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1. 发明授权

US5089516A 1-phenyl-3,5-pyrazolidinedione hydroxystyrene compounds which have tyrosine kinase inhibiting activity 失效
标题翻译：具有酪氨酸激酶抑制活性的1-苯基-3,5-二异氰酸酯化羟基苯乙烯化合物
公开(公告)号：US5089516A
公开(公告)日：1992-02-18
申请号：US584683
申请日：1990-09-19
申请人： Tadayoshi Shiraishi , Keiji Kameyama , Takeshi Domoto , Naohiro Imai , Yoshio Shimada , Yutaka Ariki , Kazunori Hosoe , Masaji Kawatsu , Ikuo Katsumi , Takayoshi Hidaka , Kiyoshi Watanabe
发明人： Tadayoshi Shiraishi , Keiji Kameyama , Takeshi Domoto , Naohiro Imai , Yoshio Shimada , Yutaka Ariki , Kazunori Hosoe , Masaji Kawatsu , Ikuo Katsumi , Takayoshi Hidaka , Kiyoshi Watanabe
IPC分类号： A61K31/425 , C07C255/34 , C07D207/38 , C07D209/34 , C07D231/36 , C07D277/20 , C07D277/36 , C07D277/54 , C07D279/16 , C07D307/58 , C07D417/12 , A61K31/415 , C07D231/04
CPC分类号： C07D277/20 , C07C255/00 , C07C255/34 , C07D207/38 , C07D209/34 , C07D231/36 , C07D277/36 , C07D277/54 , C07D279/16 , C07D307/58 , C07D417/12
摘要： A hydroxystyrene derivative represented by the formula (I): ##STR1## wherein when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : H, a C.sub.1 to C.sub.5 alkyl group or benzyl group) and R.sup.2 : benzyl group or PhSCH.sub.2, R.sup.3 and R.sup.4 are taken together to represent --CONH--CS--S--, ##STR2## (X.sup.1 : H, a halogen, methyl group, ethyl group, R.sup.7 O-- (R.sup.7 : methyl or ethyl group), nitro group, aminosulfonyl group or amino group, m.sup.1 : 1 or 2), pyridyl group, furyl group or thienyl group, n.sup.1 : an integer of 0 to 3); when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : as defined above) and R.sup.2 : benzyl group, R.sup.3 : cyano group and R.sup.4 : a carbamoyl group, or R.sup.3 and R.sup.4 are taken together to represent --CO--Y--CH.sub.2 CH.sub.2 -- (Y: O or --NH--) or ##STR3## and when R.sup.1 and R.sup.2 : a C.sub.1 to C.sub.3 alkyl group, R.sup.3 and R.sup.4 are taken together to represent ##STR4## (n.sup.1, R.sup.6 : as defined above), or a salt thereof. The hydroxystyrene derivative or a salt thereof is a compound which is useful as an active ingredient of an antiallergic agent, a 5-lipoxygenase inhibiting agent, an antibacterial agent, a tyrosine kinase inhibiting agent, an ultraviolet absorber or a reverse transcriptase inhibiting agent, and also is useful as an intermediate for preparing various organic compounds.

2. 发明授权

US4971996A Hydroxystyrene compounds which are useful as tyrosine kinase inhibitors 失效
标题翻译：可用作酪氨酸激酶抑制剂的羟基苯乙烯化合物
公开(公告)号：US4971996A
公开(公告)日：1990-11-20
申请号：US283992
申请日：1988-11-10
申请人： Tadayoshi Shiraishi , Keiji Kameyama , Takeshi Domoto , Naohiro Imai , Yoshio Shimada , Yutaka Ariki , Kazunori Hosoe , Masaji Kawatsu , Ikuo Katsumi , Takayoshi Hidaka , Kiyoshi Watanabe
发明人： Tadayoshi Shiraishi , Keiji Kameyama , Takeshi Domoto , Naohiro Imai , Yoshio Shimada , Yutaka Ariki , Kazunori Hosoe , Masaji Kawatsu , Ikuo Katsumi , Takayoshi Hidaka , Kiyoshi Watanabe
IPC分类号： B21B31/16 , A61K31/26 , A61K31/27 , A61K31/275 , A61K31/34 , A61K31/425 , B21B31/02 , B21B31/20 , B21B33/00 , B21B37/18 , B21B37/72 , C07C253/30 , C07C255/34 , C07C255/41 , C07C255/44 , C07C255/53 , C07D207/38 , C07D209/34 , C07D231/36 , C07D277/20 , C07D277/36 , C07D277/54 , C07D279/16 , C07D307/32 , C07D307/33 , C07D307/52 , C07D307/58 , C07D417/12 , C09K3/00
CPC分类号： C07D277/20 , B21B31/02 , B21B31/203 , C07C255/00 , C07C255/34 , C07D207/38 , C07D209/34 , C07D231/36 , C07D277/36 , C07D277/54 , C07D279/16 , C07D307/58 , C07D417/12
摘要： A hydroxystyrene derivative represented by the formula (I): ##STR1## wherein when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : H, a C.sub.1 to C.sub.5 alkyl group or benzyl group) and R.sup.2 : benzyl group or PhSCH.sub.2, R.sup.3 and R.sup.4 are taken together to represent --CONH--CS--S--, ##STR2## (X.sup.1 : H, a halogen, methyl group, ethyl group, R.sup.7 O-- (R.sup.7 : methyl or ethyl group), nitro group, aminosulfonyl group or amino group, m.sup.1 : 1 or 2), pyridyl group, furyl group or thienyl group, n.sup.1 : an integer of 0 to 3); when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : as defined above) and R.sup.2 : benzyl group, R.sup.3 : cyano group and R.sup.4 : a carbamoyl group, or R.sup.3 and R.sup.4 are taken together to represent --CO--Y--CH.sub.2 CH.sub.2 -- (Y: O or --NH--) or ##STR3## and when R.sup.1 and R.sup.2 : a C.sub.1 to C.sub.3 alkyl group, R.sup.3 and R.sup.4 are taken together to represent ##STR4## (n.sup.1, R.sup.6 : as defined above), or a salt thereof. The hydroxystyrene derivative or a salt thereof is a compound which is useful as an active ingredient of an antiallergic agent, a 5-lipoxygenase inhibiting agent, an antibacterial agent, a tryosine kinase inhibiting agent, an ultraviolet absorber or a reverse transcriptase inhibiting agent, and also is useful as an intermediate for preparing various organic compounds.

3. 发明授权

US4713690A Sampling clock phase correction circuit of video signal 失效
标题翻译：视频信号采样时钟相位校正电路
公开(公告)号：US4713690A
公开(公告)日：1987-12-15
申请号：US912944
申请日：1986-09-29
申请人： Shinya Watanabe , Fumihiro Tanaka , Kaneo Yamaguchi , Yoshio Shimada , Kenichi Matsushima
发明人： Shinya Watanabe , Fumihiro Tanaka , Kaneo Yamaguchi , Yoshio Shimada , Kenichi Matsushima
IPC分类号： G06K15/12 , G06K15/00 , G09G5/12 , G09G5/18 , H03L7/00 , H04N1/40 , H04N5/04
CPC分类号： H03L7/00 , G06K15/00 , H04N1/40 , G06K2215/0091
摘要： A sampling clock phase correction circuit of video signal to keep stably a phase of a sampling clock to an image signal. A delayed signal of a video sync signal is employed for a reference signal of a sampling clock generation circuit. The delay quantity of the video sync signal is controlled to sample stably the video image signal according to the comparison and discrimination of a phase relation between a sampling clock signal and a video sync signal by a phase detection circuit and a CPU circuit. A precise phase correction where a characteristic change of circuit elements by a temperature drift or the like is compensated can be attained even for a high frequency video signal exceeding 100 MHz.
摘要翻译：视频信号的采样时钟相位校正电路，用于将采样时钟的相位稳定地保持在图像信号上。视频同步信号的延迟信号用于采样时钟发生电路的参考信号。根据相位检测电路和CPU电路对采样时钟信号和视频同步信号之间的相位关系的比较和判别，控制视频同步信号的延迟量，稳定地采样视频信号。即使对于超过100MHz的高频视频信号，也可以获得通过温度漂移等对电路元件的特性变化进行补偿的精确相位校正。

4. 发明授权

US4540992A Thermal color transfer system 失效
标题翻译：热转印系统
公开(公告)号：US4540992A
公开(公告)日：1985-09-10
申请号：US482953
申请日：1983-04-07
申请人： Murato Moteki , Yoshio Shimada , Fumihiro Tanaka , Fumio Watanabe , Kazuyuki Komatsu
发明人： Murato Moteki , Yoshio Shimada , Fumihiro Tanaka , Fumio Watanabe , Kazuyuki Komatsu
IPC分类号： B41J2/325 , G01D15/10 , B41J31/02 , G03G15/01
CPC分类号： B41J2/325
摘要： A multicolored thermal transfer copying system needs an ink film having more than three colors successively. The accurate copying is performed by driving the plural platens via one metal roller, when plural thermal heads are used for transferring each color from the ink film.
摘要翻译：多色热转印复印系统需要连续地具有多于三种颜色的墨膜。当使用多个热敏头用于从油墨膜转印每种颜色时，通过一个金属辊驱动多个压板来进行精确的复印。

5. 发明授权

US4194065A Process for producing coenzyme Q 失效
标题翻译：生产辅酶Q的方法
公开(公告)号：US4194065A
公开(公告)日：1980-03-18
申请号：US843214
申请日：1977-10-18
申请人： Yoshio Shimada , Keiichi Kagotani , Norio Noda , Hajime Kawaharada , Kiyoshi Watanabe
发明人： Yoshio Shimada , Keiichi Kagotani , Norio Noda , Hajime Kawaharada , Kiyoshi Watanabe
IPC分类号： C12P7/66 , C12R1/645 , C12R1/72 , C12R1/88 , C12D13/02
CPC分类号： C12P7/66 , Y10S435/818
摘要： A process is disclosed wherein yeast cells containing coenzyme Q in large quantities are efficiently produced by aerobically cultivating a yeast, in which maximum specific growth rate is not less than 0.15 hr.sup.-1 under optimum cultural conditions, in a nutrient medium in which said yeast can grow, while maintaining the dissolved oxygen concentration in the culture broth at not less than 2 ppm and controlling the average specific growth rate through the whole period of cultivation at not more than 0.1 hr.sup.-1, and coenzyme Q is recovered from the resulting yeast cells.
摘要翻译：公开了一种方法，其中含有大量辅酶Q的酵母细胞通过有氧培养在最佳培养条件下最大比生长速度不低于0.15hr-1的酵母，在所述酵母可以在其中的营养培养基中有效地产生生长，同时保持培养肉汤中的溶解氧浓度不低于2ppm，并且将整个培养时间的平均比生长速率控制在不超过0.1小时-1，并从所得酵母细胞中回收辅酶Q 。

6. 发明授权

US4780759A Sampling clock generation circuit of video signal 失效
标题翻译：视频信号采样时钟发生电路
公开(公告)号：US4780759A
公开(公告)日：1988-10-25
申请号：US912945
申请日：1986-09-29
申请人： Kenichi Matsushima , Fumihiro Tanaka , Yoshio Shimada , Kaneo Yamaguchi , Shinya Watanabe
发明人： Kenichi Matsushima , Fumihiro Tanaka , Yoshio Shimada , Kaneo Yamaguchi , Shinya Watanabe
IPC分类号： G06K15/12 , G09G5/12 , G09G5/18 , H03L7/08 , H03L7/081 , H03L7/18 , H04N5/14 , H04N5/91 , H04N5/932 , H04N11/04 , H04N7/08 , H04N7/093
CPC分类号： H03L7/081 , H04N5/14 , H04N5/932
摘要： A recording apparatus receives a video signal containing a horizontal sync signal and a data signal comprised of a given number of image bit data arranged within each horizontal scanning period, and stores the number of image bit data in synchronization with the horizontal sync signal. A voltage-controlled oscillator produces in synchronization with the horizontal sync signal a frequency signal having a frequency higher than that of the sync signal. A divider frequency-divides the frequency signal by a given factor to produce a number of sampling pulses corresponding to the given number of image bit data. A data sampling circuit receives the data signal for sampling therefrom the number of image bit data in response to the corresponding sampling pulses to thereby write the image bit data into memory. Another divider frequency-divides the frequency signal by the product of the given factor and the given number to produce a feedback signal. A comparator compares the phase of the feedback and sync signals with each other to produce a control signal effective to maintain the VCO to continuously produce the frequency signal synchronized with the horizontal sync signal.
摘要翻译：记录装置接收包含水平同步信号的视频信号和由在每个水平扫描周期内排列的给定数量的图像比特数据构成的数据信号，并且与水平同步信号同步地存储图像比特数据的数量。压控振荡器与水平同步信号同步产生频率高于同步信号频率的频率信号。分频器将频率信号除以给定的因子以产生对应于给定数量的图像比特数据的多个采样脉冲。数据采样电路响应于相应的采样脉冲接收用于从其中采样数据信号的数据信号，从而将图像位数据写入存储器。另一个分频器将频率信号除以给定因子与给定数量的乘积，产生反馈信号。比较器将反馈和同步信号的相位彼此进行比较，以产生有效地保持VCO以连续产生与水平同步信号同步的频率信号的控制信号。

7. 发明授权

US5846793A Microbial process for biotransformation to (R)-3-chloro-1,2-propanediol 失效
标题翻译：用于生物转化成（R）-3-氯-1,2-丙二醇的微生物过程
公开(公告)号：US5846793A
公开(公告)日：1998-12-08
申请号：US632663
申请日：1990-12-27
申请人： Hideyuki Takahashi , Satoru Tsuda , Yoshio Nakamura , Masahiro Ogura , Tadayoshi Shiraishi , Yoshio Shimada , Kiyoshi Watanabe
发明人： Hideyuki Takahashi , Satoru Tsuda , Yoshio Nakamura , Masahiro Ogura , Tadayoshi Shiraishi , Yoshio Shimada , Kiyoshi Watanabe
IPC分类号： C12P41/00 , C12R1/425 , C12R1/43 , C12P7/18
CPC分类号： C12P41/001
摘要： A process for preparing optically active (R)-3-chloro-1,2-propanediol, which comprises subjecting (R,S)-3-chloro-1,2-propanediol to the reaction of a microorganism belonging to genus Serratia in a reaction mixture, and then collecting the residual (R)-3-chloro-1,2-propanediol. According to the process of the present invention, (R)-3-chloro-1,2-propanediol can be efficiently prepared starting from low cost (R,S)-3-chloro-1,2-propanediol.
摘要翻译：一种制备光学活性（R）-3-氯-1,2-丙二醇的方法，其包括使（R，S）-3-氯-1,2-丙二醇在属于沙雷氏菌属的微生物的反应中反应混合物，然后收集残留的（R）-3-氯-1,2-丙二醇。根据本发明的方法，可以从低成本（R，S）-3-氯-1,2-丙二醇开始有效制备（R）-3-氯-1,2-丙二醇。

8. 发明授权

US5202341A Hydroxystyrene compounds having tyrosine kinase inhibiting activity 失效
标题翻译：具有酪氨酸激酶抑制活性的羟基苯乙烯化合物
公开(公告)号：US5202341A
公开(公告)日：1993-04-13
申请号：US735581
申请日：1991-07-25
申请人： Tadayoshi Shiraishi , Keiji Kameyama , Takeshi Domoto , Naohiro Imai , Yoshio Shimada , Yutaka Ariki , Kazunori Hosoe , Masaji Kawatsu , Ikuo Katsumi , Takayoshi Hidaka , Kiyoshi Watanabe
发明人： Tadayoshi Shiraishi , Keiji Kameyama , Takeshi Domoto , Naohiro Imai , Yoshio Shimada , Yutaka Ariki , Kazunori Hosoe , Masaji Kawatsu , Ikuo Katsumi , Takayoshi Hidaka , Kiyoshi Watanabe
IPC分类号： A61K31/26 , C07C255/34 , C07D207/38 , C07D209/34 , C07D231/36 , C07D277/20 , C07D277/36 , C07D277/54 , C07D279/16 , C07D307/58 , C07D417/12
CPC分类号： C07D277/20 , C07C255/00 , C07C255/34 , C07D207/38 , C07D209/34 , C07D231/36 , C07D277/36 , C07D277/54 , C07D279/16 , C07D307/58 , C07D417/12
摘要： A hydroxystyrene derivative represented by the formula (I): ##STR1## wherein when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O- (R.sup.5 : H, a C.sub.1 to C.sub.5 alkyl group or benzyl group) and R.sup.2 : benzyl group or PhSCH.sub.2, R.sup.3 and R.sup.4 are taken together to represent --CONH--CS--S--, ##STR2## (X.sup.1 : H, a halogen, methyl group, ethyl group, R.sup.7 O-- (R.sup.7 : methyl or ethyl group), nitro group, aminosulfonyl group or amino group, m.sup.1 : 1 or 2), pyridyl group, furyl group or thienyl group, n.sup.1 : an integer of 0 to 3); when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : as defined above) and R.sup.2 : benzyl group, R.sup.3 : cyano group and R.sup.4 : a carbamoyl group, or R.sup.3 and R.sup.4 are taken together to represent --CO--Y--CH.sub.2 CH.sub.2 -- (Y: O or --NH--) or ##STR3## and when R.sup.1 and R.sup.2 : a C.sub.1 to C.sub.3 alkyl group, R.sup.3 and R.sup.4 are taken together to represent ##STR4## (n.sup.1, R.sup.6 : as defined above), or a salt thereof. The hydroxystyrene derivative or a salt thereof is a compound which is useful as an active ingredient of an antiallergic agent, a 5-lipoxygenase inhibiting agent, an antibacterial agent, a tyrosine kinase inhibiting agent, an ultraviolet absorber or a reverse transcriptase inhibiting agent, and also is useful as an intermediate for preparing various organic compounds.
摘要翻译：由式（I）表示的羟基苯乙烯衍生物：其中当R1和R2：苯基，苄基或苯乙基或R1：R5O-（R5：H，C1-C5烷基或苄基基团）和R 2：苄基或PhSCH 2，R 3和R 4一起表示-CONH-CS-S-，或（X1：H，卤素，甲基，乙基，R7O-（ R7：甲基或乙基），硝基，氨基磺酰基或氨基，m1：1或2），吡啶基，呋喃基或噻吩基，n1：0〜3的整数）。当R1和R2：苯基，苄基或苯乙基或R1：R5O-（R5：如上定义）和R2：苄基，R3：氰基和R4：氨基甲酰基，或R3和R4合在一起表示-CO-Y-CH 2 CH 2 - （Y：O或-NH-）或，并且当R 1和R 2为C 1至C 3烷基时，R 3和R 4一起表示（n1，R6 ：如上所定义），或其盐。羟基苯乙烯衍生物或其盐是可用作抗变应性剂的活性成分，5-脂氧合酶抑制剂，抗菌剂，酪氨酸激酶抑制剂，紫外线吸收剂或逆转录酶抑制剂的化合物，以及也可用作制备各种有机化合物的中间体。

9. 发明授权

US5017484A Process for preparing 3-chloro-1,2-propanediol 失效
标题翻译：制备3-氯-1,2-丙二醇的方法
公开(公告)号：US5017484A
公开(公告)日：1991-05-21
申请号：US933822
申请日：1986-11-24
申请人： Yoshio Nakamura , Masahiro Ogura , Yoshio Shimada , Kiyoshi Watanabe , Hideyuki Takahashi
发明人： Yoshio Nakamura , Masahiro Ogura , Yoshio Shimada , Kiyoshi Watanabe , Hideyuki Takahashi
IPC分类号： C12P41/00
CPC分类号： C12P41/001 , Y10S435/822 , Y10S435/911
摘要： A process for preparing an optically active 3-chloro-1, 2-propanediol by employing microorganism which can selectively metabolize (R)- or (S)-3-chloro-1,2-propanediol. The decomposition rate of the substrate can be accelerated and the substrate concentration can be increased by adding a compound having SH group to the reaction solution.According to the process of the present invention, the optically active 3-chloro-1,2-propanediol can be easily prepared starting from low-cost (R,S)-3-chloro-1, 2-propanediol.
摘要翻译：一种通过使用可选择性代谢（R） - 或（S）-3-氯-1,2-丙二醇的微生物制备光学活性3-氯-1,2-丙二醇的方法。通过向反应溶液中加入具有SH基团的化合物，可以促进底物的分解速度，并且可以提高底物浓度。根据本发明的方法，可以从低成本（R，S）-3-氯-1,2-丙二醇开始容易地制备光学活性的3-氯-1,2-丙二醇。

10. 发明授权

US4925969A Process for preparing ethyl-alpha-amino-gamma-oxo-gamma-phenybutyrate derivatives 失效
标题翻译：制备乙基-γ-氨基-γ-氧代-γ-苯基丁酸酯衍生物的方法
公开(公告)号：US4925969A
公开(公告)日：1990-05-15
申请号：US324497
申请日：1989-03-16
申请人： Satomi Takahashi , Yasuyoshi Ueda , Kazuhiko Yamada , Yukio Yamada , Takehiko Yamane , Yoshifumi Yanagita , Yoshio Shimada , Kiyoshi Watanabe , Michio Nomura , Takehisa Ohashi , Kenji Inoue
发明人： Satomi Takahashi , Yasuyoshi Ueda , Kazuhiko Yamada , Yukio Yamada , Takehiko Yamane , Yoshifumi Yanagita , Yoshio Shimada , Kiyoshi Watanabe , Michio Nomura , Takehisa Ohashi , Kenji Inoue
IPC分类号： C07C227/08 , C07C233/46 , C07C271/06
CPC分类号： C07C233/46 , C07C227/08 , C07C271/06
摘要： Ethyl-.beta.-benzoyacrylate is reacted with an alkali metal salt of (S)-alanine or an alkali metal salt of N.sup.6 -trifluoroacetyl-L-lysine to form the corresponding Michael addition product, and not less than an equivalent amount of acid is added after completion of the Michael addition to prevent conversion of the (S,S) form of the product to the (R,S) form.
摘要翻译：乙基-β-苯甲酸酯与（S） - 丙氨酸的碱金属盐或N6-三氟乙酰基-L-赖氨酸的碱金属盐反应形成相应的迈克尔加成产物，加入不少于等量的酸完成迈克尔加成以防止（S，S）形式的产物转化为（R，S）形式。

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