contact surface, about the lateral tip, may be provided and tissue vaporization efficiency may be improved by providing a morcellating tool on the tissue contact surface.
摘要翻译：一种改进的光纤，包括具有输入的波导，所述输入用于将聚焦的激光能量耦合到所述波导中并将传播方向上的电磁辐射传送到所述波导的内反射尖端，组织接触表面，其中从所述反射表面到所述透射表面基本上具有均匀的折射率并且通过流体流冷却。在使侧光路径内的折射率的变化最小化的同时，在组织接触表面的正下方提供主动冷却的同时，本发明可防止内部反射和光束变形，并大大提高了侧向引导探针的效率和耐久性。可以提供组织接触表面围绕侧向末端的自由旋转，并且可以通过在组织接触表面上设置一个脱毛工具来改善组织蒸发效率。

4. 发明授权

US5562657A Side fire laser catheter method and apparatus 失效
标题翻译：侧火激光导管法及装置
公开(公告)号：US5562657A
公开(公告)日：1996-10-08
申请号：US308369
申请日：1994-09-19
申请人： Stephen E. Griffin
发明人： Stephen E. Griffin
IPC分类号： A61B18/22 , A61B18/24 , A61B17/32
CPC分类号： A61B18/245 , A61B2018/2266 , A61B2018/2272
摘要： Side fire laser catheter apparatus includes a fiberoptic element having a bevelled tip fused to a cap. A secondary reflector may be disposed adjacent to the fiberoptic element as fused to the cap for reflecting any axial transmission outwardly through the cap. A lensed flat may be provided on the cap through which the laser beam is reflected to control the scattering of the light energy from the laser.
摘要翻译：侧火激光导管装置包括光纤元件，该光纤元件具有与顶盖融合的倾斜尖端。次级反射器可以邻近光纤元件设置成与盖接合，以将任何轴向透射体向外反射通过盖。透镜平面可以设置在帽上，激光束通过该平面反射以控制来自激光器的光能的散射。

5. 发明授权

US5512078A Apparatus for making linearly tapered bores in quartz tubing with a controlled laser 失效
标题翻译：用于在具有受控激光的石英管中制造线性锥形孔的装置
公开(公告)号：US5512078A
公开(公告)日：1996-04-30
申请号：US217696
申请日：1994-03-24
申请人： Stephen E. Griffin
发明人： Stephen E. Griffin
IPC分类号： C03B23/057 , C03B23/207 , G02B6/28 , G02B6/38 , C03B15/14
CPC分类号： G02B6/3803 , C03B23/057 , C03B23/207 , G02B6/2804
摘要： Method and apparatus for providing a linearly tapered bore in quartz/glass tubing includes a laser and elements for focusing the laser onto the glass tubing. The glass/quartz tubing is rotated in the laser beam and is moved vertically in the laser beam to provide a linear taper in the interior bore. The power of the laser beam is controlled and the laser beam is appropriately focused by a lens to provide a desired width of the beam at the glass/quartz tubing.
摘要翻译：用于在石英/玻璃管中提供线性锥形孔的方法和装置包括激光器和用于将激光聚焦到玻璃管上的元件。玻璃/石英管在激光束中旋转并且在激光束中垂直移动以在内孔中提供线性锥形。控制激光束的功率，激光束被透镜适当地聚焦，以在玻璃/石英管提供所需光束的宽度。

6. 发明申请

US20120034688A1 True nucleic acid amplification 审中-公开
标题翻译：真核酸扩增
公开(公告)号：US20120034688A1
公开(公告)日：2012-02-09
申请号：US12806012
申请日：2010-08-04
申请人： Stephen E. Griffin
发明人： Stephen E. Griffin
IPC分类号： C12M1/00
CPC分类号： B01L7/525 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2300/1872 , B01L2300/1883 , C12P19/34 , C12Q1/686
摘要： A system and method directed to DNA amplification with optional in situ purification, sequencing and/or detection, or a system compatible with integrated, post-amplification purification and or sequencing by capillary electrophoresis and other methods. The device is a single, helical channel formed of fused silica with heat zones defined about fixed arcs of the helix inner and/or outer circumference. The length of the helical channel and the cycle number and dwell time may be varied by altering the pitch of the helix within the cylindrical substrate. In another embodiment, the heat zone arcs lengths are also variable. In still another embodiment, multiple helical channels are available in parallel within the same structure. Separation channels may be integrated on the device for post-amplification purification and/or sequencing. One or more detection schemes may be provided on the device or seamlessly integrated with the device, for monitoring amplification and/or detecting specific products.
摘要翻译：用于任选的原位纯化，测序和/或检测的针对DNA扩增的系统和方法，或与通过毛细管电泳和其他方法的综合，扩增后纯化和/或测序兼容的系统。该装置是由熔融二氧化硅形成的单个螺旋通道，其具有限定在螺旋内部和/或外周的固定弧的加热区域。螺旋通道的长度和循环数和停留时间可以通过改变圆柱形衬底内螺旋的间距来改变。在另一个实施例中，加热区弧的长度也是可变的。在另一个实施例中，多个螺旋通道在同一结构内可以并联使用。分离通道可以整合在器件上用于后期扩增纯化和/或测序。可以在设备上提供一个或多个检测方案或与设备无缝集成，用于监视放大和/或检测特定产品。

7. 发明授权

US08285097B2 Annular side fire optical device for laterally redirecting electromagnetic radiation 有权
标题翻译：用于横向重定向电磁辐射的环形侧面火光装置
公开(公告)号：US08285097B2
公开(公告)日：2012-10-09
申请号：US12517883
申请日：2007-12-06
申请人： Stephen E. Griffin
发明人： Stephen E. Griffin
IPC分类号： G02B6/04 , G02B6/06 , A61B18/18
CPC分类号： A61B18/24 , A61B2018/2238 , A61B2018/2266 , A61B2018/2272 , G02B6/02 , G02B6/04 , Y10T29/49826
摘要： An annular side fire optical device for laterally redirecting electromagnetic radiation comprises a tapered section of silica, a conical section of silica adjoining the tapered section and an annular beveled end surface. The tapered section of silica has a diameter that increases with distance along a longitudinal axis in a direction toward a transmitting end. The conical section of silica comprises a wall of silica surrounding a conical bore. The conical bore has a diameter that increases with distance along the longitudinal axis in a direction toward the transmitting end. The annular beveled end surface is formed in the wall of silica at the transmitting end and is angled relative the longitudinal axis such that electromagnetic radiation propagating along the longitudinal axis through the conical section is reflected by the beveled end surface at an angle that is transverse to the longitudinal axis.
摘要翻译：用于横向重定向电磁辐射的环形侧面火光光学装置包括二氧化硅的锥形部分，与锥形部分相邻的二氧化硅锥形部分和环形斜面端面。二氧化硅的锥形部分的直径随着朝向发射端的方向上的纵向轴线的距离而增加。二氧化硅的锥形部分包括围绕圆锥孔的二氧化硅壁。锥形孔具有沿着纵向轴线朝向发射端的方向的距离而增加的直径。环形斜面端表面形成在发射端处的二氧化硅壁上，并且相对于纵向轴线成角度，使得沿着纵向轴线穿过圆锥形部分传播的电磁辐射由斜面端面以横向于纵轴。

8. 发明授权

US08073297B2 Side fire optical device for laterally redirecting high power electromagnetic energy 有权
标题翻译：用于横向重定向高功率电磁能的侧火光学装置
公开(公告)号：US08073297B2
公开(公告)日：2011-12-06
申请号：US12517879
申请日：2007-12-06
申请人： Stephen E. Griffin
发明人： Stephen E. Griffin
IPC分类号： G02B6/32 , B23P11/00 , A61B5/00 , A61B18/18
CPC分类号： A61B18/24 , A61B2018/2238 , A61B2018/2266 , A61B2018/2272 , G02B6/02 , G02B6/04 , Y10T29/49826
摘要： A side fire optical device comprises a cap member, a sleeve and a fiber optic segment. The cap member comprises a closed end section, a tube section having a bore, and a transmitting surface. The sleeve is received within the bore of the tube section. The sleeve includes a bore and an exterior surface that is fused to a surface of the bore of the cap member. The fiber optic segment comprises an exterior surface that is fused to a surface of the bore of the sleeve, and a beveled end surface that is positioned adjacent the transmitting surface of the cap member. The beveled end surface is angled relative to a longitudinal axis of the fiber optic segment such that electromagnetic radiation propagating along the longitudinal axis of the fiber optic segment is reflected by the beveled end surface at an angle that is transverse to the longitudinal axis and through the transmitting surface of the cap member.
摘要翻译：侧火光学装置包括盖构件，套筒和光纤段。盖构件包括封闭端部分，具有孔的管部分和透射表面。套管被容纳在管部分的孔内。套筒包括孔和外表面，该外表面与盖构件的孔的表面熔合。光纤部分包括熔合到套筒的孔的表面的外表面和邻近盖构件的透射表面定位的倾斜的端面。斜面端表面相对于光纤段的纵向轴线成角度，使得沿着光纤段的纵向轴线传播的电磁辐射被倾斜端面以横向于纵向轴线的角度反射，并通过盖部件的透光面。

9. 发明申请

US20110002584A1 ANNULAR SIDE FIRE OPTICAL DEVICE FOR LATERALLY REDIRECTING ELECTROMAGNETIC RADIATION 有权
标题翻译：用于横向重定向电磁辐射的环形侧消防光学装置
公开(公告)号：US20110002584A1
公开(公告)日：2011-01-06
申请号：US12517883
申请日：2007-12-06
申请人： Stephen E. Griffin
发明人： Stephen E. Griffin
IPC分类号： G02B6/26 , G02B6/10
CPC分类号： A61B18/24 , A61B2018/2238 , A61B2018/2266 , A61B2018/2272 , G02B6/02 , G02B6/04 , Y10T29/49826
摘要： An annular side fire optical device for laterally redirecting electromagnetic radiation comprises a tapered section of silica, a conical section of silica adjoining the tapered section and an annular beveled end surface. The tapered section of silica has a diameter that increases with distance along a longitudinal axis in a direction toward a transmitting end. The conical section of silica comprises a wall of silica surrounding a conical bore. The conical bore has a diameter that increases with distance along the longitudinal axis in a direction toward the transmitting end. The annular beveled end surface is formed in the wall of silica at the transmitting end and is angled relative the longitudinal axis such that electromagnetic radiation propagating along the longitudinal axis through the conical section is reflected by the beveled end surface at an angle that is transverse to the longitudinal axis.
摘要翻译：用于横向重定向电磁辐射的环形侧面火光光学装置包括二氧化硅的锥形部分，与锥形部分相邻的二氧化硅锥形部分和环形斜面端面。二氧化硅的锥形部分的直径随着朝向发射端的方向上的纵向轴线的距离而增加。二氧化硅的锥形部分包括围绕圆锥孔的二氧化硅壁。锥形孔具有沿着纵向轴线朝向发射端的方向的距离而增加的直径。环形斜面端表面形成在发射端处的二氧化硅壁上，并且相对于纵向轴线成角度，使得沿着纵向轴线穿过圆锥形部分传播的电磁辐射被倾斜的端面以横向于纵轴。

10. 发明授权

US07699535B2 High energy fiber terminations and methods 有权
标题翻译：高能纤维终端和方法
公开(公告)号：US07699535B2
公开(公告)日：2010-04-20
申请号：US12002464
申请日：2007-12-17
申请人： Stephen E. Griffin
发明人： Stephen E. Griffin
IPC分类号： G02B6/36
CPC分类号： G02B6/3835 , G02B6/3813 , G02B6/3855 , G02B6/4296
摘要： A ferrule and method are presented that fuses optical fibers, capillaries and the like to ferrules while reducing deformation of the fused component and the ferrule and minimizing stresses within the assembly. Reduced deformation and stress is accomplished by providing high contact angles in a symmetrical, short section of fusion in fusing the component carried by the ferrule to the ferrule. It is particularly applicable to hermetic terminations of polymer clad fiber optics where irregular glass fusion joints cause irregular light leakage at the fiber launch but benefits are significant when used for other fiber and capillary architectures as well.
摘要翻译：提出了一种套管和方法，其将光纤，毛细管等融合到套圈上，同时减少熔化部件和套圈的变形并使组件内的应力最小化。通过在对称短的熔融部分中提供高接触角来将由套圈承载的部件熔合到套圈上来实现减小的变形和应力。特别适用于聚合物包覆光纤的密封端子，其中不规则的玻璃熔合接头在纤维发射时引起不规则的光泄漏，但是当用于其它纤维和毛细管结构时，益处也是显着的。

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