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101. 发明授权

US06344351B2 (R)-transaminase from arthrobacter 失效
标题翻译：（R） - 转氨酶
公开(公告)号：US06344351B2
公开(公告)日：2002-02-05
申请号：US09794359
申请日：2001-02-28
申请人： Yukio Yamada , Akira Iwasaki , Noriyuki Kizaki , Yasuhiro Ikenaka , Masahiro Ogura , Junzo Hasegawa
发明人： Yukio Yamada , Akira Iwasaki , Noriyuki Kizaki , Yasuhiro Ikenaka , Masahiro Ogura , Junzo Hasegawa
IPC分类号： C12N910
CPC分类号： C12P13/001 , C12N9/1096 , C12P13/005 , C12P13/008 , C12P13/04 , C12P41/006 , Y10S435/83
摘要： The method for preparing an optically active (R)-amino compound characterized by the method comprising stereoselectively carrying out amino group transfer by action of an (R)-form-specific transaminase in the co-presence of a ketone compound (amino acceptor), and an amino compound (amino donor) of a racemic form or an (R)-form, to give an optically active (R)-amino compound. According to the present invention, it is made possible to easily prepare at a high yield the optically active (R)-amino compounds and the like having an aryl group and the like at their 1-position, which have been conventionally difficult to prepare.
摘要翻译：制备光学活性（R） - 氨基化合物的方法，其特征在于在酮化合物（氨基受体）的共存下通过（R） - 形式 - 特异性转氨酶的作用立体选择性地进行氨基转移的方法，和外消旋形式的氨基化合物（氨基供体）或（R） - 形式，得到光学活性（R） - 氨基化合物。根据本发明，可以容易地容易地制备其1-位上具有芳基等的光学活性（R） - 氨基化合物等，其通常难以制备。

102. 发明授权

US6083008A Optical phantom of living body and method for producing it 失效
标题翻译：活体光学幻影及其制作方法
公开(公告)号：US6083008A
公开(公告)日：2000-07-04
申请号：US145227
申请日：1998-09-01
申请人： Yukio Yamada , Yukari Tanikawa , Shuichi Takahashi , Daigo Imai
发明人： Yukio Yamada , Yukari Tanikawa , Shuichi Takahashi , Daigo Imai
IPC分类号： G09B23/28
CPC分类号： G09B23/286 , A61B2560/0233
摘要： An optical phantom of a living body includes a multiplicity of phantom layers shaped to the contours of a target part of a living body. A space portion is provided at a prescribed location inside the phantom. Inlet and outlet conduits enable liquid phantom to be supplied to the space portion and removed therefrom. This arrangement enables the space portion to be used to simulate dynamic change of physiological states, and for such changes to be measured optically.
摘要翻译：活体的光学体模具有多个形状为活体的目标部位的轮廓的假想层。空间部分设置在体模内部的规定位置。入口和出口管道使得液体体模能够被供应到空间部分并从中移除。这种布置使得空间部分能够用于模拟生理状态的动态变化，并且对于这种变化进行光学测量。

103. 外观设计

USD423212S Case for a video camera 失效
公开(公告)号：USD423212S
公开(公告)日：2000-04-25
申请号：US85682
申请日：1998-03-27
申请人： Nobumasa Sakurai , Yukio Yamada
设计人： Nobumasa Sakurai , Yukio Yamada

104. 发明授权

US5962279A Process for producing D-amino acids with composite immobilized enzyme preparation 失效
标题翻译：用复合固定化酶制剂生产D-氨基酸的方法
公开(公告)号：US5962279A
公开(公告)日：1999-10-05
申请号：US596144
申请日：1996-08-16
申请人： Hirokazu Nanba , Yukio Yamada , Kazuyoshi Yajima , Masayuki Takano , Yasuhiro Ikenaka , Satomi Takahashi , Takehisa Ohashi
发明人： Hirokazu Nanba , Yukio Yamada , Kazuyoshi Yajima , Masayuki Takano , Yasuhiro Ikenaka , Satomi Takahashi , Takehisa Ohashi
IPC分类号： C12P13/04 , C12P41/00 , C12N11/00
CPC分类号： C12P13/04 , C12P41/009
摘要： A process for the efficient production of a D-amino acid from the corresponding DL-5-substituted hydantoin by one-step reaction which comprises using a composite immobilized enzyme at a pH about neutrality, said composite immobilized enzyme being obtained by immobilizing a hydantoinase having its optimal pH within an alkaline range and a D-N-carbamyl-.alpha.-amino acid amidohydrolase having its optimal pH about neutrality in a coexisting state on an immobilizing support, simultaneously, is disclosed.
摘要翻译： PCT No.PCT / JP95 / 01257第 371日期：1996年8月16日 102（e）日期1996年8月16日PCT提交1995年6月23日PCT公布。公开号WO96 / 00296 日期1996年1月4日一种通过一步反应从相应的DL-5-取代的乙内酰脲有效生产D-氨基酸的方法，其包括在pH约为中性的情况下使用复合固定化酶，所述复合固定化酶得到通过将其最佳pH在碱性范围内的乙内酰脲固定化，并且同时具有在共存状态下具有最佳pH约中性的DN-氨基甲酰-α-氨基酸酰胺水解酶。

105. 发明授权

US5863785A Decarbamylase isolated from comamonas or blastobacter 失效
标题翻译：从comamonas或blastobacter分离的脱氨基甲酰酶
公开(公告)号：US5863785A
公开(公告)日：1999-01-26
申请号：US479639
申请日：1995-06-07
申请人： Hideaki Yamada , Sakayu Shimizu , Yasuhiro Ikenaka , Kazuyoshi Yajima , Yukio Yamada , Hirokazu Nanba , Masayuki Takano , Satomi Takahashi
发明人： Hideaki Yamada , Sakayu Shimizu , Yasuhiro Ikenaka , Kazuyoshi Yajima , Yukio Yamada , Hirokazu Nanba , Masayuki Takano , Satomi Takahashi
IPC分类号： C12P13/04 , C12P41/00 , C12N9/78 , C12N9/80
CPC分类号： C12P13/04 , C12P41/009 , Y10S435/874 , Y10S435/911
摘要： In a process for the production of a D-.alpha.-amino acid, in which an N-carbamyl-D-.alpha.-amino acid corresponding to the general formula: ##STR1## wherein R represents phenyl, hydroxy-substituted phenyl, substituted or unsubstituted alkyl, or thienyl, is converted by a microbial enzyme in an aqueous medium to a D-.alpha.-amino acid corresponding to the general formula: ##STR2## wherein R is the same as defined above, decarbamylase produced by a microorganism of the genus Comamonas, Blastobacter, Alcaligenes, Sporosarcina, Rhizobium, Bradyrhizobium or Arthrobacter is used as the enzyme converting the N-carbamyl-D-.alpha.-amino acid to the D-.alpha.-amino acid.The conversion of the N-carbamyl-D-.alpha.-amino acids to the D-.alpha.-amino acids is carried out in a neutral to alkaline pH range.
摘要翻译：在制备D-α-氨基酸的方法中，其中相应于通式为：苯基，取代或未取代的烷基或噻吩基的N-氨基甲酰基-D-α-氨基酸被转化通过微生物酶在水性介质中与对应于以下通式的D-α-氨基酸反应：其中R与上述定义相同，由Comamonas属，Blastobacter，Alcaligenes，Sporosarcina属的微生物产生的脱氨基甲酰酶，使用根瘤菌，Bradyrhizobium或节杆菌作为将N-氨基甲酰基-D-α-氨基酸转化为D-α-氨基酸的酶。 N-氨基甲酰基-D-α-氨基酸向D-α-氨基酸的转化在中性至碱性pH范围内进行。

106. 发明授权

US5035597A Apparatus for manufacturing multi-element sintered material 失效
标题翻译：多元件烧结材料制造装置
公开(公告)号：US5035597A
公开(公告)日：1991-07-30
申请号：US611438
申请日：1990-11-02
申请人： Shoji Tanaka , Hisao Yamauchi , Yukio Yamada , Masayoshi Ohnuki , Etsuji Morita , Mitsunobu Toyoshima , Yasuo Wada , Hirotaka Hinoshita , Wataru Ikeda , Etsuji Aihara , Tutomu Kobayashi , Kuniaki Suguro
发明人： Shoji Tanaka , Hisao Yamauchi , Yukio Yamada , Masayoshi Ohnuki , Etsuji Morita , Mitsunobu Toyoshima , Yasuo Wada , Hirotaka Hinoshita , Wataru Ikeda , Etsuji Aihara , Tutomu Kobayashi , Kuniaki Suguro
IPC分类号： B28B13/00 , B28B15/00 , B28B17/02 , B30B15/30 , C04B35/45 , F27D3/00 , F27D5/00 , F27D19/00 , F27D21/00
CPC分类号： C04B35/45 , B28B13/00 , B28B15/00 , B28B17/026 , B30B15/302 , F27D3/00 , F27D2003/0043 , F27D2003/0063 , F27D2019/009 , F27D21/0035 , F27D5/0068 , F27M2003/04
摘要： An apparatus for manufacturing a multielement sintered material is provided, more particularly an appartus of the automated type which weighs and mixes predetermined amounts of powdery elements, molds the mixed elements and then sinters them.
摘要翻译：本发明提供一种多元烧结材料的制造装置，更具体地说，是将预定量的粉末状元素重量混合的自动化类型，对混合元素进行成型，然后烧结。

107. 发明授权

US4945390A Image-forming apparatus 失效
标题翻译：图像形成装置
公开(公告)号：US4945390A
公开(公告)日：1990-07-31
申请号：US357021
申请日：1989-05-25
申请人： Hirofumi Hasegawa , Hiroaki Kojima , Yasuhiro Matsuura , Naoto Ohmori , Yukio Yamada
发明人： Hirofumi Hasegawa , Hiroaki Kojima , Yasuhiro Matsuura , Naoto Ohmori , Yukio Yamada
IPC分类号： B65H29/60 , B65H31/00 , B65H31/22 , G03G15/00
CPC分类号： G03G15/6552
摘要： An image-forming apparatus comprises a machine body and a paper discharge unit removably attached to the machine body. The machine body defines a face-down discharge tray on top. The paper discharge unit includes a face-up discharge tray and a discharge roller pair. A switch lever is provided in the machine body for selecting between a state in which recording paper is turned over for discharge onto the face-down discharge tray, and a second state in which the recording paper is discharged face up onto the face-up discharge tray.
摘要翻译：图像形成装置包括可拆卸地附接到机体的机体和排纸单元。机器主体在顶部限定了一个面朝下的排放托盘。排纸单元包括面朝上排出托盘和排出辊对。在机体中设置开关杆，用于在记录纸翻转状态之间选择排放到面朝下排出托盘上的第二状态和记录纸面向上排放到面朝上排出口上的第二状态托盘。

108. 发明授权

US4916480A Image forming apparatus with use of a laser beam 失效
标题翻译：使用激光束的图像形成装置
公开(公告)号：US4916480A
公开(公告)日：1990-04-10
申请号：US373990
申请日：1989-06-29
申请人： Hirofumi Hasegawa , Naoto Ohmori , Yukio Yamada , Narutaka Yoshida
发明人： Hirofumi Hasegawa , Naoto Ohmori , Yukio Yamada , Narutaka Yoshida
IPC分类号： G03B27/54 , G03G15/04 , G03G15/22 , H04N1/00 , H04N1/10
CPC分类号： H04N1/1008 , G03B27/542 , G03G15/04018 , G03G15/221 , H04N1/00254
摘要： An image forming apparatus comprising a laser beam radiating unit utilized as a light source, and an optical system that the surface of an original reflects a laser beam radiated from the radiating unit to project an image reflected from the original onto a photosensitive member. In this apparatus, an image is formed selectively in a print mode that an image results from turning on and off the laser beam, in a copy mode that a copy of an original results from exposure of the photosensitive member to the laser beam reflected from the surface of an original or in a composite mode that a composite image is formed of a copy of an original and an image resulting from turning on and off the laser beam. Further, this apparatus comprises a sensor for receiving the laser beam reflected from the surface of an original, and the image of an original and composite image are read by the sensor.
摘要翻译：一种图像形成装置，包括用作光源的激光束照射单元，以及原始表面反射从辐射单元辐射的激光束以将从原稿反射的图像突出到感光构件上的光学系统。在该装置中，以复印模式选择性地以打印和关闭激光束的图像形成的图像形成图像，其中原稿的拷贝是由感光元件的曝光引起的，原稿的表面或复合模式，合成图像由原稿的副本和从打开和关闭激光束产生的图像形成。此外，该装置包括用于接收从原件的表面反射的激光束的传感器，并且由传感器读取原始和合成图像的图像。

109. 发明授权

US4812406A Process for preparing optically active hydantoins 失效
标题翻译：制备光学活性乙内酰脲的方法
公开(公告)号：US4812406A
公开(公告)日：1989-03-14
申请号：US775090
申请日：1985-09-12
申请人： Satomi Takahashi , Yukio Yamada , Yasuyoshi Ueda , Yasuhiro Katayama , Yoshio Shimada , Kiyoshi Watanabe
发明人： Satomi Takahashi , Yukio Yamada , Yasuyoshi Ueda , Yasuhiro Katayama , Yoshio Shimada , Kiyoshi Watanabe
IPC分类号： C07D233/72 , C07D233/74 , C07D311/68 , C07D317/60 , C07D405/06 , C07D491/10 , C12P17/02 , C12P17/10 , C12P17/18 , C12P41/00 , C12R1/01 , C12R1/07 , C12R1/15 , C12R1/365 , C12P13/04
CPC分类号： C07D405/06 , C07D233/74 , C07D311/68 , C07D317/60 , C07D491/10 , C12P17/02 , C12P17/10 , C12P17/18 , C12P41/009
摘要： A process for preparing optically active hydantoins having the general formula (II): ##STR1## wherein R.sup.1 and R.sup.2, which are different from each other, are independently alkyl group, aralkyl group, aryl group, substituted alkyl group, substituted aralkyl group, or substituted aryl group, or R.sup.1 and R.sup.2 form an asymmetric cyclic compound, characterized in that one configuration of racemic N-carbamoyl-.alpha.-amino acid having the general formula (I): ##STR2## wherein R.sup.1 and R.sup.2 are as above, is enzymatically converted into the corresponding hydantoins.The present invention provides a process for an optical resolution with a high efficiency which can be used for the synthesis of (S)-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione (USAN; Sorbinil), which is an optically active hydrantoins attracting public attention as a preventive or a remedy for the particular chronic symptoms of diabetes such as cataract and neuropathy, and (S)-.alpha.-methyl-3,4-dihydroxyphenylalanine (L-methyldopa), which is an optically active amino acid widely used as antihypertensives. Further, the present invention provides a novel finding that N-carbamoyl-.alpha.-amino acid having no hydrogen atom on its .alpha.-carbon atom can be biochemically converted into hydantoins by an enzymatic cyclization reaction.
摘要翻译：制备具有通式（II）的光学活性乙内酰脲的方法：其中R1和R2彼此不同，其独立地为烷基，芳烷基，芳基，取代的烷基，取代的芳烷基基团或取代的芳基，或R 1和R 2形成不对称环状化合物，其特征在于具有通式（I）的外消旋N-氨基甲酰基-α-氨基酸的一种构型：其中R1和R2 如上所述，被酶转化成相应的乙内酰脲。本发明提供了可用于（S）-6-氟 - 螺 - [苯并二氢吡喃-4,4'-咪唑烷] -2'，5'-二酮的合成的高效光学拆分方法。（USAN; Sorbinil）是一种光学活性的水解素，引起公众的注意，作为预防或治疗糖尿病的特殊慢性症状如白内障和神经病，以及（S）-α-甲基-3,4-二羟基苯丙氨酸（L 甲基多巴），其是广泛用作抗高血压药物的光学活性氨基酸。此外，本发明提供了一种新的发现，其α-碳原子上不具有氢原子的N-氨基甲酰基-α-氨基酸可以通过酶环化反应生物化学转化成乙内酰脲。

110. 发明授权

US4492975A Gate turn-off thyristor stack 失效
标题翻译：门极关断晶闸管叠层
公开(公告)号：US4492975A
公开(公告)日：1985-01-08
申请号：US396377
申请日：1982-07-08
申请人： Yukio Yamada , Hiroshi Itahana , Hisashi Kuwana
发明人： Yukio Yamada , Hiroshi Itahana , Hisashi Kuwana
IPC分类号： H01L25/10 , H01L25/11 , H01L25/18 , H02M7/00 , H02M7/155 , H02M7/521 , H01L23/32 , H01L23/42 , H01L25/04 , H03K17/60
CPC分类号： H01L25/18 , H01L25/117 , H02M7/003 , H02M7/521 , H01L2924/0002 , H01L2924/3011
摘要： A GTO thyristor stack comprises a pair of GTO thyristors in parallel connection and a pair of diodes in anti-parallel connection therewith. The elements in one of the GTO thyristor pair and the diode pair are located in the middle of the stack structure and sandwiched by the elements in the other with all the elements stacked in electrical connection. The stack structure is clamped by a pair of clamper members.
摘要翻译： GTO晶闸管堆叠包括并联的一对GTO晶闸管和与其并联连接的一对二极管。 GTO晶闸管对和二极管对之一中的元件位于堆叠结构的中间，并且被所有元件以电连接堆叠在另一个元件中。堆叠结构由一对夹持构件夹紧。

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